[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

NO20055612L - Anti-inflammatoriske fosfonatforbindelser - Google Patents

Anti-inflammatoriske fosfonatforbindelser

Info

Publication number
NO20055612L
NO20055612L NO20055612A NO20055612A NO20055612L NO 20055612 L NO20055612 L NO 20055612L NO 20055612 A NO20055612 A NO 20055612A NO 20055612 A NO20055612 A NO 20055612A NO 20055612 L NO20055612 L NO 20055612L
Authority
NO
Norway
Prior art keywords
inflammatory
compounds
phosphonate compounds
methods
phosphonate
Prior art date
Application number
NO20055612A
Other languages
English (en)
Other versions
NO20055612D0 (no
Inventor
David Oare
Aesop Cho
William John Watkins
Peter Harold Nelson
Lee S Chong
James M Chen
Xiaowu Chen
Maria Fardis
Kuei-Ying Lin
Richard L Mackman
Hyung-Jung Pyun
Sundaramoorthi Swaminathan
Jennifer R Zhang
Carina E Cannizzaro
Thorsten A Kirschberg
Ralph F Hirschmann
Christopher P Lee
Adrian S Ray
Rosemarie Sherlock
Craig Gibbs
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of NO20055612D0 publication Critical patent/NO20055612D0/no
Publication of NO20055612L publication Critical patent/NO20055612L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • C07F9/655354—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oppfinnelsen vedrører fosforsubstituerte antiinflammatoriske forbindelser, preparater som inneholder slike forbindelser, og terapeutiske fremgangsmåter som omfatter administrering av slike forbindelser, samt fremgangsmåter og mellomprodukter som kan anvendes til fremstilling av slike forbindelser.
NO20055612A 2003-04-25 2005-11-25 Anti-inflammatoriske fosfonatforbindelser NO20055612L (no)

Applications Claiming Priority (152)

