NO20006572L - Medicines containing bisphosphonic acids and their derivatives for the prevention and treatment of autoimmune diseases and allergies - Google Patents
Medicines containing bisphosphonic acids and their derivatives for the prevention and treatment of autoimmune diseases and allergiesInfo
- Publication number
- NO20006572L NO20006572L NO20006572A NO20006572A NO20006572L NO 20006572 L NO20006572 L NO 20006572L NO 20006572 A NO20006572 A NO 20006572A NO 20006572 A NO20006572 A NO 20006572A NO 20006572 L NO20006572 L NO 20006572L
- Authority
- NO
- Norway
- Prior art keywords
- acid
- derivatives
- bisphosphonic
- autoimmune diseases
- bisphosphonic acids
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 8
- 150000007513 acids Chemical class 0.000 title abstract 5
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 3
- 206010020751 Hypersensitivity Diseases 0.000 title abstract 3
- 230000007815 allergy Effects 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- KBPGKWPDIYMIFV-UHFFFAOYSA-N (2-amino-2-imino-1-phosphonoethyl)phosphonic acid Chemical compound NC(=N)C(P(O)(O)=O)P(O)(O)=O KBPGKWPDIYMIFV-UHFFFAOYSA-N 0.000 abstract 1
- NHAOLKGXQFICNN-UHFFFAOYSA-N (amino-hydroxy-phosphonomethyl)phosphonic acid Chemical compound OP(=O)(O)C(O)(N)P(O)(O)=O NHAOLKGXQFICNN-UHFFFAOYSA-N 0.000 abstract 1
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 abstract 1
- 206010028372 Muscular weakness Diseases 0.000 abstract 1
- IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 abstract 1
- 206010039710 Scleroderma Diseases 0.000 abstract 1
- DKJJVAGXPKPDRL-UHFFFAOYSA-N Tiludronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1 DKJJVAGXPKPDRL-UHFFFAOYSA-N 0.000 abstract 1
- 206010046851 Uveitis Diseases 0.000 abstract 1
- 239000013566 allergen Substances 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 229960005236 ibandronic acid Drugs 0.000 abstract 1
- 229950006971 incadronic acid Drugs 0.000 abstract 1
- LWRDQHOZTAOILO-UHFFFAOYSA-N incadronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)NC1CCCCCC1 LWRDQHOZTAOILO-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000036473 myasthenia Effects 0.000 abstract 1
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 abstract 1
- 229960003978 pamidronic acid Drugs 0.000 abstract 1
- 239000000575 pesticide Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 229960000759 risedronic acid Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 229960005324 tiludronic acid Drugs 0.000 abstract 1
- 229960004276 zoledronic acid Drugs 0.000 abstract 1
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Anvendelse av bisfosfonsyrer og deri- vater derav for fremstilling av farma- søytiske preparater for å forebygge og behandle autoimmunsykdommer eller aller- gier, i kombinasjon med de autoantigener som spesifikt anvendes for å behandle den respektive allergi. Noen eksempler på bisfosfonsyrene og derivatene derav som anvendes i henhold til oppfinnelsen, er aminohydroksymetyliden-bisfosfonsyre (AMP), 2-amino-l-hydroksyetyliden-l,1- bisfosfonsyre (AEP), pamidronsyre, alen- dronsyre, 6-amino-l-hydroksyheksyliden- 1,1-bisfosfonsyre (AHP), amidinometylen- bisfosfonsyre (AIMP), ibandronsyre, risedronsyre, zoledronsyre, cimadronsyre og tiludronsyre. Noen eksempler på auto- immunsykdommer for hvilke bisfosfonsyrer eller derivater derav kan anvendes, inn- befatter revmatoid artritt, myasthenia gråvis, diabetes mellitus, uveitis og skleroderma. Bisfosfonsyrene eller deri- vatene derav og autoantigenene eller allergenene kan anvendes samtidig eller etter