NO323157B1 - Oligonukleotidprimerpar, sett av oligonukleotidprimere, sett for a pavise HIV-1 nukleinsyre samt fremgangsmate for a amplifisere HIV-1 nukleinsyre - Google Patents

Oligonukleotidprimerpar, sett av oligonukleotidprimere, sett for a pavise HIV-1 nukleinsyre samt fremgangsmate for a amplifisere HIV-1 nukleinsyre Download PDF

Info

Publication number: NO323157B1
Authority: NO; Norway
Prior art keywords: hiv; seq; nucleic acid; primers; primer
Prior art date: 1997-01-17

Application number

NO19980212A

Other languages

English (en)

Norwegian (no)

Other versions

NO980212D0 (no

NO980212L (no

Inventor

Shi-Da Yu Lu

Cindy Dawn Christopherson

Shirley Yee Kwok

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-17

Filing date

1998-01-16

Publication date

2007-01-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21896067&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO323157(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-01-16 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1998-01-16 Publication of NO980212D0 publication Critical patent/NO980212D0/no

1998-07-20 Publication of NO980212L publication Critical patent/NO980212L/no

2007-01-08 Publication of NO323157B1 publication Critical patent/NO323157B1/no

Links

241000713772 Human immunodeficiency virus 1 Species 0.000 title claims abstract description 95
238000000034 method Methods 0.000 title claims abstract description 48
150000007523 nucleic acids Chemical class 0.000 title claims abstract description 45
239000013615 primer Substances 0.000 title claims description 97
108020004707 nucleic acids Proteins 0.000 title claims description 41
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108091034117 Oligonucleotide Proteins 0.000 title claims description 18
239000003155 DNA primer Substances 0.000 title claims description 16
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208000031886 HIV Infections Diseases 0.000 claims abstract description 82
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239000013612 plasmid Substances 0.000 description 7
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 6
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241000276498 Pollachius virens Species 0.000 description 2
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PYMYPHUHKUWMLA-LMVFSUKVSA-N aldehydo-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 2
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AHCYMLUZIRLXAA-SHYZEUOFSA-N Deoxyuridine 5'-triphosphate Chemical compound O1[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C[C@@H]1N1C(=O)NC(=O)C=C1 AHCYMLUZIRLXAA-SHYZEUOFSA-N 0.000 description 1
238000002965 ELISA Methods 0.000 description 1
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FSVCELGFZIQNCK-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)glycine Chemical compound OCCN(CCO)CC(O)=O FSVCELGFZIQNCK-UHFFFAOYSA-N 0.000 description 1
238000012408 PCR amplification Methods 0.000 description 1
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240000002834 Paulownia tomentosa Species 0.000 description 1
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KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 1
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108020004682 Single-Stranded DNA Proteins 0.000 description 1
108010006785 Taq Polymerase Proteins 0.000 description 1
108020000999 Viral RNA Proteins 0.000 description 1
SWPYNTWPIAZGLT-UHFFFAOYSA-N [amino(ethoxy)phosphanyl]oxyethane Chemical compound CCOP(N)OCC SWPYNTWPIAZGLT-UHFFFAOYSA-N 0.000 description 1
238000000137 annealing Methods 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Virology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
AIDS & HIV (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Dental Preparations (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO19980212A 1997-01-17 1998-01-16 Oligonukleotidprimerpar, sett av oligonukleotidprimere, sett for a pavise HIV-1 nukleinsyre samt fremgangsmate for a amplifisere HIV-1 nukleinsyre NO323157B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US3774497P	1997-01-17	1997-01-17

Publications (3)

Publication Number	Publication Date
NO980212D0 NO980212D0 (no)	1998-01-16
NO980212L NO980212L (no)	1998-07-20
NO323157B1 true NO323157B1 (no)	2007-01-08

Family

ID=21896067

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19980212A NO323157B1 (no)	1997-01-17	1998-01-16	Oligonukleotidprimerpar, sett av oligonukleotidprimere, sett for a pavise HIV-1 nukleinsyre samt fremgangsmate for a amplifisere HIV-1 nukleinsyre

Country Status (21)

