NL990010I2 - Ä3HÜ-imidazo-Ä5,1-dÜ-1,2,3,5-tetrazine-4-one derivatives and pharmaceutical compositions containing these derivatives. - Google Patents

Ä3HÜ-imidazo-Ä5,1-dÜ-1,2,3,5-tetrazine-4-one derivatives and pharmaceutical compositions containing these derivatives.

Info

Publication number: NL990010I2
Authority: NL; Netherlands
Prior art keywords: derivatives; ä3hü; tetrazine; imidazo; pharmaceutical compositions
Prior art date: 1981-08-24

Application number

NL990010C

Other languages

Dutch (nl)

Other versions

NL990010I1 (en

Original Assignee

Cancer Res Campaign Tech

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-08-24

Filing date

1999-04-01

Publication date

1999-09-01

1999-04-01 Application filed by Cancer Res Campaign Tech filed Critical Cancer Res Campaign Tech

1999-07-01 Publication of NL990010I1 publication Critical patent/NL990010I1/en

1999-09-01 Publication of NL990010I2 publication Critical patent/NL990010I2/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

NL990010C 1981-08-24 1999-04-01 Ä3HÜ-imidazo-Ä5,1-dÜ-1,2,3,5-tetrazine-4-one derivatives and pharmaceutical compositions containing these derivatives. NL990010I2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8125791		1981-08-24

Publications (2)

Publication Number	Publication Date
NL990010I1 NL990010I1 (en)	1999-07-01
NL990010I2 true NL990010I2 (en)	1999-09-01

Family

ID=10524141

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NL8203286A NL192739C (en)	1981-08-24	1982-08-23	3H-imidazo-5,1-d-1,2,3,5-tetrazine-4-one derivatives and pharmaceutical compositions containing these derivatives.
NL990010C NL990010I2 (en)	1981-08-24	1999-04-01	Ä3HÜ-imidazo-Ä5,1-dÜ-1,2,3,5-tetrazine-4-one derivatives and pharmaceutical compositions containing these derivatives.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NL8203286A NL192739C (en)	1981-08-24	1982-08-23	3H-imidazo-5,1-d-1,2,3,5-tetrazine-4-one derivatives and pharmaceutical compositions containing these derivatives.

Country Status (29)

