NO312007B1 - Anvendelse av mikropartikkelsystemer, fremgangsmåter for fremstilling av mikropartikler inneholdende aktive ingredienser,samt mikropartikler og fryse- og forstövningstörkede preparater - Google Patents

Anvendelse av mikropartikkelsystemer, fremgangsmåter for fremstilling av mikropartikler inneholdende aktive ingredienser,samt mikropartikler og fryse- og forstövningstörkede preparater Download PDF

Info

Publication number: NO312007B1
Authority: NO; Norway
Prior art keywords: microparticles; active ingredient; freeze; supercritical; gas
Prior art date: 1993-09-09

Application number

NO19960973A

Other languages

English (en)

Norwegian (no)

Other versions

NO960973L (no

NO960973D0 (no

Inventor

Werner Weitschies

Dieter Heldmann

Peter Hauff

Thomas Fritzsch

Harald Stahl

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-09

Filing date

1996-03-08

Publication date

2002-03-04

1993-09-09 Priority claimed from DE19934330958 external-priority patent/DE4330958A1/de

1994-05-11 Priority claimed from DE19944416818 external-priority patent/DE4416818A1/de

1996-03-08 Application filed by Schering Ag filed Critical Schering Ag

1996-03-08 Publication of NO960973L publication Critical patent/NO960973L/no

1996-03-08 Publication of NO960973D0 publication Critical patent/NO960973D0/no

2002-03-04 Publication of NO312007B1 publication Critical patent/NO312007B1/no

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/927—Diagnostic contrast agent
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/927—Diagnostic contrast agent
- Y10S977/929—Ultrasound contrast agent

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Physics & Mathematics (AREA)
Acoustics & Sound (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Radiology & Medical Imaging (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Manufacturing Of Micro-Capsules (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Sampling And Sample Adjustment (AREA)
Catalysts (AREA)
Physical Or Chemical Processes And Apparatus (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO19960973A 1993-09-09 1996-03-08 Anvendelse av mikropartikkelsystemer, fremgangsmåter for fremstilling av mikropartikler inneholdende aktive ingredienser,samt mikropartikler og fryse- og forstövningstörkede preparater NO312007B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19934330958 DE4330958A1 (de)	1993-09-09	1993-09-09	Neue wirkstoffhaltige Mikropartikel, diese enthaltende Mittel, deren Verwendung zur ultraschallgesteuerten Freisetzung von Wirkstoffen sowie Verfahren zu deren Herstellung
DE19944416818 DE4416818A1 (de)	1994-05-11	1994-05-11	Neue wirkstoffhaltige Mikropartikel, diese enthaltende Mittel, deren Verwendung zur ultraschallgesteuerten Freisetzung von Wirkstoffen sowie Verfahren zu deren Herstellung
PCT/EP1994/002806 WO1995007072A2 (de)	1993-09-09	1994-08-25	Wirkstoffe und gas enthaltende mikropartikel

Publications (3)

Publication Number	Publication Date
NO960973L NO960973L (no)	1996-03-08
NO960973D0 NO960973D0 (no)	1996-03-08
NO312007B1 true NO312007B1 (no)	2002-03-04

Family

ID=25929477

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19960973A NO312007B1 (no)	1993-09-09	1996-03-08	Anvendelse av mikropartikkelsystemer, fremgangsmåter for fremstilling av mikropartikler inneholdende aktive ingredienser,samt mikropartikler og fryse- og forstövningstörkede preparater

Country Status (15)

Country	Link
US (2)	US6068857A (el)
EP (1)	EP0717617B1 (el)
JP (1)	JPH09502191A (el)
KR (1)	KR960704526A (el)
AT (1)	ATE197124T1 (el)
AU (2)	AU7655194A (el)
CA (1)	CA2171303C (el)
DE (1)	DE59409568D1 (el)
DK (1)	DK0717617T3 (el)
ES (1)	ES2152990T3 (el)
GR (1)	GR3035219T3 (el)
HU (1)	HUT74509A (el)
NO (1)	NO312007B1 (el)
PT (1)	PT717617E (el)
WO (1)	WO1995007072A2 (el)

