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NO822722L - Fremgangsmaate til fremstilling av benzazepin-2-oner. - Google Patents

Fremgangsmaate til fremstilling av benzazepin-2-oner.

Info

Publication number
NO822722L
NO822722L NO822722A NO822722A NO822722L NO 822722 L NO822722 L NO 822722L NO 822722 A NO822722 A NO 822722A NO 822722 A NO822722 A NO 822722A NO 822722 L NO822722 L NO 822722L
Authority
NO
Norway
Prior art keywords
oner
benzazepin
procedure
preparation
Prior art date
Application number
NO822722A
Other languages
English (en)
Other versions
NO161558B (no
NO161558C (no
Inventor
Jeffrey W H Watthey
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO822722L publication Critical patent/NO822722L/no
Publication of NO161558B publication Critical patent/NO161558B/no
Publication of NO161558C publication Critical patent/NO161558C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO822722A 1981-08-11 1982-08-10 Analogifremgangsmaate til fremstilling av antihypertensivebenzazepin-2-oner. NO161558C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29190781A 1981-08-11 1981-08-11
US31986381A 1981-11-09 1981-11-09

Publications (3)

Publication Number Publication Date
NO822722L true NO822722L (no) 1983-02-14
NO161558B NO161558B (no) 1989-05-22
NO161558C NO161558C (no) 1989-08-30

Family

ID=26967047

Family Applications (1)

Application Number Title Priority Date Filing Date
NO822722A NO161558C (no) 1981-08-11 1982-08-10 Analogifremgangsmaate til fremstilling av antihypertensivebenzazepin-2-oner.

Country Status (22)

Country Link
EP (1) EP0072352B1 (no)
KR (3) KR890003425B1 (no)
AR (3) AR240806A1 (no)
AT (1) ATE18397T1 (no)
AU (1) AU561395B2 (no)
CA (1) CA1196636A (no)
CY (1) CY1403A (no)
DD (1) DD202546A5 (no)
DE (1) DE3269625D1 (no)
DK (1) DK157881C (no)
ES (6) ES8502974A1 (no)
FI (1) FI76074C (no)
GB (1) GB2103614B (no)
GR (1) GR77256B (no)
HK (1) HK93387A (no)
HU (1) HU189628B (no)
IE (1) IE53668B1 (no)
IL (1) IL66501A (no)
NL (1) NL930112I2 (no)
NO (1) NO161558C (no)
NZ (1) NZ201555A (no)
PT (1) PT75395B (no)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4564612A (en) * 1983-04-22 1986-01-14 Takeda Chemical Industries, Ltd. Condensed, seven-membered ring compounds and their use
JPS608284A (ja) * 1983-06-29 1985-01-17 Mitsui Toatsu Chem Inc ベンゾチアゼピン誘導体およびその製造法
US4539150A (en) * 1983-06-29 1985-09-03 Mitsui Toatsu Chemicals, Inc. Benzothiazepine derivatives and their methods of preparation
AU570710B2 (en) * 1983-08-12 1988-03-24 Takeda Chemical Industries Ltd. 4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives
US4638000A (en) * 1983-08-12 1987-01-20 Takeda Chemical Industries, Ltd. Condensed seven-membered ring compounds, their production and use
IL72523A (en) * 1983-08-12 1988-06-30 Takeda Chemical Industries Ltd 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
CA1266647A (en) * 1984-06-26 1990-03-13 William H. Parsons Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists
EP0166354B1 (en) * 1984-06-26 1992-08-05 Merck & Co. Inc. Benzofused lactam compounds and pharmaceutical compositions containing them
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
DE3704661A1 (de) * 1987-02-14 1988-08-25 Hoechst Ag Annelierte azepinon- und azocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung
EP0322779A3 (en) * 1987-12-29 1991-05-08 Yoshitomi Pharmaceutical Industries, Ltd. Benzolactam compounds and pharmaceutical uses thereof
TW197945B (no) * 1990-11-27 1993-01-11 Hoechst Ag
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
NZ258889A (en) * 1992-12-11 1997-02-24 Ciba Geigy Ag 3-alkylamino-1,5-benzoxazepin- (and benzothiazepin-) 4-one derivatives and pharmaceutical compositions
GB9310075D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore
AU784646B2 (en) * 1999-11-18 2006-05-18 Antexpharma, Inc. Substituted 1-benzazepines and derivatives thereof
US7053211B2 (en) 2000-12-27 2006-05-30 Merck Patent Gmbh Process for the preparation of α-aminosubstituted carboxylic acid amides
US6919450B2 (en) 2001-03-27 2005-07-19 Ranbaxy Laboratories Limited Process for the preparation of benazepril
EP1443919A4 (en) 2001-11-16 2006-03-22 Bristol Myers Squibb Co DOUBLE INHIBITORS OF THE FATTY ACID BINDING PROTEIN OF THE ADIPOCYTES AND THE FATTY ACID BINDING PROTEIN OF KERATINOCYTES
CA2492949A1 (en) * 2002-07-26 2004-02-12 Ciba Specialty Chemicals Holding Inc. Crystalline polymorphic and amorphous forms of benazepril hydrochloride
KR100710548B1 (ko) * 2002-12-26 2007-04-24 에스케이 주식회사 (ｓ)-3-아미노-2,3,4,5-테트라히드로-2-옥소-1Ｈ-1-벤자제핀-1-아세트산 및 이의 에스테르 화합물의 제조방법
US7459474B2 (en) 2003-06-11 2008-12-02 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US8080579B2 (en) 2005-10-03 2011-12-20 The Regents Of The University Of Michigan Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2008057857A1 (en) 2006-11-01 2008-05-15 Bristol-Myers Squibb Company MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
US7968577B2 (en) 2006-11-01 2011-06-28 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
EP2998314B1 (en) 2007-06-04 2020-01-22 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US7828840B2 (en) 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
JP2011525537A (ja) 2008-06-24 2011-09-22 ブリストル−マイヤーズ スクイブ カンパニー グルココルチコイド受容体、ＡＰ−１、および／またはＮＦ−κＢ活性のシクロペンタチオフェン調節剤およびその使用
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
PL3004138T3 (pl) 2013-06-05 2024-07-29 Bausch Health Ireland Limited Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
US9593113B2 (en) 2013-08-22 2017-03-14 Bristol-Myers Squibb Company Imide and acylurea derivatives as modulators of the glucocorticoid receptor
CN113292495B (zh) * 2021-06-18 2022-09-13 迪嘉药业集团有限公司 一种 (s)-氨基化合物的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395150A (en) * 1965-02-26 1968-07-30 Squibb & Sons Inc Benzothiazepine carboxamides and derivatives thereof
GB1305278A (no) * 1970-03-12 1973-01-31

