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NO893826L - Fremgangsmaate for fremstilling av 2'-halomethyliden, 2'-ethenyliden og 2'-ethenyladenosinderivater. - Google Patents

Fremgangsmaate for fremstilling av 2'-halomethyliden, 2'-ethenyliden og 2'-ethenyladenosinderivater.

Info

Publication number
NO893826L
NO893826L NO89893826A NO893826A NO893826L NO 893826 L NO893826 L NO 893826L NO 89893826 A NO89893826 A NO 89893826A NO 893826 A NO893826 A NO 893826A NO 893826 L NO893826 L NO 893826L
Authority
NO
Norway
Prior art keywords
halomethylide
ethenylide
ethenyladenosin
derivatives
procedure
Prior art date
Application number
NO89893826A
Other languages
English (en)
Other versions
NO171857C (no
NO171857B (no
NO893826D0 (no
Inventor
James R Mccarthy
Michael L Edwards
David M Stemerick
Esa T Jarvi
Nellikunja J Prakash
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO893826D0 publication Critical patent/NO893826D0/no
Publication of NO893826L publication Critical patent/NO893826L/no
Publication of NO171857B publication Critical patent/NO171857B/no
Publication of NO171857C publication Critical patent/NO171857C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO893826A 1988-09-27 1989-09-26 Analogifremgangsmaate for fremstilling av terapeutisk aktive 2'-halomethyliden-adenosin-derivater NO171857C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24991188A 1988-09-27 1988-09-27
US38939189A 1989-08-03 1989-08-03

Publications (4)

Publication Number Publication Date
NO893826D0 NO893826D0 (no) 1989-09-26
NO893826L true NO893826L (no) 1990-03-28
NO171857B NO171857B (no) 1993-02-01
NO171857C NO171857C (no) 1993-05-12

Family

ID=26940460

Family Applications (1)

Application Number Title Priority Date Filing Date
NO893826A NO171857C (no) 1988-09-27 1989-09-26 Analogifremgangsmaate for fremstilling av terapeutisk aktive 2'-halomethyliden-adenosin-derivater

Country Status (18)

Country Link
EP (1) EP0365849B1 (no)
JP (1) JP2968002B2 (no)
KR (1) KR0146333B1 (no)
CN (1) CN1046334A (no)
AR (1) AR248283A1 (no)
AT (1) ATE111477T1 (no)
AU (1) AU621664B2 (no)
CA (1) CA1336903C (no)
DE (1) DE68918215T2 (no)
DK (1) DK171237B1 (no)
ES (1) ES2063796T3 (no)
FI (1) FI94763C (no)
HU (1) HU204843B (no)
IE (1) IE63561B1 (no)
IL (1) IL91773A (no)
NO (1) NO171857C (no)
NZ (1) NZ230766A (no)
PT (1) PT91803B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340816A (en) * 1990-10-18 1994-08-23 E. R. Squibb & Sons, Inc. Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
ES2098032T3 (es) * 1992-05-12 1997-04-16 Merrell Pharma Inc Procedimiento de preparacion de inhibidores de ribonucleotido-reductasa.
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
US5627053A (en) * 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
US5811408A (en) * 1994-07-12 1998-09-22 Yamasa Corporation 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
EP1183034B1 (en) 1999-06-09 2005-11-23 Anticancer, Inc. Modulators of methylation for control of bacterial virulence
US6579857B1 (en) 1999-06-11 2003-06-17 Evanston Northwestern Healthcare Research Institute Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
MXPA04007876A (es) * 2002-02-14 2005-06-20 Pharmasset Ltd Analogos de nucleosido fluorado modificados.
KR102072041B1 (ko) 2011-12-22 2020-01-31 앨리오스 바이오파마 인크. 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84414A0 (en) * 1986-11-14 1988-04-29 Ciba Geigy Ag N9-cyclopentyl-substituted adenine derivatives
DE3854110T2 (de) * 1987-03-19 1995-11-30 Yamasa Shoyu Kk 2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung.
NZ225906A (en) * 1987-08-26 1990-10-26 Merrell Dow Pharma Aristeromycin/adenosine derivatives and pharmaceutical compositions
ZA894534B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Novel neplanocin derivatives

Also Published As

Publication number Publication date
IE63561B1 (en) 1995-05-17
NO171857C (no) 1993-05-12
KR0146333B1 (ko) 1998-08-01
NO171857B (no) 1993-02-01
FI94763B (fi) 1995-07-14
KR900004736A (ko) 1990-04-12
IE893080L (en) 1990-03-27
CA1336903C (en) 1995-09-05
IL91773A0 (en) 1990-06-10
CN1046334A (zh) 1990-10-24
DK473289A (da) 1990-03-28
EP0365849B1 (en) 1994-09-14
AU621664B2 (en) 1992-03-19
NZ230766A (en) 1992-07-28
JPH02160769A (ja) 1990-06-20
DE68918215T2 (de) 1995-02-02
ES2063796T3 (es) 1995-01-16
JP2968002B2 (ja) 1999-10-25
EP0365849A3 (en) 1990-12-27
IL91773A (en) 1994-02-27
NO893826D0 (no) 1989-09-26
DK473289D0 (da) 1989-09-26
FI894546A0 (fi) 1989-09-26
ATE111477T1 (de) 1994-09-15
DK171237B1 (da) 1996-08-05
AR248283A1 (es) 1995-07-12
PT91803B (pt) 1995-05-31
DE68918215D1 (de) 1994-10-20
PT91803A (pt) 1990-03-30
FI894546A (fi) 1990-03-28
FI94763C (fi) 1995-10-25
HUT50844A (en) 1990-03-28
HU204843B (en) 1992-02-28
EP0365849A2 (en) 1990-05-02
AU4176089A (en) 1990-04-05

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Free format text: LAPSED IN MARCH 2001