NL1027787A1 - Pyrido(2,3-d)pyrimidine-2,4-diaminen als PDE 2 remmers. - Google Patents

Pyrido(2,3-d)pyrimidine-2,4-diaminen als PDE 2 remmers.

Info

Publication number: NL1027787A1
Authority: NL; Netherlands
Prior art keywords: pde; pyrido; diamines; pyrimidine; inhibitors
Prior art date: 2003-12-16

Application number

NL1027787A

Other languages

English (en)

Other versions

NL1027787C2 (nl

Inventor

Thomas Arthur Beyer

Robert James Chambers

Kelvin Lam

Mei Li

Andrew Ian Morrell

David Duane Thompson

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-16

Filing date

2004-12-15

Publication date

2005-06-21

2004-12-15 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2005-06-21 Publication of NL1027787A1 publication Critical patent/NL1027787A1/nl

2006-03-09 Application granted granted Critical

2006-03-09 Publication of NL1027787C2 publication Critical patent/NL1027787C2/nl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Hematology (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

NL1027787A 2003-12-16 2004-12-15 Pyrido[2,3-d]pyrimidine-2,4-diaminen als PDE 2 remmers. NL1027787C2 (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US52999403P	2003-12-16	2003-12-16
US52999403		2003-12-16

Publications (2)

Publication Number	Publication Date
NL1027787A1 true NL1027787A1 (nl)	2005-06-21
NL1027787C2 NL1027787C2 (nl)	2006-03-09

Family

ID=34710150

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL1027787A NL1027787C2 (nl)	2003-12-16	2004-12-15	Pyrido[2,3-d]pyrimidine-2,4-diaminen als PDE 2 remmers.

Country Status (39)

Country	Link
US (1)	US20070135457A1 (nl)
EP (1)	EP1697356B1 (nl)
JP (1)	JP4073944B2 (nl)
KR (1)	KR100816179B1 (nl)
CN (1)	CN100439366C (nl)
AP (1)	AP2006003632A0 (nl)
AR (1)	AR046766A1 (nl)
AT (1)	ATE387446T1 (nl)
AU (1)	AU2004303609A1 (nl)
BR (1)	BRPI0417663A (nl)
CA (1)	CA2549510A1 (nl)
CL (1)	CL2008001920A1 (nl)
DE (1)	DE602004012154T2 (nl)
DK (1)	DK1697356T3 (nl)
EA (1)	EA010424B1 (nl)
EC (1)	ECSP066643A (nl)
ES (1)	ES2299888T3 (nl)
GE (1)	GEP20094720B (nl)
GT (1)	GT200400268A (nl)
HN (1)	HN2004000538A (nl)
HR (1)	HRP20080142T3 (nl)
IL (1)	IL175813A0 (nl)
IS (1)	IS8474A (nl)
MA (1)	MA28270A1 (nl)
MX (1)	MXPA06006777A (nl)
NL (1)	NL1027787C2 (nl)
NO (1)	NO20063231L (nl)
PE (1)	PE20050681A1 (nl)
PL (1)	PL1697356T3 (nl)
PT (1)	PT1697356E (nl)
RS (1)	RS50575B (nl)
SI (1)	SI1697356T1 (nl)
SV (1)	SV2005001979A (nl)
TN (1)	TNSN06186A1 (nl)
TW (1)	TWI291961B (nl)
UA (1)	UA83091C2 (nl)
UY (1)	UY28671A1 (nl)
WO (1)	WO2005061497A1 (nl)
ZA (1)	ZA200604970B (nl)

