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NO20083488L - Selektiv N-Sulfonylering av 2-amino-trifluoralkyl substituerte alkoholer - Google Patents

Selektiv N-Sulfonylering av 2-amino-trifluoralkyl substituerte alkoholer

Info

Publication number
NO20083488L
NO20083488L NO20083488A NO20083488A NO20083488L NO 20083488 L NO20083488 L NO 20083488L NO 20083488 A NO20083488 A NO 20083488A NO 20083488 A NO20083488 A NO 20083488A NO 20083488 L NO20083488 L NO 20083488L
Authority
NO
Norway
Prior art keywords
methylmorpholine
formula
sulfonylation
selective
amino
Prior art date
Application number
NO20083488A
Other languages
English (en)
Inventor
Panolil Raveendranath
Anita Wai-Yin Chan
Jianxin Ren
Mousumi Ghosh
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20083488L publication Critical patent/NO20083488L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Prosesser for fremstilling av sulfonamid trifluoralkylsubstituerte N-(2-hydroksyalkyl) heteroaren- og benzensulfonamid-derivater med formel (I) eller formel (II) (hvor variablene er som definert i kravene) er gitt, hvilke omfatter reaksjon mellom en trifluoralkylsubstituert aminoalkohol, et sulfonylklorid og et base/løsemiddelsystem valgt fra gruppen bestående av (a) 4-metylmorfolin/isopropylacetat, (b) Hünigs base/tertahydrofuran, (c) 4-metylmorfolin/acetonitril, (d) 4-metylmorfolin/propionitril og (e) 4-metylmorfolin/ftoluen. eller Formel I Formel II
NO20083488A 2006-02-17 2008-08-12 Selektiv N-Sulfonylering av 2-amino-trifluoralkyl substituerte alkoholer NO20083488L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77430006P 2006-02-17 2006-02-17
PCT/US2007/004091 WO2007098030A1 (en) 2006-02-17 2007-02-15 Selective n-sulfonylation of 2-amino trifluoroalkyl substituted alcohols

Publications (1)

Publication Number Publication Date
NO20083488L true NO20083488L (no) 2008-09-05

Family

ID=38124142

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083488A NO20083488L (no) 2006-02-17 2008-08-12 Selektiv N-Sulfonylering av 2-amino-trifluoralkyl substituerte alkoholer

Country Status (18)

