NO970212L - Fremgangsmåte for fremstilling av enantiomerene av O-demetyltramadol - Google Patents

Fremgangsmåte for fremstilling av enantiomerene av O-demetyltramadol

Info

Publication number: NO970212L
Authority: NO; Norway
Prior art keywords: demethyltramadol; enantiomers; preparation
Prior art date: 1996-01-19

Application number

NO970212A

Other languages

English (en)

Other versions

NO970212D0 (no

NO306943B1 (no

Inventor

Helmut Buschmann

Werner Winter

Ivars Graudums

Peter Jansen

Wolfgang Werner A Strassburger

Elmar Josef Friedrichs

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-19

Filing date

1997-01-17

Publication date

1997-07-21

1997-01-17 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

1997-01-17 Publication of NO970212D0 publication Critical patent/NO970212D0/no

1997-07-21 Publication of NO970212L publication Critical patent/NO970212L/no

2000-01-17 Publication of NO306943B1 publication Critical patent/NO306943B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO970212A 1996-01-19 1997-01-17 Fremgangsmåte for fremstilling av enantiomerene av O- demetyltramadol NO306943B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19601744A DE19601744C2 (de)	1996-01-19	1996-01-19	Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol

Publications (3)

Publication Number	Publication Date
NO970212D0 NO970212D0 (no)	1997-01-17
NO970212L true NO970212L (no)	1997-07-21
NO306943B1 NO306943B1 (no)	2000-01-17

Family

ID=7783111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO970212A NO306943B1 (no)	1996-01-19	1997-01-17	Fremgangsmåte for fremstilling av enantiomerene av O- demetyltramadol

Country Status (32)

