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Application filed by Norwich Eaton Pharmaceuticals IncfiledCriticalNorwich Eaton Pharmaceuticals Inc
Publication of MY106321ApublicationCriticalpatent/MY106321A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Nitrogen Condensed Heterocyclic Rings
(AREA)
Abstract
ANTIMICROBIAL QUINOLONYL LACTAM COMPOUNDS COMPRISING A LACTAM - CONTAINING MOIETY LINKED, BY A NON- ESTER LINKING MOIETY, TO THE 3- CARBOXY GROUP OF A QUINOLONE MOIETY. THESE COMPOUNDS ARE OF THE FORMULA: WHEREIN (1) R3, R4, AND R5, TOGETHER WITH BONDS "A" AND "B", FORM ANY OF A VARIETY OF LACTAM- CONTAINING MOIETIES SIMILAR TO THOSE KNOWN IN THE ART TO HAVE ANTIMICROBIAL ACTIVITY;(2) A, R6. R7, AND R8 FORM ANY OF A VARIETY OF QUINOLONE OR NAPHTHYRIDINE STRUCTURES SIMILAR TO THOSE KNOWN IN THE ART TO HAVE ANTIMICROBIAL ACTIVITY; AND (3) Y, TOGETHER WITH R5, FORM A VARIETY OF NON-ESTER LINKING MOIETIES BETWEEN THE LACTAM-CONTAINING MOIETY AND THE QUINOLONE MOIETY.
1-substituted 7-bridged-diazabicyclo-alkyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acids,related compounds and antibacterial pharmaceutical compositions containing them