hverandre. Preparatene på basis av kombinasjonene kan anvendes i fast form, som salter, som oppløsninger eller som sprøytemidler.Use of bisphosphonic acids and derivatives thereof for the preparation of pharmaceutical preparations for the prevention and treatment of autoimmune diseases or allergies, in combination with the autoantigens specifically used to treat the respective allergy. Some examples of the bisphosphonic acids and their derivatives used according to the invention are amino hydroxymethylidene bisphosphonic acid (AMP), 2-amino-1-hydroxyethylidene-1,1-bisphosphonic acid (AEP), pamidronic acid, aldronic acid, 6-amino-1 -hydroxyhexylidene-1,1-bisphosphonic acid (AHP), amidinomethylene-bisphosphonic acid (AIMP), ibandronic acid, risedronic acid, zoledronic acid, cimadronic acid and tiludronic acid. Some examples of autoimmune diseases for which bisphosphonic acids or derivatives thereof can be used include rheumatoid arthritis, myasthenia grayish, diabetes mellitus, uveitis and scleroderma. The bisphosphonic acids or derivatives thereof and the autoantigens or allergens may be used simultaneously or in succession. The compositions based on the combinations can be used in solid form, as salts, as solutions or as pesticides.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19828450A DE19828450A1 (en) | 1998-06-26 | 1998-06-26 | Use of bisphosphonic acid compounds and autoantigens or allergens |
| PCT/DE1999/001844 WO2000000182A2 (en) | 1998-06-26 | 1999-06-24 | Medicaments containing bisphosphonic acids and derivatives thereof which are provided for preventing and treating autoimmune diseases and allergies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20006572D0 NO20006572D0 (en) | 2000-12-21 |
| NO20006572L true NO20006572L (en) | 2001-02-21 |
Family
ID=7872064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20006572A NO20006572L (en) | 1998-06-26 | 2000-12-21 | Medicines containing bisphosphonic acids and their derivatives for the prevention and treatment of autoimmune diseases and allergies |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1089761B1 (en) |
| JP (1) | JP2002519319A (en) |
| KR (1) | KR20010053211A (en) |
| AT (1) | ATE224734T1 (en) |
| AU (1) | AU740605B2 (en) |
| CA (1) | CA2334711C (en) |
| DE (2) | DE19828450A1 (en) |
| DK (1) | DK1089761T3 (en) |
| EA (1) | EA200100080A1 (en) |
| EE (1) | EE200000756A (en) |
| ES (1) | ES2184496T3 (en) |
| HR (1) | HRP20000820A2 (en) |
| HU (1) | HUP0102873A3 (en) |
| ID (1) | ID27515A (en) |
| IL (1) | IL139966A0 (en) |
| IS (1) | IS5748A (en) |
| MX (1) | MXPA00012338A (en) |
| NO (1) | NO20006572L (en) |
| NZ (1) | NZ509505A (en) |
| PL (1) | PL345287A1 (en) |
| PT (1) | PT1089761E (en) |
| SK (1) | SK19602000A3 (en) |
| TR (1) | TR200003821T2 (en) |
| WO (1) | WO2000000182A2 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002533385A (en) * | 1998-12-23 | 2002-10-08 | ヨマー、ファルマカ、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング | Use of bisphosphonates for prevention and treatment of infectious diseases |
| EP1057488A4 (en) * | 1998-12-25 | 2003-10-22 | Toray Industries | Interleukin-6 production inhibitors |
| DE20106394U1 (en) | 2001-04-11 | 2001-08-09 | Helm Pharmaceuticals Gmbh | Pharmaceutical preparation |
| PT1392325E (en) * | 2001-05-02 | 2006-10-31 | Novartis Ag | METHOD OF ADMINISTRATION OF BIFPHOSPHONATES BY INHALATION IN TREATMENT OR PREVENTION OF OSHA REOPSORCA AND OSTEOPOROSIS |
| JP4607451B2 (en) | 2001-07-20 | 2011-01-05 | バイオエージェンシー・アーゲー | Organophosphorus compounds for activating gamma / delta T cells |
