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NO960308L - Therapeutically active benzoxazines and benzothioanones - Google Patents

Therapeutically active benzoxazines and benzothioanones

Info

Publication number
NO960308L
NO960308L NO960308A NO960308A NO960308L NO 960308 L NO960308 L NO 960308L NO 960308 A NO960308 A NO 960308A NO 960308 A NO960308 A NO 960308A NO 960308 L NO960308 L NO 960308L
Authority
NO
Norway
Prior art keywords
therapeutically active
alkyl
benzothioanones
benzoxazines
alkoxy
Prior art date
Application number
NO960308A
Other languages
Norwegian (no)
Other versions
NO960308D0 (en
Inventor
Silvio Levi
Alberto Sala
Francesca Benedini
Jaques Mizrhai
Giorgio Bertolini
Gianni Gromo
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of NO960308D0 publication Critical patent/NO960308D0/en
Publication of NO960308L publication Critical patent/NO960308L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Forbindelser med den generelle formel (I) -Y-A (D hvor X er et oksygen- eller svovelatom; Y er alkylen eller cykloalkylen; A er hydroksy, alkoksy, cykloksy, merkapto, alkylsulfonyloksy, fenylsulfonyloksy, (a) eller (b) (a) _ (b) hvor R3 er en alkyl- eller alkylengruppe u-substituert med 2,3-dihydro-4H-l,3-benzoksazin-4-on-N-yl; R er hydrogen, alkyl eller fenyl; Rx og R2 er uavhengig hy- drogen, halogen, alkoksy, trifluormetyl eller -alkyl, og de farmasøytisk akseptable syre- og basesalter der- av, er nyttige som terapeutisk aktive substanser.Compounds of general formula (I) -YA (D where X is an oxygen or sulfur atom; Y is alkylene or cycloalkylene; A is hydroxy, alkoxy, cycloxy, mercapto, alkylsulfonyloxy, phenylsulfonyloxy, (a) or (b) (a) ) - (b) wherein R3 is an alkyl or alkylene group unsubstituted with 2,3-dihydro-4H-1,3-benzoxazin-4-one-N-yl; R is hydrogen, alkyl or phenyl; Rx and R2 are independently hydrogen, halogen, alkoxy, trifluoromethyl or alkyl, and the pharmaceutically acceptable acid and base salts thereof, are useful as therapeutically active substances.

NO960308A 1993-07-28 1996-01-25 Therapeutically active benzoxazines and benzothioanones NO960308L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT93MI001678A IT1264812B1 (en) 1993-07-28 1993-07-28 THERAPEUTICALLY ACTIVE BENZOSSAZINONIC AND BENZOTHIAZINONIC DERIVATIVES
PCT/EP1994/002354 WO1995004048A1 (en) 1993-07-28 1994-07-18 Benzoxazinones and benzothiazinones endowed with therapeutic activity

Publications (2)

Publication Number Publication Date
NO960308D0 NO960308D0 (en) 1996-01-25
NO960308L true NO960308L (en) 1996-03-13

Family

ID=11366700

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960308A NO960308L (en) 1993-07-28 1996-01-25 Therapeutically active benzoxazines and benzothioanones

Country Status (13)

Country Link
EP (1) EP0711286A1 (en)
JP (1) JPH09500878A (en)
CN (1) CN1128025A (en)
AU (1) AU7494594A (en)
CA (1) CA2168099A1 (en)
FI (1) FI960342A0 (en)
HU (1) HUT74587A (en)
IL (1) IL110473A0 (en)
IT (1) IT1264812B1 (en)
NO (1) NO960308L (en)
TW (1) TW277061B (en)
WO (1) WO1995004048A1 (en)
ZA (1) ZA945555B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102367239B (en) * 2011-07-20 2015-10-28 沈阳药科大学 2-aryl-2,3-dihydro-4H-1,3-benzothiazine-4-ketone derivatives and uses thereof
US9056835B2 (en) 2012-08-27 2015-06-16 The University Of Tennessee Research Foundation LPA2 receptor-specific benzoic acid derivatives
ITMI20122221A1 (en) 2012-12-21 2014-06-22 C4T S C A R L NEW COMPOUNDS OF 2,3-DIIDRO-4H-1,3-BENZOSSAZIN-4-ONE, METHOD FOR PREPARING THEM AND PHARMACEUTICAL FORM THAT INCLUDES THEM
ES2691541T3 (en) * 2013-12-19 2018-11-27 Gilead Sciences, Inc. Condensed heterocyclic compounds as ion channel modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2443M (en) * 1962-10-30 1964-04-06 Selvi & C Lab Bioterapico Thio-derivatives of benzo-oxazine having antiphlogistic, antipyretic and analgesic properties.
US3459748A (en) * 1967-04-28 1969-08-05 Squibb & Sons Inc Hydroxyalkylene-substituted benzoxazines and benzothiazines
IT1136575B (en) * 1981-04-15 1986-09-03 Coli Farma Lab ESTERS OF 2- (2-OSSIETIL) -2,3-DIIDRO-H4-1,3-BENZOSSAZIN-4-ONE WITH ANALGESIC ACTIVITY AND PROCEDURE FOR THEIR PREPARATION
IT1244472B (en) * 1990-12-14 1994-07-15 Italfarmaco Spa BENZOSSAZINONI AND BENZOTIAZINONI WITH CARDIOVASCULAR ACTIVITY
FR2680172B1 (en) * 1991-08-05 1993-11-19 Fabre Medicament Pierre NEW SUBSTITUTED PIPERAZINYLALCOYL-3 DIHYDRO-2,3 4H-BENZOXAZINE-1,3 ONES-4, THEIR PREPARATION AND THERAPEUTIC APPLICATION.
IT1254884B (en) * 1992-04-16 1995-10-11 Italfarmaco Spa BENZOSSAZINONI AND BENZOTIAZINONI WITH CARDIOVASCULAR ACTIVITY

Also Published As

Publication number Publication date
ZA945555B (en) 1995-03-03
FI960342A (en) 1996-01-25
IL110473A0 (en) 1994-10-21
IT1264812B1 (en) 1996-10-10
HU9600165D0 (en) 1996-03-28
TW277061B (en) 1996-06-01
JPH09500878A (en) 1997-01-28
ITMI931678A1 (en) 1995-01-28
FI960342A0 (en) 1996-01-25
HUT74587A (en) 1997-01-28
CN1128025A (en) 1996-07-31
CA2168099A1 (en) 1995-02-09
AU7494594A (en) 1995-02-28
ITMI931678A0 (en) 1993-07-28
EP0711286A1 (en) 1996-05-15
NO960308D0 (en) 1996-01-25
WO1995004048A1 (en) 1995-02-09

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