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NO157060C - AnalogifremgangsmŸte ved fremstilling av terapeutisk aktive carbacycliner. - Google Patents

AnalogifremgangsmŸte ved fremstilling av terapeutisk aktive carbacycliner.

Info

Publication number
NO157060C
NO157060C NO840595A NO840595A NO157060C NO 157060 C NO157060 C NO 157060C NO 840595 A NO840595 A NO 840595A NO 840595 A NO840595 A NO 840595A NO 157060 C NO157060 C NO 157060C
Authority
NO
Norway
Prior art keywords
carbacyclines
manufacturing
therapeutically active
analogy procedure
carbon atoms
Prior art date
Application number
NO840595A
Other languages
English (en)
Other versions
NO840595L (no
NO157060B (no
Inventor
Werner Skuballa
Bernd Raduchel
Helmut Vorbrueggen
Claus-Steffen Sturzebecher
Martin Haberey
Ekkehard Schillinger
Michael-Harold Town
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO840595L publication Critical patent/NO840595L/no
Publication of NO157060B publication Critical patent/NO157060B/no
Publication of NO157060C publication Critical patent/NO157060C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Basic Packing Technique (AREA)
  • Ink Jet Recording Methods And Recording Media Thereof (AREA)
  • Lubricants (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
NO840595A 1983-02-18 1984-02-17 AnalogifremgangsmŸte ved fremstilling av terapeutisk aktive carbacycliner. NO157060C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833306123 DE3306123A1 (de) 1983-02-18 1983-02-18 Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (3)

Publication Number Publication Date
NO840595L NO840595L (no) 1984-08-20
NO157060B NO157060B (no) 1987-10-05
NO157060C true NO157060C (no) 1988-01-13

Family

ID=6191513

Family Applications (1)

Application Number Title Priority Date Filing Date
NO840595A NO157060C (no) 1983-02-18 1984-02-17 AnalogifremgangsmŸte ved fremstilling av terapeutisk aktive carbacycliner.

Country Status (22)

Country Link
US (1) US5013758A (no)
EP (1) EP0119949B1 (no)
JP (1) JPH0611726B2 (no)
AT (1) ATE38831T1 (no)
AU (1) AU580728B2 (no)
CA (1) CA1251200A (no)
CS (1) CS270552B2 (no)
DD (1) DD216448A5 (no)
DE (2) DE3306123A1 (no)
DK (1) DK155828C (no)
ES (1) ES8500209A1 (no)
FI (1) FI78065C (no)
GR (1) GR81961B (no)
HU (1) HU191994B (no)
IE (1) IE56703B1 (no)
IL (1) IL70905A (no)
NO (1) NO157060C (no)
NZ (1) NZ207061A (no)
PH (1) PH21468A (no)
SU (1) SU1384196A3 (no)
YU (1) YU45173B (no)
ZA (1) ZA841198B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3608088C2 (de) * 1986-03-07 1995-11-16 Schering Ag Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
DE3610556A1 (de) * 1986-03-26 1987-10-01 Schering Ag 7-oxoprostacyclinderivate und verfahren zu ihrer herstellung
US5169960A (en) * 1987-08-11 1992-12-08 Schering Aktiengesellschaft Process for the production of E/Z mixtures of 2-(bicyclo[3.3.0]octan-3-ylidene)-acetic acid derivatives with predominant E or Z portion
DE3727065A1 (de) * 1987-08-11 1989-02-23 Schering Ag Verfahren zur herstellung von e/z-gemischen von 2-(bicyclo-(3.3.0)-octan-3-yliden) -essigsaeurederivaten mit ueberwiegendem e- oder z-anteil
US5371284A (en) * 1987-09-03 1994-12-06 Schering Corporation Phenyl acetylenic acetals
DE3835162A1 (de) * 1988-10-13 1990-04-19 Schering Ag (1s,2s,3r,5r)-2-((3s)-2-halogen-3-hydroxy-1-alken(inyl))-3-trialkylsilyloxy-7,7-(2,2-dimethyl-trimethylendioxy)-bicyclo-(3.3.0)-octan-verbindungen und verfahren zu deren herstellung
DE3909329A1 (de) * 1989-03-17 1990-09-20 Schering Ag 20-alkyl-13,14,18,18,19,19-hexadehydro-3- oxa-isocarbacyclin-derivate und ihre pharmazeutische verwendung
DE3933523A1 (de) * 1989-10-05 1991-04-11 Schering Ag Antimetastatisch wirkende mittel
GB9011588D0 (en) * 1990-05-24 1990-07-11 Wellcome Found Prostaglandin analogues for use in medicine
DE4028864A1 (de) * 1990-09-07 1992-03-12 Schering Ag Verfahren zur herstellung von e/z-mischungen von 2-(6-alkyl-bicyclo-(3.3.0)-octan-3-yliden) -essigsaeure-derivaten mit ueberwiegendem anteil des e-isomeren
WO1998011899A1 (fr) * 1996-09-17 1998-03-26 Toray Industries, Inc. Agent de potentialisation de la fonction plaquettaire et procede de traitement du dysfonctionnement plaquettaire
WO2006014930A2 (en) * 2004-07-26 2006-02-09 Cotherix, Inc. Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
CA2669763C (en) 2006-11-16 2015-02-17 Bayer Schering Pharma Aktiengesellschaft Ep2 and ep4 agonists as agents for the treatment of influenza a viral infection
BR112012008959A2 (pt) 2009-10-14 2019-09-24 Gemmus Pharma Inc tratamento de terapia de combinação para infecções virais
ES2525748T3 (es) 2009-11-13 2014-12-29 Toray Industries, Inc. Agente terapéutico o profiláctico para la diabetes
EP3884935B1 (en) 2013-08-09 2023-06-14 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3121155A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
EP0119949A1 (de) 1984-09-26
FI78065B (fi) 1989-02-28
CS270552B2 (en) 1990-07-12
YU24484A (en) 1986-06-30
YU45173B (en) 1992-05-28
ES529636A0 (es) 1984-11-01
AU2401584A (en) 1984-08-23
ZA841198B (en) 1984-09-26
DE3475302D1 (en) 1988-12-29
US5013758A (en) 1991-05-07
CA1251200A (en) 1989-03-14
HU191994B (en) 1987-04-28
DK55584A (da) 1984-08-19
EP0119949B1 (de) 1988-11-23
IE56703B1 (en) 1991-11-06
SU1384196A3 (ru) 1988-03-23
NZ207061A (en) 1987-06-30
JPH0611726B2 (ja) 1994-02-16
CS103684A2 (en) 1989-11-14
DK155828B (da) 1989-05-22
NO840595L (no) 1984-08-20
JPS59157050A (ja) 1984-09-06
NO157060B (no) 1987-10-05
DD216448A5 (de) 1984-12-12
PH21468A (en) 1987-10-28
ES8500209A1 (es) 1984-11-01
DE3306123A1 (de) 1984-09-06
IE840236L (en) 1984-08-18
DK55584D0 (da) 1984-02-08
GR81961B (no) 1984-12-12
IL70905A0 (en) 1984-05-31
IL70905A (en) 1987-02-27
FI840635A (fi) 1984-08-19
AU580728B2 (en) 1989-02-02
FI840635A0 (fi) 1984-02-16
DK155828C (da) 1989-10-09
FI78065C (fi) 1989-06-12
ATE38831T1 (de) 1988-12-15

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