Country	Link
US (1)	US5728885A (no)
EP (1)	EP0786450B1 (no)
JP (1)	JPH09216857A (no)
KR (1)	KR100507396B1 (no)
CN (1)	CN1073085C (no)
AR (1)	AR005390A1 (no)
AT (1)	ATE191454T1 (no)
AU (1)	AU705195B2 (no)
BR (1)	BR9700079A (no)
CA (1)	CA2195372C (no)
CO (1)	CO4520186A1 (no)
CZ (1)	CZ292427B6 (no)
DE (2)	DE19601744C2 (no)
DK (1)	DK0786450T3 (no)
ES (1)	ES2147341T3 (no)
GR (1)	GR3033390T3 (no)
HK (1)	HK1004810A1 (no)
HU (1)	HU223661B1 (no)
IL (1)	IL120029A (no)
IN (1)	IN181540B (no)
MY (1)	MY116593A (no)
NO (1)	NO306943B1 (no)
NZ (1)	NZ299998A (no)
PE (1)	PE29998A1 (no)
PL (1)	PL187373B1 (no)
PT (1)	PT786450E (no)
RU (1)	RU2185371C2 (no)
SI (1)	SI0786450T1 (no)
SK (1)	SK282629B6 (no)
UA (1)	UA45342C2 (no)
UY (1)	UY24438A1 (no)
ZA (1)	ZA97367B (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19712398A1 (de) *	1997-03-25	1998-10-01	Gruenenthal Gmbh	Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel
PE20010623A1 (es)	1999-10-05	2001-07-07	Gruenenthal Chemie	Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
AU1164601A (en) *	1999-11-09	2001-06-06	Darwin Discovery Limited	Therapeutic use and formulation
DE10049483A1 (de) *	2000-09-29	2002-05-02	Gruenenthal Gmbh	Substituierte 1-Aminobutan-3-ol-Derivate
DE10108123A1 (de) *	2001-02-21	2002-10-02	Gruenenthal Gmbh	Wirkstoffkombination
DE10108122A1 (de)	2001-02-21	2002-10-02	Gruenenthal Gmbh	Arzneimittel auf Basis von Tramadol
US20050176790A1 (en)	2001-02-28	2005-08-11	Johannes Bartholomaus	Pharmaceutical salts
DE10109763A1 (de) *	2001-02-28	2002-09-05	Gruenenthal Gmbh	Pharmazeutische Salze
KR100908350B1 (ko)	2001-03-16	2009-07-20	디엠아이 바이오사이언스 인코포레이티드	남성의 사정을 지연시키기 위한 약학 조성물
US6649783B2 (en)	2001-10-03	2003-11-18	Euro-Celtique, S.A.	Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
AU2002364517A1 (en)	2001-11-30	2003-06-17	Sepracor Inc.	Tramadol analogs and uses thereof
US20040248979A1 (en) *	2003-06-03	2004-12-09	Dynogen Pharmaceuticals, Inc.	Method of treating lower urinary tract disorders
DE102005033732B4 (de) *	2005-05-27	2014-02-13	Grünenthal GmbH	Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane
EP1785412A1 (en) *	2005-11-14	2007-05-16	IPCA Laboratories Limited	Tramadol recovery process
KR20140054312A (ko)	2007-02-12	2014-05-08	디엠아이 바이오사이언시스 인코포레이티드	조루 및 발기부전을 동시에 치료하는 방법
NZ579170A (en)	2007-02-12	2012-05-25	Dmi Biosciences Inc	Reducing side effects of tramadol
EP2545027A1 (de) *	2010-03-10	2013-01-16	Grünenthal GmbH	Kristalline salze und/oder cokristalle von o-desmethyltramadol
EP2383255A1 (en)	2010-04-28	2011-11-02	Lacer, S.A.	New compounds, synthesis and use thereof in the treatment of pain
EP2530072A1 (en)	2011-06-03	2012-12-05	Lacer, S.A.	New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en)	2011-07-09	2020-07-07	Syntrix Biosystems Inc.	Compositions and methods for overcoming resistance to tramadol
EP3684753A1 (en)	2017-09-18	2020-07-29	R L Fine Chem Private Limited	A process for preparation of o-desmethyltramadol and salts thereof
US11000488B2 (en)	2019-03-22	2021-05-11	Syntrix Biosystems Inc.	Treating pain using desmetramadol
CN118108610A (zh) *	2024-04-30	2024-05-31	山东新华制药股份有限公司	盐酸去甲曲马多的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1518663A1 (de) *	1965-08-02	1969-12-18	Gruenenthal Chemie	Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) *	1967-07-27	1972-03-28	Gruenenthal Chemie	1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
ZA926732B (en) *	1991-09-06	1994-03-04	Mcneilab Inc	Compositions comprising a tramadol material and any of codeine oxycodone or hydrocodone and their use
EP0566709B3 (en)	1991-09-06	2009-04-08	Ortho-McNeil-Janssen Pharmaceuticals, Inc.	Composition comprising a tramadol compound and acetaminophen, and its use
JPH06122686A (ja) *	1992-10-12	1994-05-06	Fujisawa Pharmaceut Co Ltd	ラセミ体の光学分割法