Also Published As

Publication number Publication date
KR900001191B1 (ko) 1990-02-28
PT75395B (en) 1985-11-15
IL66501A0 (en) 1982-12-31
ES8601142A1 (es) 1985-11-01
CY1403A (en) 1987-12-18
EP0072352A1 (de) 1983-02-16
HU189628B (en) 1986-07-28
DE3269625D1 (en) 1986-04-10
NL930112I2 (nl) 1996-11-01
FI76074C (fi) 1988-09-09
IL66501A (en) 1987-10-20
GB2103614A (en) 1983-02-23
EP0072352B1 (de) 1986-03-05
KR840001139A (ko) 1984-03-28
ES8602682A1 (es) 1985-12-01
ATE18397T1 (de) 1986-03-15
IE821929L (en) 1983-02-11
ES526888A0 (es) 1985-04-16
ES8604523A1 (es) 1986-02-01
CA1196636A (en) 1985-11-12
ES8504728A1 (es) 1985-04-16
GB2103614B (en) 1984-11-21
ES526886A0 (es) 1985-11-01
GR77256B (no) 1984-09-11
ES526887A0 (es) 1986-04-16
NL930112I1 (nl) 1993-10-18
AR240806A2 (es) 1991-02-28
ES530658A0 (es) 1985-12-01
HK93387A (en) 1987-12-18
ES514856A0 (es) 1985-02-01
AR241222A1 (es) 1992-02-28
DK157881C (da) 1990-07-23
DK358682A (da) 1983-02-12
NO161558B (no) 1989-05-22
KR900001190B1 (ko) 1990-02-28
AR240807A1 (es) 1991-02-28
ES526889A0 (es) 1986-02-01
FI76074B (fi) 1988-05-31
DD202546A5 (de) 1983-09-21
FI822770A0 (fi) 1982-08-09
ES8606285A1 (es) 1986-04-16
FI822770L (fi) 1983-02-12
NO161558C (no) 1989-08-30
PT75395A (en) 1982-09-01
KR890003425B1 (ko) 1989-09-20
AR240807A2 (es) 1991-02-28
IE53668B1 (en) 1989-01-04
NZ201555A (en) 1986-06-11
DK157881B (da) 1990-02-26
ES8502974A1 (es) 1985-02-01
AR240806A1 (es) 1991-02-28
AU561395B2 (en) 1987-05-07
AU8701482A (en) 1983-05-12

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Legal Events

Date Code Title Description
MK1K Patent expired

Free format text: EXPIRED IN AUGUST 2002