NO923857D0 - Nye 7-substituerte-9-substituert-amino-6-demetyl-6-deoksytetracykliner - Google Patents

Nye 7-substituerte-9-substituert-amino-6-demetyl-6-deoksytetracykliner

Info

Publication number: NO923857D0
Authority: NO; Norway
Prior art keywords: substituted; demethyl; amino; deoxytetracyclines; new
Prior art date: 1991-10-04

Application number

NO923857A

Other languages

English (en)

Other versions

NO301472B1 (no

NO923857L (no

Inventor

Joseph J Hlavka

Phaik-Eng Sum

Yakov Gluzman

Ving J Lee

Adma A Ross

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-04

Filing date

1992-10-02

Publication date

1992-10-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25092264&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO923857(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-10-02 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1992-10-02 Publication of NO923857D0 publication Critical patent/NO923857D0/no

1993-04-05 Publication of NO923857L publication Critical patent/NO923857L/no

1997-11-03 Publication of NO301472B1 publication Critical patent/NO301472B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Moulding By Coating Moulds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Furan Compounds (AREA)
Pyrrole Compounds (AREA)
Saccharide Compounds (AREA)
Hydrogenated Pyridines (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO923857A 1991-10-04 1992-10-02 Nye 7-substituerte-9-substituert amino-6-demetyl-6-deoksytetracykliner, og preparater derav NO301472B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US77157691A	1991-10-04	1991-10-04

Publications (3)

Publication Number	Publication Date
NO923857D0 true NO923857D0 (no)	1992-10-02
NO923857L NO923857L (no)	1993-04-05
NO301472B1 NO301472B1 (no)	1997-11-03

Family

ID=25092264

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
NO923857A NO301472B1 (no)	1991-10-04	1992-10-02	Nye 7-substituerte-9-substituert amino-6-demetyl-6-deoksytetracykliner, og preparater derav
NO2006015C NO2006015I2 (no)	1991-10-04	2006-11-15	Tigecyklin.
NO2017037C NO2017037I1 (no)	1991-10-04	2017-08-01	Tygacil er et antibiotika inneholdende en tetracyklinforbindelse betegnet tigecyklin

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
NO2006015C NO2006015I2 (no)	1991-10-04	2006-11-15	Tigecyklin.
NO2017037C NO2017037I1 (no)	1991-10-04	2017-08-01	Tygacil er et antibiotika inneholdende en tetracyklinforbindelse betegnet tigecyklin

Country Status (28)

