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NO941968L - Organiske salter av N,N'-diacetylcystin - Google Patents

Organiske salter av N,N'-diacetylcystin

Info

Publication number
NO941968L
NO941968L NO941968A NO941968A NO941968L NO 941968 L NO941968 L NO 941968L NO 941968 A NO941968 A NO 941968A NO 941968 A NO941968 A NO 941968A NO 941968 L NO941968 L NO 941968L
Authority
NO
Norway
Prior art keywords
diacetylcystine
organic salts
salts
organic
Prior art date
Application number
NO941968A
Other languages
English (en)
Other versions
NO941968D0 (no
NO301325B1 (no
Inventor
Carl-Magnus Andersson
Hakan Bergstrand
Edib Jakupovic
Bo-Goran Josefsson
Magnus Lindvall
Bengt Olof Sarnstrand
Eric Tenenberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO941968D0 publication Critical patent/NO941968D0/no
Publication of NO941968L publication Critical patent/NO941968L/no
Publication of NO301325B1 publication Critical patent/NO301325B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO941968A 1991-11-29 1994-05-26 Organiske salter av N,N'-diacetylcystin, farmasöytisk preparat samt anvendelse av saltene NO301325B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9103572A SE9103572D0 (sv) 1991-11-29 1991-11-29 Organic salts of n,n'-diacetyl cystine
PCT/SE1992/000807 WO1993011104A1 (en) 1991-11-29 1992-11-25 Organic salts of n, n'-diacetyl cystine

Publications (3)

Publication Number Publication Date
NO941968D0 NO941968D0 (no) 1994-05-26
NO941968L true NO941968L (no) 1994-05-26
NO301325B1 NO301325B1 (no) 1997-10-13

Family

ID=20384494

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941968A NO301325B1 (no) 1991-11-29 1994-05-26 Organiske salter av N,N'-diacetylcystin, farmasöytisk preparat samt anvendelse av saltene

Country Status (38)

Country Link
US (5) US5385904A (no)
EP (1) EP0621862B1 (no)
JP (1) JP3302018B2 (no)
KR (1) KR100256185B1 (no)
CN (1) CN1039586C (no)
AP (1) AP350A (no)
AT (1) ATE141913T1 (no)
AU (1) AU657827B2 (no)
CA (1) CA2123516A1 (no)
CZ (1) CZ282085B6 (no)
DE (1) DE69213256T2 (no)
DK (1) DK0621862T3 (no)
DZ (1) DZ1637A1 (no)
EE (1) EE03025B1 (no)
ES (1) ES2090713T3 (no)
FI (1) FI942504A0 (no)
GR (1) GR3021546T3 (no)
HK (1) HK62297A (no)
HR (1) HRP921322B1 (no)
HU (1) HU215390B (no)
IL (1) IL103778A (no)
IS (1) IS1645B (no)
LV (1) LV11949B (no)
MA (1) MA22716A1 (no)
MX (1) MX9206851A (no)
MY (1) MY110523A (no)
NO (1) NO301325B1 (no)
NZ (1) NZ245077A (no)
PL (2) PL170787B1 (no)
RU (1) RU2135468C1 (no)
SE (1) SE9103572D0 (no)
SG (1) SG73962A1 (no)
SI (1) SI9200351A (no)
SK (1) SK281697B6 (no)
TN (1) TNSN92108A1 (no)
WO (1) WO1993011104A1 (no)
YU (1) YU48594B (no)
ZA (1) ZA928739B (no)

