NO976085L - Difenylmetylen-piperidin-derivater - Google Patents

Difenylmetylen-piperidin-derivater

Info

Publication number: NO976085L
Authority: NO; Norway
Prior art keywords: piperidine derivatives; diphenylmethylene piperidine; group; diphenylmethylene; medicine
Prior art date: 1996-12-26

Application number

NO976085A

Other languages

English (en)

Other versions

NO976085D0 (no

NO317060B1 (no

Inventor

Eiichi Shirasawa

Masaaki Kageyama

Tadashi Nakajima

Takashi Nakano

Nobuaki Mori

Hideshi Sasakura

Yasushi Matsumura

Yoshitomi Morizawa

Original Assignee

Asahi Glass Co Ltd

Santen Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-26

Filing date

1997-12-23

Publication date

1998-06-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27301396&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO976085(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-12-23 Application filed by Asahi Glass Co Ltd, Santen Pharmaceutical Co Ltd filed Critical Asahi Glass Co Ltd

1997-12-23 Publication of NO976085D0 publication Critical patent/NO976085D0/no

1998-06-29 Publication of NO976085L publication Critical patent/NO976085L/no

2004-08-02 Publication of NO317060B1 publication Critical patent/NO317060B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO19976085A 1996-12-26 1997-12-23 Fluor-holdig prostaglandinderivat, anvendelse derav samt medisiner inneholdende derivatet NO317060B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP34861496		1996-12-26
JP7405497		1997-03-26
JP17247797		1997-06-27

Publications (3)

Publication Number	Publication Date
NO976085D0 NO976085D0 (no)	1997-12-23
NO976085L true NO976085L (no)	1998-06-29
NO317060B1 NO317060B1 (no)	2004-08-02

Family

ID=27301396

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO19976085A NO317060B1 (no)	1996-12-26	1997-12-23	Fluor-holdig prostaglandinderivat, anvendelse derav samt medisiner inneholdende derivatet
NO2009006C NO2009006I2 (no)	1996-12-26	2009-03-06	isopropyl(5Z)-7{(1R, 2R, 3R, 5S)-2-[(IE)-3,3-difluor-4-fenoksybut-l-enyl]-3,5-dihydroksycyklopentyl}hept-5-enoat eller 16-fenoksy-15-deoksy-15,15-difluor-17,18,19,20-tetranorprostaglandin F2a isopropyl ester

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO2009006C NO2009006I2 (no)	1996-12-26	2009-03-06	isopropyl(5Z)-7{(1R, 2R, 3R, 5S)-2-[(IE)-3,3-difluor-4-fenoksybut-l-enyl]-3,5-dihydroksycyklopentyl}hept-5-enoat eller 16-fenoksy-15-deoksy-15,15-difluor-17,18,19,20-tetranorprostaglandin F2a isopropyl ester

Country Status (16)

Country	Link
US (2)	US5886035A (no)
EP (1)	EP0850926B1 (no)
JP (2)	JP3480549B2 (no)
KR (1)	KR100526282B1 (no)
CN (1)	CN1108289C (no)
AT (1)	ATE225770T1 (no)
CA (1)	CA2225761C (no)
DE (2)	DE69716226T2 (no)
DK (1)	DK0850926T3 (no)
ES (1)	ES2187719T3 (no)
FR (1)	FR11C0020I2 (no)
LU (1)	LU91943I2 (no)
NL (1)	NL300407I2 (no)
NO (2)	NO317060B1 (no)
PT (1)	PT850926E (no)
TW (1)	TW536534B (no)

