NO327294B1 - Sammensetning for dannelse av et enterisk belegg pa et oralt preparat, preparatet forsynt med et enterisk belegg og fremgangsmate for fremstilling av et slikt preparat. - Google Patents

Sammensetning for dannelse av et enterisk belegg pa et oralt preparat, preparatet forsynt med et enterisk belegg og fremgangsmate for fremstilling av et slikt preparat. Download PDF

Info

Publication number: NO327294B1
Authority: NO; Norway
Prior art keywords: oral preparation; enteric coating; alginic acid; composition; coating
Prior art date: 1996-06-06

Application number

NO19985699A

Other languages

English (en)

Norwegian (no)

Other versions

NO985699D0 (no

NO985699L (no

Inventor

Jorn Marcussen

Erik Brandsborg

Original Assignee

Bifodan As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-06

Filing date

1998-12-04

Publication date

2009-06-02

1998-12-04 Application filed by Bifodan As filed Critical Bifodan As

1998-12-04 Publication of NO985699D0 publication Critical patent/NO985699D0/no

1999-02-08 Publication of NO985699L publication Critical patent/NO985699L/no

2009-06-02 Publication of NO327294B1 publication Critical patent/NO327294B1/no

Links

239000000203 mixture Substances 0.000 title claims abstract description 30
238000009505 enteric coating Methods 0.000 title claims abstract description 27
239000002702 enteric coating Substances 0.000 title claims abstract description 27
238000002360 preparation method Methods 0.000 title claims description 40
238000000034 method Methods 0.000 title claims description 6
235000010443 alginic acid Nutrition 0.000 claims abstract description 27
229920000615 alginic acid Polymers 0.000 claims abstract description 27
239000000783 alginic acid Substances 0.000 claims abstract description 26
229960001126 alginic acid Drugs 0.000 claims abstract description 26
150000004781 alginic acids Chemical class 0.000 claims abstract description 26
239000002245 particle Substances 0.000 claims abstract description 19
239000002775 capsule Substances 0.000 claims abstract description 17
239000011230 binding agent Substances 0.000 claims abstract description 15
239000007788 liquid Substances 0.000 claims abstract description 8
239000008188 pellet Substances 0.000 claims abstract description 6
239000003826 tablet Substances 0.000 claims abstract description 6
235000021120 animal protein Nutrition 0.000 claims abstract description 3
239000007864 aqueous solution Substances 0.000 claims abstract description 3
229920000159 gelatin Polymers 0.000 claims abstract description 3
235000019322 gelatine Nutrition 0.000 claims abstract description 3
239000000416 hydrocolloid Substances 0.000 claims abstract description 3
235000013311 vegetables Nutrition 0.000 claims abstract description 3
239000008199 coating composition Substances 0.000 claims description 13
241000894006 Bacteria Species 0.000 claims description 12
238000000576 coating method Methods 0.000 claims description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
239000011248 coating agent Substances 0.000 claims description 8
239000007903 gelatin capsule Substances 0.000 claims description 6
238000004519 manufacturing process Methods 0.000 claims description 6
235000015872 dietary supplement Nutrition 0.000 claims description 5
229920000161 Locust bean gum Polymers 0.000 claims description 4
235000010420 locust bean gum Nutrition 0.000 claims description 4
239000000711 locust bean gum Substances 0.000 claims description 4
108010010803 Gelatin Proteins 0.000 claims description 2
239000008273 gelatin Substances 0.000 claims description 2
235000011852 gelatine desserts Nutrition 0.000 claims description 2
239000003232 water-soluble binding agent Substances 0.000 claims description 2
235000013912 Ceratonia siliqua Nutrition 0.000 abstract 1
240000008886 Ceratonia siliqua Species 0.000 abstract 1