Country Link
US (1) US7838550B2 (no)
EP (1) EP1984347A1 (no)
JP (1) JP2009527476A (no)
KR (1) KR20080094685A (no)
CN (1) CN101384579A (no)
AR (1) AR059517A1 (no)
AU (1) AU2007217966A1 (no)
BR (1) BRPI0707742A2 (no)
CA (1) CA2637615A1 (no)
CR (1) CR10158A (no)
EC (1) ECSP088684A (no)
GT (1) GT200800154A (no)
IL (1) IL192929A0 (no)
NO (1) NO20083488L (no)
PE (1) PE20080109A1 (no)
RU (1) RU2008131051A (no)
TW (1) TW200732295A (no)
WO (1) WO2007098030A1 (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162498A0 (en) 2001-12-20 2005-11-20 Bristol Myers Squibb Co (N-sulphonamido) acetamide derivatives and pharmaceutical compositions containing the same
CL2004000647A1 (es) * 2003-03-31 2005-02-04 Wyeth Corp Compuestos derivados de heterociclicos de sulfonamida que contienen fluoro y trifluoro alquilo; composicion farmaceutica; kit farmaceutico; procedimiento de preparacion; y su uso como inhibidores de beta amiloides para tratar alzheimer, angiopatia am
US7476762B2 (en) * 2006-04-21 2009-01-13 Wyeth Methods for preparing sulfonamide compounds
US7550629B2 (en) * 2006-04-21 2009-06-23 Wyeth Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors
PE20090824A1 (es) * 2007-07-16 2009-07-24 Wyeth Corp Proceso para la preparacion de trifluoralquil-fenil sulfonamidas y de sulfonamidas heterociclicas
CL2008002060A1 (es) * 2007-07-16 2008-11-21 Wyeth Corp Compuestos derivados de sulfonamida, inhibidores de la produccion de beta amiloide; metodo de preparacion; composicion farmaceutica; kit farmaceutico; y uso en el tratamiento de enfermedades tales como alzheimer, angiopatia amiloide, sindrome de down, entre otras.
WO2009012203A1 (en) * 2007-07-16 2009-01-22 Wyeth Processes and intermediates for the preparation of heterocyclic sulfonamide compounds
US8084477B2 (en) * 2007-10-31 2011-12-27 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
US8093276B2 (en) * 2007-10-31 2012-01-10 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
WO2009137657A1 (en) * 2008-05-08 2009-11-12 Bristol-Myers Squibb Company 2-aryl glycinamide derivatives
US8044077B2 (en) 2009-03-19 2011-10-25 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production
US7977362B2 (en) 2009-03-20 2011-07-12 Bristol-Myers Squibb Company Alpha-(N-benzenesulfonamido)cycloalkyl derivatives
US20110071199A1 (en) * 2009-03-20 2011-03-24 Bristol-Myers Squibb Company Thiophenyl Sulfonamides for the Treatment of Alzheimer's Disease
TW201043269A (en) * 2009-04-14 2010-12-16 Bristol Myers Squibb Co Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound
US8252821B2 (en) * 2009-04-14 2012-08-28 Bristol-Myers Squibb Company Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795890A (en) 1995-09-27 1998-08-18 Ono Pharmaceutical Co., Ltd. Sulfonamide derivatives
JPH09241262A (ja) 1996-03-08 1997-09-16 Kao Corp ３−オキサ−２，７−ジアザビシクロ〔３．３．０〕オクタン誘導体
US5962231A (en) 1997-09-30 1999-10-05 Incyte Pharmaceuticals, Inc. Human glutathione-S-transferase
CA2309332C (en) 1997-11-12 2002-12-03 Bayer Aktiengesellschaft 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
JPH11343279A (ja) 1998-03-16 1999-12-14 Shionogi & Co Ltd スルホンアミド誘導体およびそれらを含有するＴＮＦ―α産生抑制剤
GB9805520D0 (en) 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
DE19827640A1 (de) 1998-06-20 1999-12-23 Bayer Ag 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone
TR200201638T2 (tr) 1999-12-24 2002-11-21 Bayer Aktiengesellschaft Yeni imidazo[1,3,5]triazinonlar ve kullanımları
EP1261609B1 (de) 1999-12-24 2004-11-03 Bayer HealthCare AG Triazolotriazinone und ihre verwendung
SG128491A1 (en) 2000-12-13 2007-01-30 Wyeth Arqule Inc Heterocyclic sulfonamide inhibitors of beta amyloid production
US6657070B2 (en) 2000-12-13 2003-12-02 Wyeth Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
HUP0402522A2 (hu) 2001-12-11 2005-03-29 Wyeth Eljárás királisan tiszta béta-amino-alkoholok előállítására
TW200307539A (en) 2002-02-01 2003-12-16 Bristol Myers Squibb Co Cycloalkyl inhibitors of potassium channel function
US7288547B2 (en) 2002-03-11 2007-10-30 Schering Ag CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents
EP1483260A1 (de) 2002-03-11 2004-12-08 Schering Aktiengesellschaft Cdk inhibitorische 2-heteroaryl-pyrimidine, deren herstellung und verwendung als arzneimittel
TW200403058A (en) 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
BR0311767A (pt) 2002-06-11 2005-03-08 Wyeth Corp Compostos inibidores de sulfonamida substituìda da produção de beta amilóide, suas composições e usos
WO2004078731A1 (fr) 2003-03-06 2004-09-16 'chemical Diversity Research Institute', Ltd. Acides quinoline-carboxyliques et leurs derives et bibliotheque focalisee
CL2004000647A1 (es) 2003-03-31 2005-02-04 Wyeth Corp Compuestos derivados de heterociclicos de sulfonamida que contienen fluoro y trifluoro alquilo; composicion farmaceutica; kit farmaceutico; procedimiento de preparacion; y su uso como inhibidores de beta amiloides para tratar alzheimer, angiopatia am
EP1709003B1 (en) 2004-01-16 2009-09-23 Wyeth Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole
US7687666B2 (en) * 2006-02-17 2010-03-30 Wyeth Methods for preparing sulfonamide substituted alcohols and intermediates thereof

Also Published As

Publication number Publication date
WO2007098030A1 (en) 2007-08-30
AR059517A1 (es) 2008-04-09
US7838550B2 (en) 2010-11-23
BRPI0707742A2 (pt) 2011-05-10
GT200800154A (es) 2008-10-21
JP2009527476A (ja) 2009-07-30
WO2007098030A8 (en) 2007-10-25
CN101384579A (zh) 2009-03-11
US20070197800A1 (en) 2007-08-23
RU2008131051A (ru) 2010-03-27
AU2007217966A1 (en) 2007-08-30
CA2637615A1 (en) 2007-08-30
TW200732295A (en) 2007-09-01
CR10158A (es) 2008-10-29
EP1984347A1 (en) 2008-10-29
ECSP088684A (es) 2008-09-29
PE20080109A1 (es) 2008-04-01
KR20080094685A (ko) 2008-10-23
IL192929A0 (en) 2009-02-11

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Legal Events

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