NO20072609L - Malonamid-derivater - Google Patents
Malonamid-derivaterInfo
- Publication number
- NO20072609L NO20072609L NO20072609A NO20072609A NO20072609L NO 20072609 L NO20072609 L NO 20072609L NO 20072609 A NO20072609 A NO 20072609A NO 20072609 A NO20072609 A NO 20072609A NO 20072609 L NO20072609 L NO 20072609L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- halogen
- hydroxy
- substituted
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
I Oppfinnelsen angår forbindelser med den generelle formel I hvor R er halogen, lavere alkyl eller lavere alkyl substituert med halogen; R1 er hydrogen, lavere alkyl eller lavere alkyl substituert med halogen eller hydroksy eller er lavere alkenyl, -(CH2)n-cykloalkyl, -(CH2)n-COR' eller er benzyl, eventuelt substituert med halogen eller er -(CH2)n-morfolinyl; R' er lavere alkoksy, hydroksy eller amino; R2 er hydrogen, lavere alkyl eller di-lavere alkyl, lavere alkyl substituert med halogen eller hydroksy eller er benzyl eller cykloalkyl; R3 er lavere alkyl eller lavere alkyl substituert med halogen eller er benzyl, eventuelt substituert med to halogenatomer eller er -(CH2)n-cykloalkyl eller -(CH2)n-pyridinyl; X er -CR4R4'- eller - CR4R4'-O-; R4/R4' er uavhengig av hverandre hydrogen, halogen, lavere alkyl, lavere alkoksy, hydroksy eller -CH2-2-[1,3]dioksalan-; n er 0, 1 eller 2; farmasøytisk egnede syreaddisjonssalter derav og alle former av optisk rene enantiomerer, racemater eller diastereomerer og diastereomer-blandinger derav for behandling av Alzheimer's sykdom.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106395 | 2004-12-08 | ||
| EP05100816 | 2005-02-07 | ||
| PCT/EP2005/012834 WO2006061136A2 (en) | 2004-12-08 | 2005-12-01 | Malonamide derivatives as inhibitors of gamma-secretase for the treatment of alzheimer’s disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20072609L true NO20072609L (no) | 2007-06-19 |
Family
ID=36293585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20072609A NO20072609L (no) | 2004-12-08 | 2007-05-24 | Malonamid-derivater |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7211573B2 (no) |
| EP (1) | EP1828151B1 (no) |
| JP (1) | JP4979590B2 (no) |
| KR (1) | KR100890678B1 (no) |
| CN (1) | CN101072760B (no) |
| AR (1) | AR053987A1 (no) |
| AT (1) | ATE504580T1 (no) |
| AU (1) | AU2005313582B8 (no) |
| BR (1) | BRPI0518615A2 (no) |
| CA (1) | CA2589196A1 (no) |
| DE (1) | DE602005027388D1 (no) |
| DK (1) | DK1828151T3 (no) |
| HK (1) | HK1114840A1 (no) |
| IL (1) | IL183293A0 (no) |
| MX (1) | MX2007006504A (no) |
| NO (1) | NO20072609L (no) |
| NZ (1) | NZ555184A (no) |
| PL (1) | PL1828151T3 (no) |
| PT (1) | PT1828151E (no) |
| RU (1) | RU2402538C2 (no) |
| TW (1) | TWI349005B (no) |
| WO (1) | WO2006061136A2 (no) |
| ZA (1) | ZA200705018B (no) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009002538A (es) | 2006-09-20 | 2009-03-20 | Hoffmann La Roche | Derivados de 4-oxo-2,3,4,5-tetrahidro-benzo[b][1,4]diazepina. |
| KR101150574B1 (ko) | 2007-02-02 | 2012-05-30 | 에프. 호프만-라 로슈 아게 | 6-옥소-6,7-다이하이드로-5ｈ-다이벤조［ｂ,ｄ］아제핀-7-일 유도체 |
| US8741889B2 (en) * | 2008-01-11 | 2014-06-03 | Hoffmann-La Roche Inc | Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor |
| RU2010133489A (ru) * | 2008-01-11 | 2012-02-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | Применение ингибиторов гамма-секретазы для лечения рака |
| JP6877365B2 (ja) | 2015-06-11 | 2021-05-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 標的化されたＮｏｔｃｈ経路阻害剤 |
