NO20025054L - Oksidasjonsprosess for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre - Google Patents

Oksidasjonsprosess for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre

Info

Publication number: NO20025054L
Authority: NO; Norway
Prior art keywords: alpha; beta; preparation; androst; dien
Prior art date: 2000-07-21

Application number

NO20025054A

Other languages

English (en)

Other versions

NO324836B1 (no

NO20025054D0 (no

Inventor

Frederick David Albinson

Steven John Coote

John Malcolm Robinson

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-21

Filing date

2002-10-21

Publication date

2002-11-05

2002-10-21 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2002-10-21 Publication of NO20025054D0 publication Critical patent/NO20025054D0/no

2002-11-05 Publication of NO20025054L publication Critical patent/NO20025054L/no

2007-12-17 Publication of NO324836B1 publication Critical patent/NO324836B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

NO20025054A 2000-07-21 2002-10-21 Fremgangsmate for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre NO324836B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0017988.7A GB0017988D0 (en)	2000-07-21	2000-07-21	Novel process
PCT/GB2001/003289 WO2002008243A1 (en)	2000-07-21	2001-07-20	Oxidation process for preparing the intermediate 6.alpha.,9.alpha.-difluoro-11.beta.,17.alpha.-dihydroxy-16.alpha.-methyl-androst-1,4-dien-3-one 17.beta.-carboxylic acid

Publications (3)

Publication Number	Publication Date
NO20025054D0 NO20025054D0 (no)	2002-10-21
NO20025054L true NO20025054L (no)	2002-11-05
NO324836B1 NO324836B1 (no)	2007-12-17

Family

ID=9896132

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20025054A NO324836B1 (no)	2000-07-21	2002-10-21	Fremgangsmate for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre

Country Status (26)

Country	Link
US (1)	US20040043974A1 (no)
EP (1)	EP1301526B1 (no)
JP (1)	JP2004504403A (no)
KR (1)	KR100787293B1 (no)
CN (1)	CN1315864C (no)
AT (1)	ATE398628T1 (no)
AU (2)	AU7090601A (no)
BR (1)	BR0110430A (no)
CA (1)	CA2406963A1 (no)
CY (1)	CY1108553T1 (no)
CZ (1)	CZ302592B6 (no)
DE (1)	DE60134472D1 (no)
DK (1)	DK1301526T3 (no)
ES (1)	ES2307628T3 (no)
GB (1)	GB0017988D0 (no)
HK (1)	HK1056179B (no)
HU (1)	HUP0301108A3 (no)
IL (2)	IL152348A0 (no)
MX (1)	MXPA02010967A (no)
NO (1)	NO324836B1 (no)
NZ (1)	NZ522083A (no)
PL (1)	PL206652B1 (no)
PT (1)	PT1301526E (no)
SI (1)	SI1301526T1 (no)
WO (1)	WO2002008243A1 (no)
ZA (1)	ZA200208372B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6787532B2 (en)	2000-08-05	2004-09-07	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivatives
US6777400B2 (en)	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6777399B2 (en)	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6858596B2 (en)	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivative
US6759398B2 (en)	2000-08-05	2004-07-06	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative
US6750210B2 (en)	2000-08-05	2004-06-15	Smithkline Beecham Corporation	Formulation containing novel anti-inflammatory androstane derivative
US6858593B2 (en)	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
UA77656C2 (en)	2001-04-07	2007-01-15	Glaxo Group Ltd	S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
GB2389530B (en)	2002-06-14	2007-01-10	Cipla Ltd	Pharmaceutical compositions
IL150654A (en)	2002-07-09	2006-12-10	Ori Lerman	Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate
EP1466920A1 (en) *	2003-04-04	2004-10-13	Alpharma APS	Process for the preparation of steroidal 17 beta-carbothioates
AU2004226318B2 (en) *	2003-04-04	2008-06-05	Xellia Pharmaceuticals Aps	Process for the preparation of steroidal carbothioic acid derivatives and intermediates
EP1526139A1 (en) *	2003-10-24	2005-04-27	S.N.I.F.F. Italia S.P.A.	A process for preparing highly pure androstane 17-beta-carboxylic acids and androstane 17-beta-carbothioic acid fluoromethyl esters
GB0612027D0 (en)	2006-06-16	2006-07-26	Glaxo Group Ltd	Novel process
NO331891B1 (no) *	2007-03-20	2012-04-30	Clavis Pharma Asa	Kjemiske forbindelser, et farmasoytisk preparat inneholdende slike forbindelser, samt anvendelse derav for behandling av kreft, inflammasjon og KOLS
PT105139B (pt) *	2010-06-01	2013-01-29	Hovione Farmaciencia S A	Método para a monofluorometilação de substratos orgânicos para preparação de compostos orgânicos biologicamente activos
EP2611821A2 (en)	2010-09-01	2013-07-10	Cadila Healthcare Limited	Process for preparing fluticasone propionate/furoate

