NO20053955L - Pyrazolo [1,5-A] pyrimidinderivater - Google Patents
Pyrazolo [1,5-A] pyrimidinderivater Download PDFInfo
- Publication number
- NO20053955L NO20053955L NO20053955A NO20053955A NO20053955L NO 20053955 L NO20053955 L NO 20053955L NO 20053955 A NO20053955 A NO 20053955A NO 20053955 A NO20053955 A NO 20053955A NO 20053955 L NO20053955 L NO 20053955L
- Authority
- NO
- Norway
- Prior art keywords
- tokyo
- pyrazolo
- pyrimidine derivatives
- kinase
- chome
- Prior art date
Links
- LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical class N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 title abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010005949 Bone cancer Diseases 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 208000018084 Bone neoplasm Diseases 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001066 destructive effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0304665A GB0304665D0 (en) | 2003-02-28 | 2003-02-28 | Compounds |
| US50069503P | 2003-09-08 | 2003-09-08 | |
| GB0329446A GB0329446D0 (en) | 2003-12-19 | 2003-12-19 | Compounds |
| PCT/JP2004/002522 WO2004076458A1 (en) | 2003-02-28 | 2004-03-01 | Pyrazolo[1,5-a]pyrimidine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20053955D0 NO20053955D0 (no) | 2005-08-25 |
| NO20053955L true NO20053955L (no) | 2005-09-22 |
Family
ID=32931047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20053955A NO20053955L (no) | 2003-02-28 | 2005-08-25 | Pyrazolo [1,5-A] pyrimidinderivater |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7557110B2 (es) |
| EP (1) | EP1599482A4 (es) |
| JP (1) | JP4564485B2 (es) |
| KR (1) | KR20050115252A (es) |
| AU (1) | AU2004215481B2 (es) |
| BR (1) | BRPI0407834A (es) |
| CA (1) | CA2516824A1 (es) |
| CO (1) | CO5650257A2 (es) |
| MA (1) | MA27711A1 (es) |
| MX (1) | MXPA05008955A (es) |
| NO (1) | NO20053955L (es) |
| WO (1) | WO2004076458A1 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO337520B1 (no) * | 2004-02-11 | 2016-05-02 | Pharmacopeia Drug Discovery Inc | Pyrazolopyrimidinderivater som syklinavhengige kinaseinhibitorer, anvendelse derav for fremstilling av et medikament og farmasøytiske preparater som inneholder én eller flere slike forbindelser. |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7205308B2 (en) * | 2002-09-04 | 2007-04-17 | Schering Corporation | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US20070270408A1 (en) * | 2003-04-11 | 2007-11-22 | Novo Nordisk A/S | Pharmaceutical use of substituted pyrazolo[1,5-a]pyrimidines |
| BRPI0414238A (pt) * | 2003-09-09 | 2006-10-31 | Ono Pharmaceutical Co | antagonistas de crf e compostos heterobicìclicos |
| JPWO2005035516A1 (ja) * | 2003-10-10 | 2006-12-21 | 小野薬品工業株式会社 | 新規縮合複素環化合物およびその用途 |
| DE10357565A1 (de) * | 2003-12-10 | 2005-07-07 | Bayer Cropscience Ag | Pyrazolopyrimidine |
| DE102004008807A1 (de) * | 2004-02-20 | 2005-09-08 | Bayer Cropscience Ag | Pyrazolopyrimidine |
| WO2006033796A1 (en) * | 2004-09-17 | 2006-03-30 | Wyeth | SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES AND PROCESS FOR MAKING SAME |
| EP1802623A1 (en) * | 2004-10-12 | 2007-07-04 | Novo Nordisk A/S | 11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds |
| ES2327145T3 (es) * | 2004-12-21 | 2009-10-26 | Schering Corporation | Anatagonistas del receptor de adenosina a2a de pirazolo(1,5-a)pirimidina sustituidos. |
| DE102005007534A1 (de) | 2005-02-17 | 2006-08-31 | Bayer Cropscience Ag | Pyrazolopyrimidine |
| CA2601717A1 (en) * | 2005-03-17 | 2006-09-21 | Teijin Pharma Limited | Pyrazolopyrimidine derivative or pharmaceutically acceptable salt thereof |
| US7473694B2 (en) | 2005-03-17 | 2009-01-06 | Teijin Pharma Limited | Pyrazolopyrimidine derivatives or pharmaceutically acceptable salts thereof |
| US7417053B2 (en) | 2005-04-07 | 2008-08-26 | Teijin Pharma Limited | Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof |
| EP1922321A1 (en) * | 2005-08-09 | 2008-05-21 | Eirx Therapeutics Ltd | Pyrazoloý1,5-a¨pyrimidine compounds and pharmaceutical compositions containing them |
| WO2007024680A1 (en) | 2005-08-22 | 2007-03-01 | Amgen Inc. | Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators |
| US7723336B2 (en) | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| US20070078136A1 (en) * | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| CN101312977B (zh) * | 2005-09-22 | 2012-06-13 | 布里斯托尔-迈尔斯.斯奎布公司 | 用作激酶调节剂的稠合杂环化合物 |