239000001828 Gelatine Substances 0.000 abstract 1
230000037406 food intake Effects 0.000 abstract 1
239000013543 active substance Substances 0.000 description 8
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
210000002784 stomach Anatomy 0.000 description 5
230000015572 biosynthetic process Effects 0.000 description 4
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
239000004006 olive oil Substances 0.000 description 4
235000008390 olive oil Nutrition 0.000 description 4
239000003960 organic solvent Substances 0.000 description 4
239000000126 substance Substances 0.000 description 4
230000015556 catabolic process Effects 0.000 description 3
230000000694 effects Effects 0.000 description 3
235000019359 magnesium stearate Nutrition 0.000 description 3
239000000463 material Substances 0.000 description 3
231100000331 toxic Toxicity 0.000 description 3
230000002588 toxic effect Effects 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
229920001817 Agar Polymers 0.000 description 2
229920000623 Cellulose acetate phthalate Polymers 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
239000008272 agar Substances 0.000 description 2
-1 carboxymethylethyl Chemical group 0.000 description 2
238000006731 degradation reaction Methods 0.000 description 2
235000013373 food additive Nutrition 0.000 description 2
239000002778 food additive Substances 0.000 description 2
210000004051 gastric juice Anatomy 0.000 description 2
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
239000004310 lactic acid Substances 0.000 description 2
235000014655 lactic acid Nutrition 0.000 description 2
244000005700 microbiome Species 0.000 description 2
230000007935 neutral effect Effects 0.000 description 2
239000011236 particulate material Substances 0.000 description 2
230000001681 protective effect Effects 0.000 description 2
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
239000004925 Acrylic resin Substances 0.000 description 1
229920000178 Acrylic resin Polymers 0.000 description 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
229920003134 Eudragit® polymer Polymers 0.000 description 1
206010028813 Nausea Diseases 0.000 description 1
235000021314 Palmitic acid Nutrition 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
206010047700 Vomiting Diseases 0.000 description 1
238000010306 acid treatment Methods 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000000654 additive Substances 0.000 description 1
229940072056 alginate Drugs 0.000 description 1
235000010410 calcium alginate Nutrition 0.000 description 1
239000000648 calcium alginate Substances 0.000 description 1
229960002681 calcium alginate Drugs 0.000 description 1
OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 1
238000005266 casting Methods 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
229940081734 cellulose acetate phthalate Drugs 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000001816 cooling Methods 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
235000019441 ethanol Nutrition 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
238000000265 homogenisation Methods 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
230000007794 irritation Effects 0.000 description 1
239000004922 lacquer Substances 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
230000008693 nausea Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
239000008055 phosphate buffer solution Substances 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
229920000447 polyanionic polymer Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
238000005507 spraying Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000008673 vomiting Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/065—Microorganisms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Nutrition Science (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Jellies, Jams, And Syrups (AREA)

