NL2001953A1 - Method for manufacture of escitalopram. - Google Patents

Method for manufacture of escitalopram.

Info

Publication number: NL2001953A1
Authority: NL; Netherlands
Prior art keywords: escitalopram; manufacture
Prior art date: 2007-09-11

Application number

NL2001953A

Other languages

English (en)

Other versions

NL2001953C2 (nl

Inventor

Carla De Faveri

Florian Anton Martin Huber

Robert James Dancer

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-09-11

Filing date

2008-09-04

Publication date

2008-12-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735675&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL2001953(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-09-04 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2008-12-22 Publication of NL2001953A1 publication Critical patent/NL2001953A1/nl

2009-05-07 Application granted granted Critical

2009-05-07 Publication of NL2001953C2 publication Critical patent/NL2001953C2/nl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NL2001953A 2007-09-11 2008-09-04 Method for manufacture of escitalopram. NL2001953C2 (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA200701314		2007-09-11
DK200701314		2007-09-11

Publications (2)

Publication Number	Publication Date
NL2001953A1 true NL2001953A1 (nl)	2008-12-22
NL2001953C2 NL2001953C2 (nl)	2009-05-07

Family

ID=39735675

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL2001953A NL2001953C2 (nl)	2007-09-11	2008-09-04	Method for manufacture of escitalopram.

Country Status (52)

Country	Link
EP (2)	EP2397461A1 (nl)
JP (1)	JP4966933B2 (nl)
KR (1)	KR101054224B1 (nl)
CN (1)	CN101386583A (nl)
AR (2)	AR068174A1 (nl)
AT (2)	ATE518829T1 (nl)
AU (1)	AU2008212055C1 (nl)
BE (1)	BE1017548A6 (nl)
BG (1)	BG110206A (nl)
BR (1)	BRPI0804121B1 (nl)
CA (1)	CA2638499C (nl)
CH (1)	CH697885B1 (nl)
CL (1)	CL2008002686A1 (nl)
CO (1)	CO6140012A1 (nl)
CY (2)	CY2600B1 (nl)
CZ (1)	CZ2008537A3 (nl)
DE (1)	DE102008046530A1 (nl)
DK (2)	DK2061753T3 (nl)
EA (1)	EA012787B1 (nl)
EE (1)	EE00864U1 (nl)
ES (2)	ES2334875B1 (nl)
FI (1)	FI121570B (nl)
FR (1)	FR2920766A1 (nl)
GB (1)	GB2448848B (nl)
GR (1)	GR1006595B (nl)
HR (2)	HRP20080425A2 (nl)
HU (1)	HUP0800549A2 (nl)
IE (1)	IES20080708A2 (nl)
IL (1)	IL193845A (nl)
IS (1)	IS8758A (nl)
LT (1)	LT5577B (nl)
LU (1)	LU91479B1 (nl)
LV (1)	LV13813B (nl)
ME (1)	ME00176B (nl)
MX (1)	MX2008011451A (nl)
MY (1)	MY144210A (nl)
NL (1)	NL2001953C2 (nl)
NO (1)	NO20083756L (nl)
NZ (1)	NZ570884A (nl)
PL (2)	PL386026A1 (nl)
PT (2)	PT104169A (nl)
RO (1)	RO125301A2 (nl)
RS (2)	RS20080401A (nl)
SE (1)	SE533041C2 (nl)
SG (1)	SG151195A1 (nl)
SI (2)	SI22567A2 (nl)
SK (1)	SK500302008A3 (nl)
TR (2)	TR200907629A2 (nl)
TW (1)	TWI391383B (nl)
UA (2)	UA43461U (nl)
WO (1)	WO2009033488A1 (nl)
ZA (1)	ZA200807753B (nl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1987016A1 (en)	2005-07-27	2008-11-05	Aurobindo Pharma Limited	An improved process for the preparation of escitalopram
CN102796065A (zh) *	2011-05-27	2012-11-28	江苏豪森医药集团连云港宏创医药有限公司	一种制备光学纯度高的艾司西酞普兰的方法
CN104119240A (zh) *	2013-04-23	2014-10-29	中国人民解放军军事医学科学院毒物药物研究所	(S)-(-)-α-甲胺基苯丙酮的制备方法
CN103497145B (zh) *	2013-10-10	2016-01-27	南昌大学	一种光学纯多奈哌齐的制备工艺
CN104119248A (zh) *	2014-08-08	2014-10-29	广东东阳光药业有限公司	S-西酞普兰的制备方法
ES2881105T3 (es)	2014-11-14	2021-11-26	Zhejiang Huahai Pharm Co Ltd	Método para la resolución del producto intermedio de citalopram 5-cianodiol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8814057D0 (en) *	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
AR034612A1 (es)	2001-06-25	2004-03-03	Lundbeck & Co As H	Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) *	2001-07-13	2004-03-17	Lundbeck & Co As H	Metodo para la preparacion de escitalopram
IS7239A (is) *	2001-12-14	2004-04-29	H. Lundbeck A/S	Aðferð til framleiðslu á essítalóprami
PL207847B1 (pl)	2002-12-23	2011-02-28	Lundbeck & Co As H	Sposób wytwarzania racemicznego 4-[4-(dimetyloamino)-1-(4'-fluorofenylo)-1- hydroksybutylo]-3-(hydroksymetylo)-benzonitrylu) i /lub R-lub S-4-[4-(dimetyloamino)-1-(4'-fluorofenylo)-1-hydroksybutylo]-3-( hydroksymetylo)- benzonitrylu) i sposób wytwarzania racemicznego citalopramu, R-citalopramu i/lub S-citalopramu
AU2003242990A1 (en) *	2003-01-17	2004-08-13	Pulla Reddy Muddasani	Processes for the preparation of escitalopram and its precursor
US20090018351A1 (en) *	2003-11-12	2009-01-15	Dr. Reddy's Laboratories, Inc.	Preparation of escitalopram
EP1877394A1 (en) *	2005-04-04	2008-01-16	Jubilant Organosys Limited	Process for the preparation of escitalopram or its acid addition salts
EP1987016A1 (en) *	2005-07-27	2008-11-05	Aurobindo Pharma Limited	An improved process for the preparation of escitalopram