Country	Link
JP (1)	JPS5843975A (en)
KR (1)	KR890000094B1 (en)
AT (1)	AT380256B (en)
AU (1)	AU571430B2 (en)
BE (1)	BE894175A (en)
CA (1)	CA1197247A (en)
CH (1)	CH655114A5 (en)
DE (2)	DE19975037I2 (en)
DK (1)	DK161147C (en)
ES (1)	ES8400438A1 (en)
FI (1)	FI73434C (en)
FR (1)	FR2511679A1 (en)
GB (1)	GB2104522B (en)
GE (1)	GEP19960641B (en)
GR (1)	GR76863B (en)
HU (1)	HU186107B (en)
IE (1)	IE53408B1 (en)
IL (1)	IL66606A (en)
IT (1)	IT1152505B (en)
LT (1)	LT2436B (en)
LU (1)	LU84347A1 (en)
LV (2)	LV5511A3 (en)
NL (2)	NL192739C (en)
NZ (1)	NZ201668A (en)
OA (1)	OA07174A (en)
SE (1)	SE448543B (en)
SU (1)	SU1447284A3 (en)
UA (1)	UA5971A1 (en)
ZA (1)	ZA826120B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5260291A (en) *	1981-08-24	1993-11-09	Cancer Research Campaign Technology Limited	Tetrazine derivatives
GB2125402B (en) *	1982-08-17	1985-11-13	May & Baker Ltd	New tetrazine derivatives
FR2531958B1 (en) *	1982-08-17	1986-10-31	May & Baker Ltd	NEW DERIVATIVES
US4517182A (en) *	1983-05-24	1985-05-14	Warner-Lambert Company	3-(Haloethyl)-4-oxopyrazolo-[5,1-d]-1,2,3,5-tetrazine-8-carboxamide composition
GB8616125D0 (en) *	1986-07-02	1986-08-06	May & Baker Ltd	Compositions of matter
AU622330B2 (en) *	1989-06-23	1992-04-02	Takeda Chemical Industries Ltd.	Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
EP2275425A1 (en) *	2003-12-30	2011-01-19	Chemagis Ltd.	Novel crystalline forms of temozolomide
MX2007008781A (en)	2005-01-21	2007-09-11	Astex Therapeutics Ltd	Pharmaceutical compounds.
AR060635A1 (en)	2006-04-27	2008-07-02	Banyu Pharma Co Ltd	DERIVATIVES OF 1,2-DIHIDRO-3H-PIRAZOLO [3,4-D] PIRIMIDIN-3-ONA, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THEIR USE IN THE TREATMENT OF CANCER
JP2008081492A (en)	2006-08-31	2008-04-10	Banyu Pharmaceut Co Ltd	New aminopyridine derivative having aurora a selective inhibitory action
US8883790B2 (en)	2006-10-12	2014-11-11	Astex Therapeutics Limited	Pharmaceutical combinations
WO2008044041A1 (en)	2006-10-12	2008-04-17	Astex Therapeutics Limited	Pharmaceutical combinations
WO2009054332A1 (en)	2007-10-23	2009-04-30	Banyu Pharmaceutical Co., Ltd.	Pyridone-substituted-dihydropyrazolopyrimidinone derivative
PE20091101A1 (en) *	2007-12-18	2009-07-26	Pharminox Ltd	3-SUBSTITUTED-4-OXO-3,4-DIHYDRO-IMIDAZO [5,1-d] [1,2,3,5-TETRACINE-8-CARBOXYL ACID AMIDES AND ITS USE
CA2744560A1 (en) *	2008-11-24	2010-05-27	Reliance Life Sciences Pvt. Ltd.	Process for the preparation of tetrazine derivatives
EP2403339B1 (en)	2009-03-06	2017-01-18	Merck Sharp & Dohme Corp.	Combination cancer therapy with an akt inhibitor and other anticancer agents
US9024018B2 (en)	2009-06-23	2015-05-05	Pharminox Limited	3-substituted-8-substituted-3H-imidazo[5,1-d][1,2,3,5]tetrazin-4-one compounds and their use
RU2462466C1 (en) *	2011-06-24	2012-09-27	Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан"	Substituted azolo[1,2,4,5]tetrazines - inhibitors of antibacterial serine-threonine protein kinases
WO2013055985A1 (en)	2011-10-12	2013-04-18	Children's Medical Center Corporation	Combinatorial compositions and methods of treating hemoglobinopathies
IL261721B (en)	2016-03-15	2022-07-01	Oryzon Genomics Sa	Combinations of lsd1 inhibitors for use in the treatment of solid tumors
KR101847342B1 (en) *	2017-05-08	2018-04-11	(주)센텍코리아	Wearable body fat burning measurement device

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2932305A1 (en) *	1979-08-09	1981-02-26	Basf Ag	Pyrrolo-, pyrazolo-, imidazo- and thiazolo-tetrazin-4-one derivs. - prepd. from amino-azole cpds. by diazotisation and reaction with isocyanate