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WO2007070872A1 (en) *	2005-12-15	2007-06-21	Rigel Pharmaceuticals, Inc.	Kinase inhibitors and their uses
EP2070541A4 (en) *	2006-09-21	2011-04-13	Toshiki Oguro	MEANS FOR PROMOTING REGENERATION OF HARD FABRIC
JP5472638B2 (ja) *	2008-03-18	2014-04-16	日産化学工業株式会社	１−（置換フェニル）−１−置換シリルエーテル、アルコールまたはケトンの製造方法および中間体
WO2010062366A1 (en) *	2008-10-31	2010-06-03	Arginetix, Inc.	Compositions and methods of treating endothelial disorders
WO2011011312A1 (en)	2009-07-22	2011-01-27	Merck Sharp & Dohme Corp.	Quinolinone pde2 inhibitors
US8440710B2 (en)	2009-10-15	2013-05-14	Hoffmann-La Roche Inc.	HSL inhibitors useful in the treatment of diabetes
US9540379B2 (en)	2011-01-31	2017-01-10	Boehringer Ingelheim International Gmbh	(1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases
EA201391558A1 (ru)	2011-04-20	2014-05-30	Глэксо Груп Лимитед	Тетрагидропиразоло[1,5-а]пиримидины как противотуберкулезные соединения
CA2869730A1 (en)	2012-04-25	2013-10-31	Takeda Pharmaceutical Company Limited	Nitrogenated heterocyclic compound
JP6205356B2 (ja)	2012-07-13	2017-09-27	武田薬品工業株式会社	複素環化合物
US20140045856A1 (en)	2012-07-31	2014-02-13	Boehringer Ingelheim International Gmbh	4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes
JP6280912B2 (ja)	2013-03-14	2018-02-14	武田薬品工業株式会社	複素環化合物
ES2950424T3 (es)	2013-07-03	2023-10-09	Takeda Pharmaceuticals Co	Compuesto de amida
EP3018126A4 (en)	2013-07-03	2016-12-07	Takeda Pharmaceuticals Co	HETEROCYCLIC CONNECTION
JPWO2015012328A1 (ja) *	2013-07-24	2017-03-02	武田薬品工業株式会社	複素環化合物
WO2015096651A1 (en)	2013-12-23	2015-07-02	Merck Sharp & Dohme Corp.	Pyrimidone carboxamide compounds as pde2 inhibitors
JP6696904B2 (ja)	2014-01-08	2020-05-20	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	製剤および医薬組成物
RU2712165C2 (ru) *	2014-08-01	2020-01-24	Фирмениш Са	Твердая дисперсия амидных пищевых ароматизаторов
CN107205993B (zh)	2014-12-06	2021-03-09	细胞内治疗公司	有机化合物
CA2969594A1 (en)	2014-12-06	2016-06-09	Intra-Cellular Therapies, Inc.	Pde2 inhibiting organic compounds
WO2016145614A1 (en)	2015-03-17	2016-09-22	Merck Sharp & Dohme Corp.	Triazolyl pyrimidinone compounds as pde2 inhibitors
WO2016154081A1 (en)	2015-03-26	2016-09-29	Merck Sharp & Dohme Corp.	Pyrazolyl pyrimidinone compounds as pde2 inhibitors
EP3291817B1 (en)	2015-05-05	2019-10-02	Merck Sharp & Dohme Corp.	Heteroaryl-pyrimidinone compounds as pde2 inhibitors
WO2016183741A1 (en)	2015-05-15	2016-11-24	Merck Sharp & Dohme Corp.	Pyrimidinone amide compounds as pde2 inhibitors
WO2016191935A1 (en)	2015-05-29	2016-12-08	Merck Sharp & Dohme Corp.	6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors
WO2016192083A1 (en)	2015-06-04	2016-12-08	Merck Sharp & Dohme Corp.	Dihydropyrazolopyrimidinone compounds as pde2 inhibitors
US10647727B2 (en)	2015-06-25	2020-05-12	Merck Sharp & Dohme Corp.	Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors
WO2017000277A1 (en)	2015-07-01	2017-01-05	Merck Sharp & Dohme Corp.	Substituted triazolo bicycliccompounds as pde2 inhibitors
WO2017000276A1 (en)	2015-07-01	2017-01-05	Merck Sharp & Dohme Corp.	Bicyclic heterocyclic compounds as pde2 inhibitors
EP3156405A1 (en)	2015-10-13	2017-04-19	Boehringer Ingelheim International GmbH	Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
GB201700814D0 (en)	2017-01-17	2017-03-01	Liverpool School Tropical Medicine	Compounds
JP2021504466A (ja)	2017-11-23	2021-02-15	オスロウニヴェルシティホスピタルホーエフ	頻脈の治療
CN109758458B (zh) *	2019-03-05	2021-02-23	中国人民解放军陆军军医大学第二附属医院	抑制Crif1与PKA相互作用的化合物的应用
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US2926166A (en) *	1954-01-04	1960-02-23	Burroughs Wellcome Co	Pyrido (2, 3-d) pyrimidine compounds and method of making
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PE20030008A1 (es) *	2001-06-19	2003-01-22	Bristol Myers Squibb Co	Inhibidores duales de pde 7 y pde 4