1996
- 1996-01-19 DE DE19601744A patent/DE19601744C2/de not_active Expired - Fee Related
- 1996-12-18 PE PE1996000931A patent/PE29998A1/es not_active Application Discontinuation
- 1996-12-21 DK DK96120727T patent/DK0786450T3/da active
- 1996-12-21 EP EP96120727A patent/EP0786450B1/de not_active Expired - Lifetime
- 1996-12-21 ES ES96120727T patent/ES2147341T3/es not_active Expired - Lifetime
- 1996-12-21 SI SI9630187T patent/SI0786450T1/xx unknown
- 1996-12-21 PT PT96120727T patent/PT786450E/pt unknown
- 1996-12-21 DE DE59604885T patent/DE59604885D1/de not_active Expired - Lifetime
- 1996-12-21 AT AT96120727T patent/ATE191454T1/de active
- 1996-12-23 NZ NZ299998A patent/NZ299998A/en not_active IP Right Cessation
- 1996-12-30 MY MYPI96005545A patent/MY116593A/en unknown
- 1996-12-30 CO CO96068522A patent/CO4520186A1/es unknown
1997
- 1997-01-07 AR ARP970100068A patent/AR005390A1/es active IP Right Grant
- 1997-01-09 IN IN46CA1997 patent/IN181540B/en unknown
- 1997-01-10 UY UY24438A patent/UY24438A1/es not_active IP Right Cessation
- 1997-01-10 BR BR9700079A patent/BR9700079A/pt not_active Application Discontinuation
- 1997-01-16 ZA ZA97367A patent/ZA97367B/xx unknown
- 1997-01-16 HU HU9700140A patent/HU223661B1/hu not_active IP Right Cessation
- 1997-01-17 IL IL12002997A patent/IL120029A/xx not_active IP Right Cessation
- 1997-01-17 CZ CZ1997157A patent/CZ292427B6/cs not_active IP Right Cessation
- 1997-01-17 PL PL97318002A patent/PL187373B1/pl not_active IP Right Cessation
- 1997-01-17 CA CA002195372A patent/CA2195372C/en not_active Expired - Fee Related
- 1997-01-17 US US08/784,078 patent/US5728885A/en not_active Expired - Lifetime
- 1997-01-17 SK SK67-97A patent/SK282629B6/sk not_active IP Right Cessation
- 1997-01-17 RU RU97100984/04A patent/RU2185371C2/ru not_active IP Right Cessation
- 1997-01-17 CN CN97102072A patent/CN1073085C/zh not_active Expired - Fee Related
- 1997-01-17 KR KR1019970001204A patent/KR100507396B1/ko not_active IP Right Cessation
- 1997-01-17 AU AU12216/97A patent/AU705195B2/en not_active Ceased
- 1997-01-17 NO NO970212A patent/NO306943B1/no not_active IP Right Cessation
- 1997-01-17 JP JP9006904A patent/JPH09216857A/ja not_active Ceased
- 1997-01-17 UA UA97010174A patent/UA45342C2/uk unknown
1998
- 1998-05-08 HK HK98103999A patent/HK1004810A1/xx not_active IP Right Cessation
2000
- 2000-05-09 GR GR20000401077T patent/GR3033390T3/el unknown

Also Published As

Publication number	Publication date
IL120029A0 (en)	1997-04-15
HUP9700140A2 (hu)	1998-01-28
AR005390A1 (es)	1999-04-28
PL318002A1 (en)	1997-07-21
JPH09216857A (ja)	1997-08-19
SK282629B6 (sk)	2002-10-08
PE29998A1 (es)	1998-08-08
HU9700140D0 (en)	1997-03-28
IL120029A (en)	2000-01-31
DE19601744A1 (de)	1997-07-31
AU1221697A (en)	1997-07-24
MY116593A (en)	2004-02-28
MX9700523A (es)	1997-07-31
ZA97367B (en)	1997-07-17
HUP9700140A3 (en)	2000-03-28
DE59604885D1 (de)	2000-05-11
BR9700079A (pt)	1998-11-10
US5728885A (en)	1998-03-17
CN1073085C (zh)	2001-10-17
DK0786450T3 (da)	2000-07-10
UA45342C2 (uk)	2002-04-15
RU2185371C2 (ru)	2002-07-20
KR100507396B1 (ko)	2005-12-20
NZ299998A (en)	1998-01-26
CZ15797A3 (cs)	1998-05-13
NO970212D0 (no)	1997-01-17
PL187373B1 (pl)	2004-06-30
SI0786450T1 (en)	2000-08-31
ATE191454T1 (de)	2000-04-15
IN181540B (no)	1998-07-11
UY24438A1 (es)	1997-01-10
CO4520186A1 (es)	1997-10-15
GR3033390T3 (en)	2000-09-29
HK1004810A1 (en)	1998-12-11
CZ292427B6 (cs)	2003-09-17
SK6797A3 (en)	1997-08-06
CA2195372A1 (en)	1997-07-20
CA2195372C (en)	2005-08-30
CN1167107A (zh)	1997-12-10
HU223661B1 (hu)	2004-11-29
NO306943B1 (no)	2000-01-17
EP0786450B1 (de)	2000-04-05
DE19601744C2 (de)	1998-04-16
EP0786450A2 (de)	1997-07-30
ES2147341T3 (es)	2000-09-01
EP0786450A3 (de)	1997-10-15
KR970059161A (ko)	1997-08-12
PT786450E (pt)	2000-08-31
AU705195B2 (en)	1999-05-20

Publication	Publication Date	Title
NO970212D0 (no)	1997-01-17	Fremgangsmåte for fremstilling av enantiomerene av O-demetyltramadol
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Legal Events

Date	Code	Title	Description
2014-08-25	MM1K	Lapsed by not paying the annual fees