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NO20012961D0 - Tricyclic farnesyl protein transferase inhibitors - Google Patents

Tricyclic farnesyl protein transferase inhibitors

Info

Publication number
NO20012961D0
NO20012961D0 NO20012961A NO20012961A NO20012961D0 NO 20012961 D0 NO20012961 D0 NO 20012961D0 NO 20012961 A NO20012961 A NO 20012961A NO 20012961 A NO20012961 A NO 20012961A NO 20012961 D0 NO20012961 D0 NO 20012961D0
Authority
NO
Norway
Prior art keywords
protein transferase
transferase inhibitors
farnesyl protein
tricyclic farnesyl
tricyclic
Prior art date
Application number
NO20012961A
Other languages
Norwegian (no)
Other versions
NO20012961L (en
Inventor
Arthur G Taveras
Ronald J Doll
Alan Bruce Cooper
Johan A Ferreira
Timothy Guzi
Alan K Mallams
Dinanath F Rane
Viyyoor Moopil Girijavallabhan
Adriano Afonso
Cynthia J Aki
Jianping Chao
Carmen Alvarez
Joseph M Kelly
Tarik Lalwani
Jagdish A Desai
James J S Wang
Jay Weinstein
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO20012961D0 publication Critical patent/NO20012961D0/en
Publication of NO20012961L publication Critical patent/NO20012961L/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Electroluminescent Light Sources (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20012961A 1998-12-18 2001-06-15 Tricyclic farnesyl protein transferase inhibitors NO20012961L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21639898A 1998-12-18 1998-12-18
PCT/US1999/027939 WO2000037459A1 (en) 1998-12-18 1999-12-16 Tricyclic farnesyl protein transferase inhibitors

Publications (2)

Publication Number Publication Date
NO20012961D0 true NO20012961D0 (en) 2001-06-15
NO20012961L NO20012961L (en) 2001-08-16

Family

ID=22806914

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20012961A NO20012961L (en) 1998-12-18 2001-06-15 Tricyclic farnesyl protein transferase inhibitors

Country Status (20)

Country Link
EP (1) EP1140902A1 (en)
JP (1) JP2002533336A (en)
KR (1) KR20010081116A (en)
CN (1) CN1326850C (en)
AR (1) AR021718A1 (en)
AU (1) AU776558B2 (en)
BR (1) BR9916314A (en)
CA (1) CA2354779A1 (en)
CO (1) CO5160350A1 (en)
CZ (1) CZ20011950A3 (en)
HU (1) HUP0202152A2 (en)
IL (1) IL143408A0 (en)
NO (1) NO20012961L (en)
NZ (1) NZ511878A (en)
PE (1) PE20001342A1 (en)
PL (1) PL348293A1 (en)
SK (1) SK7592001A3 (en)
TR (1) TR200101755T2 (en)
WO (1) WO2000037459A1 (en)
ZA (1) ZA200104233B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1326850C (en) 1998-12-18 2007-07-18 先灵公司 Tricyclic farnesyl protein transferase inhibitors
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
WO2002056884A2 (en) * 2001-01-22 2002-07-25 Schering Corporation Treatment of malaria with farnesyl protein transferase inhibitors
AU2002257114A1 (en) * 2001-04-06 2002-10-21 Schering Corporation Treatment of malaria with farsenyl protein transferase inhibitors
MX2007007074A (en) 2004-12-13 2007-09-04 Schering Corp Novel farnesyl protein transferase inhibitors and their use to treat cancer.
WO2006065794A1 (en) 2004-12-14 2006-06-22 Schering Corporation Farnesyl protein transferase inhibitors and methods for treating proliferative diseases
CA2637572A1 (en) * 2006-01-19 2007-07-26 Schering Corporation Piperazine derivatives as farnesyl protein transferase inhibitors
CN106132947B (en) 2014-03-19 2019-08-09 Vps-3有限公司 The preparation method of compound
WO2015143188A1 (en) * 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and proceses for their preparation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Pharmaceutical compositions for inhibition of g-protein function and for treatment of proliferative diseases containing tricyclic compounds some such compounds and process for preparing part of them
US5712280A (en) 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5801175A (en) 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases and pharmaceutical compositions comprising them
PE92098A1 (en) * 1996-07-31 1998-12-31 Schering Corp TRICYCLIC N-CYANOIMINES USEFUL AS PROTEIN TRANSFERASE INHIBITORS FARNESILO
ATE273299T1 (en) * 1997-06-17 2004-08-15 Schering Corp BENZPYRIDO CYCLOHEPTAN DERIVATIVES WITH FARNESYL PROTEIN TRANSFERASE INHIBITING EFFECT
CN1326850C (en) 1998-12-18 2007-07-18 先灵公司 Tricyclic farnesyl protein transferase inhibitors

Also Published As

Publication number Publication date
IL143408A0 (en) 2002-04-21
ZA200104233B (en) 2002-08-22
CZ20011950A3 (en) 2001-12-12
CN1326850C (en) 2007-07-18
CN1334811A (en) 2002-02-06
AU776558B2 (en) 2004-09-16
NZ511878A (en) 2003-10-31
AR021718A1 (en) 2002-07-31
SK7592001A3 (en) 2002-03-05
CO5160350A1 (en) 2002-05-30
WO2000037459A1 (en) 2000-06-29
PL348293A1 (en) 2002-05-20
NO20012961L (en) 2001-08-16
BR9916314A (en) 2001-10-02
HUP0202152A2 (en) 2002-10-28
AU2030700A (en) 2000-07-12
KR20010081116A (en) 2001-08-27
CA2354779A1 (en) 2000-06-29
EP1140902A1 (en) 2001-10-10
PE20001342A1 (en) 2000-12-09
TR200101755T2 (en) 2001-09-21
JP2002533336A (en) 2002-10-08

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application