NO822091L - WATER-BASED AEROSOL FORMULATIONS. - Google Patents

Abstract

Aerosol formulations on. water base consisting of 0.01 -. 6 weight? of at least one insecticide and / or acaricide active substance from the class carbamates, pyrethroids, acetic acid ester derivatives and / or phosphoric acid ester derivatives, 0,1 - 2 weight? of at least one emulsifier, 5 - A0 weight? of at least one organic solvent,. 20 - 70 weight? water, '. 10 - 50 weight? propellant,. and possibly 0.1 - 6th weight? additives, ■. as the sum of the component-. ten each time amounts to 100 ?. The formulations can be prepared by mixing the active. som substance or substances, emulsifier, organic solvent, as well as any additives, mixes the mixture with water, and adds to 1 a spray can of propellant. The aero sun formulations can be used in household and hygiene areas, resp. in agriculture and horticulture.

Description

The invention relates to new water-based aerosol formulations, a method for their production, and their use in the household and hygiene sector, as well as in plant protection.

It is already known to apply active substances in the household and hygiene area, as well as in plant protection - with the help of spray cans, in which the active substances in the aerosol formulations are contained dissolved in organic solvents. With this type of expulsion, relatively large quantities of organic solvents are atomised, which on the one hand is expensive, and on the other hand is also undesirable for ecological reasons. To remove this negative factor as far as possible, it was therefore developed aerosol formulations in which part of the organic solvents have been replaced with water. A decisive disadvantage of the hitherto known aerosol formulations of this type is, however, that they show a clearly lesser effect than the corresponding water-free aerosol formulations (cf. Bundesgesundheitsblatt 24, no. 10, pages I63-I65 (1981)).

New water-based aerosol formulations have now been found which consist of

0.01 - 6% by weight of at least one insecticide and/or acaricide-active substance from the class of carbamates, pyrethroids, acetic acid ester derivatives and/or phosphoric acid ester derivatives,

possibly 0.1 - 6% by weight of additives

as the sum of the components each time amounts to 100% by weight.

Furthermore, it was found that the water-based aerosol formulations according to the invention can be prepared by mixing a solution of 0.01 - 6% by weight of at least one insecticide and/or acaricide active substance from the class of carbamates, pyrethroids, acetic acid ester derivatives and/or phosphoric acid ester derivatives,

0.172% by weight of at least one emulsifier,

5 - 40 weight</>"" of at least one organic solvent,

as well

optionally 0.1 - 6% by weight of additives

with 20 - 60 wt$ of water,

and the resulting mixture is mixed in a spray can with 10-50% by weight of propellant,

since the sum of the components each time amounts to 100 weight$.

Finally, it was found that the water-based aerosol formulation according to the invention can be used in the household and hygiene area, resp. in agriculture and horticulture.

It is to be considered very surprising that the water-based aerosol formulations according to the invention containing insecticide and/or acaricide-active substances from the class of carbamates, pyrethroids, acetic acid ester derivatives and/or phosphoric acid ester derivatives have a better effect than the corresponding previously known water-free aerosol formulations. Such a "superior" effect could not be expected due to the state of the art, for according to early experience, the aqueous aerosol formulations each time have a better activity than the analogous aqueous aerosol formulations.

The water-based aerosol formulations according to the invention differ from the corresponding earlier known water-free aerosol formulations, however, not only by an unexpectedly higher effect, but also by the fact that less organic solvents are required. Thereby, the water-based aerosol formulation according to the invention can be

still more cost-effective than equivalent water-free aerosol formulations. Moreover, in the case of the aerosol formulation according to the invention, the ecological load is reduced by means of organic solvents.

The aerosol formulations according to the invention on water-based ice contain at least one insecticide and/or acaricide-active substance from the class of carbamates, pyrethroids, acetic acid ester derivatives and/or phosphoric acid ester derivatives. As examples of such active substances, the following should be mentioned in detail: 2- isopropoxy-phenyl-N-methyl carbarnate

2, 2, 2-trichloro1-(3.7.4-dichlorophenyl)-ethyl acetate

α-cyano-m-phenoxybenzene (1R, 3R)-3-(2,2-dibromovinyl>-2,2-dimethylcyclopropane-1-carboxylate. chrysanthemum acid-(2,3,4,5-tetrahydrophthalimidomethyl ester) 3-(2 ,2-dichlorovinyl)-2,2-dimethyl-cyclopropane-carboxylic acid-α-cyano-3-cenoxy-4-fluorobenzyl ester

3-(2,2-Dichlorovinyl)-2,2-dimethyl-cyclopropane-carboxylic acid (pentafluorophenyl)-methyl ester

natural pyrethrum

0,0-diethyl-thionophosphoryl-α-oximino-phenylacetic acid nitrile 0,0-diethyl-thionophosphoryl-α-oximino-(2-chlorophenyl)-acetic acid nitrile.