Application Number Priority Date Filing Date Title
US46556003P 2003-04-25 2003-04-25
US46540603P 2003-04-25 2003-04-25
US46574903P 2003-04-25 2003-04-25
US46548103P 2003-04-25 2003-04-25
US46541903P 2003-04-25 2003-04-25
US46544903P 2003-04-25 2003-04-25
US46563803P 2003-04-25 2003-04-25
US46537703P 2003-04-25 2003-04-25
US46533203P 2003-04-25 2003-04-25
US46558103P 2003-04-25 2003-04-25
US46565803P 2003-04-25 2003-04-25
US46553103P 2003-04-25 2003-04-25
US46543303P 2003-04-25 2003-04-25
US46574603P 2003-04-25 2003-04-25
US46554703P 2003-04-25 2003-04-25
US46575603P 2003-04-25 2003-04-25
US46542403P 2003-04-25 2003-04-25
US46584403P 2003-04-25 2003-04-25
US46534203P 2003-04-25 2003-04-25
US46548003P 2003-04-25 2003-04-25
US46533503P 2003-04-25 2003-04-25
US46542003P 2003-04-25 2003-04-25
US46553203P 2003-04-25 2003-04-25
US46569503P 2003-04-25 2003-04-25
US46547903P 2003-04-25 2003-04-25
US46564003P 2003-04-25 2003-04-25
US46538003P 2003-04-25 2003-04-25
US46563203P 2003-04-25 2003-04-25
US46562003P 2003-04-25 2003-04-25
US46537303P 2003-04-25 2003-04-25
US46545203P 2003-04-25 2003-04-25
US46568203P 2003-04-25 2003-04-25
US46568303P 2003-04-25 2003-04-25
US46542203P 2003-04-25 2003-04-25
US49330203P 2003-08-07 2003-08-07
US49330303P 2003-08-07 2003-08-07
US49330903P 2003-08-07 2003-08-07
US49331003P 2003-08-07 2003-08-07
US49553303P 2003-08-15 2003-08-15
US49537503P 2003-08-15 2003-08-15
US49561403P 2003-08-15 2003-08-15
US49547203P 2003-08-15 2003-08-15
US49536603P 2003-08-15 2003-08-15
US49538003P 2003-08-15 2003-08-15
US49566103P 2003-08-15 2003-08-15
US49547103P 2003-08-15 2003-08-15
US49545503P 2003-08-15 2003-08-15
US49527603P 2003-08-15 2003-08-15
US49575703P 2003-08-15 2003-08-15
US49542703P 2003-08-15 2003-08-15
US49556303P 2003-08-15 2003-08-15
US49527403P 2003-08-15 2003-08-15
US49566003P 2003-08-15 2003-08-15
US49538903P 2003-08-15 2003-08-15
US49546003P 2003-08-15 2003-08-15
US49553203P 2003-08-15 2003-08-15
US49575403P 2003-08-15 2003-08-15
US49559703P 2003-08-15 2003-08-15
US49574803P 2003-08-15 2003-08-15
US49569103P 2003-08-15 2003-08-15
US49567903P 2003-08-15 2003-08-15
US49553003P 2003-08-15 2003-08-15
US49539803P 2003-08-15 2003-08-15
US49553703P 2003-08-15 2003-08-15
US49574903P 2003-08-15 2003-08-15
US49541403P 2003-08-15 2003-08-15
US49552903P 2003-08-15 2003-08-15
US49542503P 2003-08-15 2003-08-15
US49529503P 2003-08-15 2003-08-15
US49568003P 2003-08-15 2003-08-15
US49539303P 2003-08-15 2003-08-15
US49541603P 2003-08-15 2003-08-15
US49545603P 2003-08-15 2003-08-15
US51397303P 2003-10-24 2003-10-24
US51411303P 2003-10-24 2003-10-24
US51413103P 2003-10-24 2003-10-24
US51439403P 2003-10-24 2003-10-24
US51409703P 2003-10-24 2003-10-24
US51420303P 2003-10-24 2003-10-24
US51417403P 2003-10-24 2003-10-24
US51405103P 2003-10-24 2003-10-24
US51397903P 2003-10-24 2003-10-24
US51356303P 2003-10-24 2003-10-24
US51446403P 2003-10-24 2003-10-24
US51411103P 2003-10-24 2003-10-24
US51359203P 2003-10-24 2003-10-24
US51359303P 2003-10-24 2003-10-24
US51432403P 2003-10-24 2003-10-24
US51407503P 2003-10-24 2003-10-24
US51404403P 2003-10-24 2003-10-24
US51408503P 2003-10-24 2003-10-24
US51394503P 2003-10-24 2003-10-24
US51433403P 2003-10-24 2003-10-24
US51448103P 2003-10-24 2003-10-24
US51397003P 2003-10-24 2003-10-24
US51432503P 2003-10-24 2003-10-24
US51414403P 2003-10-24 2003-10-24
US51420103P 2003-10-24 2003-10-24
US51356103P 2003-10-24 2003-10-24
US51424403P 2003-10-24 2003-10-24
US51410703P 2003-10-24 2003-10-24
US51414003P 2003-10-24 2003-10-24
US51395003P 2003-10-24 2003-10-24
US51396103P 2003-10-24 2003-10-24
US51407203P 2003-10-24 2003-10-24
US51397503P 2003-10-24 2003-10-24
US51439303P 2003-10-24 2003-10-24
US51445303P 2003-10-24 2003-10-24
US51356203P 2003-10-24 2003-10-24
US51416103P 2003-10-24 2003-10-24
US51358903P 2003-10-24 2003-10-24
US51442403P 2003-10-24 2003-10-24
US51395103P 2003-10-24 2003-10-24
US51397603P 2003-10-24 2003-10-24
US51395303P 2003-10-24 2003-10-24
US51428003P 2003-10-24 2003-10-24
US51429803P 2003-10-24 2003-10-24
US51420503P 2003-10-24 2003-10-24
US51394603P 2003-10-24 2003-10-24
US51353003P 2003-10-24 2003-10-24
US51357903P 2003-10-24 2003-10-24
US51446603P 2003-10-24 2003-10-24
US51358803P 2003-10-24 2003-10-24
US51411603P 2003-10-24 2003-10-24
US51432603P 2003-10-24 2003-10-24
US51417503P 2003-10-24 2003-10-24
US51405403P 2003-10-24 2003-10-24
US51394703P 2003-10-24 2003-10-24
US51353103P 2003-10-24 2003-10-24
US51416003P 2003-10-24 2003-10-24
US51413003P 2003-10-24 2003-10-24
US51394803P 2003-10-24 2003-10-24
US51452203P 2003-10-24 2003-10-24
US51414303P 2003-10-24 2003-10-24
US51436003P 2003-10-24 2003-10-24
US51420403P 2003-10-24 2003-10-24
US51398203P 2003-10-24 2003-10-24
US51445003P 2003-10-24 2003-10-24
US51411003P 2003-10-24 2003-10-24
US51402103P 2003-10-24 2003-10-24
US51394403P 2003-10-24 2003-10-24
US51420203P 2003-10-24 2003-10-24
US51397703P 2003-10-24 2003-10-24
US51425803P 2003-10-24 2003-10-24
US51420003P 2003-10-24 2003-10-24
US51420603P 2003-10-24 2003-10-24
US51409803P 2003-10-24 2003-10-24
US51397103P 2003-10-24 2003-10-24
US51392403P 2003-10-24 2003-10-24
US53216003P 2003-12-22 2003-12-22
US53194003P 2003-12-22 2003-12-22
PCT/US2004/013198 WO2004100960A2 (en) 2003-04-25 2004-04-26 Anti-inflammatory phosphonate compounds

Publications (2)