2008
- 2008-08-29 FI FI20085807A patent/FI121570B/fi not_active IP Right Cessation
- 2008-08-29 NZ NZ570884A patent/NZ570884A/en not_active IP Right Cessation
- 2008-09-01 TW TW097133379A patent/TWI391383B/zh active
- 2008-09-01 IE IE20080708A patent/IES20080708A2/en not_active IP Right Cessation
- 2008-09-01 NO NO20083756A patent/NO20083756L/no unknown
- 2008-09-01 GB GB0815773A patent/GB2448848B/en not_active Expired - Fee Related
- 2008-09-02 EA EA200801797A patent/EA012787B1/ru not_active IP Right Cessation
- 2008-09-02 LV LVP-08-154A patent/LV13813B/lv unknown
- 2008-09-02 IL IL193845A patent/IL193845A/en active IP Right Grant
- 2008-09-02 HR HR20080425A patent/HRP20080425A2/hr not_active Application Discontinuation
- 2008-09-02 JP JP2008224435A patent/JP4966933B2/ja active Active
- 2008-09-02 IS IS8758A patent/IS8758A/is unknown
- 2008-09-02 BG BG110206A patent/BG110206A/en unknown
- 2008-09-03 ME MEP-2008-101A patent/ME00176B/me unknown
- 2008-09-03 AR ARP080103832A patent/AR068174A1/es active IP Right Grant
- 2008-09-03 LT LT2008068A patent/LT5577B/lt not_active IP Right Cessation
- 2008-09-04 RS RSP-2008/0401A patent/RS20080401A/sr unknown
- 2008-09-04 NL NL2001953A patent/NL2001953C2/nl not_active IP Right Cessation
- 2008-09-04 MY MYPI20083415A patent/MY144210A/en unknown
- 2008-09-04 PL PL386026A patent/PL386026A1/pl unknown
- 2008-09-04 CZ CZ20080537A patent/CZ2008537A3/cs unknown
- 2008-09-05 SI SI200800207A patent/SI22567A2/sl not_active IP Right Cessation
- 2008-09-05 HU HU0800549A patent/HUP0800549A2/hu unknown
- 2008-09-08 MX MX2008011451A patent/MX2008011451A/es active IP Right Grant
- 2008-09-08 AU AU2008212055A patent/AU2008212055C1/en active Active
- 2008-09-09 EE EEU200800091U patent/EE00864U1/xx not_active IP Right Cessation
- 2008-09-09 PT PT104169A patent/PT104169A/pt not_active IP Right Cessation
- 2008-09-09 ZA ZA200807753A patent/ZA200807753B/en unknown
- 2008-09-09 SE SE0801929A patent/SE533041C2/sv not_active IP Right Cessation
- 2008-09-10 CL CL2008002686A patent/CL2008002686A1/es unknown
- 2008-09-10 EP EP11172640A patent/EP2397461A1/en not_active Withdrawn
- 2008-09-10 PT PT08801398T patent/PT2061753E/pt unknown
- 2008-09-10 SG SG200806650-8A patent/SG151195A1/en unknown
- 2008-09-10 FR FR0856077A patent/FR2920766A1/fr active Pending
- 2008-09-10 DK DK08801398.2T patent/DK2061753T3/da active
- 2008-09-10 SK SK50030-2008A patent/SK500302008A3/sk unknown
- 2008-09-10 UA UAU200811050U patent/UA43461U/uk unknown
- 2008-09-10 CA CA2638499A patent/CA2638499C/en not_active Expired - Fee Related
- 2008-09-10 EP EP08801398A patent/EP2061753B1/en active Active
- 2008-09-10 ES ES200802582A patent/ES2334875B1/es not_active Expired - Fee Related
- 2008-09-10 GR GR20080100581A patent/GR1006595B/el not_active IP Right Cessation
- 2008-09-10 ES ES08801398T patent/ES2368294T3/es active Active
- 2008-09-10 UA UAU200901635U patent/UA41919U/uk unknown
- 2008-09-10 RS RS20110394A patent/RS51909B/en unknown
- 2008-09-10 AT AT08801398T patent/ATE518829T1/de active
- 2008-09-10 DE DE102008046530A patent/DE102008046530A1/de not_active Withdrawn
- 2008-09-10 CO CO08095718A patent/CO6140012A1/es not_active Application Discontinuation
- 2008-09-10 SI SI200830361T patent/SI2061753T1/sl unknown
- 2008-09-10 CN CNA2008101686272A patent/CN101386583A/zh active Pending
- 2008-09-10 CY CY0800015A patent/CY2600B1/xx unknown
- 2008-09-10 WO PCT/DK2008/050222 patent/WO2009033488A1/en active Application Filing
- 2008-09-10 DK DKPA200801265A patent/DK177075B1/da not_active IP Right Cessation
- 2008-09-10 PL PL08801398T patent/PL2061753T3/pl unknown
- 2008-09-11 KR KR1020080090058A patent/KR101054224B1/ko active IP Right Grant
- 2008-09-11 CH CH01450/08A patent/CH697885B1/de not_active IP Right Cessation
- 2008-09-11 TR TR2009/07629A patent/TR200907629A2/xx unknown
- 2008-09-11 AT AT0048708U patent/AT10984U1/de not_active IP Right Cessation
- 2008-09-11 LU LU91479A patent/LU91479B1/fr active
- 2008-09-11 BE BE2008/0498A patent/BE1017548A6/fr not_active IP Right Cessation
- 2008-09-11 TR TR2008/06903A patent/TR200806903A2/xx unknown
- 2008-09-11 RO ROA200800706A patent/RO125301A2/ro unknown
- 2008-09-11 BR BRPI0804121-0A patent/BRPI0804121B1/pt active IP Right Grant
2011
- 2011-09-07 HR HR20110636T patent/HRP20110636T1/hr unknown
- 2011-10-07 CY CY20111100963T patent/CY1111924T1/el unknown
2017
- 2017-06-26 AR ARP170101761A patent/AR108885A2/es unknown

