NO20033147L - Process for the preparation of pure ondansetron hydrochloride dihydrate - Google Patents

Process for the preparation of pure ondansetron hydrochloride dihydrate

Info

Publication number: NO20033147L
Authority: NO; Norway
Prior art keywords: preparation; hydrochloride dihydrate; ondansetron hydrochloride; pure ondansetron; pure
Prior art date: 2001-01-11

Application number

NO20033147A

Other languages

Norwegian (no)

Other versions

NO20033147D0 (en

Inventor

Ramy Lidor Hadas

Eliezer Bachar

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-11

Filing date

2003-07-09

Publication date

2003-09-02

2003-07-09 Application filed by Teva Pharma filed Critical Teva Pharma

2003-07-09 Publication of NO20033147D0 publication Critical patent/NO20033147D0/en

2003-09-02 Publication of NO20033147L publication Critical patent/NO20033147L/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Otolaryngology (AREA)
Anesthesiology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

NO20033147A 2001-01-11 2003-07-09 Process for the preparation of pure ondansetron hydrochloride dihydrate NO20033147L (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US26105201P	2001-01-11	2001-01-11
PCT/US2002/000853 WO2002055492A2 (en)	2001-01-11	2002-01-11	An improved process for preparing pure ondansetron hydrochloride dihydrate

Publications (2)

Publication Number	Publication Date
NO20033147D0 NO20033147D0 (en)	2003-07-09
NO20033147L true NO20033147L (en)	2003-09-02

Family

ID=22991757

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20033147A NO20033147L (en)	2001-01-11	2003-07-09	Process for the preparation of pure ondansetron hydrochloride dihydrate

Country Status (21)

Country	Link
EP (1)	EP1355881A4 (en)
JP (1)	JP2004526692A (en)
KR (3)	KR20030068583A (en)
CN (2)	CN101045704A (en)
AU (1)	AU2002236753B2 (en)
CA (1)	CA2433720A1 (en)
CZ (1)	CZ20032090A3 (en)
DE (1)	DE02703115T1 (en)
ES (1)	ES2219201T1 (en)
HR (1)	HRP20030631A2 (en)
HU (1)	HUP0400767A2 (en)
IL (1)	IL156835A0 (en)
IS (1)	IS6869A (en)
MX (1)	MXPA03006215A (en)
NO (1)	NO20033147L (en)
PL (1)	PL368837A1 (en)
SK (1)	SK9892003A3 (en)
TR (1)	TR200401460T3 (en)
WO (1)	WO2002055492A2 (en)
YU (1)	YU56103A (en)
ZA (1)	ZA200305338B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE364611T1 (en)	2002-04-29	2007-07-15	Teva Gyogyszergyar Zartkoeruee	METHOD FOR PRODUCING 1,2,3,9-TETRAHYDRO-9-METHYL-3-(2-METHYL-1H-IMIDAZOL-1-YL)METHYLÖ-H-CARBAZOL-4-ONE
HU225885B1 (en) *	2002-10-17	2007-11-28	Richter Gedeon Nyrt	Process for producing ondansetron hydrochlorid dihydrate of high purity
FI6164U1 (en) *	2003-01-09	2004-03-15	Synthon Bv	Ondansetronformer
GB2398071B (en) *	2003-01-24	2006-06-07	Synthon Bv	Process for making ondansetron and intermediate thereof
US7696356B2 (en)	2004-08-17	2010-04-13	Taro Pharmaceutical Industries Limited	Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
WO2006046253A1 (en) *	2004-10-26	2006-05-04	Ipca Laboratories Limited	A one-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1h-imidazole-1-yl)methyl]-4h-carbazol-4-o

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4695578A (en) *	1984-01-25	1987-09-22	Glaxo Group Limited	1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
GB8630071D0 (en) *	1986-12-17	1987-01-28	Glaxo Group Ltd	Medicaments
IL155644A0 (en) *	2000-10-30	2003-11-23	Teva Pharma	Novel crystal and solvate forms of ondansetron hydrochloride and processes for their preparation

2002
- 2002-01-11 KR KR10-2003-7009221A patent/KR20030068583A/en active IP Right Grant
- 2002-01-11 CN CNA2006101667179A patent/CN101045704A/en active Pending
- 2002-01-11 TR TR2004/01460T patent/TR200401460T3/xx unknown
- 2002-01-11 PL PL02368837A patent/PL368837A1/en not_active Application Discontinuation
- 2002-01-11 SK SK989-2003A patent/SK9892003A3/en not_active Application Discontinuation
- 2002-01-11 KR KR1020067020069A patent/KR20060113792A/en not_active Application Discontinuation
- 2002-01-11 CZ CZ20032090A patent/CZ20032090A3/en unknown
- 2002-01-11 IL IL15683502A patent/IL156835A0/en unknown
- 2002-01-11 ZA ZA200305338A patent/ZA200305338B/en unknown
- 2002-01-11 HU HU0400767A patent/HUP0400767A2/en unknown
- 2002-01-11 JP JP2002556165A patent/JP2004526692A/en active Pending
- 2002-01-11 KR KR1020077010146A patent/KR20070054749A/en not_active Application Discontinuation
- 2002-01-11 DE DE02703115T patent/DE02703115T1/en active Pending
- 2002-01-11 AU AU2002236753A patent/AU2002236753B2/en not_active Expired - Fee Related
- 2002-01-11 MX MXPA03006215A patent/MXPA03006215A/en unknown
- 2002-01-11 YU YU56103A patent/YU56103A/en unknown
- 2002-01-11 ES ES02703115T patent/ES2219201T1/en active Pending
- 2002-01-11 CA CA002433720A patent/CA2433720A1/en not_active Abandoned
- 2002-01-11 CN CNA028062019A patent/CN1496350A/en active Pending
- 2002-01-11 WO PCT/US2002/000853 patent/WO2002055492A2/en active Application Filing
- 2002-01-11 EP EP02703115A patent/EP1355881A4/en not_active Withdrawn
2003
- 2003-07-08 IS IS6869A patent/IS6869A/en unknown
- 2003-07-09 NO NO20033147A patent/NO20033147L/en not_active Application Discontinuation
- 2003-08-06 HR HR20030631A patent/HRP20030631A2/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2433720A1 (en)	2002-07-18
SK9892003A3 (en)	2004-05-04
ZA200305338B (en)	2004-07-12
MXPA03006215A (en)	2005-02-17
EP1355881A2 (en)	2003-10-29
CZ20032090A3 (en)	2004-08-18
WO2002055492A3 (en)	2003-02-13
CN1496350A (en)	2004-05-12
HUP0400767A2 (en)	2004-07-28
CN101045704A (en)	2007-10-03
KR20030068583A (en)	2003-08-21
NO20033147D0 (en)	2003-07-09
AU2002236753B2 (en)	2007-06-28
HRP20030631A2 (en)	2005-06-30
IS6869A (en)	2003-07-08
DE02703115T1 (en)	2004-10-21
IL156835A0 (en)	2004-02-08
WO2002055492A2 (en)	2002-07-18
YU56103A (en)	2006-05-25
TR200401460T3 (en)	2004-08-23
ES2219201T1 (en)	2004-12-01
KR20070054749A (en)	2007-05-29
PL368837A1 (en)	2005-04-04
EP1355881A4 (en)	2004-03-31
JP2004526692A (en)	2004-09-02
KR20060113792A (en)	2006-11-02

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Legal Events

Date	Code	Title	Description
2006-08-28	FC2A	Withdrawal, rejection or dismissal of laid open patent application