[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

NO921679L - PURIN NUCLEOSIDE PHOSPHORYLASE INHIBITORS - Google Patents

PURIN NUCLEOSIDE PHOSPHORYLASE INHIBITORS

Info

Publication number
NO921679L
NO921679L NO92921679A NO921679A NO921679L NO 921679 L NO921679 L NO 921679L NO 92921679 A NO92921679 A NO 92921679A NO 921679 A NO921679 A NO 921679A NO 921679 L NO921679 L NO 921679L
Authority
NO
Norway
Prior art keywords
nucleoside phosphorylase
phosphorylase inhibitors
purin
purin nucleoside
inhibitors
Prior art date
Application number
NO92921679A
Other languages
Norwegian (no)
Other versions
NO921679D0 (en
NO301423B1 (en
Inventor
Iii John A Secrist
Mark David Erion
John A Montgomery
Steven E Ealick
Wayne C Guida
Shri Niwas
Original Assignee
Biocryst Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/429,098 external-priority patent/US4985434A/en
Priority claimed from US07/429,099 external-priority patent/US5008265A/en
Priority claimed from US07/429,100 external-priority patent/US4985433A/en
Priority claimed from US07/429,097 external-priority patent/US5008270A/en
Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc
Publication of NO921679D0 publication Critical patent/NO921679D0/en
Publication of NO921679L publication Critical patent/NO921679L/en
Publication of NO301423B1 publication Critical patent/NO301423B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/35—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/40—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO921679A 1989-10-31 1992-04-29 Analogous Process for Preparation of Purine Nucleoside Phosphorylase Inhibitors NO301423B1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US07/429,098 US4985434A (en) 1989-10-31 1989-10-31 7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimidin-4-ones and pharamceutical uses and compositions containing the same
US07/429,099 US5008265A (en) 1989-10-31 1989-10-31 2-amino-7-(alicyclomethyl)-3H,5H,-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US07/429,100 US4985433A (en) 1989-10-31 1989-10-31 2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US07/429,097 US5008270A (en) 1989-10-31 1989-10-31 2-amino-7-(heterocyclomethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US44279889A 1989-11-29 1989-11-29
PCT/US1990/005756 WO1991006548A1 (en) 1989-10-31 1990-10-12 Inhibitors of purine nucleoside phosphorylase

Publications (3)

Publication Number Publication Date
NO921679D0 NO921679D0 (en) 1992-04-29
NO921679L true NO921679L (en) 1992-06-17
NO301423B1 NO301423B1 (en) 1997-10-27

Family

ID=27541578

Family Applications (1)

Application Number Title Priority Date Filing Date
NO921679A NO301423B1 (en) 1989-10-31 1992-04-29 Analogous Process for Preparation of Purine Nucleoside Phosphorylase Inhibitors

Country Status (9)

Country Link
EP (1) EP0500653A4 (en)
JP (1) JP2866478B2 (en)
AU (1) AU654264B2 (en)
CA (1) CA2072123C (en)
FI (1) FI103972B1 (en)
HU (1) HUT61765A (en)
LV (1) LV10100B (en)
NO (1) NO301423B1 (en)
WO (1) WO1991006548A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726311A (en) * 1989-11-29 1998-03-10 Biocryst Pharmaceuticals, Inc. 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo 3,2-d!pyrimidine and pharmaceutical uses and compositions containing the same
US5236926A (en) * 1992-02-03 1993-08-17 Warner-Lambert Company 9-substituted-8-halo or -8-hydroxy-9-deazaguanines as inhibitors or PNP for pharmaceutical compositions
RU94046387A (en) * 1992-04-21 1996-09-27 Биокрист Фармасьютикалз Derivatives of pyrimidine, method of their synthesis, pharmaceutical composition, its use and intermediate compounds
EP0784624A1 (en) * 1994-10-05 1997-07-23 Chiroscience Limited Purine and guanine compounds as inhibitors of pnp
GB9520364D0 (en) * 1995-10-05 1995-12-06 Chiroscience Ltd Compouundds
GB9520363D0 (en) * 1995-10-05 1995-12-06 Chiroscience Ltd Compounds
JP2002500658A (en) * 1997-05-29 2002-01-08 ノバルティス アクチエンゲゼルシャフト 2-amino-7- (1-substituted-2-hydroxyethyl) -3,5-dihydropyrrolo [3,2-d] pyrimidin-4-one
US6174888B1 (en) 1998-05-28 2001-01-16 Novartis Ag 2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydropyrrolo[3,2-D]pyrimidin-4-ones
JP4496586B2 (en) * 2000-01-24 2010-07-07 日産化学工業株式会社 Process for producing quinolylacrylonitrile and its intermediate
RU2330042C2 (en) * 2002-08-21 2008-07-27 Альберт Эйнштейн Колледж Оф Медсин Оф Йешива Юниверсити Nucleoside phosphorylases and nucleosidases inhibitors
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
EP2225226B1 (en) 2007-12-26 2016-08-17 Critical Outcome Technologies, Inc. Compounds and their use in a method for treatment of cancer
EP2318406B1 (en) 2008-07-17 2016-01-27 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
EP3235818A3 (en) 2010-04-01 2018-03-14 Critical Outcome Technologies, Inc. Compounds for the treatment of hiv