Publication Number Publication Date
NO20055612D0 NO20055612D0 (no) 2005-11-25
NO20055612L true NO20055612L (no) 2006-01-20

Family

ID=39767037

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055612A NO20055612L (no) 2003-04-25 2005-11-25 Anti-inflammatoriske fosfonatforbindelser

Country Status (5)

Country Link
EP (1) EP1663254A2 (no)
KR (1) KR20060028632A (no)
MX (1) MXPA05011294A (no)
NO (1) NO20055612L (no)
WO (1) WO2004100960A2 (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5069463B2 (ja) 2003-04-25 2012-11-07 ギリアード サイエンシーズ， インコーポレイテッド 抗ウイルス性ホスホネート類似物
PL1778251T3 (pl) 2004-07-27 2011-09-30 Gilead Sciences Inc Koniugaty fosfonianowo-nukleozydowe jako środki przeciw wirusowi HIV
DE102005057924A1 (de) * 2005-12-05 2007-06-06 Merck Patent Gmbh Pyridazinonderivate
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
BRPI0915878A2 (pt) 2008-07-08 2015-11-03 Gilead Sciences Inc sais ou hidratos de compostos inibidores de hiv, seu uso e composição farmacêutica que os compreende
AR094621A1 (es) 2010-04-01 2015-08-19 Idenix Pharmaceuticals Inc Compuestos y composiciones farmacéuticas para el tratamiento de infecciones virales
WO2012154321A1 (en) 2011-03-31 2012-11-15 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
EA201791460A1 (ru) 2014-12-26 2017-12-29 Эмори Юниверсити N4-гидроксицитидин и связанные с ним производные и варианты противовирусного применения
ES2892402T3 (es) 2017-08-01 2022-02-04 Gilead Sciences Inc Formas cristalinas de ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-il)-4-fluoro-2,5-dihidrofuran-2-il)oxi)metil)(fenoxi)fosforil)-L-alaninato de etilo para tratar infecciones virales
WO2019113462A1 (en) 2017-12-07 2019-06-13 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CN115353932B (zh) * 2022-09-07 2023-10-20 江门市和馨香精技术有限公司 用于控制皂化速度的香精组合物及其应用、冷制皂

Also Published As

Publication number Publication date
WO2004100960A8 (en) 2008-04-24
NO20055612D0 (no) 2005-11-25
KR20060028632A (ko) 2006-03-30
MXPA05011294A (es) 2006-03-15
WO2004100960A2 (en) 2004-11-25
EP1663254A2 (en) 2006-06-07

Similar Documents

Publication Publication Date Title
NO20071078L (no) Antivirale forbindelser
NO20070866L (no) Antivirale forbindelser.
NO20090596L (no) Antivirale fosfinatforbindelser
CY1119669T1 (el) Παραγωγα 1-φαινυλ-2-πυριδινυλ-αλκυλ-αλκοολων ως αναστολεις φωσφοδιεστερασης
DK1206474T3 (da) Sulfonylphenylpyrazolforbindelser anvendelige som cox-2-inhibitorer
NO20055130L (no) Aminocykloheksyleter-forbindelser og deres anvendelse
SE0301700D0 (sv) Novel compounds
CY1111225T1 (el) Νεα πεπτιδια ως αναστολεις πρωτεασης νs3-σερινης ιου ηπατiτιδας c
NO20060978L (no) Farmasoytiske blandingr for behandling av prematur ejakulasjon ved pulmonal inhalering
SE0101675D0 (sv) Novel composition
UA86591C2 (ru) Пирролодигидроизохинолины как ингибиторы pde10, фармацевтическая композиция на их основе
WO2005046603A3 (en) Pyridine compounds
ECSP045004A (es) Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades andrógeno dependientes
NO20055590L (no) Kinaseinhiberende fosfonatanaloger
SE0301372D0 (sv) Novel compounds
HK1092467A1 (en) N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses n-
IS7691A (is) Lyfjasamsetningar til að meðhöndla æxli
DE502004002571D1 (de) Substituierte 3-pyrrolidin-indol-derivate
NO20062605L (no) Farmasoytisk formulering inneholdende smakssubstanser med forbedrede farmasoytiske egenskaper
DK1315506T3 (da) Phospholipidderivater af valproinsyre og blandinger deraf
TNSN06012A1 (en) Emulsifying systems containing azetidine derivatives
NO20055612L (no) Anti-inflammatoriske fosfonatforbindelser
CY1107230T1 (el) Υποκατεστημενες ενωσεις 1-φαιναιθυλοπιπεριδινης, οι οποιες μεταξυ αλλων χρησιμοποιουνται σαν αναλγητικα
NO20065898L (no) 1-heterocyklyl-1,5-dihydro-pyrido[3,2-b]indol-2-oner
IS2799B (is) Kladribínefnablöndur til inngjafar um munn

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application