Country	Link
EP (1)	EP0536515B1 (no)
JP (1)	JP3186863B2 (no)
KR (1)	KR100269072B1 (no)
CN (1)	CN1048240C (no)
AT (1)	ATE211128T1 (no)
AU (1)	AU654049B2 (no)
BR (1)	BR1100853A (no)
CA (1)	CA2079692C (no)
CL (1)	CL2004001623A1 (no)
CZ (2)	CZ284159B6 (no)
DE (4)	DE69232302T4 (no)
DK (1)	DK0536515T3 (no)
ES (1)	ES2168254T3 (no)
FI (1)	FI114911B (no)
HK (1)	HK1011348A1 (no)
HU (2)	HU219973B (no)
IL (3)	IL103320A (no)
LU (1)	LU91279I2 (no)
MX (1)	MX9205532A (no)
NL (1)	NL300244I2 (no)
NO (3)	NO301472B1 (no)
NZ (1)	NZ244585A (no)
PL (4)	PL175957B1 (no)
PT (1)	PT536515E (no)
SG (1)	SG52361A1 (no)
SK (2)	SK280837B6 (no)
TW (1)	TW275616B (no)
ZA (1)	ZA927607B (no)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5420272A (en) *	1992-08-13	1995-05-30	American Cyanamid Company	7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) *	1992-08-13	1994-02-08	American Cyanamid Company	Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5328902A (en) *	1992-08-13	1994-07-12	American Cyanamid Co.	7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5834450A (en) *	1994-02-17	1998-11-10	Pfizer Inc.	9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
EA005118B1 (ru)	1999-09-14	2004-10-28	Трастис Оф Тафтс Коллидж	Замещенный аналог тетрациклина (варианты) и способ его получения (варианты)
US8106225B2 (en)	1999-09-14	2012-01-31	Trustees Of Tufts College	Methods of preparing substituted tetracyclines with transition metal-based chemistries
JP2004505012A (ja)	2000-03-31	2004-02-19	トラスティーズ・オブ・タフツ・カレッジ	７−および９−カルバメート、尿素、チオ尿素、チオカルバメート、およびヘテロアリール−アミノ置換テトラサイクリン化合物
EP2308863A1 (en) *	2000-05-15	2011-04-13	Paratek Pharmaceuticals, Inc.	7-substituted fused ring tetracycline compounds
HU229577B1 (en) *	2000-07-07	2014-02-28	Tufts College	9-substituted minocycline derivatives
US7094806B2 (en)	2000-07-07	2006-08-22	Trustees Of Tufts College	7, 8 and 9-substituted tetracycline compounds
EA201000388A1 (ru)	2001-03-13	2010-10-29	Пэрэтек Фамэсьютикэлс, Инк.	Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта
WO2002072506A2 (en)	2001-03-13	2002-09-19	Paratek Pharmaceuticals, Inc.	7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en)	2001-03-13	2009-06-30	Paratek Pharmaceuticals, Inc.	9-aminomethyl substituted minocycline compounds
EP1241160A1 (en)	2001-03-13	2002-09-18	Glaxo Group Limited	Tetracycline derivatives and their use as antibiotic agents
AU2002254714C1 (en) *	2001-04-24	2010-01-07	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds for the treatment of malaria
WO2003005971A2 (en)	2001-07-13	2003-01-23	Paratek Pharmaceuticals, Inc.	Tetracycline compounds having target therapeutic activities
WO2003055441A2 (en)	2001-08-02	2003-07-10	Paratek Pharmaceuticals, Inc.	Medicaments
JP2005514410A (ja)	2002-01-08	2005-05-19	パラテックファーマシューティカルズインコーポレイテッド	４−デジメチルアミノテトラサイクリン化合物
CN102531948A (zh) *	2002-03-08	2012-07-04	帕拉特克药品公司	氨基-甲基取代的四环素类化合物
EP2298323A3 (en)	2003-07-09	2011-05-11	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds
UA83266C2 (en) *	2003-12-08	2008-06-25	Уайет	Oxazole derivatives of tetracyclines
EP1753713B1 (en)	2004-05-21	2016-07-27	President and Fellows of Harvard College	Synthesis of tetracyclines and analogues thereof
PA8652001A1 (es)	2004-11-05	2006-10-13	Wyeth Corp	Metabolitos glucuronidos de tigeciclina y epimeros de los mismos
AR057649A1 (es)	2005-05-27	2007-12-12	Wyeth Corp	Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
JP2009507793A (ja) *	2005-08-31	2009-02-26	ワイス	グリシルサイクリンの９−アミノカルボニル置換誘導体
AU2007249695A1 (en)	2006-05-15	2007-11-22	Paratek Pharmaceuticals, Inc.	Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
DK2225253T3 (da)	2007-11-29	2012-08-27	Actelion Pharmaceuticals Ltd	Phosphonsyrederivater og deres anvendelse som p2y12- receptorantagonister
PT2271348T (pt)	2008-03-28	2018-04-16	Paratek Pharm Innc	Formulação de comprimido oral de composto de tetraciclina
ITMI20080807A1 (it)	2008-05-05	2009-11-06	Antibioticos Spa	Procedimento per la preparazione di tigeciclina in forma amorfa
TWI585071B (zh)	2008-05-23	2017-06-01	派洛泰克藥物股份有限公司	四環素化合物之甲苯磺酸鹽及同素異形體
HUE026562T2 (hu) *	2008-08-08	2016-06-28	Tetraphase Pharmaceuticals Inc	C7-fluor-helyettesített tetraciklin vegyületek
EP2424834B1 (en)	2009-04-30	2018-07-11	President and Fellows of Harvard College	Synthesis of tetracyclines and intermediates thereof
CA2761241C (en)	2009-05-08	2018-02-27	Tetraphase Pharmaceuticals, Inc.	Tetracycline compounds
CN105622496B (zh) *	2009-08-28	2019-03-05	四相制药公司	四环素类化合物
AU2011252919B2 (en)	2010-05-12	2017-01-19	Melinta Therapeutics, Inc.	Tetracycline compositions
WO2013013504A1 (zh) *	2011-07-26	2013-01-31	山东亨利医药科技有限责任公司	替加环素衍生物
EA036088B1 (ru)	2012-08-31	2020-09-25	Тетрафейз Фармасьютикалс, Инк.	Тетрациклиновые соединения
EP3068370A2 (en)	2013-11-12	2016-09-21	Galenicum Health S.L.	Stable pharmaceutical compositions
JP7492335B2 (ja)	2016-10-19	2024-05-29	テトラフェースファーマシューティカルズ，インコーポレイテッド	エラバサイクリンの結晶形