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EP0930296B2 (en) *	1996-09-17	2005-11-02	Asahi Glass Company Ltd.	Fluorinated prostaglandin derivatives and medicines
US6225348B1 (en)	1998-08-20	2001-05-01	Alfred W. Paulsen	Method of treating macular degeneration with a prostaglandin derivative
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IL143477A (en)	2001-05-31	2009-07-20	Finetech Pharmaceutical Ltd	Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives
WO2001055102A1 (fr) *	2000-01-28	2001-08-02	Asahi Glass Company, Limited	Nouveau derive difluoroprostaglandine
PT1321144E (pt) *	2000-09-13	2011-03-10	Santen Pharmaceutical Co Ltd	Colírio
KR101027454B1 (ko) *	2002-08-23	2011-04-06	산텐 세이야꾸 가부시키가이샤	라타노프로스트를 유효 성분으로 하는 안정한 점안액
CA2498233C (en)	2002-09-09	2012-08-14	Santen Pharmaceutical Co., Ltd.	Clear ophthalmic solution comprising latanoprost as active ingredient
ATE450264T1 (de) *	2003-07-31	2009-12-15	Santen Pharmaceutical Co Ltd	Prostaglandin enthaltendes produkt
RU2006124568A (ru) *	2003-12-08	2008-01-20	Квэлкомм Инкорпорейтед (US)	Интерфейс с высокой скоростью передачи данных с улучшенной синхронизацией линии связи
WO2006062184A1 (ja) *	2004-12-09	2006-06-15	Santen Pharmaceutical Co., Ltd.	分子内にフッ素原子を有するプロスタグランジン含有製品
JP4753178B2 (ja) *	2004-12-24	2011-08-24	参天製薬株式会社	プロスタグランジンＦ２α誘導体含有製品
DK1864666T3 (da)	2005-03-31	2012-10-29	Asahi Glass Co Ltd	Beskyttelsesmiddel til en retinal neuronal celle indeholdende prostaglandin-F2-alfa-derivat som aktiv ingrediens
JP5100025B2 (ja) *	2005-03-31	2012-12-19	旭硝子株式会社	プロスタグランジンＦ２α誘導体を有効成分として含む網膜神経細胞保護剤
KR20070119726A (ko)	2005-04-13	2007-12-20	우베 고산 가부시키가이샤	인다졸 유도체를 유효 성분으로서 함유하는 망막신경세포보호제
EP1917239A1 (en) *	2005-06-29	2008-05-07	Pfizer, Inc.	Fluoroprostaglandins nitroderivatives
JP4851467B2 (ja) *	2006-02-07	2012-01-11	株式会社アールテック・ウエノ	プロスタグランジン誘導体の製造法
US7666912B2 (en) *	2006-03-23	2010-02-23	Massachusetts Eye And Ear Infirmary	Compositions and methods for reducing body fat
FR2918891B1 (fr) *	2007-07-20	2009-09-25	Thea Sa Lab	Solution ophtalmique a base de prostaglandines sans conservateur
EP2127638A1 (en)	2008-05-30	2009-12-02	Santen Pharmaceutical Co., Ltd	Method and composition for treating ocular hypertension and glaucoma
MX2011002383A (es) *	2008-09-04	2011-04-07	Santen Pharma Co Ltd	Agente para promover el crecimiento del pelo que contiene un derivado de 15,15-difluoroprostaglandina f2a como ingrediente activo.
US20110293549A1 (en)	2009-02-03	2011-12-01	Athena Cosmetics, Inc.	Composition, method and kit for enhancing hair
CN103079535B (zh)	2010-08-02	2016-10-12	Ac专利控股公司	用于增强毛发的组合物、方法和试剂盒
ES2579990T3 (es)	2011-01-19	2016-08-18	Terakine Therapeutics, Inc.	Métodos y composiciones para tratar el síndrome metabólico
TW201729813A (zh)	2011-02-04	2017-09-01	Kowa Co Ltd	青光眼預防或治療之藥物療法
US8426471B1 (en)	2011-12-19	2013-04-23	Topokine Therapeutics, Inc.	Methods and compositions for reducing body fat and adipocytes
WO2013118058A1 (en) *	2012-02-07	2013-08-15	Dr.Reddys Laboratories Limited	Amine salts of prostaglandin analogs
EP2857002A4 (en)	2012-05-30	2015-12-09	Asahi Glass Co Ltd	COMPOSITION FOR CAPILLARY GROWTH
JP5877620B2 (ja)	2012-11-21	2016-03-08	トポカインセラピューティックス，インコーポレイテッド	体脂肪を局所的に増大させるための方法および組成物
NO2753788T3 (no)	2013-05-10	2018-06-16
WO2014186504A1 (en)	2013-05-15	2014-11-20	Topokine Therapeutics, Inc.	Methods and compositions for topical delivery of prostaglandins to subcutaneous fat
CN103570549B (zh) *	2013-10-11	2016-01-27	天泽恩源（天津）制药有限公司	一种合成他氟前列素的方法
CN103804195B (zh) *	2014-01-26	2016-06-15	天泽恩源（天津）制药有限公司	一种合成他氟前列素的方法
CN103819436A (zh) *	2014-02-21	2014-05-28	天泽恩源（天津）医药技术有限公司	(3aR,4R,5R,6aS)-4-((E)-3,3-二氟-4-苯氧基丁-1-烯-1-基)-2-氧代六氢-2H-环戊烷[b]呋喃-5-基苯甲酸酯的一种晶型及相应晶体的制备方法
WO2015200425A1 (en)	2014-06-27	2015-12-30	Topokine Therapeutics, Inc.	Topical dosage regimen
KR20160116402A (ko)	2015-03-30	2016-10-10	연성정밀화학(주)	타플루프로스트의 제조방법
MX2018003462A (es)	2015-09-22	2018-09-06	Graybug Vision Inc	Compuestos y composiciones para el tratamiento de trastornos oculares.
CN107226790A (zh) *	2016-03-25	2017-10-03	苏州朗科生物技术有限公司	一种高纯度他氟前列素及其类似化合物的制备方法及中间体化合物
GR1009040B (el)	2016-04-19	2017-05-19	Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων	Φαρμακευτικο οφθαλμικο σκευασμα ελευθερο συντηρητικου
WO2018033854A1 (en)	2016-08-15	2018-02-22	Santen Pharmaceutical Co., Ltd.	Ophthalmic composition and a method for treating ocular hypertension and glaucoma
CN108299192A (zh) *	2017-01-10	2018-07-20	江苏恒瑞医药股份有限公司	一种他氟前列素酸的金属盐化合物结晶形式及其制备方法
CN106986766B (zh) *	2017-05-08	2021-01-12	扬子江药业集团有限公司	他氟前列素的制备方法
CN112457277B (zh) *	2020-12-16	2022-06-28	西安国康瑞金制药有限公司	一种他氟前列腺素的制备方法
CN115322095A (zh) *	2021-01-27	2022-11-11	Ａｇｃ株式会社	他氟前列素的纯化方法
CN112832150B (zh) *	2021-01-27	2022-06-24	中交第三公路工程局有限公司	一种涵洞通道等立面垂直凿毛装置
CN116120268A (zh) *	2023-03-06	2023-05-16	南京华威医药科技集团有限公司	一种他氟前列素中间体杂质及其制备方法
CN116425707A (zh) *	2023-03-31	2023-07-14	南京华威医药科技集团有限公司	一种他氟前列素中间体异构体杂质及其制备方法