Also Published As

Publication number	Publication date
CY2600B1 (en)	2010-03-03
AR108885A2 (es)	2018-10-03
TWI391383B (zh)	2013-04-01
TR200907629A2 (tr)	2009-11-23
ES2334875A1 (es)	2010-03-16
SE0801929L (sv)	2009-03-12
LV13813B (en)	2008-11-20
FI20085807A0 (fi)	2008-08-29
FI20085807A (fi)	2009-03-12
BRPI0804121B1 (pt)	2022-04-12
LT2008068A (en)	2009-03-25
GB0815773D0 (en)	2008-10-08
MEP10108A (en)	2010-10-10
SE533041C2 (sv)	2010-06-15
EA012787B1 (ru)	2009-12-30
JP2009149600A (ja)	2009-07-09
AU2008212055A1 (en)	2009-03-26
DE102008046530A1 (de)	2009-03-19
CN101386583A (zh)	2009-03-18
UA41919U (uk)	2009-06-10
ES2368294T3 (es)	2011-11-16
EP2061753A1 (en)	2009-05-27
MX2008011451A (es)	2009-03-10
GR20080100581A (el)	2009-04-30
HRP20080425A2 (hr)	2010-04-30
PT2061753E (pt)	2011-09-14
HUP0800549A2 (en)	2009-03-02
GB2448848A (en)	2008-10-29
RS51909B (en)	2012-02-29
ES2334875B1 (es)	2010-10-27
ME00176B (me)	2011-02-10
IS8758A (is)	2009-03-12
EA200801797A2 (ru)	2008-12-30
GB2448848B (en)	2011-01-26
EP2397461A1 (en)	2011-12-21
IES20080708A2 (en)	2009-03-18
KR101054224B1 (ko)	2011-08-08
ZA200807753B (en)	2009-04-29
KR20090027185A (ko)	2009-03-16
AU2008212055B2 (en)	2010-08-12
EP2061753B1 (en)	2011-08-03
HRP20110636T1 (hr)	2011-10-31
SI22567A2 (sl)	2008-12-31
BRPI0804121A2 (pt)	2009-09-29
PT104169A (pt)	2009-02-02
HU0800549D0 (en)	2008-10-28
SK500302008A3 (sk)	2009-04-06
CL2008002686A1 (es)	2009-01-02
BRPI0804121A8 (pt)	2021-04-13
BE1017548A6 (fr)	2008-11-04
LT5577B (lt)	2009-06-25
CY1111924T1 (el)	2015-11-04
GR1006595B (el)	2009-11-16
PL386026A1 (pl)	2009-02-16
DK200801265A (en)	2009-03-12
BG110206A (en)	2009-03-31
PL2061753T3 (pl)	2011-12-30
TR200806903A2 (tr)	2009-03-23
UA43461U (uk)	2009-08-25
SG151195A1 (en)	2009-04-30
CZ2008537A3 (cs)	2009-03-18
CA2638499A1 (en)	2008-11-21
DK177075B1 (da)	2011-06-14
NL2001953C2 (nl)	2009-05-07
CO6140012A1 (es)	2010-03-19
EA200801797A3 (ru)	2009-02-27
AT10984U1 (de)	2010-02-15
CA2638499C (en)	2010-09-28
TW200906814A (en)	2009-02-16
RS20080401A (en)	2010-03-02
MY144210A (en)	2011-08-15
CH697885B1 (de)	2009-03-13
ATE518829T1 (de)	2011-08-15
AU2008212055C1 (en)	2011-06-02
NZ570884A (en)	2010-03-26
LU91479B1 (fr)	2010-03-11