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3636010A (en) *	1968-12-23	1972-01-18	Ciba Geigy Corp	Esters of steroid-17-carboxylic acids
US4188385A (en) *	1978-04-05	1980-02-12	Syntex (U.S.A.) Inc.	Thioetianic acid derivatives
US4198336A (en) *	1978-04-05	1980-04-15	Syntex (U.S.A.) Inc.	Chemical process for preparing androsta-4-ene 17α-carboxylic acids
NL187577C (nl) *	1978-04-05	1991-11-18	Sibla Srl	3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4263289A (en) *	1978-04-05	1981-04-21	Syntex (U.S.A.) Inc.	Thio etianic acid derivatives
GB2088877B (en) *	1980-02-15	1984-07-04	Glaxo Group Ltd	Androstane 17 carbothioates
US5646136A (en) *	1994-01-04	1997-07-08	Duke University	Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
TR199801247T2 (xx) *	1995-12-29	1998-11-23	Glaxo Group Limited	17.beta.-karboksi, karbotio t�revleri ve amid androstan t�revleri.
US20020133032A1 (en) *	2000-02-25	2002-09-19	Jufang Barkalow	Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
CN1198736C (zh) *	2000-04-04	2005-04-27	国际人造丝公司	包含胺官能团接枝的聚(乙烯醇)的吸墨性涂料组合物、由其制备的吸墨介质及其制备方法
US6777400B2 (en) *	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions

2000
- 2000-07-21 GB GBGB0017988.7A patent/GB0017988D0/en not_active Ceased
2001
- 2001-07-20 US US10/333,537 patent/US20040043974A1/en not_active Abandoned
- 2001-07-20 BR BR0110430-6A patent/BR0110430A/pt not_active Application Discontinuation
- 2001-07-20 DE DE60134472T patent/DE60134472D1/de not_active Expired - Lifetime
- 2001-07-20 CN CNB018114407A patent/CN1315864C/zh not_active Expired - Fee Related
- 2001-07-20 AU AU7090601A patent/AU7090601A/xx active Pending
- 2001-07-20 ES ES01949791T patent/ES2307628T3/es not_active Expired - Lifetime
- 2001-07-20 KR KR1020027014367A patent/KR100787293B1/ko not_active IP Right Cessation
- 2001-07-20 PT PT01949791T patent/PT1301526E/pt unknown
- 2001-07-20 HU HU0301108A patent/HUP0301108A3/hu unknown
- 2001-07-20 DK DK01949791T patent/DK1301526T3/da active
- 2001-07-20 AT AT01949791T patent/ATE398628T1/de active
- 2001-07-20 PL PL359462A patent/PL206652B1/pl not_active IP Right Cessation
- 2001-07-20 CA CA002406963A patent/CA2406963A1/en not_active Abandoned
- 2001-07-20 NZ NZ522083A patent/NZ522083A/en not_active IP Right Cessation
- 2001-07-20 MX MXPA02010967A patent/MXPA02010967A/es active IP Right Grant
- 2001-07-20 EP EP01949791A patent/EP1301526B1/en not_active Expired - Lifetime
- 2001-07-20 WO PCT/GB2001/003289 patent/WO2002008243A1/en active IP Right Grant
- 2001-07-20 IL IL15234801A patent/IL152348A0/xx active IP Right Grant
- 2001-07-20 JP JP2002514148A patent/JP2004504403A/ja active Pending
- 2001-07-20 SI SI200130851T patent/SI1301526T1/sl unknown
- 2001-07-20 CZ CZ20023472A patent/CZ302592B6/cs not_active IP Right Cessation
- 2001-07-20 AU AU2001270906A patent/AU2001270906B2/en not_active Ceased
2002
- 2002-10-17 IL IL152348A patent/IL152348A/en not_active IP Right Cessation
- 2002-10-17 ZA ZA200208372A patent/ZA200208372B/en unknown
- 2002-10-21 NO NO20025054A patent/NO324836B1/no not_active IP Right Cessation
2003
- 2003-09-17 HK HK03106680.9A patent/HK1056179B/zh not_active IP Right Cessation
2008
- 2008-09-03 CY CY20081100942T patent/CY1108553T1/el unknown