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US5747459A (en) * 1991-02-04 1998-05-05 Nestec, Ltd. Method for insuring adequate intracellular glutathione in tissue
US5430045A (en) * 1992-04-23 1995-07-04 Free Radical Sciences, Inc. Method of reducing or preventing bone marrow hypoplasia
US5447712A (en) * 1993-12-09 1995-09-05 Free Radical Sciences Method of reducing cyclophosphamide induced hemorrhagic cystitis
SE9500897D0 (sv) * 1995-03-14 1995-03-14 Astra Ab The pharmacological use of certain cystine derivatives
SE9602262D0 (sv) * 1996-06-06 1996-06-06 Astra Ab New use of derivatives of cystine
AR007398A1 (es) * 1996-06-18 1999-10-27 Astrazeneca Ab Proceso para preparar sales inorganicas de n-n'-diacetilcistina
SE9602416D0 (sv) * 1996-06-18 1996-06-18 Astra Ab New forms of an organic salt of N'N-diacetylcystine
US6017959A (en) * 1996-06-18 2000-01-25 Astra Aktiebolag Forms of organic salts of N,N'-diacetylcystine
CN1059907C (zh) * 1997-05-23 2000-12-27 中国石油化工集团公司巴陵石化岳阳石油化工总厂 一种含共轭二烯轻聚合物的选择氢化方法
US20030203006A1 (en) * 1997-10-29 2003-10-30 Ajinomoto Co. Inc. Immunomodulator
US6197749B1 (en) * 1997-10-29 2001-03-06 Ajinomoto Co., Inc. Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes
SE9800932D0 (sv) * 1998-03-20 1998-03-20 Astra Ab New compunds
EP1004302A3 (en) * 1998-10-29 2003-06-04 Ajinomoto Co., Inc. Immunomodulator
SE9900438D0 (sv) * 1999-02-10 1999-02-10 Astra Ab The pharmacological use of certian cystine derivatives
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
SE518784C2 (sv) * 2000-12-27 2002-11-19 Nactilus Ab "N-Acetyl-L-cystein med kompositioner för behandling av neoplasier"
WO2002072040A1 (fr) * 2001-03-13 2002-09-19 Ajinomoto Co., Inc. Produits cosmetiques ou preparations a usage externe pour la peau
ATE385193T1 (de) 2002-03-20 2008-02-15 Mannkind Corp Inhalationsgerät
KR101273120B1 (ko) 2004-08-20 2013-06-13 맨카인드 코포레이션 다이케토피페라진 합성의 촉매 작용
ES2540886T3 (es) 2004-08-23 2015-07-14 Mannkind Corporation Sales de dicetopiperazina para la administración de fármacos
CN104324366B (zh) 2005-09-14 2016-10-05 曼金德公司 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法
ES2647080T3 (es) 2006-02-22 2017-12-19 Mannkind Corporation Un método para mejorar las propiedades farmacéuticas de micropartículas que comprenden dicetopiperazina y un agente activo
US8438729B2 (en) * 2006-03-09 2013-05-14 Canon Kabushiki Kaisha Method of producing liquid discharge head
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
DK2293833T3 (en) 2008-06-13 2016-05-23 Mannkind Corp DRY POWDER INHALER AND MEDICINAL ADMINISTRATION SYSTEM
CA2728523C (en) * 2008-06-20 2020-03-10 Mannkind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
DK2405963T3 (da) 2009-03-11 2013-12-16 Mannkind Corp Apparat, system og fremgangsmåde til at måle modstand i en inhalator
SG176738A1 (en) 2009-06-12 2012-01-30 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
AU2012236150B2 (en) 2011-04-01 2016-03-31 Mannkind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
BR112014009686A2 (pt) 2011-10-24 2018-08-07 Mannkind Corp composição analgésica inalável, pó seco e método para tratar dor
CN102491926B (zh) * 2011-12-15 2013-09-25 青岛市药品检验所 一种硫普罗宁二硫化物的制备和纯化方法
CN108057154B (zh) 2012-07-12 2021-04-16 曼金德公司 干粉药物输送系统和方法
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
US10421729B2 (en) 2013-03-15 2019-09-24 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US20230157939A1 (en) * 2020-04-28 2023-05-25 Conopco, Inc., D/B/A Unilever Personal care compositions with enhanced solubility actives
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US3952115A (en) * 1975-04-02 1976-04-20 The Procter & Gamble Company Fortification of foodstuffs with N-acyl derivatives of sulfur-containing L-amino acid esters
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FR2503151A1 (fr) * 1981-04-02 1982-10-08 Morelle Jean Butyryminoacides soufres. mode de preparation. emploi comme element keratogenique chez l'homme et l'animal et comme agent de fertilisation chez les vegetaux
GB2097256B (en) * 1981-04-02 1985-05-30 Morelle Jean V Compositions containing n-butyryl alphaaminoacids
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US4724239A (en) * 1985-09-16 1988-02-09 Morgan Lee R Method of treating chemical ulcers with N,N'-diacetylcystine, N-acetyl homocysteine and N-acetyl cysteine
US4827016A (en) 1985-09-16 1989-05-02 Morgan Lee R Method and compounds for reducing dermal inflammations
US4708965A (en) * 1985-09-16 1987-11-24 Morgan Lee R Method of treating herpes virus infections with N,N'-diacetylcystine and derivatives
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AT402931B (de) * 1986-11-07 1997-09-25 Pharmacia Gmbh Verfahren zur herstellung von neuen cystinverbindungen und derenverwendung
SE8704542D0 (sv) * 1987-11-19 1987-11-19 Draco Ab New derivatives of cysteine
IL98310A (en) * 1990-06-08 1996-08-04 Astra Ab Medicinal preparations containing a history of cystine
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Also Published As