1982
- 1982-08-05 OA OA57766BISD patent/OA07174A/en unknown
- 1982-08-12 IL IL66606A patent/IL66606A/en not_active IP Right Cessation
- 1982-08-23 AT AT0319182A patent/AT380256B/en not_active IP Right Cessation
- 1982-08-23 ZA ZA826120A patent/ZA826120B/en unknown
- 1982-08-23 CH CH5007/82A patent/CH655114A5/en not_active IP Right Cessation
- 1982-08-23 FI FI822921A patent/FI73434C/en not_active IP Right Cessation
- 1982-08-23 UA UA3482389A patent/UA5971A1/en unknown
- 1982-08-23 FR FR8214461A patent/FR2511679A1/en active Granted
- 1982-08-23 AU AU87493/82A patent/AU571430B2/en not_active Expired
- 1982-08-23 DE DE1999175037 patent/DE19975037I2/en active Active
- 1982-08-23 SE SE8204817A patent/SE448543B/en not_active IP Right Cessation
- 1982-08-23 GB GB08224155A patent/GB2104522B/en not_active Expired
- 1982-08-23 NZ NZ201668A patent/NZ201668A/en unknown
- 1982-08-23 GR GR69093A patent/GR76863B/el unknown
- 1982-08-23 IT IT22938/82A patent/IT1152505B/en active Protection Beyond IP Right Term
- 1982-08-23 NL NL8203286A patent/NL192739C/en not_active IP Right Cessation
- 1982-08-23 HU HU822708A patent/HU186107B/en unknown
- 1982-08-23 CA CA000409950A patent/CA1197247A/en not_active Expired
- 1982-08-23 ES ES515176A patent/ES8400438A1/en not_active Expired
- 1982-08-23 DK DK377882A patent/DK161147C/en not_active IP Right Cessation
- 1982-08-23 SU SU823482389A patent/SU1447284A3/en active
- 1982-08-23 LU LU84347A patent/LU84347A1/en unknown
- 1982-08-23 IE IE2026/82A patent/IE53408B1/en not_active IP Right Cessation
- 1982-08-23 KR KR8203774A patent/KR890000094B1/en active
- 1982-08-23 DE DE19823231255 patent/DE3231255A1/en active Granted
- 1982-08-23 BE BE0/208860A patent/BE894175A/en not_active IP Right Cessation
- 1982-08-23 JP JP57144902A patent/JPS5843975A/en active Granted
1993
- 1993-06-19 LV LV930621A patent/LV5511A3/en unknown
- 1993-09-29 LT LTRP1286A patent/LT2436B/en not_active IP Right Cessation
- 1993-11-16 GE GEAP19931653A patent/GEP19960641B/en unknown
- 1993-12-03 LV LV931303A patent/LV5621A3/en unknown
1999
- 1999-04-01 NL NL990010C patent/NL990010I2/en unknown

Also Published As

Publication number	Publication date
BE894175A (en)	1983-02-23
UA5971A1 (en)	1994-12-29
ES515176A0 (en)	1983-11-01
DK161147B (en)	1991-06-03
NL990010I1 (en)	1999-07-01
ES8400438A1 (en)	1983-11-01
DK377882A (en)	1983-02-25
KR890000094B1 (en)	1989-03-07
FI73434B (en)	1987-06-30
ATA319182A (en)	1985-09-15
SE8204817L (en)	1983-02-25
CA1197247A (en)	1985-11-26
FI822921A0 (en)	1982-08-23
CH655114A5 (en)	1986-03-27
KR840001175A (en)	1984-03-28
LV5621A3 (en)	1994-05-10
AU571430B2 (en)	1988-04-21
AU8749382A (en)	1983-03-03
ZA826120B (en)	1983-07-27
LV5511A3 (en)	1994-03-10
IE822026L (en)	1983-02-24
SE8204817D0 (en)	1982-08-23
HU186107B (en)	1985-06-28
SU1447284A3 (en)	1988-12-23
AT380256B (en)	1986-05-12
GR76863B (en)	1984-09-04
FR2511679B1 (en)	1985-02-01
JPS5843975A (en)	1983-03-14
IT1152505B (en)	1987-01-07
JPH045029B2 (en)	1992-01-30
FR2511679A1 (en)	1983-02-25
IL66606A (en)	1987-07-31
FI822921L (en)	1983-02-25
OA07174A (en)	1984-04-30
IE53408B1 (en)	1988-11-09
LU84347A1 (en)	1983-06-07
DE19975037I2 (en)	2001-06-13
GB2104522A (en)	1983-03-09
SE448543B (en)	1987-03-02
GB2104522B (en)	1985-06-12
DK161147C (en)	1991-11-18
GEP19960641B (en)	1996-11-15
NL8203286A (en)	1983-03-16
FI73434C (en)	1987-10-09
NZ201668A (en)	1985-08-16
LT2436B (en)	1994-02-15
IL66606A0 (en)	1982-12-31
NL192739C (en)	1998-01-06
IT8222938A0 (en)	1982-08-23
NL192739B (en)	1997-09-01
DE3231255A1 (en)	1983-03-03
DE3231255C2 (en)	1992-02-27