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1994
- 1994-08-25 CA CA002171303A patent/CA2171303C/en not_active Expired - Fee Related
- 1994-08-25 ES ES94926878T patent/ES2152990T3/es not_active Expired - Lifetime
- 1994-08-25 DK DK94926878T patent/DK0717617T3/da active
- 1994-08-25 US US08/605,174 patent/US6068857A/en not_active Expired - Fee Related
- 1994-08-25 HU HU9600599A patent/HUT74509A/hu unknown
- 1994-08-25 EP EP94926878A patent/EP0717617B1/de not_active Expired - Lifetime
- 1994-08-25 AU AU76551/94A patent/AU7655194A/en not_active Abandoned
- 1994-08-25 PT PT94926878T patent/PT717617E/pt unknown
- 1994-08-25 AT AT94926878T patent/ATE197124T1/de not_active IP Right Cessation
- 1994-08-25 DE DE59409568T patent/DE59409568D1/de not_active Expired - Fee Related
- 1994-08-25 WO PCT/EP1994/002806 patent/WO1995007072A2/de active IP Right Grant
- 1994-08-25 KR KR1019960701192A patent/KR960704526A/ko not_active Application Discontinuation
- 1994-08-25 JP JP7508417A patent/JPH09502191A/ja not_active Ceased
1996
- 1996-03-08 NO NO19960973A patent/NO312007B1/no unknown
1998
- 1998-07-17 AU AU77299/98A patent/AU7729998A/en not_active Abandoned
1999
- 1999-12-13 US US09/459,578 patent/US6284280B1/en not_active Expired - Fee Related
2001
- 2001-01-11 GR GR20010400035T patent/GR3035219T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1995007072A2 (de)	1995-03-16
PT717617E (pt)	2001-04-30
AU7729998A (en)	1998-09-10
NO960973L (no)	1996-03-08
US6284280B1 (en)	2001-09-04
JPH09502191A (ja)	1997-03-04
AU7655194A (en)	1995-03-27
NO960973D0 (no)	1996-03-08
HUT74509A (en)	1997-01-28
ES2152990T3 (es)	2001-02-16
CA2171303C (en)	2006-06-06
DK0717617T3 (da)	2001-02-05
CA2171303A1 (en)	1995-03-16
GR3035219T3 (en)	2001-04-30
WO1995007072A3 (de)	1995-04-06
HU9600599D0 (en)	1996-05-28
US6068857A (en)	2000-05-30
KR960704526A (ko)	1996-10-09
DE59409568D1 (de)	2000-11-30
ATE197124T1 (de)	2000-11-15
EP0717617B1 (de)	2000-10-25
EP0717617A1 (de)	1996-06-26

Publication	Publication Date	Title
NO312007B1 (no)	2002-03-04	Anvendelse av mikropartikkelsystemer, fremgangsmåter for fremstilling av mikropartikler inneholdende aktive ingredienser,samt mikropartikler og fryse- og forstövningstörkede preparater
RU2109521C1 (ru)	1998-04-27	Способ получения диагностического средства, содержащего полые микрокапсулы, полые микрокапсулы (варианты) и способ диагностики с их использованием
EP0663840B1 (en)	2003-12-10	Preparation of microcapsules
JP2001506590A (ja)	2001-05-22	有効成分を含むミクロ粒子、該粒子を含む薬剤、有効成分の超音波制御放出のためのその使用ならびにその製造方法
RU2125466C1 (ru)	1999-01-27	Ультразвуковая контрастная среда, содержащая газонаполненные микрочастицы, способ получения микрочастиц (варианты), газонаполненные микрочастицы
DE4416818A1 (de)	1995-11-16	Neue wirkstoffhaltige Mikropartikel, diese enthaltende Mittel, deren Verwendung zur ultraschallgesteuerten Freisetzung von Wirkstoffen sowie Verfahren zu deren Herstellung
Ameta et al.	2015	Ultrasound Contrast Agents: Sonochemical Preparation