| EP3700904B1 (en) | 2017-10-24 | 2023-07-19 | Bayer AG | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| KR20210088619A (ko) * | 2018-11-07 | 2021-07-14 | 추가이 세이야쿠 가부시키가이샤 | O-치환 세린 유도체의 제조 방법 |
| US20220298157A1 (en) | 2019-04-24 | 2022-09-22 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one compounds |
| US20220378762A1 (en) | 2019-04-24 | 2022-12-01 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| CA3137610A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one compounds |
| CN112300019A (zh) * | 2019-07-31 | 2021-02-02 | 华东师范大学 | 一种邻乙酰氨基苯丁酸类化合物的制备方法 |
| WO2021198020A1 (en) | 2020-03-31 | 2021-10-07 | Bayer Aktiengesellschaft | 3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one derivatives as egfr inhibitors for the treatment of cancer |
| CR20230440A (es) | 2021-03-09 | 2023-10-26 | Basf Se | Malonamidas y su uso como herbicidas |
| EP4391808A1 (en) * | 2021-08-25 | 2024-07-03 | Basf Se | Herbicidal malonamides |
| MX2024002599A (es) * | 2021-08-31 | 2024-03-22 | Basf Se | Malonamidas herbicidas que contienen un sistema de anillos condensados. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002241368A (ja) * | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
| WO1999067219A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| DK1511718T3 (da) * | 2002-05-29 | 2009-06-22 | Hoffmann La Roche | N-acylaminobenzenderivater som selektive monoaminoxidase B-inhibitorer |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| ES2311795T3 (es) | 2003-02-04 | 2009-02-16 | F. Hoffmann-La Roche Ag | Derivados de malonamida como inhibidores de gamma-secretasa. |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| RS20060146A (en) | 2003-09-09 | 2008-06-05 | F.Hoffmann-La Roche Ag., | Malonamide derivatives blocking the activity of gama-secretase |
| KR100867035B1 (ko) | 2003-10-06 | 2008-11-04 | 에프. 호프만-라 로슈 아게 | 감마-세크레타제 저해제로서 유용한 치환된다이벤조-아제핀 및 벤조-다이아제핀 유도체 |
-
2005
- 2005-11-30 US US11/289,176 patent/US7211573B2/en not_active Expired - Fee Related
- 2005-12-01 WO PCT/EP2005/012834 patent/WO2006061136A2/en active Application Filing
- 2005-12-01 CN CN2005800421635A patent/CN101072760B/zh not_active Expired - Fee Related
- 2005-12-01 NZ NZ555184A patent/NZ555184A/en not_active IP Right Cessation
- 2005-12-01 KR KR1020077015604A patent/KR100890678B1/ko not_active IP Right Cessation
- 2005-12-01 AU AU2005313582A patent/AU2005313582B8/en not_active Ceased
- 2005-12-01 PT PT05811672T patent/PT1828151E/pt unknown
- 2005-12-01 CA CA002589196A patent/CA2589196A1/en not_active Abandoned
- 2005-12-01 MX MX2007006504A patent/MX2007006504A/es active IP Right Grant
- 2005-12-01 DE DE602005027388T patent/DE602005027388D1/de active Active
- 2005-12-01 EP EP05811672A patent/EP1828151B1/en active Active
- 2005-12-01 BR BRPI0518615-3A patent/BRPI0518615A2/pt not_active IP Right Cessation
- 2005-12-01 RU RU2007120211/04A patent/RU2402538C2/ru not_active IP Right Cessation
- 2005-12-01 PL PL05811672T patent/PL1828151T3/pl unknown
- 2005-12-01 DK DK05811672.4T patent/DK1828151T3/da active
- 2005-12-01 JP JP2007544779A patent/JP4979590B2/ja not_active Expired - Fee Related
- 2005-12-01 AT AT05811672T patent/ATE504580T1/de active
- 2005-12-07 AR ARP050105106A patent/AR053987A1/es unknown
- 2005-12-07 TW TW094143269A patent/TWI349005B/zh not_active IP Right Cessation
-
2007
- 2007-05-17 IL IL183293A patent/IL183293A0/en unknown
- 2007-05-24 NO NO20072609A patent/NO20072609L/no not_active Application Discontinuation