2004
- 2004-12-06 AU AU2004303609A patent/AU2004303609A1/en not_active Abandoned
- 2004-12-06 UA UAA200606683A patent/UA83091C2/ru unknown
- 2004-12-06 SI SI200430637T patent/SI1697356T1/sl unknown
- 2004-12-06 BR BRPI0417663-4A patent/BRPI0417663A/pt not_active IP Right Cessation
- 2004-12-06 DE DE602004012154T patent/DE602004012154T2/de not_active Expired - Fee Related
- 2004-12-06 JP JP2006544574A patent/JP4073944B2/ja not_active Expired - Fee Related
- 2004-12-06 RS RSP-2008/0172A patent/RS50575B/sr unknown
- 2004-12-06 WO PCT/IB2004/004013 patent/WO2005061497A1/en active Application Filing
- 2004-12-06 GE GEAP20049461A patent/GEP20094720B/en unknown
- 2004-12-06 AT AT04801323T patent/ATE387446T1/de not_active IP Right Cessation
- 2004-12-06 AP AP2006003632A patent/AP2006003632A0/xx unknown
- 2004-12-06 ES ES04801323T patent/ES2299888T3/es not_active Expired - Lifetime
- 2004-12-06 CN CNB2004800376743A patent/CN100439366C/zh not_active Expired - Fee Related
- 2004-12-06 PL PL04801323T patent/PL1697356T3/pl unknown
- 2004-12-06 PT PT04801323T patent/PT1697356E/pt unknown
- 2004-12-06 MX MXPA06006777A patent/MXPA06006777A/es active IP Right Grant
- 2004-12-06 EA EA200600973A patent/EA010424B1/ru not_active IP Right Cessation
- 2004-12-06 US US10/595,766 patent/US20070135457A1/en not_active Abandoned
- 2004-12-06 DK DK04801323T patent/DK1697356T3/da active
- 2004-12-06 KR KR1020067011800A patent/KR100816179B1/ko not_active IP Right Cessation
- 2004-12-06 CA CA002549510A patent/CA2549510A1/en not_active Abandoned
- 2004-12-06 EP EP04801323A patent/EP1697356B1/en not_active Expired - Lifetime
- 2004-12-15 AR ARP040104668A patent/AR046766A1/es not_active Application Discontinuation
- 2004-12-15 GT GT200400268A patent/GT200400268A/es unknown
- 2004-12-15 TW TW093138972A patent/TWI291961B/zh active
- 2004-12-15 UY UY28671A patent/UY28671A1/es not_active Application Discontinuation
- 2004-12-15 NL NL1027787A patent/NL1027787C2/nl not_active IP Right Cessation
- 2004-12-16 HN HN2004000538A patent/HN2004000538A/es unknown
- 2004-12-16 SV SV2004001979A patent/SV2005001979A/es not_active Application Discontinuation
2005
- 2005-01-03 PE PE2005000028A patent/PE20050681A1/es not_active Application Discontinuation
2006
- 2006-05-18 IS IS8474A patent/IS8474A/is unknown
- 2006-05-22 IL IL175813A patent/IL175813A0/en unknown
- 2006-06-15 ZA ZA200604970A patent/ZA200604970B/en unknown
- 2006-06-15 EC EC2006006643A patent/ECSP066643A/es unknown
- 2006-06-16 MA MA29113A patent/MA28270A1/fr unknown
- 2006-06-16 TN TNP2006000186A patent/TNSN06186A1/fr unknown
- 2006-07-11 NO NO20063231A patent/NO20063231L/no not_active Application Discontinuation
2008
- 2008-03-28 HR HR20080142T patent/HRP20080142T3/xx unknown
- 2008-06-27 CL CL200801920A patent/CL2008001920A1/es unknown

Also Published As

Publication number	Publication date
AP2006003632A0 (en)	2006-06-30
DE602004012154T2 (de)	2009-03-12
GT200400268A (es)	2005-09-20
IL175813A0 (en)	2006-10-05
ECSP066643A (es)	2006-10-25
WO2005061497A1 (en)	2005-07-07
EP1697356B1 (en)	2008-02-27
TWI291961B (en)	2008-01-01
PE20050681A1 (es)	2005-10-04
KR20060105776A (ko)	2006-10-11
US20070135457A1 (en)	2007-06-14
CN100439366C (zh)	2008-12-03
MXPA06006777A (es)	2006-08-23
HRP20080142T3 (en)	2008-06-30
ES2299888T3 (es)	2008-06-01
HN2004000538A (es)	2008-02-21
UY28671A1 (es)	2005-07-29
KR100816179B1 (ko)	2008-03-28
UA83091C2 (en)	2008-06-10
CA2549510A1 (en)	2005-07-07
EA200600973A1 (ru)	2006-10-27
EA010424B1 (ru)	2008-08-29
TW200522952A (en)	2005-07-16
CL2008001920A1 (es)	2008-10-17
DE602004012154D1 (de)	2008-04-10
IS8474A (is)	2006-05-18
CN1894245A (zh)	2007-01-10
TNSN06186A1 (fr)	2007-11-15
NL1027787C2 (nl)	2006-03-09
DK1697356T3 (da)	2009-01-12
JP2007513996A (ja)	2007-05-31
AU2004303609A1 (en)	2005-07-07
SV2005001979A (es)	2005-12-13
ZA200604970B (en)	2007-11-28
PT1697356E (pt)	2008-05-05
RS50575B (sr)	2010-05-07
MA28270A1 (fr)	2006-11-01
NO20063231L (no)	2006-07-11
GEP20094720B (en)	2009-06-25
BRPI0417663A (pt)	2007-04-03
EP1697356A1 (en)	2006-09-06
AR046766A1 (es)	2005-12-21
PL1697356T3 (pl)	2008-07-31
JP4073944B2 (ja)	2008-04-09
ATE387446T1 (de)	2008-03-15
SI1697356T1 (sl)	2008-06-30

Publication	Publication Date	Title
NL1027787A1 (nl)	2005-06-21	Pyrido(2,3-d)pyrimidine-2,4-diaminen als PDE 2 remmers.
HK1093503A1 (en)	2007-03-02	Pyrido 2, 1-a-isoquinoline derivatives as ddp-IV inhibitors
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AP2005003353A0 (en)	2005-09-30	Diazepinoindole derivatives as kinase inhibitors.
HK1088893A1 (en)	2006-11-17	Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimidoÄ1,2-aÜ pyrimidin-4-one derivatives
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