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NO20040471L - 5,6,6a,1 1b-tetrahydro-7-oksa-5-azabenzo[c]fluoren-6-karboksylsyrederivater som NMDA-antagonister - Google Patents

5,6,6a,1 1b-tetrahydro-7-oksa-5-azabenzo[c]fluoren-6-karboksylsyrederivater som NMDA-antagonister

Info

Publication number
NO20040471L
NO20040471L NO20040471A NO20040471A NO20040471L NO 20040471 L NO20040471 L NO 20040471L NO 20040471 A NO20040471 A NO 20040471A NO 20040471 A NO20040471 A NO 20040471A NO 20040471 L NO20040471 L NO 20040471L
Authority
NO
Norway
Prior art keywords
azabenzo
oxa
tetrahydro
carboxylic acid
acid derivatives
Prior art date
Application number
NO20040471A
Other languages
English (en)
Inventor
Werner Günter Englberger
Michael Przewosny
Matthias Gerlach
Corinna Maul
Elke Reissmüller
Utz-Peter Jagusch
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of NO20040471L publication Critical patent/NO20040471L/no

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
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  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)

Abstract

Det er beskrevet substituerte 5,6,6a,l lb-tetrahydro-7-oksa-5-azabenzo[c]fluoren-6-karboksylsyrederivater, samt fremgangsmåter for deres fremstilling, legemidler inneholdende disse forbindelsene og deres anvendelse for fremstilling av legemidler for bestemte indikasjoner, spesielt for behandling av smerte.
NO20040471A 2001-08-03 2004-02-02 5,6,6a,1 1b-tetrahydro-7-oksa-5-azabenzo[c]fluoren-6-karboksylsyrederivater som NMDA-antagonister NO20040471L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10137487A DE10137487A1 (de) 2001-08-03 2001-08-03 Substituierte 5,6,6a,11b-Tetrahydro-7-oxa-6-aza- benzo[c]fluoren-6-carbonsäurederivate
PCT/EP2002/008886 WO2003014124A1 (de) 2001-08-03 2002-08-05 SUBSTITUIERTE 5,6,6a,11b-TETRAHYDRO-7-OXA-5-AZA-BENZO'C!FLUOREN-6-CARBONSÄUREDERIVATE ALS NMDA-ANTAGONISTEN

Publications (1)

Publication Number Publication Date
NO20040471L true NO20040471L (no) 2004-02-02

Family

ID=7693857

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20040471A NO20040471L (no) 2001-08-03 2004-02-02 5,6,6a,1 1b-tetrahydro-7-oksa-5-azabenzo[c]fluoren-6-karboksylsyrederivater som NMDA-antagonister

Country Status (21)

Country Link
US (1) US7199130B2 (no)
EP (1) EP1412361B1 (no)
JP (1) JP2005500374A (no)
KR (1) KR20040020078A (no)
CN (1) CN1697836A (no)
AT (1) ATE402178T1 (no)
BR (1) BR0211734A (no)
CA (1) CA2456124A1 (no)
CO (1) CO5550438A2 (no)
DE (2) DE10137487A1 (no)
EC (1) ECSP044968A (no)
ES (1) ES2310211T3 (no)
HU (1) HUP0400800A3 (no)
IL (1) IL160160A0 (no)
MX (1) MXPA04000953A (no)
NO (1) NO20040471L (no)
NZ (1) NZ531372A (no)
PL (1) PL368073A1 (no)
RU (1) RU2004106533A (no)
WO (1) WO2003014124A1 (no)
ZA (1) ZA200401725B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10304950A1 (de) * 2003-02-06 2004-08-19 Grünenthal GmbH Herstellung von Tetrahydrochinolinbenzofuranen
KR20050021629A (ko) * 2003-08-25 2005-03-07 학교법인 이화학당 신규한 벤조플루오렌 디온계 화합물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386839B1 (en) * 1989-03-08 1997-01-15 Merck Sharp & Dohme Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders
DE19536809A1 (de) * 1995-10-02 1997-04-03 Basf Ag Heterocyclisch substituierte Salicylsäurederivate
US5925527A (en) * 1997-02-04 1999-07-20 Trega Biosciences, Inc. Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries
GB9706294D0 (en) * 1997-03-26 1997-05-14 Glaxo Wellcome Spa Heterocyclic compound
MY125037A (en) * 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
DE10005302A1 (de) * 2000-02-07 2002-01-17 Gruenenthal Gmbh Substituierte 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate

Also Published As

Publication number Publication date
MXPA04000953A (es) 2004-04-20
IL160160A0 (en) 2004-07-25
DE50212538D1 (de) 2008-09-04
BR0211734A (pt) 2004-09-21
RU2004106533A (ru) 2005-07-27
ZA200401725B (en) 2005-01-31
EP1412361A1 (de) 2004-04-28
KR20040020078A (ko) 2004-03-06
US7199130B2 (en) 2007-04-03
CA2456124A1 (en) 2003-02-20
WO2003014124A1 (de) 2003-02-20
CN1697836A (zh) 2005-11-16
ECSP044968A (es) 2004-03-23
NZ531372A (en) 2005-03-24
JP2005500374A (ja) 2005-01-06
HUP0400800A2 (hu) 2004-07-28
HUP0400800A3 (en) 2007-09-28
DE10137487A1 (de) 2003-03-27
ATE402178T1 (de) 2008-08-15
US20040248889A1 (en) 2004-12-09
EP1412361B1 (de) 2008-07-23
CO5550438A2 (es) 2005-08-31
ES2310211T3 (es) 2009-01-01
PL368073A1 (en) 2005-03-21

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