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NO179075C - Fremgangsmåte for fremstilling av human lymfotoksin samt antistoff mot dette - Google Patents

Fremgangsmåte for fremstilling av human lymfotoksin samt antistoff mot dette

Info

Publication number
NO179075C
NO179075C NO852173A NO852173A NO179075C NO 179075 C NO179075 C NO 179075C NO 852173 A NO852173 A NO 852173A NO 852173 A NO852173 A NO 852173A NO 179075 C NO179075 C NO 179075C
Authority
NO
Norway
Prior art keywords
antibody
preparation
human lymphotoxin
lymphotoxin
human
Prior art date
Application number
NO852173A
Other languages
English (en)
Other versions
NO852173L (no
NO179075B (no
Inventor
Bharat Bhushan Aggarwal
Timothy Scott Bringman
Patrick William Gray
Glenn Evan Nedwin
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/616,502 external-priority patent/US4959457A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of NO852173L publication Critical patent/NO852173L/no
Publication of NO179075B publication Critical patent/NO179075B/no
Publication of NO179075C publication Critical patent/NO179075C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C07K16/242—Lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C07K14/5255—Lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
NO852173A 1984-05-31 1985-05-30 Fremgangsmåte for fremstilling av human lymfotoksin samt antistoff mot dette NO179075C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61650384A 1984-05-31 1984-05-31
US06/616,502 US4959457A (en) 1984-05-31 1984-05-31 Anti-lymphotoxin
US73231285A 1985-05-09 1985-05-09

Publications (3)

Publication Number Publication Date
NO852173L NO852173L (no) 1985-12-02
NO179075B NO179075B (no) 1996-04-22
NO179075C true NO179075C (no) 1996-07-31

Family

ID=27417179

Family Applications (1)

Application Number Title Priority Date Filing Date
NO852173A NO179075C (no) 1984-05-31 1985-05-30 Fremgangsmåte for fremstilling av human lymfotoksin samt antistoff mot dette

Country Status (23)