Also Published As

Publication number	Publication date
JP2004504403A (ja)	2004-02-12
HUP0301108A2 (hu)	2003-08-28
NO324836B1 (no)	2007-12-17
GB0017988D0 (en)	2000-09-13
CN1437610A (zh)	2003-08-20
IL152348A0 (en)	2003-05-29
IL152348A (en)	2008-08-07
WO2002008243A1 (en)	2002-01-31
US20040043974A1 (en)	2004-03-04
ZA200208372B (en)	2004-02-11
ES2307628T3 (es)	2008-12-01
DK1301526T3 (da)	2008-10-06
PL206652B1 (pl)	2010-09-30
MXPA02010967A (es)	2003-03-27
CN1315864C (zh)	2007-05-16
CA2406963A1 (en)	2002-01-31
CZ302592B6 (cs)	2011-07-27
NO20025054D0 (no)	2002-10-21
CZ20023472A3 (cs)	2003-04-16
NZ522083A (en)	2004-06-25
BR0110430A (pt)	2003-07-08
AU2001270906B2 (en)	2005-10-13
CY1108553T1 (el)	2014-04-09
HK1056179B (zh)	2009-07-17
DE60134472D1 (de)	2008-07-31
KR100787293B1 (ko)	2007-12-20
ATE398628T1 (de)	2008-07-15
PT1301526E (pt)	2008-09-09
PL359462A1 (en)	2004-08-23
KR20030028736A (ko)	2003-04-10
AU7090601A (en)	2002-02-05
SI1301526T1 (sl)	2008-10-31
HK1056179A1 (en)	2004-02-06
HUP0301108A3 (en)	2008-04-28
EP1301526A1 (en)	2003-04-16
EP1301526B1 (en)	2008-06-18

Publication	Publication Date	Title
NO20025054L (no)	2002-11-05	Oksidasjonsprosess for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre
BG105457A (en)	2001-12-29	Method for the preparation of citalopram
CO4970765A1 (es)	2000-11-07	Composiciones de bajo ph que contienen acido para el cuidado personal que exhiben picazon reducida
MXPA04000634A (es)	2004-04-20	Barra de detergente mejorada y un proceso para fabricacion.
BR0211826A (pt)	2005-06-28	Imidazopiridinas tricìclicas
BG106939A (en)	2003-03-31	Method for the preparation of citalopram
HK1068877A1 (en)	2005-05-06	Process for the production of beraprost and its salts
BR0213814A (pt)	2004-10-19	Processos para a fabricação de 3-hidroxi-n, 1,6-trialquil-4-oxo-1, 4-diidro piridino-2-carboxamida
ATE266618T1 (de)	2004-05-15	Verfahren zur herstellung von zwischenprodukten für pestizide
JO2433B1 (en)	2008-04-17	Preparation of heterocyclic lindane landscapes
DE502005008867D1 (de)	2010-03-04	Verfahren zur herstellung von 2,5-dimethylphenylessigsäure
SE0201938D0 (sv)	2002-06-20	New process
ATE257145T1 (de)	2004-01-15	Verfahren zur herstellung von isobornylmethacrylat
EA200300400A1 (ru)	2003-10-30	17α-ФТОРАЛКИЛСТЕРОИДЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ЭТИ СОЕДИНЕНИЯ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ
DE60014103D1 (de)	2004-10-28	Verfahren zur herstellung von debromohymenialdisin und deren analogen
DE60021410D1 (de)	2005-08-25	Verfahren zur herstellung von ketiminen
DE60204014D1 (de)	2005-06-09	Chlormethylierung von thiophene
ES8608488A1 (es)	1986-06-16	Un metodo para preparar nuevas 1-aminoalquil-amino-4-arilo- xipiperidinas sustituidas
ATE247632T1 (de)	2003-09-15	Verfahren zur herstellung von cyanessigsäureestern
HU0001287D0 (en)	2000-06-28	New intermediate and process for its production
WO2003029267A3 (es)	2003-06-19	PROCEDIMIENTO PARA LA OBTENCION DE 17β-(SUSTITUIDO)-3-OXO-Δ1,2-4-AZAESTEROIDES E INTERMEDIOS
DK0474666T3 (da)	1995-02-06	Oxidativ fremstilling af A-nor-17-beta-carboxy-3,5-seco-androstan-5-on-syre
WO2002070450A3 (de)	2002-10-24	Verfahren zur herstellung von glycerinsäuren
JPS5488221A (en)	1979-07-13	Preparation of azo-compound

Legal Events

Date	Code	Title	Description
2014-02-24	MM1K	Lapsed by not paying the annual fees