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3338963A (en) *	1960-10-28	1967-08-29	American Cyanamid Co	Tetracycline compounds
US3579579A (en) *	1968-04-18	1971-05-18	American Cyanamid Co	Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines

1992
- 1992-08-21 DE DE69232302T patent/DE69232302T4/de not_active Expired - Lifetime
- 1992-08-21 PT PT92114281T patent/PT536515E/pt unknown
- 1992-08-21 SG SG1996003437A patent/SG52361A1/en unknown
- 1992-08-21 AT AT92114281T patent/ATE211128T1/de active
- 1992-08-21 DE DE69232302A patent/DE69232302D1/de not_active Expired - Lifetime
- 1992-08-21 ES ES92114281T patent/ES2168254T3/es not_active Expired - Lifetime
- 1992-08-21 DE DE1992632302 patent/DE122006000058I1/de active Pending
- 1992-08-21 EP EP92114281A patent/EP0536515B1/en not_active Expired - Lifetime
- 1992-08-21 DE DE200612000058 patent/DE122006000058I2/de active Active
- 1992-08-21 DK DK92114281T patent/DK0536515T3/da active
- 1992-08-27 TW TW081106768A patent/TW275616B/zh not_active IP Right Cessation
- 1992-09-29 MX MX9205532A patent/MX9205532A/es unknown
- 1992-09-30 CZ CS922984A patent/CZ284159B6/cs not_active IP Right Cessation
- 1992-09-30 CZ CZ973093A patent/CZ309397A3/cs not_active IP Right Cessation
- 1992-09-30 SK SK2984-92A patent/SK280837B6/sk not_active IP Right Cessation
- 1992-09-30 HU HU9203110A patent/HU219973B/hu unknown
- 1992-09-30 SK SK1149-99A patent/SK284826B6/sk not_active IP Right Cessation
- 1992-10-01 NZ NZ244585A patent/NZ244585A/en not_active IP Right Cessation
- 1992-10-01 IL IL10332092A patent/IL103320A/en not_active IP Right Cessation
- 1992-10-01 IL IL11959092A patent/IL119590A/xx not_active IP Right Cessation
- 1992-10-02 PL PL92310718A patent/PL175957B1/pl unknown
- 1992-10-02 PL PL92310717A patent/PL172282B1/pl unknown
- 1992-10-02 PL PL92310719A patent/PL176333B1/pl unknown
- 1992-10-02 ZA ZA927607A patent/ZA927607B/xx unknown
- 1992-10-02 AU AU26183/92A patent/AU654049B2/en not_active Expired
- 1992-10-02 FI FI924454A patent/FI114911B/fi active Protection Beyond IP Right Term
- 1992-10-02 PL PL92296143A patent/PL173311B1/pl unknown
- 1992-10-02 CA CA002079692A patent/CA2079692C/en not_active Expired - Lifetime
- 1992-10-02 KR KR1019920018122A patent/KR100269072B1/ko not_active IP Right Cessation
- 1992-10-02 NO NO923857A patent/NO301472B1/no not_active IP Right Cessation
- 1992-10-03 CN CN92112130A patent/CN1048240C/zh not_active Expired - Lifetime
- 1992-10-05 JP JP28811492A patent/JP3186863B2/ja not_active Expired - Lifetime
1995
- 1995-04-28 HU HU95P/P00116P patent/HU211172A9/hu active Protection Beyond IP Right Term
1996
- 1996-11-10 IL IL11959096A patent/IL119590A0/xx unknown
1997
- 1997-05-12 BR BR1100853-9A patent/BR1100853A/pt active IP Right Grant
1998
- 1998-11-27 HK HK98112374A patent/HK1011348A1/xx not_active IP Right Cessation
2004
- 2004-06-25 CL CL200401623A patent/CL2004001623A1/es unknown
2006
- 2006-10-11 LU LU91279C patent/LU91279I2/fr unknown
- 2006-10-23 NL NL300244C patent/NL300244I2/nl unknown
- 2006-11-15 NO NO2006015C patent/NO2006015I2/no unknown
2017
- 2017-08-01 NO NO2017037C patent/NO2017037I1/no unknown