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US5166178B1 (en) *	1987-09-18	1998-07-21	R Tech Ueno Ltd	Ocular hypotensive agents
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1997
- 1997-12-12 JP JP34334397A patent/JP3480549B2/ja not_active Expired - Lifetime
- 1997-12-17 TW TW086119094A patent/TW536534B/zh not_active IP Right Cessation
- 1997-12-18 US US08/993,017 patent/US5886035A/en not_active Expired - Lifetime
- 1997-12-22 EP EP97122702A patent/EP0850926B1/en not_active Expired - Lifetime
- 1997-12-22 AT AT97122702T patent/ATE225770T1/de active
- 1997-12-22 DE DE69716226T patent/DE69716226T2/de not_active Expired - Lifetime
- 1997-12-22 PT PT97122702T patent/PT850926E/pt unknown
- 1997-12-22 ES ES97122702T patent/ES2187719T3/es not_active Expired - Lifetime
- 1997-12-22 DE DE122008000050C patent/DE122008000050I2/de active Active
- 1997-12-22 DK DK97122702T patent/DK0850926T3/da active
- 1997-12-23 NO NO19976085A patent/NO317060B1/no not_active IP Right Cessation
- 1997-12-23 CA CA002225761A patent/CA2225761C/en not_active Expired - Lifetime
- 1997-12-26 KR KR1019970074620A patent/KR100526282B1/ko not_active IP Right Cessation
- 1997-12-26 CN CN97126331A patent/CN1108289C/zh not_active Expired - Lifetime
1998
- 1998-08-03 US US09/127,804 patent/US5985920A/en not_active Expired - Lifetime
2003
- 2003-07-31 JP JP2003284134A patent/JP3994074B2/ja not_active Expired - Lifetime
2009
- 2009-03-06 NO NO2009006C patent/NO2009006I2/no not_active IP Right Cessation
- 2009-09-02 NL NL300407C patent/NL300407I2/nl unknown
2011
- 2011-06-21 FR FR11C0020C patent/FR11C0020I2/fr active Active
2012
- 2012-02-15 LU LU91943C patent/LU91943I2/fr unknown