As emulsifiers contained in aerosol formulations according to the invention, polyoxyethylene sorbitan fatty acid esters and sorbitan fatty acid esters are preferably taken into account. As an example, mention should be made of: polyoxyethylene sorbitan monolaurate, monopolyamide monostearate and monooleate in each case average 20 -C^-CB^-O group per molecule, further sorbitah, monolaurate, -monopalmitate, -monostearate,

-tristearate, -monooleate and -trioleate.

The emulsifiers may be contained in aerosol formulations! according to the invention alone or in the form of mixtures.

As organic solvents are contained

in the aerosol formulations according to the invention the following are preferably used: saturated aliphatic hydrocarbons with a boiling point between 150°C and 250°C such as dodecane and deodorized kerosenes, further low-boiling chlorinated aliphatic hydrocarbons such as methylene chloride, further alcohols with up to 3 carbon atoms, such as ethanol , n-propanol and isopropanol, and

and also low-boiling ketones such as acetone and methyl ethyl ketone.

The organic solvents can be contained individually or in the form of mixtures.

As water, in the case of the aerosol formulation according to the invention, it is preferably distilled water.

Mixtures of propane and butane are preferably taken into account as propellants contained in the aerosol formulation according to the invention.

Additives that can be contained in the water-based aerosol formulations according to the invention include synergists, fragrances and stabilizers.

As examples for synergists, piperonyl butoxide should be mentioned.

As odorants, perfume oil comes into consideration. Particular mention should be made of fragrances marketed by the company Haarmann & Reimer GmbH Holzminden, under the designation "Frischduft 760 712 H + R".

Examples of stabilizers include sodium benzoate and amphoteric surfactants.

In the water-based aerosol formulation according to the invention, the percentages of the contained components can be varied within specific ranges. The amount of active substance or active substances are usually between 0.01 and 6% by weight, preferably between 0.04 and 3% by weight. The amount of emulsifier usually amounts to 0.1 to 2% by weight, preferably. 0.2 to 1.5 wt#. Organic solvents are usually present in amounts between 45% by weight, preferably between 6> and 35% by weight. The amount of propellant is usually between 10 and 50% by weight, preferably between 20 and 40% by weight. Additives may be contained in amounts from 0.1 to 6% by weight, preferably 0.5 to 5% by weight.

The percentage amount of water in the aerosol formulation according to the invention appears each time as a difference from 100% by weight and the sum of the percentage amounts of the other components. Usually they are contained between 20 and

70% by weight, preferably between 30 and 65% by weight, water.

In the production of the aerosol formulations according to the invention on a water basis according to the method according to the invention, all components which have already been mentioned in connection with the description of the aerosol formulations themselves can be used. Preferably, the substances that were listed above as preferred or exemplary are taken into account.

When carrying out the method according to the invention, the reaction temperatures can be varied within a specific range. Generally, one works at temperatures between 0°C and 50°C, preferably between 10°C and 30°C.

When carrying out the method according to the invention, one usually proceeds so that a solution of active substance resp. active substances, emulsifiers and organic solvents as well as any additives are placed in an atomizing box in which the desired amount of water is already contained, then the atomizing box is closed with a valve, and the propellant is added according to usual methods. The order in which the components are put together during manufacture

of the organic phase is variable. Similarly, the mixing of the organic phase with water and the addition of propellant can be varied in the usual way.

The water-based aerosol formulations according to the invention can be applied in the prepared form. The amount used is therefore based on the concentration in which the active substance is contained, and according to the indication each time.

Application of the water-based aerosol formulation according to the invention takes place using usual methods. Thus, for example, plants and/or their living area can be sprayed with the formulation. Furthermore, it is possible to spray surfaces or objects on which the active components will unfold their effect with the formulation. If the active components are to work at rest, the formulation is sprayed into these rooms.

The production and use of the water-based aerosol formulation according to the invention disclosed. of the following examples.

Production examples

Example 1

For the preparation of a water-based aerosol formulation, 40 g of distilled water are placed in an atomizer can with a gross volume of 120 ml and mixed with a solution containing 2 g of 2-isopropoxyphenyl-N-methylcarbamate, 0.2 g of 2,2-dimethyl-3- (2-methylpropenyl)-cyclopropanecarboxylic acid-3,4,5,6-tetrahydrophthalimidomethyl ester, 1 g of piperonyl butoxide, 1 g of sorbitol monooleate, 0.2 g of the odorant obtained from the company Haarmann S Reimer GmbH, Holzminden, under the designation "Frischduft 760 712 H + R", 10 g methylene chloride and 15.6 g isopropanol. The pre-atomization box is then equipped with a valve, and filled with 30 g of a propellant gas mixture consisting of 15% by weight of propane and 85% by weight of butane.

