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NO944691L - Fremgangsmåte for fremstilling av N- karboksyalkyl-1,4,7,10-tetraazasyklododekan og N- yalkyl-tri-N-karboksyalkyl-1,4,8,11-tetraazasyklotradekanderivater og deres metallkomplekser - Google Patents

Fremgangsmåte for fremstilling av N- karboksyalkyl-1,4,7,10-tetraazasyklododekan og N- yalkyl-tri-N-karboksyalkyl-1,4,8,11-tetraazasyklotradekanderivater og deres metallkomplekser

Info

Publication number
NO944691L
NO944691L NO944691A NO944691A NO944691L NO 944691 L NO944691 L NO 944691L NO 944691 A NO944691 A NO 944691A NO 944691 A NO944691 A NO 944691A NO 944691 L NO944691 L NO 944691L
Authority
NO
Norway
Prior art keywords
carboxyalkyl
tri
tetraazacyclododecane
derivatives
metal complexes
Prior art date
Application number
NO944691A
Other languages
English (en)
Other versions
NO944691D0 (no
NO302232B1 (no
Inventor
Ulf Tilstam
Helmut Borner
Klaus Nickisch
Heinz Gries
Johannes Platzek
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO944691D0 publication Critical patent/NO944691D0/no
Publication of NO944691L publication Critical patent/NO944691L/no
Publication of NO302232B1 publication Critical patent/NO302232B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO19944691A 1992-06-04 1994-12-05 Fremgangsmate for fremstilling av N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,7,10-tetraazasyklododekan- og N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,8,11-tetraazasyklotetradekanderivater og deres metallkomplekser NO302232B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4218744A DE4218744C2 (de) 1992-06-04 1992-06-04 Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
PCT/EP1993/001362 WO1993024469A1 (de) 1992-06-04 1993-05-28 VERFAHREN ZUR HERSTELLUNG VON N-β-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,7,10-TETRAAZACYCLODODECAN- UND N-β-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,8,11-TETRAAZACYCLOTETRADECAN-DERIVATEN UND DEREN METALLKOMPLEXE

Publications (3)

Publication Number Publication Date
NO944691D0 NO944691D0 (no) 1994-12-05
NO944691L true NO944691L (no) 1994-12-05
NO302232B1 NO302232B1 (no) 1998-02-09

Family

ID=6460555

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19944691A NO302232B1 (no) 1992-06-04 1994-12-05 Fremgangsmate for fremstilling av N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,7,10-tetraazasyklododekan- og N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,8,11-tetraazasyklotetradekanderivater og deres metallkomplekser

Country Status (16)

Country Link
US (1) US5386028A (no)
EP (1) EP0643705B1 (no)
JP (1) JP3565843B2 (no)
KR (1) KR100269081B1 (no)
AT (1) ATE178321T1 (no)
CA (1) CA2137243C (no)
CZ (1) CZ282873B6 (no)
DE (2) DE4218744C2 (no)
DK (1) DK0643705T3 (no)
ES (1) ES2131582T3 (no)
GR (1) GR3030604T3 (no)
HU (1) HU213951B (no)
IL (1) IL105807A (no)
NO (1) NO302232B1 (no)
SK (1) SK281901B6 (no)
WO (1) WO1993024469A1 (no)

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US6045776A (en) * 1996-12-04 2000-04-04 Schering Aktiengesellschaft Process for the production of metal-complex carboxylic acid amides
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US20050033106A1 (en) * 2003-07-08 2005-02-10 Wing Tak Wong Synthesis of tris N-alkylated 1,4,7,10-tetraazacyclododecanes
EP2365962B1 (en) 2008-11-07 2017-07-05 Massachusetts Institute of Technology Aminoalcohol lipidoids and uses thereof
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
EP2691443B1 (en) 2011-03-28 2021-02-17 Massachusetts Institute of Technology Conjugated lipomers and uses thereof
CA2833659C (en) 2011-04-21 2019-12-03 Bayer Intellectual Property Gmbh Preparation of high-purity gadobutrol
EP2771319B1 (en) 2011-10-27 2022-03-02 Massachusetts Institute of Technology Amino acid derivatives functionalized on the n- terminal capable of forming drug incapsulating microspheres
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KR101693400B1 (ko) * 2014-09-17 2017-01-05 에스티팜 주식회사 칼코부트롤의 제조방법
KR101653064B1 (ko) * 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법
HUE062274T2 (hu) 2015-06-19 2023-10-28 Massachusetts Inst Technology Alkenil-szubsztituált 2,5-piperazindionok és alkalmazásuk hatóanyag alanyba vagy sejtbe történõ célbajuttatására szolgáló készítményekben
CA3038036C (en) 2016-09-27 2024-01-23 Bayer Pharma Aktiengesellschaft Method for producing the crystalline form of modification a of calcobutrol
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
EP3820853A4 (en) * 2018-07-10 2022-08-17 Biophore India Pharmaceuticals Pvt. Ltd. PROCESS FOR THE PREPARATION OF 2,2',2''-( 10-((2R,3S)-1,3,4-TRIHYDROXY BUTAN-2-YL)-1,4,7,10-TETRAAZACYCLODODECAN-1,4 ,7-TRIYL)-TRIACETIC ACID AND THEIR COMPLEXES
KR101979836B1 (ko) * 2019-01-02 2019-05-21 동국생명과학 주식회사 칼코부트롤의 제조방법
WO2024030772A1 (en) * 2022-08-01 2024-02-08 Portland State University High relaxivity contrast agents and stereoselective preparation

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KR920000335A (ko) * 1990-06-18 1992-01-29 리챠드 지. 워터맨 영상제로서 거대환상 아미노포스폰산 착체의 용도
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Also Published As

Publication number Publication date
CA2137243C (en) 2005-09-20
DE59309488D1 (de) 1999-05-06
KR950701918A (ko) 1995-05-17
KR100269081B1 (ko) 2000-10-16
ES2131582T3 (es) 1999-08-01
ATE178321T1 (de) 1999-04-15
HU213951B (en) 1997-11-28
HU9403464D0 (en) 1995-03-28
WO1993024469A1 (de) 1993-12-09
JP3565843B2 (ja) 2004-09-15
NO944691D0 (no) 1994-12-05
SK281901B6 (sk) 2001-09-11
CZ301594A3 (en) 1995-08-16
US5386028A (en) 1995-01-31
CZ282873B6 (cs) 1997-11-12
DE4218744C2 (de) 1997-11-06
IL105807A0 (en) 1993-09-22
CA2137243A1 (en) 1993-12-09
NO302232B1 (no) 1998-02-09
DE4218744A1 (de) 1993-12-09
IL105807A (en) 1998-12-06
DK0643705T3 (da) 1999-10-25
JPH07507067A (ja) 1995-08-03
SK148794A3 (en) 1995-07-11
HUT71263A (en) 1995-11-28
EP0643705B1 (de) 1999-03-31
GR3030604T3 (en) 1999-10-29
EP0643705A1 (de) 1995-03-22

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: BAYER INTELLECTUAL PROPERTY GMBH, DE

MK1K Patent expired