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NO20065060L - Pharmaceutical combinations containing benzoxazine for the treatment of respiratory disorders - Google Patents

Pharmaceutical combinations containing benzoxazine for the treatment of respiratory disorders

Info

Publication number
NO20065060L
NO20065060L NO20065060A NO20065060A NO20065060L NO 20065060 L NO20065060 L NO 20065060L NO 20065060 A NO20065060 A NO 20065060A NO 20065060 A NO20065060 A NO 20065060A NO 20065060 L NO20065060 L NO 20065060L
Authority
NO
Norway
Prior art keywords
treatment
respiratory disorders
pharmaceutical combinations
combinations containing
containing benzoxazine
Prior art date
Application number
NO20065060A
Other languages
Norwegian (no)
Other versions
NO337714B1 (en
Inventor
Christoph Hoenke
Andreas Schnapp
Klaus Rudolf
Michael P Pieper
Ingo Konetzki
Sabine Pestel
Michel Pairet
Philipp Lustenberger
Thierry Bouyssou
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34966478&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20065060(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE102004019540A external-priority patent/DE102004019540A1/en
Priority claimed from DE102004052987A external-priority patent/DE102004052987A1/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of NO20065060L publication Critical patent/NO20065060L/en
Publication of NO337714B1 publication Critical patent/NO337714B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Det beskrives nye medikamentkombinasjoner som foruten én eller flere, fortrinnsvis én, forbindelse med den generelle formel (I), hvor restene R1, R2 og R3 kan ha de betydninger som er angitt i patentkravene, inneholder minst ett ytterligere virkestoff 2. Fremgangsmåter for fremstilling av disse, så vel som deres anvendelse som legemiddel er beskrevet.New drug combinations are disclosed which, besides one or more, preferably one, compounds of general formula (I), wherein residues R1, R2 and R3 may have the meanings specified in the claims, contain at least one additional active ingredient 2. Processes for the preparation of these as well as their use as a drug are described.

NO20065060A 2004-04-22 2006-11-02 Drug combinations containing benzoxazines and their use in the treatment of respiratory disorders NO337714B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102004019540A DE102004019540A1 (en) 2004-04-22 2004-04-22 Composition, useful for treatment of e.g. inflammatory and obstructive respiratory complaint, sinus rhythm in heart in atrioventricular block and circulatory shock, comprises 6-hydroxy-4H-benzo1,4oxazin-3-one derivatives and other actives
DE102004052987A DE102004052987A1 (en) 2004-11-03 2004-11-03 Composition, useful for treatment of e.g. inflammatory and obstructive respiratory complaint, sinus rhythm in heart in atrioventricular block and circulatory shock, comprises 6-hydroxy-4H-benzo1,4oxazin-3-one derivatives and other actives
EP05002496 2005-02-07
PCT/EP2005/004073 WO2005102349A1 (en) 2004-04-22 2005-04-18 Pharmaceutical combinations containing benzoxazine for treating respiratory diseases

Publications (2)

Publication Number Publication Date
NO20065060L true NO20065060L (en) 2006-11-21
NO337714B1 NO337714B1 (en) 2016-06-06

Family

ID=34966478

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20065060A NO337714B1 (en) 2004-04-22 2006-11-02 Drug combinations containing benzoxazines and their use in the treatment of respiratory disorders
NO2016022C NO2016022I1 (en) 2004-04-22 2016-12-01 Olodaterol (as hydrochloride) - (6-hydroxy-8- {1-hydroxy-2- [2- (4-methoxy-phenyl) -1,1-dimethyl-ethylamino] -ethyl} -4H-benzo [1,4 ] oxazin-3-one) and thiotropium (as bromide monohydrate)

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2016022C NO2016022I1 (en) 2004-04-22 2016-12-01 Olodaterol (as hydrochloride) - (6-hydroxy-8- {1-hydroxy-2- [2- (4-methoxy-phenyl) -1,1-dimethyl-ethylamino] -ethyl} -4H-benzo [1,4 ] oxazin-3-one) and thiotropium (as bromide monohydrate)

Country Status (32)