| GB0307989D0 (en) * | 2003-04-07 | 2003-05-14 | Mcewen Lab Ltd | Therapeutic composition |
| WO2006024024A2 (en) * | 2004-08-23 | 2006-03-02 | Teva Pharmaceutical Industries Ltd. | Solid and crystalline ibandronate sodium and processes for preparation thereof |
| WO2007032808A1 (en) * | 2005-09-12 | 2007-03-22 | Dr. Reddy's Laboratories Ltd. | Crystalline trihydrate of zoledronic acid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0826048B2 (en) * | 1991-09-05 | 1996-03-13 | 東レ株式会社 | Methanediphosphonic acid derivative, production method thereof and pharmaceutical use thereof |
| DE69622157T2 (en) * | 1995-01-23 | 2003-03-13 | Xenotech Inc., Fremont | COMPOSITION TO PREVENT OSTEOLYSIS AND METASTASES |
-
1998
- 1998-06-26 DE DE19828450A patent/DE19828450A1/en not_active Withdrawn
-
1999
- 1999-06-24 SK SK1960-2000A patent/SK19602000A3/en unknown
- 1999-06-24 AT AT99941383T patent/ATE224734T1/en active
- 1999-06-24 IL IL13996699A patent/IL139966A0/en unknown
- 1999-06-24 PT PT99941383T patent/PT1089761E/en unknown
- 1999-06-24 ES ES99941383T patent/ES2184496T3/en not_active Expired - Lifetime
- 1999-06-24 HU HU0102873A patent/HUP0102873A3/en unknown
- 1999-06-24 CA CA002334711A patent/CA2334711C/en not_active Expired - Fee Related
- 1999-06-24 DK DK99941383T patent/DK1089761T3/en active
- 1999-06-24 WO PCT/DE1999/001844 patent/WO2000000182A2/en not_active Application Discontinuation
- 1999-06-24 EP EP99941383A patent/EP1089761B1/en not_active Expired - Lifetime
- 1999-06-24 JP JP2000556767A patent/JP2002519319A/en active Pending
- 1999-06-24 ID IDW20002676A patent/ID27515A/en unknown
- 1999-06-24 NZ NZ509505A patent/NZ509505A/en not_active IP Right Cessation
- 1999-06-24 PL PL99345287A patent/PL345287A1/en unknown
- 1999-06-24 DE DE59902856T patent/DE59902856D1/en not_active Expired - Lifetime
- 1999-06-24 KR KR1020007014813A patent/KR20010053211A/en not_active Application Discontinuation
- 1999-06-24 MX MXPA00012338A patent/MXPA00012338A/en unknown
- 1999-06-24 EA EA200100080A patent/EA200100080A1/en unknown
- 1999-06-24 AU AU55033/99A patent/AU740605B2/en not_active Ceased
- 1999-06-24 TR TR2000/03821T patent/TR200003821T2/en unknown
- 1999-06-24 EE EEP200000756A patent/EE200000756A/en unknown
-
2000
- 2000-11-29 HR HR20000820A patent/HRP20000820A2/en not_active Application Discontinuation
- 2000-12-01 IS IS5748A patent/IS5748A/en unknown
- 2000-12-21 NO NO20006572A patent/NO20006572L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA200100080A1 (en) | 2001-06-25 |
| NO20006572D0 (en) | 2000-12-21 |
| PT1089761E (en) | 2003-02-28 |
| WO2000000182A2 (en) | 2000-01-06 |
| DK1089761T3 (en) | 2003-02-03 |
| DE59902856D1 (en) | 2002-10-31 |
| HUP0102873A2 (en) | 2001-12-28 |
| EE200000756A (en) | 2002-04-15 |
| ES2184496T3 (en) | 2003-04-01 |
| JP2002519319A (en) | 2002-07-02 |
| CA2334711A1 (en) | 2000-01-06 |
| NZ509505A (en) | 2002-11-26 |
| KR20010053211A (en) | 2001-06-25 |
| MXPA00012338A (en) | 2003-04-25 |
| AU740605B2 (en) | 2001-11-08 |
| PL345287A1 (en) | 2001-12-03 |
| IS5748A (en) | 2000-12-01 |
| EP1089761B1 (en) | 2002-09-25 |
| WO2000000182A3 (en) | 2000-03-30 |
| EP1089761A2 (en) | 2001-04-11 |
| ID27515A (en) | 2001-04-12 |
| IL139966A0 (en) | 2002-02-10 |
| HRP20000820A2 (en) | 2001-12-31 |
| DE19828450A1 (en) | 1999-12-30 |
| ATE224734T1 (en) | 2002-10-15 |
| AU5503399A (en) | 2000-01-17 |
| SK19602000A3 (en) | 2001-07-10 |
| CA2334711C (en) | 2006-12-05 |
| HUP0102873A3 (en) | 2002-04-29 |
| TR200003821T2 (en) | 2001-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |