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NO20003730L - Triazolo-pyridazinderivater som ligander for GABA reseptorer - Google Patents

Triazolo-pyridazinderivater som ligander for GABA reseptorer

Info

Publication number
NO20003730L
NO20003730L NO20003730A NO20003730A NO20003730L NO 20003730 L NO20003730 L NO 20003730L NO 20003730 A NO20003730 A NO 20003730A NO 20003730 A NO20003730 A NO 20003730A NO 20003730 L NO20003730 L NO 20003730L
Authority
NO
Norway
Prior art keywords
triazolo
ligands
pyridazine derivatives
gaba receptors
gaba
Prior art date
Application number
NO20003730A
Other languages
English (en)
Other versions
NO315516B1 (no
NO20003730D0 (no
Inventor
William Robert Carling
Jose Luis Castro Pineiro
Ian James Collins
Alexander Richard Guiblin
Timothy Harrison
Andrew Madin
Kevin William Moore
Michael Geoffrey Neil Russell
Gayle Scott
Leslie Joseph Street
Original Assignee
Merck Sharp & Dohne Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9801233.9A external-priority patent/GB9801233D0/en
Priority claimed from GBGB9821517.1A external-priority patent/GB9821517D0/en
Application filed by Merck Sharp & Dohne Ltd filed Critical Merck Sharp & Dohne Ltd
Publication of NO20003730D0 publication Critical patent/NO20003730D0/no
Publication of NO20003730L publication Critical patent/NO20003730L/no
Publication of NO315516B1 publication Critical patent/NO315516B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20003730A 1998-01-21 2000-07-20 Triazolo-pyridazinderivater som ligander for GABA-reseptorer NO315516B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9801233.9A GB9801233D0 (en) 1998-01-21 1998-01-21 Therapeutic agents
GBGB9821517.1A GB9821517D0 (en) 1998-10-02 1998-10-02 Therapeutic agents
PCT/GB1999/000103 WO1999037644A1 (en) 1998-01-21 1999-01-13 Triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (3)

Publication Number Publication Date
NO20003730D0 NO20003730D0 (no) 2000-07-20
NO20003730L true NO20003730L (no) 2000-09-20
NO315516B1 NO315516B1 (no) 2003-09-15

Family

ID=26312988

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20003730A NO315516B1 (no) 1998-01-21 2000-07-20 Triazolo-pyridazinderivater som ligander for GABA-reseptorer

Country Status (24)

Country Link
US (2) US6579875B1 (no)
EP (1) EP1049696A1 (no)
JP (1) JP2002501066A (no)
KR (1) KR20010034257A (no)
CN (1) CN1110498C (no)
AU (1) AU748737B2 (no)
BG (1) BG104671A (no)
BR (1) BR9906905A (no)
CA (1) CA2315763A1 (no)
CZ (1) CZ290883B6 (no)
EA (1) EA002755B1 (no)
EE (1) EE200000430A (no)
GE (1) GEP20032868B (no)
HR (1) HRP20000492A2 (no)
HU (1) HUP0100575A3 (no)
IL (1) IL136442A0 (no)
IS (1) IS5540A (no)
MX (1) MXPA00007135A (no)
NO (1) NO315516B1 (no)
NZ (1) NZ504870A (no)
PL (1) PL341652A1 (no)
SK (1) SK10922000A3 (no)
WO (1) WO1999037644A1 (no)
YU (1) YU43800A (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1110498C (zh) * 1998-01-21 2003-06-04 默克·夏普-道姆公司 作为gaba受体的配体的三唑并－哒嗪衍生物
GB9929685D0 (en) 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0017543D0 (en) 2000-07-17 2000-09-06 Merck Sharp & Dohme Therapeutic agents
JP4867350B2 (ja) * 2003-12-19 2012-02-01 宇部興産株式会社 ４−置換−４−シアノテトラヒドロピラン化合物の製法
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
PT1966214T (pt) * 2005-12-21 2017-02-03 Janssen Pharmaceutica Nv Triazolpiridazinas como moduladores de tirosina quinase
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
AU2007249435A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 HT receptor mediated neurogenesis
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2123619A1 (de) 2008-05-20 2009-11-25 Bayer Schering Pharma AG Neue [F-18]-Markierte L-Glutaminsäure-und L-Glutaminderivate (II), ihre Verwendung sowie Verfahren zu ihrer Herstellung
MX2011002278A (es) * 2008-08-29 2011-04-14 Concert Pharmaceuticals Inc Derivados de triazolo-piridazina sustituidos.
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2011005520A1 (en) 2009-06-23 2011-01-13 Concert Pharmaceuticals, Inc. Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
ME02847B (me) 2009-07-27 2018-01-20 Gilead Sciences Inc Fuzionisana heterociklična jedinjenja kao modulatori jonskih kanala
WO2012050907A2 (en) 2010-09-28 2012-04-19 The Regents Of The University Of California Gaba agonists in the treatment of disorders associated with metabolic syndrome and gaba combinations in treatment or prophylaxis of type i diabetes
KR20140033377A (ko) 2011-05-10 2014-03-18 길리애드 사이언시즈, 인코포레이티드 나트륨 채널 조절제로서의 융합된 헤테로시클릭 화합물
NO3175985T3 (no) 2011-07-01 2018-04-28
UY34171A (es) 2011-07-01 2013-01-31 Gilead Sciences Inc Compuestos heterocíclicos fusionados como moduladores del canal iónico
GB201321745D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
JP7105696B2 (ja) 2016-02-29 2022-07-25 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 感染症を治療するステープル化細胞内ターゲティング抗微生物ペプチド
CN107344936B (zh) * 2016-05-06 2022-06-03 上海赛默罗生物科技有限公司 三唑哒嗪类衍生物、其制备方法、药物组合物和用途
AU2018304230A1 (en) 2017-07-19 2020-02-06 Dana-Farber Cancer Institute, Inc. Stabilized anti-microbial peptides for the treatment of antibiotic-resistant bacterial infections

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230705A (en) * 1976-09-22 1980-10-28 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety
CA1080712A (en) * 1976-09-22 1980-07-01 Jay D. Albright Hypotensive agents
US4112095A (en) * 1976-10-07 1978-09-05 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents
PH12424A (en) 1976-10-26 1979-02-15 American Cyanamid Co Method of treating anxiety in mammals
US4260755A (en) 1979-10-31 1981-04-07 American Cyanamid Company Novel 6-phenyl and substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines
US4260756A (en) * 1979-11-15 1981-04-07 American Cyanamid Company 6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines
FI81350C (fi) 1982-01-18 1990-10-10 Lepetit Spa Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat.
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US4654343A (en) * 1985-10-31 1987-03-31 American Cyanamid Company N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
IL127911A0 (en) * 1996-07-25 1999-11-30 Merck Sharp & Dohme Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
CN1110498C (zh) * 1998-01-21 2003-06-04 默克·夏普-道姆公司 作为gaba受体的配体的三唑并－哒嗪衍生物

Also Published As

Publication number Publication date
PL341652A1 (en) 2001-04-23
US6828322B2 (en) 2004-12-07
CZ290883B6 (cs) 2002-11-13
WO1999037644A1 (en) 1999-07-29
HRP20000492A2 (en) 2000-12-31
YU43800A (sh) 2002-12-10
EP1049696A1 (en) 2000-11-08
EA200000783A1 (ru) 2000-12-25
NZ504870A (en) 2002-11-26
JP2002501066A (ja) 2002-01-15
HUP0100575A3 (en) 2003-03-28
SK10922000A3 (sk) 2001-03-12
BG104671A (en) 2001-05-31
MXPA00007135A (es) 2002-11-07
KR20010034257A (ko) 2001-04-25
US20040063714A1 (en) 2004-04-01
IL136442A0 (en) 2001-06-14
HUP0100575A2 (hu) 2001-09-28
AU2065799A (en) 1999-08-09
CN1288465A (zh) 2001-03-21
IS5540A (is) 2000-06-16
NO315516B1 (no) 2003-09-15
GEP20032868B (en) 2003-01-27
CN1110498C (zh) 2003-06-04
EE200000430A (et) 2001-12-17
BR9906905A (pt) 2000-10-10
AU748737B2 (en) 2002-06-13
NO20003730D0 (no) 2000-07-20
EA002755B1 (ru) 2002-08-29
CA2315763A1 (en) 1999-07-29
US6579875B1 (en) 2003-06-17
CZ20002691A3 (cs) 2000-12-13

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