NL169182C - Werkwijze voor de bereiding van een geneesmiddel met hypotensieve werking en verlaagde sedatieve neveneffecten op basis van fluorbevattende arylmethylaminoderivaten en werkwijze voor de bereiding van geneeskrachtige fluorbevattende arylmethylaminoderivaten, geschikt voor gebruik daarbij. - Google Patents

Werkwijze voor de bereiding van een geneesmiddel met hypotensieve werking en verlaagde sedatieve neveneffecten op basis van fluorbevattende arylmethylaminoderivaten en werkwijze voor de bereiding van geneeskrachtige fluorbevattende arylmethylaminoderivaten, geschikt voor gebruik daarbij.

Info

Publication number: NL169182C
Authority: NL; Netherlands
Prior art keywords: preparation; methylaminoderatives; fluoratic; fluoramethane; medicinally
Prior art date: 1976-05-24

Application number

NLAANVRAGE7705727,A

Other languages

English (en)

Dutch (nl)

Other versions

NL169182B (nl

NL7705727A (nl

Original Assignee

Science Union & Cie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-05-24

Filing date

1977-05-24

Publication date

1982-06-16

1977-05-24 Application filed by Science Union & Cie filed Critical Science Union & Cie

1977-11-28 Publication of NL7705727A publication Critical patent/NL7705727A/xx

1982-01-18 Publication of NL169182B publication Critical patent/NL169182B/xx

1982-06-16 Application granted granted Critical

1982-06-16 Publication of NL169182C publication Critical patent/NL169182C/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
- C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Thiazole And Isothizaole Compounds (AREA)

NLAANVRAGE7705727,A 1976-05-24 1977-05-24 Werkwijze voor de bereiding van een geneesmiddel met hypotensieve werking en verlaagde sedatieve neveneffecten op basis van fluorbevattende arylmethylaminoderivaten en werkwijze voor de bereiding van geneeskrachtige fluorbevattende arylmethylaminoderivaten, geschikt voor gebruik daarbij. NL169182C (nl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR7615601A FR2358890A1 (fr)	1976-05-24	1976-05-24	Nouvelles aryl trifluoroethylamines, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant

Publications (3)

Publication Number	Publication Date
NL7705727A NL7705727A (nl)	1977-11-28
NL169182B NL169182B (nl)	1982-01-18
NL169182C true NL169182C (nl)	1982-06-16

Family

ID=9173528

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NLAANVRAGE7705727,A NL169182C (nl)	1976-05-24	1977-05-24	Werkwijze voor de bereiding van een geneesmiddel met hypotensieve werking en verlaagde sedatieve neveneffecten op basis van fluorbevattende arylmethylaminoderivaten en werkwijze voor de bereiding van geneeskrachtige fluorbevattende arylmethylaminoderivaten, geschikt voor gebruik daarbij.

Country Status (21)

