NL7100213A - 1,2,3,4-tetrahydrocarbazole derivs - anti-inflammatories - Google Patents
1,2,3,4-tetrahydrocarbazole derivs - anti-inflammatoriesInfo
- Publication number
- NL7100213A NL7100213A NL7100213A NL7100213A NL7100213A NL 7100213 A NL7100213 A NL 7100213A NL 7100213 A NL7100213 A NL 7100213A NL 7100213 A NL7100213 A NL 7100213A NL 7100213 A NL7100213 A NL 7100213A
- Authority
- NL
- Netherlands
- Prior art keywords
- alkyl
- tetrahydrocarbazole
- derivs
- inflammatories
- ketocyclohexane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Title compds. of formula (I): where N = 0-2, and R1 and R2 = H, OH, hal, NO2, (1-6C) alkyl, (1-6C) O-alkyl, NH2, or alkylenedioxy, but R1 and R2 are not both H, and salts, esters and amides of I, are antiinflammatories with no ulcerogenic activity. I are prepd. by the Fischer indole synthesis, i.e. cyclisation of a substd. 3-ketocyclohexane (alkyl) carboxylic acid phenyl hydrazone, opt in the presence of a catalyst, e.g. a Cu or Zn salt and/or cyclising reagent, e.g. POCl3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7100213A NL7100213A (en) | 1971-01-08 | 1971-01-08 | 1,2,3,4-tetrahydrocarbazole derivs - anti-inflammatories |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7100213A NL7100213A (en) | 1971-01-08 | 1971-01-08 | 1,2,3,4-tetrahydrocarbazole derivs - anti-inflammatories |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7100213A true NL7100213A (en) | 1972-07-11 |
Family
ID=19812207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7100213A NL7100213A (en) | 1971-01-08 | 1971-01-08 | 1,2,3,4-tetrahydrocarbazole derivs - anti-inflammatories |
Country Status (1)
| Country | Link |
|---|---|
| NL (1) | NL7100213A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008065408A2 (en) | 2006-11-30 | 2008-06-05 | Hunter-Fleming Limited | Modulation of prostaglandin/cyclooxygenase metabolic pathways |
| US10398678B2 (en) * | 2011-10-17 | 2019-09-03 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
-
1971
- 1971-01-08 NL NL7100213A patent/NL7100213A/en unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008065408A2 (en) | 2006-11-30 | 2008-06-05 | Hunter-Fleming Limited | Modulation of prostaglandin/cyclooxygenase metabolic pathways |
| WO2008065408A3 (en) * | 2006-11-30 | 2008-11-20 | Hunter Fleming Ltd | Modulation of prostaglandin/cyclooxygenase metabolic pathways |
| EP2147673A1 (en) * | 2006-11-30 | 2010-01-27 | Hunter-Fleming Limited | Modulation of prostaglandin/cyclooxygenase metabolic pathways |
| US10398678B2 (en) * | 2011-10-17 | 2019-09-03 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
| US11738004B2 (en) | 2011-10-17 | 2023-08-29 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
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