Country Link
EP (2) EP0164965B1 (no)
JP (3) JP2521703B2 (no)
AR (1) AR245219A1 (no)
AT (2) ATE95243T1 (no)
AU (1) AU599303B2 (no)
BG (1) BG60256B2 (no)
CA (1) CA1340641C (no)
CZ (1) CZ283148B6 (no)
DE (2) DE3587597T2 (no)
DK (1) DK171531B1 (no)
ES (1) ES8802182A1 (no)
FI (1) FI93025C (no)
GR (1) GR851317B (no)
HU (1) HU204085B (no)
IE (1) IE63487B1 (no)
IL (1) IL75318A (no)
NO (1) NO179075C (no)
NZ (1) NZ212207A (no)
PL (1) PL155410B1 (no)
PT (1) PT80573B (no)
RO (1) RO100383A2 (no)
SK (1) SK278333B6 (no)
YU (1) YU47735B (no)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT72786B (en) 1980-04-03 1983-01-10 Biogen Nv Process for producing dna sequences recombinant dna molecules and human fibroplast interferon-like polypeptides
NZ212207A (en) 1984-05-31 1991-07-26 Genentech Inc Recombinant lymphotoxin
US5683688A (en) * 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
JP2557053B2 (ja) * 1984-12-21 1996-11-27 バイオジェン インコーポレイテッド 腫瘍壊死因子の精製、製造および使用法
JPS62195285A (ja) * 1986-02-19 1987-08-28 Kanegafuchi Chem Ind Co Ltd リンホトキシン発現ベクタ−及びそれを用いるリンホトキシンの製造方法
AU603768B2 (en) * 1985-07-04 1990-11-29 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Lymphotoxin dna, lymphotoxin expression vector, lymphotoxin resistant cell, transformant with lymphotoxin expression vector and process for preparing lymphotoxin
JPS62111928A (ja) * 1985-10-15 1987-05-22 Kanegafuchi Chem Ind Co Ltd 新規リンホトキシン
US5403725A (en) * 1985-12-24 1995-04-04 Denki Kagaku Kogyo Kabushiki Kaisha Method for production of lymphotoxin (TNFB) in cell line A-C5-8
JP2548204B2 (ja) * 1987-06-27 1996-10-30 電気化学工業株式会社 新生理活性ポリペプチド
EP0230781B1 (en) * 1985-12-24 1992-07-22 Denki Kagaku Kogyo Kabushiki Kaisha Lymphotoxin gene, method for its production, and lymphotoxin
EP0230574A3 (en) * 1986-01-31 1989-03-22 Yale University Pharmaceutical compositions against infections caused by lav/htlv iii virus and the use thereof
JPS62181298A (ja) * 1986-02-05 1987-08-08 Kyowa Hakko Kogyo Co Ltd ヒトリンホトキシンポリペプチド誘導体
DE3620656A1 (de) * 1986-06-20 1987-12-23 Basf Ag Polypeptide mit lymphotoxin-aktivitaet oder lymphotoxin-aehnlicher aktivitaet, ihre herstellung und verwendung
JPS63105680A (ja) * 1986-10-22 1988-05-10 Kanegafuchi Chem Ind Co Ltd ヒト・リンホトキシン発現ベクタ−、該発現ベクタ−による形質転換細胞および該細胞を用いるリンホトキシンの製造方法
JP2636862B2 (ja) * 1986-12-24 1997-07-30 武田薬品工業株式会社 組み換え型ヒトリンホトキシン
US5175268A (en) * 1986-12-24 1992-12-29 Takeda Chemical Industries, Ltd. DNA encoding recombinant human lymphotoxin
FI884798A (fi) * 1987-10-28 1989-04-29 Eisai Co Ltd Rekombinantlymfotoxin.
DE3837012A1 (de) * 1988-01-15 1989-07-27 Knoll Ag Verwendung von tnf und lt zur herstellung von arzneimitteln
GB2217326B (en) * 1988-04-08 1991-11-20 British Bio Technology Synthetic gene encoding human tumour necrosis factor beta.
EP0338497A3 (en) * 1988-04-22 1990-05-16 Takeda Chemical Industries, Ltd. Bispecific hybrid monoclonal antibody
JPH023698A (ja) * 1988-06-20 1990-01-09 Denki Kagaku Kogyo Kk ヒトリンホトキシンに対するモノクローナル抗体及びそれら抗体を産生するハイブリドーマ、並びにそれら抗体を用いたヒトリンホトキシンの精製方法、測定方法及び測定試薬
CA2001756A1 (en) * 1988-10-31 1991-04-30 Seiichi Uesugi New human lymphotoxin n-end deletion mutant
JPH03106821A (ja) * 1989-09-20 1991-05-07 Denki Kagaku Kogyo Kk 抗腫瘍剤
US5200176A (en) * 1989-10-06 1993-04-06 Genentech, Inc. Method for protection of ischemic tissues using tumor nerosis factor
US5370870A (en) * 1989-10-06 1994-12-06 Genentech, Inc. Method for protection against reactive oxygen species
IL97779A (en) * 1990-04-10 2000-01-31 Genentech Inc Compositions for cytoprotection against radiation and chemotherapy injury or risk thereof
US5747023A (en) * 1994-07-01 1998-05-05 Genentech, Inc. Cancer therapy using lymphotoxin
WO1996022790A1 (en) * 1995-01-23 1996-08-01 Xenotech Incorporated Composition to ameliorate osteolysis and metastasis
US5925351A (en) 1995-07-21 1999-07-20 Biogen, Inc. Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
US6998116B1 (en) 1996-01-09 2006-02-14 Genentech, Inc. Apo-2 ligand
DE69939732D1 (de) 1998-01-15 2008-11-27 Genentech Inc Apo-2 ligand
AU2003302386B2 (en) * 2002-11-26 2010-04-01 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US20050163782A1 (en) 2003-06-27 2005-07-28 Biogen Idec Ma Inc. Modified binding molecules comprising connecting peptides
WO2005067477A2 (en) * 2003-12-08 2005-07-28 Centocor, Inc. Anti-human lymphotoxin alpha antibodies, compositions, methods and uses
CN1980957A (zh) 2004-03-23 2007-06-13 比奥根艾迪克Ma公司 受体偶联剂及其治疗用途
WO2006074399A2 (en) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. Multispecific binding molecules comprising connecting peptides
KR20090078349A (ko) * 2006-10-12 2009-07-17 제넨테크, 인크. 림포톡신-알파에 대한 항체
BRPI0718283A2 (pt) 2006-10-20 2013-11-12 Biogen Idec Inc Tratamento de distúrbios desmielinizantes
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins
RU2716164C2 (ru) * 2014-04-25 2020-03-06 Наурекс, Инк. Стабильные композиции нейроактивных пептидов