NO19985699A 1996-06-06 1998-12-04 Sammensetning for dannelse av et enterisk belegg pa et oralt preparat, preparatet forsynt med et enterisk belegg og fremgangsmate for fremstilling av et slikt preparat. NO327294B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK63696		1996-06-06
PCT/DK1997/000252 WO1997046224A1 (en)	1996-06-06	1997-06-06	Enteric coating, comprising alginic acid, for an oral preparation

Publications (3)

Publication Number	Publication Date
NO985699D0 NO985699D0 (no)	1998-12-04
NO985699L NO985699L (no)	1999-02-08
NO327294B1 true NO327294B1 (no)	2009-06-02

Family

ID=8095832

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19985699A NO327294B1 (no)	1996-06-06	1998-12-04	Sammensetning for dannelse av et enterisk belegg pa et oralt preparat, preparatet forsynt med et enterisk belegg og fremgangsmate for fremstilling av et slikt preparat.

Country Status (14)

Country	Link
US (1)	US6455052B1 (de)
EP (1)	EP0952824B1 (de)
JP (1)	JP2000514406A (de)
KR (1)	KR20000016331A (de)
CN (1)	CN1147291C (de)
AT (1)	ATE277605T1 (de)
AU (1)	AU717817B2 (de)
BR (1)	BR9709535A (de)
CA (1)	CA2257378C (de)
DE (1)	DE69730991T2 (de)
IL (1)	IL127378A (de)
NO (1)	NO327294B1 (de)
NZ (1)	NZ333182A (de)
WO (1)	WO1997046224A1 (de)

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CN1034489A (zh) *	1987-12-11	1989-08-09	福建省水产研究所	一种制作肠溶胶囊的方法
US5733575A (en) *	1994-10-07	1998-03-31	Bpsi Holdings, Inc.	Enteric film coating compositions, method of coating therewith, and coated forms
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1997
- 1997-06-06 CA CA002257378A patent/CA2257378C/en not_active Expired - Lifetime
- 1997-06-06 WO PCT/DK1997/000252 patent/WO1997046224A1/en active IP Right Grant
- 1997-06-06 IL IL12737897A patent/IL127378A/xx not_active IP Right Cessation
- 1997-06-06 NZ NZ333182A patent/NZ333182A/xx not_active IP Right Cessation
- 1997-06-06 AT AT97924938T patent/ATE277605T1/de not_active IP Right Cessation
- 1997-06-06 JP JP10500114A patent/JP2000514406A/ja active Pending
- 1997-06-06 US US09/194,922 patent/US6455052B1/en not_active Expired - Lifetime
- 1997-06-06 KR KR1019980709904A patent/KR20000016331A/ko not_active Application Discontinuation
- 1997-06-06 AU AU30263/97A patent/AU717817B2/en not_active Expired
- 1997-06-06 CN CNB971959986A patent/CN1147291C/zh not_active Expired - Lifetime
- 1997-06-06 EP EP97924938A patent/EP0952824B1/de not_active Expired - Lifetime
- 1997-06-06 DE DE69730991T patent/DE69730991T2/de not_active Expired - Lifetime
- 1997-06-06 BR BR9709535-4A patent/BR9709535A/pt not_active IP Right Cessation
1998
- 1998-12-04 NO NO19985699A patent/NO327294B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NZ333182A (en)	2000-03-27
AU3026397A (en)	1998-01-05
AU717817B2 (en)	2000-04-06
DE69730991T2 (de)	2006-02-23
NO985699D0 (no)	1998-12-04
KR20000016331A (ko)	2000-03-25
DE69730991D1 (de)	2004-11-04
CN1223573A (zh)	1999-07-21
CN1147291C (zh)	2004-04-28
IL127378A0 (en)	1999-10-28
BR9709535A (pt)	2000-01-11
CA2257378A1 (en)	1997-12-11
ATE277605T1 (de)	2004-10-15
US6455052B1 (en)	2002-09-24
EP0952824B1 (de)	2004-09-29
WO1997046224A1 (en)	1997-12-11
CA2257378C (en)	2009-04-07
EP0952824A1 (de)	1999-11-03
JP2000514406A (ja)	2000-10-31
NO985699L (no)	1999-02-08
IL127378A (en)	2003-07-31

Publication	Publication Date	Title
NO327294B1 (no)	2009-06-02	Sammensetning for dannelse av et enterisk belegg pa et oralt preparat, preparatet forsynt med et enterisk belegg og fremgangsmate for fremstilling av et slikt preparat.
CA2500663C (en)	2013-05-28	Enteric composition for the manufacture of soft capsule wall
JP2773959B2 (ja)	1998-07-09	大腸内放出性固形製剤
CA2306566C (en)	2008-06-17	Low temperature coatings
JP2653996B2 (ja)	1997-09-17	徐放性薬剤
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JP5087167B2 (ja)	2012-11-28	ビフィズス菌大腸デリバリーカプセル及びその製造方法
US5882715A (en)	1999-03-16	Method of preparing an oral preparation provided on the outer side with an enteric coating, as well as an oral preparation obtained by the method
AU2015329445B2 (en)	2017-11-30	Method of manufacturing enteric seamless soft capsule
WO2006048895A1 (en)	2006-05-11	Aqueous pharmaceutical coating
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KR20100022200A (ko)	2010-03-02	매스틱을 함유하는 대장염 치료제의 약제학적 조성물 및 대장 타게팅 약물 송달 시스템

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2017-06-12	MK1K	Patent expired