Country Link
EP (2) EP1781298B1 (en)
JP (1) JP2007533683A (en)
KR (2) KR101287460B1 (en)
AR (1) AR049262A1 (en)
AT (1) ATE539754T1 (en)
AU (1) AU2005235419B2 (en)
BE (1) BE2015C065I2 (en)
BR (1) BRPI0510080B8 (en)
CA (1) CA2559699C (en)
CY (3) CY1113890T1 (en)
DK (2) DK1781298T3 (en)
EA (1) EA013157B1 (en)
EC (1) ECSP066947A (en)
ES (2) ES2380370T3 (en)
FI (1) FIC20170005I1 (en)
HU (1) HUS1500058I1 (en)
IL (2) IL177685A (en)
LT (1) LTC1781298I2 (en)
LU (1) LU93066I2 (en)
MY (1) MY148945A (en)
NL (1) NL300779I2 (en)
NO (2) NO337714B1 (en)
NZ (1) NZ550797A (en)
PE (1) PE20060462A1 (en)
PL (2) PL1781298T4 (en)
PT (2) PT1781298E (en)
SG (1) SG152237A1 (en)
SI (2) SI2422786T1 (en)
TW (2) TWI372056B (en)
UY (1) UY28861A1 (en)
WO (1) WO2005102349A1 (en)
ZA (1) ZA200606624B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO343363B1 (en) * 2005-10-10 2019-02-11 Boehringer Ingelheim Int Drug formulation, use of the drug formulation for the manufacture of a pharmaceutical composition for the treatment of respiratory diseases and inhalation kits containing the same

Families Citing this family (19)

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US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024452A1 (en) * 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosol formulation for the inhalation of beta agonists
US7923455B2 (en) * 2005-01-28 2011-04-12 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of heart failure comprising administration of an anticholinergic
EP1855689A1 (en) * 2005-02-16 2007-11-21 Boehringer Ingelheim International GmbH Pharmaceutical compositions comprising anticholinergics and etiprednol
JP5270343B2 (en) 2005-08-15 2013-08-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Beta mimetic manufacturing method
TWI396541B (en) 2005-10-10 2013-05-21 Boehringer Ingelheim Int Novel combinations of medicaments for the treatment of respiratory diseases
JP5257073B2 (en) * 2005-11-10 2013-08-07 ボーダー、ニコラス・エス Soft anticholinergic ester
CA2642239A1 (en) * 2006-02-16 2007-08-23 Boehringer Ingelheim International Gmbh Drug combinations for the treatment of respiratory tract diseases
CA2660186A1 (en) 2006-08-07 2008-02-14 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of respiratory diseases
UY30543A1 (en) * 2006-08-18 2008-03-31 Boehringer Ingelheim Int AEROSOL FORMULATION FOR INHALATION OF BETA- AGONISTS
UY30542A1 (en) * 2006-08-18 2008-03-31 Boehringer Ingelheim Int AEROSOL FORMULATION FOR INHALATION OF BETA AGONISTS
JP2010507617A (en) * 2006-10-26 2010-03-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel pharmaceutical compositions for the treatment of respiratory and digestive disorders
EP1921070A1 (en) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclic heterocycles, medicaments comprising them, their use and process for their preparation
ME01461B (en) 2008-02-07 2014-04-20 Boehringer Ingelheim Int Spirocyclic heterocycles, medicaments containing said compounds, use thereof and method for their production
WO2010015522A1 (en) 2008-08-08 2010-02-11 Boehringer Ingelheim International Gmbh Cyclohexyloxy-substituted heterocyclics, medicines containing these compounds and method for the production thereof
CA2744655A1 (en) * 2008-11-27 2010-06-03 Boehringer Ingelheim International Gmbh Novel powdered crystalline medicines for inhalation
WO2014016548A2 (en) 2012-07-27 2014-01-30 Cipla Limited Pharmaceutical composition
EP2906218B1 (en) 2012-10-09 2016-12-14 Boehringer Ingelheim International GmbH Beta-2-adrenoceptor agonist for the treatment of cough

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US4460581A (en) * 1982-10-12 1984-07-17 Boehringer Ingelheim Kg (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
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SE453566B (en) 1986-03-07 1988-02-15 Draco Ab POWDER INHALATOR DEVICE
SG45171A1 (en) 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
DE4318455A1 (en) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Capsule holder
DE19536902A1 (en) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Miniature fluid pressure generating device
CN1426401A (en) * 2000-04-27 2003-06-25 贝林格尔英格海姆法玛公司 Novel, slow-acting betamimetics, method for their production and their use as medicaments
BR0114584A (en) 2000-10-12 2003-08-26 Boehringer Ingelheim Pharma Crystalline monohydrate, processes for its preparation and its application for the preparation of a medicament
KR100971616B1 (en) 2001-06-22 2010-07-22 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 Crystalline anticholinergic method for its production and pharmaceutical composition comprising the same
DE10130371A1 (en) * 2001-06-23 2003-01-02 Boehringer Ingelheim Pharma New drug compositions based on anticholinergics, corticosteroids and betamimetics
ES2203327B1 (en) * 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. NEW QUINUCLIDINE CARBAMATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE10230751A1 (en) * 2002-07-09 2004-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug compositions based on new anticholinergics and EGFR kinase inhibitors
DE10246374A1 (en) * 2002-10-04 2004-04-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg New 4-(2-alkylamino-1-hydroxyethyl)-3-alkoxy-benzene-1,2-diol derivatives, are beta-mimetics having a long duration of action, useful e.g. for treating asthma, chronic obstructive pulmonary disease or arrhythmia
DE10253282A1 (en) 2002-11-15 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Treatment of chronic obstructive pulmonary disease, using new or known N-substituted 2-amino-1-(benz-(1,4)-oxazin-3-on-8-yl)-ethanol derivative beta-mimetic agents, suitable for once-daily administration