Publication	Publication Date	Title
MX9203176A (en)	1992-07-01	1,2,4-TRIAZOLONES SUBSTITUTED WITH PHENOXYETHYLL AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
NL192201B (en)	1996-11-01	Pharmacologically active phenylaminoalkylcyclobutane compounds and compositions containing these compounds.
IT8220611A0 (en)	1982-04-06	TOPICAL PHARMACEUTICAL COMPOSITIONS.
NL990010I2 (en)	1999-09-01	Ä3HÜ-imidazo-Ä5,1-dÜ-1,2,3,5-tetrazine-4-one derivatives and pharmaceutical compositions containing these derivatives.
IL66501A (en)	1987-10-20	Benzazepine-2-one derivatives,their manufacture and pharmaceutical compositions containing them
DE3267350D1 (en)	1985-12-19	5,6,7-trinor-4,8-inter-m-phenylene pgi derivatives and pharmaceutical compositions containing them
IT1190824B (en)	1988-02-24	PHARMACEUTICAL COMPOSITION CONTAINING 24.25-DIHYDROXICOLECALCIFEROL AS ACTIVE INGREDIENT
IT7926662A0 (en)	1979-10-19	PHARMACEUTICAL COMPOSITION CONTAINING 3,4-DI-HYDRO-3-OXO-2-QUINOXALINES.
NZ185539A (en)	1979-12-11	Cis-4a-aryl-2-substituted-2,3,4,4a,5,6,7,7a-octa hydro-1h-2-pyrindines and pharmaceutical compositions
BE896711A (en)	1983-09-01	ANTI-ULCER PHARMACEUTICAL COMPOSITIONS.
DE3268487D1 (en)	1986-02-27	2,3,4-trinor-m-inter-phenylene-prostaglandin derivatives, their preparation and pharmaceutical compositions
NZ184185A (en)	1979-04-26	3,5,5-trimethylhexanoyl-ferrocene and pharmaceutical compositions
IT1186667B (en)	1987-12-04	2,1,3-BENZOTHIADIAZOLS AND 2,1,3-BENZOXYADIAZOLS, THEIR PREPARATION AND THEIR APPLICATION AS MEDICATIONS
IL64932A0 (en)	1982-04-30	Pharmaceutical compositions containing certain 2-azolylmethyl 1,3-dioxolane and-dioxane derivatives
IT1206513B (en)	1989-04-27	PHARMACEUTICAL COMPOSITIONS ANTIBIOTIC-IMMUNOSTIMULANT ADAPTITY.
NL193821B (en)	2000-08-01	Pharmaceutical preparation.
NL190120C (en)	1993-11-01	2,3-DIHYDRO-4H-1-BENZOPYRAN-4-ON-0-CARBAMOYLOXIMES AND THEIR PHARMACEUTICAL PREPARATION THEREOF.
NL174646C (en)	1984-07-16	6,7-DIMETHOXY-4-AMINO-2-PIPERIDINOQUINAZOLINS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
NZ185996A (en)	1980-04-28	6, 7-methylene-3-oxo-d-homo-17a-pregna-4, 16-dienes and pharmaceutical compositions
IT8223097A0 (en)	1982-09-02	5-PHENOXYPHENYL-TETRAHYDRO-1,3,5-THIADIAZIN-4-ONI.
IT8124920A0 (en)	1981-11-09	NEW PHARMACEUTICAL COMPOSITION.
IT8247665A0 (en)	1982-01-28	PHARMACEUTICAL COMPOSITION BASED ON TIACROMANE DERIVATIVES, WITH HEMOBIOLOGICAL PROPERTIES
DK264082A (en)	1982-12-13	1,2,3,4,4A, 9B-HEXAHYDRO-4A-PIPERAZINYLMETHYL-4-DIBENZOFURANON DIBENZOFURANODE DERIVATIVES
IL66465A0 (en)	1982-12-31	1,2-dithiol-3-ylideneammonium derivatives,process for the preparation thereof and pharmaceutical compositions comprising the same
FI823694L (en)	1983-05-05	N-SUBSTITUTES ERGOLIN- OCH 9,10-DIDEHYDRO-ERGOLIN-8-CARBOXIAMID-8-AMINOMETHYL DERIVATIVES, DERAS FRAMSTAELLNING OCH DERAS PHARMACEUTICAL COMPOSITION