| WO2007044441A2 (en) * | 2005-10-06 | 2007-04-19 | Schering Corporation | Use of pyrazolo [1 , 5 -a] pyrimidine derivatives for inhibiting protein kinases methods for inhibiting protein kinases |
| WO2007051810A2 (en) * | 2005-11-01 | 2007-05-10 | Transtech Pharma | Pharmaceutical use of substituted amides |
| CN101355938A (zh) * | 2005-11-01 | 2009-01-28 | 高点制药有限责任公司 | 取代的酰胺的药学应用 |
| US20100168083A1 (en) * | 2006-03-21 | 2010-07-01 | Soren Ebdrup | Adamantane derivatives for the treatment of the metabolic syndrome |
| JP5255559B2 (ja) * | 2006-03-31 | 2013-08-07 | アボット・ラボラトリーズ | インダゾール化合物 |
| JP2009532418A (ja) | 2006-04-07 | 2009-09-10 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型活性化合物 |
| EP1878721A1 (en) * | 2006-07-13 | 2008-01-16 | Novo Nordisk A/S | 4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors |
| WO2008006702A1 (en) * | 2006-07-13 | 2008-01-17 | High Point Pharmaceuticals, Llc. | 11beta-hydroxysteroid dehydrogenase type 1 active compounds |
| EP1900739A1 (en) * | 2006-08-30 | 2008-03-19 | Cellzome Ag | Diazolodiazine derivatives as kinase inhibitors |
| JP5274805B2 (ja) * | 2006-09-20 | 2013-08-28 | 三菱化学株式会社 | フッ素化芳香族化合物の製造方法 |
| EP1918291A1 (en) * | 2006-10-30 | 2008-05-07 | Novartis AG | 3-Aminocarbonyl-substituted fused pyrazolo-derivatives as protein kinase modulators |
| EP2129652A2 (en) * | 2007-02-23 | 2009-12-09 | High Point Pharmaceuticals, LLC | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
| JP2010519239A (ja) * | 2007-02-23 | 2010-06-03 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | １１−ベータ−ヒドロキシステロイドデヒドロゲナーゼの阻害因子としてのｎ−アドマンチルベンザミド |
| US20110003856A1 (en) * | 2007-02-23 | 2011-01-06 | Soren Ebdrup | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
| MX2009008228A (es) * | 2007-02-23 | 2009-08-12 | High Point Pharmaceuticals Llc | N-adamantil benzamidas como inhibidores de la dehidrogenasa 11-beta-hidroxiesteroide. |
| EA200970841A1 (ru) * | 2007-03-09 | 2010-04-30 | ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Фармацевтическое применение замещенных амидов |
| CA2681934A1 (en) * | 2007-03-28 | 2008-10-02 | High Point Pharmaceuticals, Llc | 11beta-hsd1 active compounds |
| WO2008127924A1 (en) * | 2007-04-11 | 2008-10-23 | High Point Pharmaceuticals, Llc. | Novel compounds |
| CN101711106B (zh) * | 2007-04-24 | 2013-02-06 | 高点制药有限责任公司 | 取代的酰胺类的药物应用 |
| ATE522249T1 (de) | 2007-07-26 | 2011-09-15 | Novartis Ag | Organische verbindungen |
| JP2010536926A (ja) | 2007-08-27 | 2010-12-02 | ビーエーエスエフ ソシエタス・ヨーロピア | 無脊椎動物系害虫を防除するためのピラゾール化合物 |
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2004
- 2004-03-01 EP EP04716064A patent/EP1599482A4/en not_active Withdrawn
- 2004-03-01 WO PCT/JP2004/002522 patent/WO2004076458A1/en active Application Filing
- 2004-03-01 US US10/547,080 patent/US7557110B2/en not_active Expired - Fee Related
- 2004-03-01 KR KR1020057015871A patent/KR20050115252A/ko not_active Application Discontinuation
- 2004-03-01 CA CA002516824A patent/CA2516824A1/en not_active Abandoned
- 2004-03-01 MX MXPA05008955A patent/MXPA05008955A/es unknown
- 2004-03-01 JP JP2006502687A patent/JP4564485B2/ja not_active Expired - Fee Related
- 2004-03-01 AU AU2004215481A patent/AU2004215481B2/en not_active Expired - Fee Related
- 2004-03-01 BR BRPI0407834-9A patent/BRPI0407834A/pt not_active IP Right Cessation
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2005
- 2005-08-12 MA MA28441A patent/MA27711A1/fr unknown
- 2005-08-25 NO NO20053955A patent/NO20053955L/no not_active Application Discontinuation
- 2005-08-26 CO CO05085412A patent/CO5650257A2/es not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO337520B1 (no) * | 2004-02-11 | 2016-05-02 | Pharmacopeia Drug Discovery Inc | Pyrazolopyrimidinderivater som syklinavhengige kinaseinhibitorer, anvendelse derav for fremstilling av et medikament og farmasøytiske preparater som inneholder én eller flere slike forbindelser. |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1599482A1 (en) | 2005-11-30 |
| MXPA05008955A (es) | 2006-02-22 |
| US7557110B2 (en) | 2009-07-07 |
| MA27711A1 (fr) | 2006-01-02 |
| AU2004215481B2 (en) | 2010-11-11 |
| WO2004076458A1 (en) | 2004-09-10 |
| KR20050115252A (ko) | 2005-12-07 |
| CA2516824A1 (en) | 2004-09-10 |
| NO20053955D0 (no) | 2005-08-25 |
| JP4564485B2 (ja) | 2010-10-20 |
| CO5650257A2 (es) | 2006-06-30 |
| EP1599482A4 (en) | 2008-10-01 |
| JP2006519226A (ja) | 2006-08-24 |
| AU2004215481A1 (en) | 2004-09-10 |
| BRPI0407834A (pt) | 2006-02-14 |
| US20060189632A1 (en) | 2006-08-24 |
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