Country	Link
US (3)	US4267345A (el)
JP (2)	JPS584715B2 (el)
AR (2)	AR219296A1 (el)
AT (1)	AT350062B (el)
AU (1)	AU517715B2 (el)
BE (1)	BE854908A (el)
CH (1)	CH625795A5 (el)
DE (1)	DE2723464C2 (el)
ES (1)	ES459086A1 (el)
FR (1)	FR2358890A1 (el)
GB (2)	GB1564269A (el)
GR (1)	GR61659B (el)
HU (1)	HU177039B (el)
IL (1)	IL52137A (el)
NL (1)	NL169182C (el)
NZ (1)	NZ184175A (el)
OA (1)	OA05668A (el)
PH (1)	PH13880A (el)
PT (1)	PT66584B (el)
SE (1)	SE7705986L (el)
SU (2)	SU725561A3 (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2444673A1 (fr) *	1978-12-20	1980-07-18	Science Union & Cie	Nouvelles trifluoroethylamines, leurs procedes d'obtention et leur emploi comme medicament
US4348247A (en) *	1979-02-26	1982-09-07	Rockwell International Corporation	Method of fabricating a reinforced tubular structure
DE3465993D1 (en) *	1983-08-11	1987-10-15	Synthelabo	Indole derivatives, their preparation and their therapeutical application
JPH06312412A (ja) *	1992-06-10	1994-11-08	Nippon Hume Pipe Co Ltd	模様付き複合コンクリート製品およびその成形方法
AUPP020297A0 (en) *	1997-11-05	1997-11-27	University Of Melbourne, The	A novel receptor, and compounds which bind thereto
WO2002083133A1 (en) *	2001-04-16	2002-10-24	University Of Virginia Patent Foundation	Novel oral general anesthetics and metabolitically resistant anticonvulsants
EP2070923A1 (de)	2007-12-11	2009-06-17	Bayer CropScience AG	Insektizide Iminoheterocyclen
UY32940A (es) *	2009-10-27	2011-05-31	Bayer Cropscience Ag	Amidas sustituidas con halogenoalquilo como insecticidas y acaricidas
AR085509A1 (es)	2011-03-09	2013-10-09	Bayer Cropscience Ag	Indol- y bencimidazolcarboxamidas como insecticidas y acaricidas
WO2014026984A1 (de)	2012-08-17	2014-02-20	Bayer Cropscience Ag	Azaindolcarbonsäure- und -thiocarbonsäureamide als insektizide und akarizide

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2889351A (en) *	1956-05-25	1959-06-02	Pfizer & Co C	Therapeutic agents
US3626067A (en) *	1965-07-01	1971-12-07	Du Pont	Substituted oxazolines, useful as pharmaceuticals
US3453284A (en) *	1966-01-19	1969-07-01	Du Pont	Certain 2-(substituted-anilino)-2-oxazolines
DE1670751A1 (de) *	1966-09-27	1970-12-23	Bayer Ag	Verfahren zur Herstellung von 2-Phenylamino-2-oxazolinen
US3622067A (en) *	1969-06-13	1971-11-23	Ok Partnership Ltd	Document coder
BE754832A (fr) *	1969-08-14	1971-02-15	Beecham Group Ltd	Iminazolines
USRE27133E (en)	1970-03-20	1971-06-01		Cdj)zco
US4102890A (en) *	1972-12-28	1978-07-25	Science-Union Et Cie, Societe Francaise De Recherche Medicale	2-Amino oxazolines and process for making the same
GB1453703A (en) *	1972-12-28	1976-10-27	Science Union & Cie	Substituted cyclopropylmethylamines processes for their preparation and pharmaceutical compositions containing them
FR2269341B1 (el) *	1974-04-30	1978-07-28	Castaigne Sa
GB1475513A (en) *	1974-06-20	1977-06-01	Science Union & Cie	Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them