Country	Link
US (1)	US5908743A (fr)
EP (1)	EP0854197B1 (fr)
JP (1)	JP2838084B2 (fr)
KR (1)	KR100257438B1 (fr)
CN (1)	CN1208469C (fr)
AT (1)	ATE345400T1 (fr)
AU (1)	AU693066B1 (fr)
BR (1)	BRPI9800337B8 (fr)
CA (1)	CA2222769C (fr)
CZ (1)	CZ288064B6 (fr)
DE (1)	DE69836395T2 (fr)
DK (1)	DK0854197T3 (fr)
ES (1)	ES2276436T3 (fr)
HK (1)	HK1010896A1 (fr)
HU (1)	HU223384B1 (fr)
IL (1)	IL122906A (fr)
NO (1)	NO323157B1 (fr)
PL (1)	PL191989B1 (fr)
RU (1)	RU2186112C2 (fr)
TW (1)	TW400386B (fr)
UA (1)	UA47432C2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19850186A1 (de) *	1998-10-30	2000-05-25	Roche Diagnostics Gmbh	Neue Primer und Sonden zum Nachweis von HIV
DE19900511C2 (de)	1999-01-08	2001-03-15	Deutsches Krebsforsch	Molekularbiologische Marker für die analytische Elektronenmikroskopie
US6245511B1 (en) *	1999-02-22	2001-06-12	Vialogy Corp	Method and apparatus for exponentially convergent therapy effectiveness monitoring using DNA microarray based viral load measurements
US6582920B2 (en)	2000-09-01	2003-06-24	Gen-Probe Incorporated	Amplification of HIV-1 RT sequences for detection of sequences associated with drug-resistance mutations
JP4965793B2 (ja) *	2000-09-01	2012-07-04	ジェン−プローブ・インコーポレーテッド	薬剤耐性突然変異と関連する配列検出のためのｈｉｖ−１配列の増幅
US6770752B2 (en)	2001-01-09	2004-08-03	Becton, Dickinson And Company	Sequences for detection of HIV-1
EP1317960A1 (fr) *	2001-12-06	2003-06-11	PamGene B.V.	Système et procédé d'analyse du sang et cartouche jetable pour l'utilisation avec ce système ou procédé
WO2004094986A2 (fr) *	2003-04-16	2004-11-04	Handylab, Inc.	Systeme et procede de detection electrochimique de composes biologiques
US8484000B2 (en)	2004-09-02	2013-07-09	Vialogy Llc	Detecting events of interest using quantum resonance interferometry
JP5058804B2 (ja) *	2004-09-14	2012-10-24	アルゴスセラピューティクス，インコーポレイティド	病原体の株非依存的増幅およびそれに対するワクチン
CN100340673C (zh) *	2005-02-03	2007-10-03	上海科华生物工程股份有限公司	人类免疫缺陷病毒hiv－1核酸扩增－荧光定量检测试剂盒
CN101144771B (zh) *	2006-09-11	2012-05-30	中山大学达安基因股份有限公司	检测人类免疫缺陷病毒的试剂盒
WO2008119081A1 (fr)	2007-03-28	2008-10-02	Signal Diagnostics	Système et procédé pour une résolution élevée d'acides nucléiques pour détecter des variations de séquence
US8221981B2 (en) *	2007-07-30	2012-07-17	Argos Therapeutics, Inc.	Primers and probes for the amplification and detection of HIV Gag, Rev and Nef polynucleotides
US10669574B2 (en)	2008-11-18	2020-06-02	XCR Diagnostics, Inc.	DNA amplification technology
US10113206B2 (en) *	2010-02-24	2018-10-30	Grifols Therapeutics Inc.	Methods, compositions, and kits for determining human immunodeficiency virus (HIV)
PL2643460T3 (pl) *	2011-06-15	2018-01-31	Grifols Therapeutics Inc	Sposoby, kompozycje i zestawy do oznaczania ludzkiego wirusa niedoboru odporności (HIV)
US10370707B2 (en)	2013-10-09	2019-08-06	Fluoresentric, Inc.	Multiplex probes

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5386022A (en) *	1985-03-28	1995-01-31	Hoffman-La Roche Inc.	Primes and probes for the amplification and detection of aids associated nucleic acids
US5389512A (en) *	1988-10-07	1995-02-14	Hoffman-La Roche Inc.	Method for determining the relative amount of a viral nucleic acid segment in a sample by the polymerase chain reaction
US5695926A (en) *	1990-06-11	1997-12-09	Bio Merieux	Sandwich hybridization assays using very short capture probes noncovalently bound to a hydrophobic support
KR100325554B1 (ko) *	1993-03-26	2002-11-02	젠-프로브 인코포레이티드	사람의면역결핍 바이러스타입1의검출
JP3026843B2 (ja) *	1993-07-23	2000-03-27	ジェン−プローブ・インコーポレーテッド	核酸増幅の促進法
WO1995014109A1 (fr) *	1993-11-19	1995-05-26	U.S. Department Of The Army	Amplification type pcr quantitative a rendement eleve pour echantillons cliniques a vih
US5665545A (en) *	1994-11-28	1997-09-09	Akzo Nobel N.V.	Terminal repeat amplification method
US5599662A (en) *	1995-02-17	1997-02-04	Hoffmann-La Roche Inc.	Oliconucleotide primers and probes for the detection of HIV-1
US5702926A (en) *	1996-08-22	1997-12-30	Becton, Dickinson And Company	Nicking of DNA using boronated nucleotides