Also Published As

Publication number	Publication date
NL300407I1 (nl)	2009-11-02
US5985920A (en)	1999-11-16
PT850926E (pt)	2003-02-28
CA2225761A1 (en)	1998-06-26
NL300407I2 (nl)	2010-03-01
CN1187486A (zh)	1998-07-15
JP2004002462A (ja)	2004-01-08
CN1108289C (zh)	2003-05-14
DK0850926T3 (da)	2003-02-17
TW536534B (en)	2003-06-11
NO2009006I1 (no)	2009-03-16
NO2009006I2 (no)	2012-03-05
JP3480549B2 (ja)	2003-12-22
DE69716226D1 (de)	2002-11-14
DE122008000050I2 (de)	2011-06-16
EP0850926A3 (en)	1999-06-16
NO976085D0 (no)	1997-12-23
NO317060B1 (no)	2004-08-02
JP3994074B2 (ja)	2007-10-17
FR11C0020I2 (fr)	2012-03-16
FR11C0020I1 (no)	2011-07-29
ES2187719T3 (es)	2003-06-16
JPH1171344A (ja)	1999-03-16
KR100526282B1 (ko)	2006-05-17
DE122008000050I1 (de)	2009-01-29
EP0850926B1 (en)	2002-10-09
KR19980064718A (ko)	1998-10-07
US5886035A (en)	1999-03-23
ATE225770T1 (de)	2002-10-15
EP0850926A2 (en)	1998-07-01
LU91943I2 (fr)	2012-04-16
CA2225761C (en)	2009-04-21
DE69716226T2 (de)	2003-06-05

Publication	Publication Date	Title
NO976085D0 (no)	1997-12-23	Difenylmetylen-piperidin-derivater
ES2066000T3 (es)	1995-03-01	Compuestos derivados de pirimidinediona, metodo de produccion de los mismos y agentes antirritmicos que los contienen.
FI914187A (fi)	1992-03-08	Menetelmä valmistaa kaavan /I/ mukaista 1-metyylikarbapeneemijohdosta
PT916651E (pt)	2004-01-30	DERIVADOS DE áCIDO FENILALQUILCARBOXILICO
DK0882728T3 (da)	2003-01-06	1-methylcarbapenemderivater
EP1034783A4 (en)	2001-03-28	AMIDE DERIVATIVES
DE68913835D1 (de)	1994-04-21	N-substituierte Amid-Derivate.
DE69123757D1 (de)	1997-01-30	Epoxysuccinamidsäurederivat
DE69018335D1 (de)	1995-05-11	Imidazochinolonderivate.
ATE122892T1 (de)	1995-06-15	Zusammensetzung gegen katarakt.
ATE71364T1 (de)	1992-01-15	Fluor enthaltende vitamin-d2-derivate.
ES2149180T3 (es)	2000-11-01	Derivado de pirazolotiazolopirimidina.
DE3782229D1 (de)	1992-11-19	Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten.
AU1317688A (en)	1988-09-22	Benzoxazine derivatives and processes for preparation thereof

Legal Events

Date	Code	Title	Description
2012-03-05	SPCG	Granted supplementary protection certificate	Free format text: PRODUCT NAME: TAFLOTAN OEYEDRAPER; NAT. REG. NO/DATE: 07-4894 20081009; FIRST REG. NO/DATE: DK , 43230 20080430 Spc suppl protection certif: 2009006 Filing date: 20090306 Extension date: 20221223
2018-01-08	MK1K	Patent expired
2018-10-01	SPCS	Change of name or address of the owner of a supplementary protection certificate	Owner name: SANTEN PHARMACEUTICAL CO LTD, JP Spc suppl protection certif: 2009006

Date

Code

Title

Description

2012-03-05

SPCG

Granted supplementary protection certificate

Free format text: PRODUCT NAME: TAFLOTAN OEYEDRAPER; NAT. REG. NO/DATE: 07-4894 20081009; FIRST REG. NO/DATE: DK , 43230 20080430

Spc suppl protection certif: 2009006

Filing date: 20090306

Extension date: 20221223

2018-01-08

MK1K

Patent expired

2018-10-01

SPCS

Change of name or address of the owner of a supplementary protection certificate

Owner name: SANTEN PHARMACEUTICAL CO LTD, JP