Publication number Publication date
KR100256185B1 (ko) 2000-05-15
PL171336B1 (en) 1997-04-30
US5385904A (en) 1995-01-31
CA2123516A1 (en) 1993-06-10
SK281697B6 (sk) 2001-06-11
YU48594B (sh) 1998-12-23
ZA928739B (en) 1993-06-09
MY110523A (en) 1998-07-31
AP9200448A0 (en) 1993-01-31
US5824681A (en) 1998-10-20
SE9103572D0 (sv) 1991-11-29
SG73962A1 (en) 2000-07-18
EE03025B1 (et) 1997-08-15
YU99092A (sh) 1995-12-04
NO941968D0 (no) 1994-05-26
JPH07501539A (ja) 1995-02-16
SI9200351A (en) 1993-06-30
HRP921322A2 (en) 1996-10-31
EP0621862B1 (en) 1996-08-28
DE69213256T2 (de) 1997-01-23
PL170787B1 (en) 1997-01-31
FI942504A (fi) 1994-05-27
CZ282085B6 (cs) 1997-05-14
SK63294A3 (en) 1995-02-08
ATE141913T1 (de) 1996-09-15
CN1039586C (zh) 1998-08-26
NZ245077A (en) 1995-04-27
DE69213256D1 (de) 1996-10-02
HK62297A (en) 1997-05-16
EP0621862A1 (en) 1994-11-02
LV11949A (lv) 1998-01-20
US5693858A (en) 1997-12-02
CZ129794A3 (en) 1995-01-18
US5804582A (en) 1998-09-08
CN1073683A (zh) 1993-06-30
WO1993011104A1 (en) 1993-06-10
IL103778A (en) 1997-08-14
IS1645B (is) 1997-03-25
HUT70851A (en) 1995-11-28
MX9206851A (es) 1993-05-01
IS3949A (is) 1993-05-30
DZ1637A1 (fr) 2002-02-17
HU215390B (hu) 1998-12-28
MA22716A1 (fr) 1993-07-01
LV11949B (en) 1998-07-20
FI942504A0 (fi) 1994-05-27
HRP921322B1 (en) 1998-12-31
HU9401473D0 (en) 1994-08-29
AU3099692A (en) 1993-06-28
IL103778A0 (en) 1993-04-04
NO301325B1 (no) 1997-10-13
JP3302018B2 (ja) 2002-07-15
AU657827B2 (en) 1995-03-23
TNSN92108A1 (fr) 1993-06-08
ES2090713T3 (es) 1996-10-16
GR3021546T3 (en) 1997-02-28
AP350A (en) 1994-08-09
RU2135468C1 (ru) 1999-08-27
DK0621862T3 (da) 1996-09-16
US5650538A (en) 1997-07-22

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