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO343363B1 (en) * 2005-10-10 2019-02-11 Boehringer Ingelheim Int Drug formulation, use of the drug formulation for the manufacture of a pharmaceutical composition for the treatment of respiratory diseases and inhalation kits containing the same

Also Published As

Publication number Publication date
BRPI0510080B1 (en) 2020-08-18
ATE539754T1 (en) 2012-01-15
ECSP066947A (en) 2007-01-26
SI1781298T1 (en) 2012-04-30
CY1115719T1 (en) 2017-01-25
BRPI0510080A (en) 2007-10-16
PL1781298T4 (en) 2017-07-31
KR20070015592A (en) 2007-02-05
CY1113890T1 (en) 2016-07-27
PL2422786T3 (en) 2015-02-27
NO337714B1 (en) 2016-06-06
JP2007533683A (en) 2007-11-22
BRPI0510080B8 (en) 2021-05-25
WO2005102349A1 (en) 2005-11-03
FIC20170005I1 (en) 2017-01-13
EA200601846A1 (en) 2007-04-27
DK1781298T3 (en) 2012-05-07
EP2422786A1 (en) 2012-02-29
IL226562A0 (en) 2013-06-27
PT2422786E (en) 2014-11-12
IL177685A0 (en) 2006-12-31
SG152237A1 (en) 2009-05-29
AR049262A1 (en) 2006-07-12
HUS1500058I1 (en) 2016-01-28
AU2005235419A1 (en) 2005-11-03
TWI374739B (en) 2012-10-21
TW201231055A (en) 2012-08-01
CA2559699A1 (en) 2005-11-03
BE2015C065I2 (en) 2024-08-08
EP1781298A1 (en) 2007-05-09
NO2016022I2 (en) 2016-12-01
ZA200606624B (en) 2008-01-08
PE20060462A1 (en) 2006-06-19
SI2422786T1 (en) 2014-12-31
CY2017014I2 (en) 2017-11-14
NO2016022I1 (en) 2016-12-01
UY28861A1 (en) 2005-11-30
LU93066I2 (en) 2016-07-11
EA013157B1 (en) 2010-02-26
EP1781298B1 (en) 2012-01-04
PT1781298E (en) 2012-02-03
MY148945A (en) 2013-06-14
PL1781298T3 (en) 2012-06-29
NZ550797A (en) 2010-08-27
TWI372056B (en) 2012-09-11
DK2422786T3 (en) 2014-11-17
IL177685A (en) 2013-10-31
AU2005235419B2 (en) 2010-11-04
KR101287460B1 (en) 2013-07-23
ES2380370T3 (en) 2012-05-11
EP2422786B1 (en) 2014-08-13
KR20130049840A (en) 2013-05-14
CY2017014I1 (en) 2017-11-14
ES2523518T3 (en) 2014-11-26
NL300779I2 (en) 2017-11-02
LTC1781298I2 (en) 2018-09-25
CA2559699C (en) 2012-06-19

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Free format text: PRODUCT NAME: OLODATEROL HYDROKLORID OG TIOTROPIUM BROMIDMONOHYDRAT; NAT. REG. NO/DATE: 14-10100 20150618; FIRST REG. NO/DATE: NL/H/3157-3158/01/DC 20150609

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Filing date: 20161201

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Free format text: PRODUCT NAME: OLODATEROL HYDROKLORID OG TIOTROPIUM BROMIDMONOHYDRAT; NAT. REG. NO/DATE: 14-10100 20150618; FIRST REG. NO/DATE: NL/H/3157-3158/01/DC 20150609

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Extension date: 20300418

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Free format text: PRODUCT NAME: OLODATEROL HYDROKLORID OG TIOTROPIUM BROMIDMONOHYDRAT; NAT. REG. NO/DATE: 14-10100 20150618; FIRST REG. NO/DATE: 5653019/5653027 20150609

Spc suppl protection certif: 2016022

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Extension date: 20300418