According to the method indicated in example 1, the aerosol formulations listed in the following examples are also produced.

Example 2

Example 3

Example 4

Example 5

Example 6 Example 7

Example 8

Example 9

Example 10

Example 11 Example 12

Example 13

Example, 14 Example 15

Example 16

Example 17 Example 18

Example 19

Example 21

Example 22

Example 23 Example 24

Example 25

Comparative examples Example I.

Example II Example III

Example IV

Example V Example VI

Example VII

Application examples Example A Aero solar test Test animal: Musea domestica

(resistant)

In two identical rooms A and B, each of 30 m 3 content, 3 wire cages are hung from the ceiling and 20 3-4 day old flies of the Musea domestica type are hung at each wire cage, so that there are 60 flies in each room.

The room temperature in both rooms is 22°C. Through a flap in the door of both rooms, 16.9 g of the formulation according to example 14 are now sprayed into room A, and 16.9 g of the formulation according to example I into room B. The condition of the test animals is then constantly checked from the outside through a glass window, and the determine the times (minutes) in which 50% (K.d.50) resp. 100% (K.d.100) of the flies have fallen down in the back position, (knock down).

The determined values appear in the following table.

Example B Aerosol sample Test animal: Musea domestica

iresist ent)

In three identical rooms A and B and C, each of 30 m 3 content, 3 wire cages are hung from the ceiling each time before each trial. Each wire cage contains 20 flies of 3-4 days of age. The temperature in the rooms is 22°C. In order, spray per room 16.9 g can contents from pre-dusting cans through a flap in the door into the room. Through a window in the door, the condition of the test animals is constantly checked, and it is determined in times (minutes) during which 50% (K.d.50) and in which 100% (K.d.100) of the flies

has fallen into a back position (knock down). In this way, several spray can formulations are tested in sequence. Between the individual tests, the rooms are thoroughly aired until they are again insecticide-free.

The used formulations of the determined values appear in the following tables.

Claims (10)

1. Water-based aerosol formulations. characterized in that they consist of 0.01 - 6 by weight of at least one insecticide and/or acaricide active substance from the class of carbamates, pyrethroids, acetic acid ester derivatives and/or phosphoric acid ester derivatives, 0.1 - 40% by weight of at least one emulsifier, 5 - 40% by weight of at least one organic solvent, 20 - 70% by weight of water, 10 - 50% by weight of propellant, as well as optionally 0.1 - 6 by weight of additives, the sum of the components each time amounting to 100% by weight. 2. Aerosol formulations according to claim 1, characterized in that the insecticide and/or acaricide active substance contains 2-isopropoxy-phenyl-N-methylca^ bamati- 3. Aerosol formulations according to claim 1, characterized in that the active ingredient contains 2,2-dimethyl-3-(2-methylpropenyl)-cyclopropanecarboxylic acid-3,4,5,6-tetrahydrophthalimido-methyl ester. 4. Aerosol formulations according to claim 1, characterized in that the active ingredient contains 2,2-dimethyl-3-(2-methylpropenyl)-cyclopropanecarboxylic acid-3,4,5,6-tetrahydrophthalimido-methyl ester. 5. Aerosol formulations according to claim 1, characterized in that the active ingredient contains 3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropanecarboxylic acid-α-cyano-3-phenoxy-4-fluorobenzyl ester. 6. Aerosol formulations according to claim 1, characterized in that the active substance contains 3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropanecarboxylic acid (pentafluorophenyl)-methyl ester. 7. Aerosol formulations according to claim 1, characterized in that the active substance contains 0,0-diethylthionophosphoryl-α-oximino-phenylacetic acid nitrile. 8. Aerosol formulations according to claim 1, characterized in that the active substance contains 0,0-diethylthionophosphoryl-o-oximino-(2-chlorophenyl)-acetic acid nitrile. 9. Method for the production of water-based aerosol formulations characterized in that a solution of 0.01 - 6 by weight of at least one insecticide and/or acaricide active substance from the class of carbamates, pyrethroids, acetic acid ester derivatives and/or phosphoric acid ester derivatives, 0.1 - 2 by weight of at least one emulsifier, 5 - 40 by weight of at least one organic solvent, as well possibly 0.1 - 6 by weight of additives are mixed with 20 - 70 by weight of water, and the resulting mixture is mixed in a spray can with 10 - 50% propellant as the sum of the components each time amounts to 10 by weight. 10. Use of aerosol formulations according to claim 1 in the household and hygiene area or in agriculture and horticulture.