Also Published As

Publication number	Publication date
NO301472B1 (no)	1997-11-03
HUT63145A (en)	1993-07-28
CA2079692C (en)	2004-06-08
EP0536515B1 (en)	2001-12-19
NL300244I1 (nl)	2007-01-02
FI114911B (fi)	2005-01-31
MX9205532A (es)	1993-04-01
JPH05255219A (ja)	1993-10-05
DE69232302D1 (de)	2002-01-31
FI924454A0 (fi)	1992-10-02
KR930007894A (ko)	1993-05-20
CZ284159B6 (cs)	1998-08-12
SK284826B6 (sk)	2005-12-01
NZ244585A (en)	1995-07-26
AU2618392A (en)	1993-04-08
AU654049B2 (en)	1994-10-20
CZ284209B6 (cs)	1998-09-16
FI924454A (fi)	1993-04-05
NO2017037I2 (no)	2017-08-01
PL296143A1 (en)	1993-05-31
DE69232302T2 (de)	2002-08-14
DE122006000058I2 (de)	2007-09-13
HU211172A9 (en)	1995-11-28
TW275616B (no)	1996-05-11
SG52361A1 (en)	1998-09-28
HU219973B (hu)	2001-10-28
CN1072172A (zh)	1993-05-19
CA2079692A1 (en)	1993-04-05
KR100269072B1 (ko)	2000-10-16
NO923857L (no)	1993-04-05
IL119590A0 (en)	1997-02-18
CZ309397A3 (cs)	1998-09-16
ATE211128T1 (de)	2002-01-15
PT536515E (pt)	2002-05-31
BR1100853A (pt)	1999-12-07
IL119590A (en)	1999-03-12
LU91279I2 (fr)	2006-12-11
NO2006015I1 (no)	2006-11-27
IL103320A0 (en)	1993-03-15
JP3186863B2 (ja)	2001-07-11
DE69232302T4 (de)	2003-02-13
CN1048240C (zh)	2000-01-12
PL172282B1 (pl)	1997-08-29
PL173311B1 (pl)	1998-02-27
EP0536515A1 (en)	1993-04-14
SK280837B6 (sk)	2000-08-14
HK1011348A1 (en)	1999-07-09
SK114999A3 (en)	2000-07-11
PL176333B1 (pl)	1999-05-31
HU9203110D0 (en)	1992-12-28
IL103320A (en)	1998-12-06
DE122006000058I1 (de)	2007-01-18
NL300244I2 (nl)	2007-01-02
ZA927607B (en)	1993-04-13
ES2168254T3 (es)	2002-06-16
NO2006015I2 (no)	2011-03-14
NO2017037I1 (no)	2017-08-01
PL175957B1 (pl)	1999-03-31
SK298492A3 (en)	1995-03-08
DK0536515T3 (da)	2002-04-08
CZ298492A3 (en)	1993-05-12
CL2004001623A1 (es)	2005-06-03

Publication	Publication Date	Title
NO923856D0 (no)	1992-10-02	Nye 9-amino-7-substituerte-6-demetyl-6-deoksytetracykliner
DK0536515T3 (da)	2002-04-08	Nye 7-substitueret-9-substitueret amino-6-demethyl-6-deoxytetracycliner

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