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Publication number	Publication date
UA47432C2 (uk)	2002-07-15
IL122906A (en)	2000-11-21
CZ288064B6 (cs)	2001-04-11
EP0854197A2 (fr)	1998-07-22
BRPI9800337B1 (pt)	2014-04-08
EP0854197B1 (fr)	2006-11-15
CN1191975A (zh)	1998-09-02
DE69836395T2 (de)	2007-09-27
CA2222769C (fr)	2001-06-12
US5908743A (en)	1999-06-01
PL324327A1 (en)	1998-07-20
NO980212D0 (no)	1998-01-16
AU693066B1 (en)	1998-06-18
NO980212L (no)	1998-07-20
BRPI9800337B8 (pt)	2023-05-02
TW400386B (en)	2000-08-01
PL191989B1 (pl)	2006-07-31
BRPI9800337A (pt)	1999-06-29
JP2838084B2 (ja)	1998-12-16
EP0854197A3 (fr)	1999-04-07
ATE345400T1 (de)	2006-12-15
HUP9800053A2 (hu)	1998-08-28
HU223384B1 (hu)	2004-06-28
CA2222769A1 (fr)	1998-07-17
JPH10210990A (ja)	1998-08-11
RU2186112C2 (ru)	2002-07-27
IL122906A0 (en)	1998-08-16
DE69836395D1 (de)	2006-12-28
KR100257438B1 (ko)	2000-05-15
KR19980070560A (ko)	1998-10-26
HUP9800053A3 (en)	1999-11-29
CZ14998A3 (cs)	1998-08-12
HK1010896A1 (en)	1999-07-02
CN1208469C (zh)	2005-06-29
DK0854197T3 (da)	2007-03-19
HU9800053D0 (en)	1998-03-30
ES2276436T3 (es)	2007-06-16

Publication	Publication Date	Title
NO323157B1 (no)	2007-01-08	Oligonukleotidprimerpar, sett av oligonukleotidprimere, sett for a pavise HIV-1 nukleinsyre samt fremgangsmate for a amplifisere HIV-1 nukleinsyre
US5599662A (en)	1997-02-04	Oliconucleotide primers and probes for the detection of HIV-1
JP3936798B2 (ja)	2007-06-27	Ｒｎａ標的配列の増幅方法
US5962665A (en)	1999-10-05	Nucleic acid primers and probes for detecting HIV-1 and HIV-2
KR100189229B1 (ko)	1999-06-01	핵산 증폭을 강화하는 방법
US6001558A (en)	1999-12-14	Amplification and detection of HIV-1 and/or HIV 2
JPH04211399A (ja)	1992-08-03	核酸の増幅法
JP2000505312A (ja)	2000-05-09	標的核酸配列増幅
EP0747488B1 (fr)	2003-07-09	Procédés et trousse des détection des taux de pre-amplification d'une séquence cible d'acide nucléique à partir des taux de post-amplification des produits
AU1232099A (en)	1999-05-24	Specific and sensitive method for detecting nucleic acids
US20100009412A1 (en)	2010-01-14	Novel Oligonucleotide Primers and Methods for DNA Replication
NO324530B1 (no)	2007-11-12	Fremgangsmate for amplifisering og detektering av en malnukleinsyre
AU2017363168B2 (en)	2023-07-06	Compositions and methods for detecting or quantifying hepatitis B virus
EP0418960A2 (fr)	1991-03-27	Procédé pour la dÀ©tection des acides nucléiques utilisant une concentration de primer impartie dans la réaction de polymérase en chaîne
US20090061413A1 (en)	2009-03-05	Isothermal screening of hiv-1 related nucleic acids
AU2016202864B2 (en)	2018-02-15	Assay for detecting and quantifying HIV-1
MXPA98000480A (en)	1999-02-24	Cebadores for vi detection

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