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NO960016L - New acylated pseudopeptides with trifluoromethyl substituted 2-azabicyclooctane - Google Patents

New acylated pseudopeptides with trifluoromethyl substituted 2-azabicyclooctane

Info

Publication number
NO960016L
NO960016L NO960016A NO960016A NO960016L NO 960016 L NO960016 L NO 960016L NO 960016 A NO960016 A NO 960016A NO 960016 A NO960016 A NO 960016A NO 960016 L NO960016 L NO 960016L
Authority
NO
Norway
Prior art keywords
carbon atoms
straight chain
stands
different
branched
Prior art date
Application number
NO960016A
Other languages
Norwegian (no)
Other versions
NO960016D0 (en
Inventor
Siegfried Raddatz
Hanno Wild
Dieter Habich
Wolfgang Roben
Jutta Hansen
Arnold Paessens
Kerstin Henninger
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO960016D0 publication Critical patent/NO960016D0/en
Publication of NO960016L publication Critical patent/NO960016L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det blir beskrevet nye acylerte pseudopeptider med trifluormetyl-substituerte 2-azabicyklo-oktan med den generelle formel (I) hvor R1 står for en rest med formel eller N. ;x hvor A, D, E, L og T er Ilke eller forskjellige og står for hydrogen, halogen, rettkjedet eller forgrenet alkyl ned opptil 4 karbonatoner, morfollnyl, fenyltlo eller cykloalkyl med 3 til 6 karbonatomer, R2 står for rettkjedet eller forgrenet acyl ned opptil 20 karbonatomer, som eventuelt er substituert med karboksy, med rettkjedet eller forgrenet alkoksykar- bonyl ned opptil 6 karbonatomer eller med en gruppe med formelen -KR3R4, hvor . R3 og 'R4 er like eller forskjellige og «tar for hydrogen, fenyl eller rettkjedet eller forgrenet alkyl ned opptil 6 karbonatomer, står for en rest med formelen -CO-XR5R6 eller P(0)(OR7)(OR8), hvor R8 og R6 har den ovenfor angitte betydning for R3 og R4 og er Ilke eller forskjellige, R7 og R8 er Ilke eller forskjellige og står for hydrogen eller rettkjedet eller forgrenet alkyl med opptil 4 karbonatomer, eller står for rettkjedet eller forgrenet alkoksy med opptil 6 karbonatomer, som eventuelt er substituert med dlfluormetyl, dlfluormetoksy, trlfluonnetoksy eller trlfluormetyl, eller for en rest med formlene HA c", ^° Hf og deres salter.New acylated pseudopeptides of trifluoromethyl-substituted 2-azabicyclooctane of general formula (I) are disclosed wherein R 1 represents a residue of formula or N. x where A, D, E, L and T are Ilke or different and stands for hydrogen, halogen, straight chain or branched alkyl down to 4 carbon atoms, morpholyl, phenylthlo or cycloalkyl having 3 to 6 carbon atoms, R2 stands for straight chain or branched acyl down to 20 carbon atoms optionally substituted by carboxy, straight chain or branched alkox - bonyl down to 6 carbon atoms or with a group of the formula -KR3R4, where. R 3 and 'R 4 are the same or different and' takes for hydrogen, phenyl or straight chain or branched alkyl down to 6 carbon atoms, represents a residue of the formula -CO-XR 5 R 6 or P (O) (OR 7) (OR 8), where R 8 and R6 is as defined above for R3 and R4 and is Ilk or different, R7 and R8 are Ilk or different and stands for hydrogen or straight chain or branched alkyl of up to 4 carbon atoms, or stands for straight chain or branched alkoxy of up to 6 carbon atoms, which is optionally substituted with difluoromethyl, difluoromethoxy, trifluoromethoxy or trifluoromethyl, or for a residue of the formulas HA c "," Hf and their salts.

NO960016A 1995-01-04 1996-01-03 New acylated pseudopeptides with trifluoromethyl substituted 2-azabicyclooctane NO960016L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19500120A DE19500120A1 (en) 1995-01-04 1995-01-04 New acylated pseudopeptides with trifluoromethyl-substituted 2-azabicyclooctane

Publications (2)

Publication Number Publication Date
NO960016D0 NO960016D0 (en) 1996-01-03
NO960016L true NO960016L (en) 1996-07-05

Family

ID=7750986

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960016A NO960016L (en) 1995-01-04 1996-01-03 New acylated pseudopeptides with trifluoromethyl substituted 2-azabicyclooctane

Country Status (15)

Country Link
EP (1) EP0720987A1 (en)
JP (1) JPH08259594A (en)
KR (1) KR960029345A (en)
CN (1) CN1134940A (en)
AU (1) AU4067895A (en)
CA (1) CA2166374A1 (en)
CZ (1) CZ1296A3 (en)
DE (1) DE19500120A1 (en)
FI (1) FI960015A (en)
HU (1) HUT74805A (en)
IL (1) IL116622A0 (en)
NO (1) NO960016L (en)
NZ (1) NZ280729A (en)
PL (1) PL312146A1 (en)
SK (1) SK1296A3 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20001420A1 (en) * 1998-12-23 2000-12-18 Pfizer CCR5 MODULATORS
US6448245B1 (en) 2000-05-04 2002-09-10 The United States Of America As Represented By The Department Of Health And Human Services Methods of and compounds for inhibiting calpains
AU2004298486A1 (en) 2003-12-12 2005-06-30 Wyeth Quinolines useful in treating cardiovascular disease
JP4831410B2 (en) 2006-02-28 2011-12-07 東亞合成株式会社 Antiviral peptides and antiviral agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1408675A (en) 1973-03-16 1975-10-01 Allen & Hanburys Ltd Amides derived from quinoxaline
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
DE4126485A1 (en) 1991-08-10 1993-02-11 Bayer Ag TRIFLUOROMETHYL-CONTAINING PSEUDOPEPTIDE
TW372972B (en) 1992-10-23 1999-11-01 Novartis Ag Antiretroviral acyl compounds

Also Published As

Publication number Publication date
DE19500120A1 (en) 1996-07-11
HU9503927D0 (en) 1996-03-28
SK1296A3 (en) 1996-08-07
KR960029345A (en) 1996-08-17
JPH08259594A (en) 1996-10-08
CA2166374A1 (en) 1996-07-05
NZ280729A (en) 1996-08-27
NO960016D0 (en) 1996-01-03
PL312146A1 (en) 1996-07-08
FI960015A0 (en) 1996-01-02
FI960015A (en) 1996-07-05
CZ1296A3 (en) 1997-05-14
AU4067895A (en) 1996-07-11
IL116622A0 (en) 1996-03-31
CN1134940A (en) 1996-11-06
HUT74805A (en) 1997-02-28
EP0720987A1 (en) 1996-07-10

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