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NO20070155L - 5-amino-2,4,7-triokso-3,4,7,8-tetrahydro-2H-pyrido[2,3-D]pyrimidinderivater og relaterte forbindelser for behandling av kreft - Google Patents

5-amino-2,4,7-triokso-3,4,7,8-tetrahydro-2H-pyrido[2,3-D]pyrimidinderivater og relaterte forbindelser for behandling av kreft

Info

Publication number
NO20070155L
NO20070155L NO20070155A NO20070155A NO20070155L NO 20070155 L NO20070155 L NO 20070155L NO 20070155 A NO20070155 A NO 20070155A NO 20070155 A NO20070155 A NO 20070155A NO 20070155 L NO20070155 L NO 20070155L
Authority
NO
Norway
Prior art keywords
agent
treatment
cancer
antitumor
trioxo
Prior art date
Application number
NO20070155A
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English (en)
Other versions
NO338355B1 (no
Inventor
Hisashi Kawasaki
Hiroyuki Abe
Kazuhide Hayakawa
Tetsuya Iida
Shinichi Kikuchi
Takayuki Yamaguchi
Toyomichi Nanayama
Hironori Kurachi
Masahiro Tamaru
Yoshikazu Hori
Mitsuru Takahashi
Takayuki Yoshida
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of NO20070155L publication Critical patent/NO20070155L/no
Publication of NO338355B1 publication Critical patent/NO338355B1/no

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/12—Antivirals
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

Den foreliggende oppfinnelsen er relatert til en pyrimidinforbindelse representert ved formel (I) hvori hvert symbol er som definert i spesifikasjonen, et farmasøytisk akseptabelt salt derav, og et farmasøytisk middel for profylaksen eller behandlingen av en sykdom forårsaket ved uønsket celleproliferasjon, spesielt et antitumormiddel, som inneholder slik forbindelse. Forbindelsen av den foreliggende oppfinnelsen har overlegen undertrykkende virkning mot uønsket celleproliferasjon, spesielt en antitumorvirkning, og er nyttig som et antitumormiddel for profylaksen eller behandlingen av kreft, antireumatoidmiddel og lignende. I tillegg, ved den kombinerte anvendelsen med annet antitumormiddel slik som et alkylerende middel, en metabolismeantagonist og lignende, kan den være et mer effektivt antitumormiddel.
NO20070155A 2004-06-11 2007-01-09 5-amino-2,4,7-triokso-3,4,7,8-tetrahydro-2H-pyrido[2,3-D]pyrimidinderivater og relaterte forbindelser for behandling av kreft NO338355B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004174770 2004-06-11
JP2004327111 2004-11-10
PCT/JP2005/011082 WO2005121142A1 (en) 2004-06-11 2005-06-10 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2h-pyrido’2,3-d! pyrimidine derivatives and related compounds for the treatment of cancer

Publications (2)

Publication Number Publication Date
NO20070155L true NO20070155L (no) 2007-02-13
NO338355B1 NO338355B1 (no) 2016-08-08

Family

ID=34970318

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20070155A NO338355B1 (no) 2004-06-11 2007-01-09 5-amino-2,4,7-triokso-3,4,7,8-tetrahydro-2H-pyrido[2,3-D]pyrimidinderivater og relaterte forbindelser for behandling av kreft
NO2016021C NO2016021I1 (no) 2004-06-11 2016-11-24 5-amino-2,4,7-triokso-3,4,7,8-tetrahydro-2Hpyrido[2,3-D]pyrimidinderivater og relaterte forbindelser for behandling av kreft

Family Applications After (1)

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NO2016021C NO2016021I1 (no) 2004-06-11 2016-11-24 5-amino-2,4,7-triokso-3,4,7,8-tetrahydro-2Hpyrido[2,3-D]pyrimidinderivater og relaterte forbindelser for behandling av kreft

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Country Link
EP (3) EP1761528B1 (no)
JP (3) JP4163738B2 (no)
KR (1) KR100883289B1 (no)
CN (2) CN101006086B (no)
AT (1) ATE383360T1 (no)
AU (1) AU2005252110B2 (no)
BR (1) BRPI0511967B8 (no)
CA (2) CA2569850C (no)
CY (3) CY1107253T1 (no)
DE (1) DE602005004286T2 (no)
DK (2) DK1761528T3 (no)
ES (2) ES2297723T3 (no)
HK (1) HK1107084A1 (no)
HR (2) HRP20080018T3 (no)
IL (1) IL179671A0 (no)
LU (1) LU92602I2 (no)
ME (1) ME01480B (no)
MX (1) MXPA06014478A (no)
NL (1) NL300701I1 (no)
NO (2) NO338355B1 (no)
NZ (1) NZ552090A (no)
PL (2) PL2298768T3 (no)
PT (2) PT1761528E (no)
RS (2) RS50569B (no)
RU (1) RU2364596C2 (no)
SI (2) SI1761528T1 (no)
WO (1) WO2005121142A1 (no)

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WO2011106298A1 (en) 2010-02-25 2011-09-01 Dana-Farber Cancer Institute, Inc. Braf mutations conferring resistance to braf inhibitors
WO2013169858A1 (en) 2012-05-08 2013-11-14 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy

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