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NO20064186L - Substituerte pyrazolin sammensetninger for a redusere triglycerider i blod - Google Patents

Substituerte pyrazolin sammensetninger for a redusere triglycerider i blod

Info

Publication number
NO20064186L
NO20064186L NO20064186A NO20064186A NO20064186L NO 20064186 L NO20064186 L NO 20064186L NO 20064186 A NO20064186 A NO 20064186A NO 20064186 A NO20064186 A NO 20064186A NO 20064186 L NO20064186 L NO 20064186L
Authority
NO
Norway
Prior art keywords
compositions
reduce blood
substituted pyrazoline
blood triglycerides
substituted
Prior art date
Application number
NO20064186A
Other languages
English (en)
Inventor
Rosa Cuberes Altisen
Bonifacio Silva
Jordi Frigola-Costanza
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04021974A external-priority patent/EP1637522A1/en
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of NO20064186L publication Critical patent/NO20064186L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
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  • Health & Medical Sciences (AREA)
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  • Diabetes (AREA)
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  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
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Abstract

Foreliggende oppfinnelse angår substituerte pyrazolin forbindelser, fremgangsmåte for deres fremstilling, medikamenter som omfatter disse forbindelsene så vel som deres anvendelse for fremstilling av et medikament for behandling av mennesker og dyr.
NO20064186A 2004-02-17 2006-09-15 Substituerte pyrazolin sammensetninger for a redusere triglycerider i blod NO20064186L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ES200400378 2004-02-17
US80453404A 2004-03-19 2004-03-19
EP04021974A EP1637522A1 (en) 2004-09-16 2004-09-16 Substituted pyrazoline compounds for reducing triglycerides in blood
PCT/EP2005/001465 WO2005077909A1 (en) 2004-02-17 2005-02-14 Substituted pyrazoline compounds for reducing triglycerides in blood

Publications (1)

Publication Number Publication Date
NO20064186L true NO20064186L (no) 2006-11-14

Family

ID=34864786

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20064186A NO20064186L (no) 2004-02-17 2006-09-15 Substituerte pyrazolin sammensetninger for a redusere triglycerider i blod

Country Status (10)

Country Link
EP (1) EP1718619A1 (no)
JP (1) JP2007522252A (no)
KR (1) KR20060135815A (no)
AU (1) AU2005212817A1 (no)
BR (1) BRPI0507790A (no)
CA (1) CA2556568A1 (no)
IL (1) IL177454A0 (no)
NO (1) NO20064186L (no)
RU (1) RU2006133260A (no)
WO (1) WO2005077909A1 (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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WO2005044785A1 (en) 2003-10-30 2005-05-19 Merck & Co., Inc. Aralkyl amines as cannabinoid receptor modulators
TW200533657A (en) * 2004-02-17 2005-10-16 Esteve Labor Dr Substituted pyrazoline compounds, their preparation and use as medicaments
ES2326723B1 (es) * 2005-07-15 2010-05-11 Laboratorios Del Dr. Esteve, S.A. Uso de compuestos de pirazol sustituidos y combinaciones de los mismos para el tratamiento del sindrome metabolico.
WO2007009706A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood
ES2326725B1 (es) * 2005-07-15 2010-05-11 Laboratorios Del Dr. Esteve, S.A. Uso de compuestos de pirazolina sustituidos para el tratamiento de trastornos alimentarios, que incluyen la obesidad o el sindrome metabolico en pacientes con diabetes desarrollada.
WO2007009683A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr.Esteve, S.A. Pharmaceutical formulations of substituted pyrazoline compounds
ES2336883B1 (es) * 2005-07-15 2011-03-22 Laboratorios Del Dr. Esteve, S.A. Compuestos de pirazolina sustituidos, con una estereoquimica predeterminada, para la reduccion de trigliceridos en sangre.
EP1743637A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazole compounds and combinations thereof for the treatment of the metabolic syndrome
EP1743639A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of coagulation related diseases
EP1745781A1 (en) * 2005-07-15 2007-01-24 Laboratorios Del Dr. Esteve, S.A. Combination of pyrazoline type cannabinoid receptor antagonist and statin
WO2007009698A1 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A Combination of pyrazoline type cannabinoid receptor antagonist and statin
EP1749527A1 (en) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of the lipid parameters of the metabolic syndrome
EP1749526A1 (en) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes
ES2327203B1 (es) * 2005-07-15 2010-06-07 Laboratorios Del Dr. Esteve, S.A. Uso de compuestos de pirazolina sustituidos para el tratamiento de trastornos relacionados con la coagulacion.
ES2326857B1 (es) * 2005-07-15 2010-05-11 Laboratorios Del Dr. Esteve, S.A. Uso de compuestos de pirazolina sustituidos para el tratamiento de los parametros lipidicos del sindrome metabolico.
EP1743889A1 (en) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Sustituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood
EP1746090A1 (en) * 2005-07-15 2007-01-24 Laboratorios del Dr. Esteve S.A. Sustituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood
EP1944295A1 (en) * 2007-01-15 2008-07-16 Laboratorios del Dr. Esteve S.A. Non-racemic mixtures of (R)-N-piperidinyl-5-(4-chlorophenyl)1-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide and (S)-N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide
EP1944296A1 (en) * 2007-01-15 2008-07-16 Laboratorios del Dr. Esteve S.A. Amorphous phase of a substituted pyrazoline, its preparation and use as medicaments
EP1946779A1 (en) * 2007-01-16 2008-07-23 Laboratorios del Dr. Esteve S.A. Combination of substituted pyrazolines and agent for treating dyslipidemia
EP1947088A1 (en) * 2007-01-17 2008-07-23 Laboratorios del Dr. Esteve S.A. Substituted pyrazoline compounds with ACAT inhibition activity, their preparation and use as medicaments
EP1950203A1 (en) * 2007-01-24 2008-07-30 Laboratorios del Dr. Esteve S.A. Substituted pyrazoline compounds with ACAT, their preparation and use as medicaments
US20100099712A1 (en) * 2007-01-17 2010-04-22 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds with acat inhibition activity
EP2114892A1 (en) * 2007-01-17 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. Substituted pyrazoline compounds with acat inhibition activity, their preparation and use as medicaments
KR101395658B1 (ko) 2012-09-20 2014-05-16 서울대학교산학협력단 4-(5-(2-메톡시페닐)-3-(p-톨릴)-4,5-디하이드로-1H-피라졸-1-일)-4-옥소부탄산을 포함하는 골대사성 질환의 예방 및 치료용 조성물
KR101466377B1 (ko) * 2012-10-22 2014-12-01 건국대학교 산학협력단 디메톡시페닐디히드로피라졸릴나프탈레놀 유도체 및 그 제법 및 항암제로서의 용도
DK2920165T3 (en) * 2012-11-16 2017-01-16 Bristol Myers Squibb Co Dihydropyrazol-GPR40-MODULATORS
CA2891551A1 (en) * 2012-11-16 2014-05-22 Bristol-Myers Squibb Company Dihydropyrazole gpr40 modulators

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BRPI0507790A (pt) 2007-07-17
AU2005212817A1 (en) 2005-08-25
KR20060135815A (ko) 2006-12-29
EP1718619A1 (en) 2006-11-08
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