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE53176B1 (en) * 1978-12-22 1988-08-17 Biogen Nv Recombinant dna molecules and their method of production
NZ201918A (en) 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
ZA834976B (en) * 1982-07-30 1984-08-29 Genentech Inc Human lymphotoxin
FI82266C (fi) * 1982-10-19 1991-02-11 Cetus Corp Foerfarande foer framstaellning av il-2 -mutein.
EP0135797A3 (de) * 1983-08-30 1987-11-11 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Herstellung von Lymphotoxin und von Lymphotoxin-mRNA
DE3331108A1 (de) * 1983-08-30 1985-05-02 Boehringer Ingelheim International GmbH, 6507 Ingelheim Verfahren zur herstellung von lymphotoxin und von lymphotoxin-mrna
NZ212207A (en) 1984-05-31 1991-07-26 Genentech Inc Recombinant lymphotoxin

Also Published As

Publication number Publication date
IE930589L (en) 1985-11-30
NZ212207A (en) 1991-07-26
JPH07250692A (ja) 1995-10-03
IE851321L (en) 1985-11-30
FI852143A0 (fi) 1985-05-29
JP2521703B2 (ja) 1996-08-07
ATE195323T1 (de) 2000-08-15
JPS6156197A (ja) 1986-03-20
CA1340641C (en) 1999-07-13
EP0509553B1 (en) 2000-08-09
IL75318A (en) 1994-08-26
CZ283148B6 (cs) 1998-01-14
PT80573B (pt) 1987-08-19
DK171531B1 (da) 1996-12-23
AU4320385A (en) 1985-12-05
BG60256B1 (bg) 1994-03-24
EP0509553A1 (en) 1992-10-21
ES543695A0 (es) 1988-04-16
YU91985A (en) 1988-12-31
DK241385D0 (da) 1985-05-30
DK241385A (da) 1985-12-01
PL253739A1 (en) 1986-03-11
BG60256B2 (bg) 1994-03-24
DE3588225T2 (de) 2001-04-05
SK393085A3 (en) 1996-11-06
HU204085B (en) 1991-11-28
SK278333B6 (en) 1996-11-06
IL75318A0 (en) 1985-09-29
NO852173L (no) 1985-12-02
EP0164965B1 (en) 1993-09-29
JP2804237B2 (ja) 1998-09-24
EP0164965A3 (en) 1988-04-06
ATE95243T1 (de) 1993-10-15
PT80573A (en) 1985-06-01
HUT37814A (en) 1986-02-28
FI93025B (fi) 1994-10-31
ES8802182A1 (es) 1988-04-16
JPH07291995A (ja) 1995-11-07
DE3587597D1 (de) 1993-11-04
GR851317B (no) 1985-11-25
NO179075B (no) 1996-04-22
FI93025C (fi) 1995-02-10
DE3587597T2 (de) 1994-06-01
FI852143L (fi) 1985-12-01
RO100383A2 (ro) 1991-10-17
IE63487B1 (en) 1995-05-03
AR245219A1 (es) 1993-12-30
AU599303B2 (en) 1990-07-19
YU47735B (sh) 1996-01-08
PL155410B1 (en) 1991-11-29
EP0164965A2 (en) 1985-12-18
DE3588225D1 (de) 2000-09-14
CZ393085A3 (en) 1997-07-16
RO100383B1 (ro) 1991-03-01

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