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5988484A (en) * 1982-11-09 1984-05-22 Takeda Chem Ind Ltd Novel 7-deazapurine derivative
CA1293727C (en) * 1986-08-26 1991-12-31 Catherine Rose Kostlan 9-deazaguanines
US4921858A (en) * 1986-10-24 1990-05-01 Warner-Lambert Company 7-deazaguanines as immunomodulators
CA1294960C (en) * 1986-10-24 1992-01-28 Thomas C. Malone 7-deazaguanines as immunomodulators
DE3726044A1 (en) * 1987-02-11 1988-08-25 Bayer Ag ACARICIDES ON THE BASIS OF AZOMETHINE DERIVATIVES AND AZOMETHINE OF 2,3-DIAMINOMALEAINSAURENITRILE
US4927830A (en) * 1988-04-08 1990-05-22 The Regents Of The University Of Michigan Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents
AU640649B2 (en) * 1989-02-27 1993-09-02 Biocryst Pharmaceuticals, Inc. 9-substituted-8-unsubstituted-9-deazaguanines
US4985433A (en) * 1989-10-31 1991-01-15 Biocryst, Inc. 2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US4985434A (en) * 1989-10-31 1991-01-15 Biocryst, Inc. 7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimidin-4-ones and pharamceutical uses and compositions containing the same

Also Published As

Publication number Publication date
FI103972B (en) 1999-10-29
JPH05504551A (en) 1993-07-15
CA2072123A1 (en) 1991-05-01
HU9201450D0 (en) 1992-09-28
JP2866478B2 (en) 1999-03-08
WO1991006548A1 (en) 1991-05-16
LV10100A (en) 1994-05-10
AU654264B2 (en) 1994-11-03
NO921679D0 (en) 1992-04-29
LV10100B (en) 1995-08-20
FI921900A0 (en) 1992-04-28
EP0500653A1 (en) 1992-09-02
AU6712590A (en) 1991-05-31
FI103972B1 (en) 1999-10-29
FI921900A (en) 1992-04-28
EP0500653A4 (en) 1995-08-23
CA2072123C (en) 2001-06-12
NO301423B1 (en) 1997-10-27
HUT61765A (en) 1993-03-01

Similar Documents

Publication Publication Date Title
DE3856154D1 (en) Adenosine derivatives
DE19575021I2 (en) Therapeutic nucleosides
LV5781B4 (en) Healing Nucleoside
MC1992A1 (en) FLUOROCYTIDINE DERIVATIVES
DK0434450T3 (en) Therapeutic nucleosides
DK23489D0 (en) nucleoside
DK375989A (en) purine derivatives
NO921679D0 (en) PURIN NUCLEOSIDE PHOSPHORYLASE INHIBITORS
DK564088A (en) nucleoside
ATE141282T1 (en) ARISTEROMYCIN/ADENOSINE DERIVATIVES
KR880701730A (en) Heteroaromatic derivative of adenosine
DK630589D0 (en) 2 ', 3'-DIDEOXYPURINNUCLEOSID / purine nucleoside phosphorylase inhibitor COMPOSITION
DK458485A (en) purine derivatives
OA09697A (en) Nucleoside derivatives
DE68914750D1 (en) Therapeutic nucleosides.
DK626989D0 (en) adenosine
MC1934A1 (en) PYRIMIDINE DERIVATIVES
DK71187A (en) purine derivatives
DK95791A (en) nucleoside analogues
DK339189D0 (en) purine derivatives
KR900700498A (en) Anti-tumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds
NO921776D0 (en) Nucleoside derivative
ATE104675T1 (en) THERAPEUTIC NUCLEOSIDES.
ATE77386T1 (en) THERAPEUTIC NUCLEOSIDES.
NO931264D0 (en) Nucleoside derivative

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN APRIL 2002