NO20083756L (no)	2009-03-12
EE00864U1 (et)	2009-10-15
SI2061753T1 (sl)	2011-10-28
DK2061753T3 (da)	2011-09-26
WO2009033488A1 (en)	2009-03-19
FI121570B (fi)	2011-01-14
RO125301A2 (ro)	2010-03-30
FR2920766A1 (fr)	2009-03-13
JP4966933B2 (ja)	2012-07-04
AR068174A1 (es)	2009-11-11
IL193845A (en)	2011-03-31

Publication	Publication Date	Title
BRPI0814466A2 (pt)	2015-01-20	Método.
BRPI1011414A2 (pt)	2016-03-15	"método."
BRPI0814359A2 (pt)	2015-08-11	Método
BRPI0817226A2 (pt)	2015-06-16	Método
BRPI0817726A2 (pt)	2015-03-31	Método
BRPI1008021A2 (pt)	2015-08-25	Método para fabricação de 2,6-dioxabiciclo-(3.3.0)-octano-4,8-diona
BRPI0812176A2 (pt)	2014-12-02	Método de cimentar poço
BRPI0815717A2 (pt)	2015-02-10	Compostos de imidazopirazina.
BRPI0813569A2 (pt)	2014-12-23	Método de inspeção.
BRPI0925037A2 (pt)	2015-08-11	Composição contendo piceatanol e método de produzir a composição contendo piceatanol.
BRPI0922208A2 (pt)	2018-05-22	método de mineração de minerio.
CR10353A (es)	2009-01-09	Nuevos compuestos.
BRPI0716528A2 (pt)	2013-09-17	mÉtodo de estabilizaÇço
FI20065363A0 (fi)	2006-05-30	Erotusmenetelmä
BRPI1008674A2 (pt)	2015-08-25	Métodos de redução do desenvolvimento de pragas resistentes.
BRPI0810416A2 (pt)	2014-10-14	Método de hidroformação
BRPI0907448A2 (pt)	2015-07-14	Instrumentos.
NL2001953A1 (nl)	2008-12-22	Method for manufacture of escitalopram.
NL1036308A1 (nl)	2009-06-22	Lithographic method.
DK2504321T3 (da)	2014-07-14	Fremgangsmåde til fremstilling af 5,5-disubstituerede 2-isoxazoliner
DK2393795T3 (da)	2013-04-08	Fremgangsmåde til fremstilling af hydroxymethyldiphenyloxiraner og tilsvarende 1-azolylmethyl-1,2-diphenyloxiraner
BRPI0815419A2 (pt)	2015-02-03	Método de produção
NL2002886A1 (nl)	2009-11-17	Prognostic method.
IT1396642B1 (it)	2012-12-14	Statore.
ITRM20080037A1 (it)	2009-07-24	Procedimento per la ultrapurificazione di alginati.

Legal Events

Date	Code	Title	Description
2009-05-06	RD2N	Patents in respect of which a decision has been taken or a report has been made (novelty report)	Effective date: 20090303
2009-07-01	PD2B	A search report has been drawn up
2012-04-11	V1	Lapsed because of non-payment of the annual fee	Effective date: 20120401