1976
- 1976-05-24 FR FR7615601A patent/FR2358890A1/fr active Granted
1977
- 1977-05-20 IL IL52137A patent/IL52137A/xx unknown
- 1977-05-23 GB GB26511/78A patent/GB1564269A/en not_active Expired
- 1977-05-23 AU AU25376/77A patent/AU517715B2/en not_active Expired
- 1977-05-23 SE SE7705986A patent/SE7705986L/xx unknown
- 1977-05-23 GB GB21613/77A patent/GB1564268A/en not_active Expired
- 1977-05-23 CH CH632677A patent/CH625795A5/fr not_active IP Right Cessation
- 1977-05-23 AT AT368277A patent/AT350062B/de not_active IP Right Cessation
- 1977-05-23 GR GR53532A patent/GR61659B/el unknown
- 1977-05-23 BE BE177800A patent/BE854908A/xx unknown
- 1977-05-23 NZ NZ184175A patent/NZ184175A/xx unknown
- 1977-05-23 PT PT66584A patent/PT66584B/pt unknown
- 1977-05-24 PH PH19810A patent/PH13880A/en unknown
- 1977-05-24 AR AR267755A patent/AR219296A1/es active
- 1977-05-24 ES ES459086A patent/ES459086A1/es not_active Expired
- 1977-05-24 DE DE2723464A patent/DE2723464C2/de not_active Expired
- 1977-05-24 OA OA56177A patent/OA05668A/xx unknown
- 1977-05-24 JP JP52060367A patent/JPS584715B2/ja not_active Expired
- 1977-05-24 HU HU77SI1577A patent/HU177039B/hu unknown
- 1977-05-24 NL NLAANVRAGE7705727,A patent/NL169182C/xx not_active IP Right Cessation
- 1977-05-24 SU SU772481553A patent/SU725561A3/ru active
1978
- 1978-10-18 AR AR274117A patent/AR222022A1/es active
- 1978-12-20 SU SU782699403A patent/SU791234A3/ru active
1979
- 1979-04-19 US US06/031,386 patent/US4267345A/en not_active Expired - Lifetime
1980
- 1980-02-22 JP JP2149380A patent/JPS55127390A/ja active Pending
- 1980-08-18 US US06/179,169 patent/US4315019A/en not_active Expired - Lifetime
- 1980-10-15 US US06/197,170 patent/US4315020A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES459086A1 (es)	1978-04-16
OA05668A (fr)	1981-05-31
DE2723464C2 (de)	1983-08-11
JPS584715B2 (ja)	1983-01-27
AT350062B (de)	1979-05-10
ATA368277A (de)	1978-10-15
CH625795A5 (el)	1981-10-15
US4315020A (en)	1982-02-09
PT66584A (fr)	1977-06-01
NZ184175A (en)	1979-07-11
BE854908A (fr)	1977-11-23
HU177039B (hu)	1981-06-28
SU791234A3 (ru)	1980-12-23
US4315019A (en)	1982-02-09
AU2537677A (en)	1978-11-30
SE7705986L (sv)	1977-11-25
SU725561A3 (ru)	1980-03-30
DE2723464A1 (de)	1977-12-08
US4267345A (en)	1981-05-12
FR2358890B1 (el)	1978-12-15
GR61659B (en)	1978-12-05
AR219296A1 (es)	1980-08-15
GB1564269A (en)	1980-04-02
NL169182B (nl)	1982-01-18
PT66584B (fr)	1978-10-20
GB1564268A (en)	1980-04-02
AU517715B2 (en)	1981-08-20
IL52137A (en)	1982-01-31
PH13880A (en)	1980-10-24
NL7705727A (nl)	1977-11-28
JPS5325565A (en)	1978-03-09
FR2358890A1 (fr)	1978-02-17
IL52137A0 (en)	1977-07-31
AR222022A1 (es)	1981-04-15
JPS55127390A (en)	1980-10-02

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NL7614190A (nl)	1977-07-07	Werkwijze voor de bereiding van een farmaceutisch preparaat.
NL7704218A (nl)	1977-10-25	Corticoiden, werkwijze voor het bereiden daar- van, alsmede werkwijze voor het bereiden van een geneesmiddel met anti-inflammatorische werking.
NL179053C (nl)	1986-07-01	N-gesubstitueerde moranolinederivaten, werkwijze voor de bereiding ervan, alsmede werkwijze voor de bereiding van een geneesmiddel met een dergelijk derivaat erin.
NL7711969A (nl)	1978-05-03	Werkwijze voor de bereiding van een farmaceu- tisch preparaat met allergie- en astmawerende werking.
NL7700424A (nl)	1977-08-08	Werkwijze voor de bereiding van een farmaceu- tisch preparaat.
NL7714628A (nl)	1978-07-04	Gedisubstitueerde piperazinen, werkwijze voor de bereiding daarvan en dergelijke piperazinen bevattende geneesmiddelen.
NL7701509A (nl)	1977-08-16	Werkwijze voor de bereiding van verbindingen met anti-arrythmische werking, werkwijze voor de be- reiding van een geneesmiddel met anti-arrythmische werking en een dergelijke geneesmiddel.
NL7604502A (nl)	1976-11-02	Werkwijze voor de bereiding van een geneesmiddel met anti-iflammatore werking, een geneesmiddel met een dergelijke werking en een werkwijze voor de bereiding van de werkzame verbindingen.

Legal Events

Date	Code	Title	Description
1983-01-17	V1	Lapsed because of non-payment of the annual fee