- 2007-06-04 ZA ZA200705018A patent/ZA200705018B/xx unknown
-
2008
- 2008-04-29 HK HK08104728.3A patent/HK1114840A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI349005B (en) | 2011-09-21 |
| DK1828151T3 (da) | 2011-05-16 |
| WO2006061136A2 (en) | 2006-06-15 |
| ZA200705018B (en) | 2010-04-28 |
| KR20070086979A (ko) | 2007-08-27 |
| JP4979590B2 (ja) | 2012-07-18 |
| RU2007120211A (ru) | 2009-01-20 |
| KR100890678B1 (ko) | 2009-03-26 |
| PT1828151E (pt) | 2011-06-16 |
| TW200626568A (en) | 2006-08-01 |
| ATE504580T1 (de) | 2011-04-15 |
| PL1828151T3 (pl) | 2011-09-30 |
| US20060122168A1 (en) | 2006-06-08 |
| CN101072760B (zh) | 2011-12-28 |
| NZ555184A (en) | 2010-01-29 |
| CN101072760A (zh) | 2007-11-14 |
| BRPI0518615A2 (pt) | 2008-11-25 |
| EP1828151B1 (en) | 2011-04-06 |
| HK1114840A1 (en) | 2008-11-14 |
| RU2402538C2 (ru) | 2010-10-27 |
| AU2005313582A8 (en) | 2011-06-16 |
| CA2589196A1 (en) | 2006-06-15 |
| MX2007006504A (es) | 2007-06-22 |
| US7211573B2 (en) | 2007-05-01 |
| AU2005313582B2 (en) | 2011-06-02 |
| AU2005313582B8 (en) | 2011-06-16 |
| WO2006061136A3 (en) | 2006-08-03 |
| AR053987A1 (es) | 2007-05-30 |
| DE602005027388D1 (de) | 2011-05-19 |
| JP2008522994A (ja) | 2008-07-03 |
| AU2005313582A1 (en) | 2006-06-15 |
| EP1828151A2 (en) | 2007-09-05 |
| IL183293A0 (en) | 2007-09-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20072609L (no) | Malonamid-derivater | |
| MXPA04009784A (es) | Tiazolidin-4-carbonitrilos y analogos y su uso como inhibidores de dipeptidil-peptidas. | |
| NO20083917L (no) | Malonamidderivater som gammasekretaseinhibitorer | |
| JP2008526999A5 (no) | ||
| NO20062689L (no) | Azabisykliske heterosykler som modulatorer for kannabinoidreseptorer | |
| AR037418A1 (es) | Derivados de benzotiazol | |
| CY1112127T1 (el) | 4-φαινυλαμινο-κιναζολιν-6-υλ-αμιδια | |
| NO20073465L (no) | Benzotiazol-derivater | |
| SE0104334D0 (sv) | Therapeutic agents | |
| NO20062370L (no) | Amidderivater | |
| NO20062704L (no) | Azabicykliske heterocykler som cannabinoide reseptormodulatorer | |
| CY1106679T1 (el) | Αζαδικυκλικες ετεροκυκλικες ενωσεις ως τροποποιητες κανναβινοειδους υποδοχεα | |
| EA200601287A1 (ru) | Производные (3-оксо-3,4-дигидрохиноксалин-2-иламино) бензамида и родственные соединения в качестве ингибиторов гликогенфосфорилазы для лечения диабета и ожирения | |
| DE60236719D1 (de) | Purinderivate als antagonisten an purinergen rezeptoren | |
| NO20053748L (no) | Pyrrolopyridazinderivater. | |
| WO2007039781A3 (en) | 1,2,4-oxadioi.e derivatives with activity at the metabotropic clutamate receptors | |
| AR041298A1 (es) | Derivados de pirrolidona como inhibidores de maob | |
| NO20070837L (no) | Pyrido-pyrido pyrimidinderivater, fremstilling derav samt terapeutisk anvendelse for behandling av cancer. | |
| TW201111375A (en) | N-substituted cyclic amino derivative | |
| NO20052699L (no) | 4(fenylpiperazinyl-metyl)benzamid-derivater og deres anvendelse ved behandling av smerte og gastrointestinale lidelser. | |
| RU2003130070A (ru) | Производные бигуанида | |
| NO20070972L (no) | Benzyloksyderivater som MAOB-inhibitorer | |
| BR0318533A (pt) | azolidinacarbonitrilas e seu uso como inibidores de dpp-iv | |
| SI1968957T1 (sl) | Substituirani tiazoli in njihova uporaba za pripravo zdravil | |
| AR041116A1 (es) | Metodos para tratar pacientes que sufen el sindrome de piernas inquietas o desordenes relacionados |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |