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MXPA06011629A - Derivados de diarilamina como bloqueadores del canal de calcio. - Google Patents

Derivados de diarilamina como bloqueadores del canal de calcio.

Info

Publication number
MXPA06011629A
MXPA06011629A MXPA06011629A MXPA06011629A MXPA06011629A MX PA06011629 A MXPA06011629 A MX PA06011629A MX PA06011629 A MXPA06011629 A MX PA06011629A MX PA06011629 A MXPA06011629 A MX PA06011629A MX PA06011629 A MXPA06011629 A MX PA06011629A
Authority
MX
Mexico
Prior art keywords
alkyl
membered aromatic
moiety
substituted
nonaromatic
Prior art date
Application number
MXPA06011629A
Other languages
English (en)
Inventor
Terrance P Snutch
Hassan Pajouhesh
Hossein Pajouhesh
Yanbing Ding
Original Assignee
Neuromed Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/821,584 external-priority patent/US20040259866A1/en
Application filed by Neuromed Pharmaceuticals Ltd filed Critical Neuromed Pharmaceuticals Ltd
Priority claimed from PCT/CA2005/000544 external-priority patent/WO2005097779A1/en
Publication of MXPA06011629A publication Critical patent/MXPA06011629A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se divulgan compuestos de piperazina/4-aminopiperidina sustituidos con N-diarilaminoalquilo de la formula (I), en donde cada uno de A y B es independientemente una porcion aromatica o no aromatica, carbociclica o heterociclica de 6 miembros o es un aminoalquilo y en donde uno y solamente uno de A y B puede ser H o alquilo de (1-8C) o en donde A y B conjuntamente forman una porcion aromatica o no aromatica, carbociclica o heterociclica de 6 miembros opcionalmente sustituida; R1 es H o alquilo de (1-8C), Z es N o CHNR2 en donde R2 es H o alquilo de (1-8C), X es alquileno de (1-4C) de cadena recta en donde opcionalmente por lo menos un carbono adyacente a un nitrogeno esta en la forma de C=O; cada R3 es un sustituyente independiente; n=0-2; Ar es un anillo aromatico o heteroaromatico de seis miembros; en donde cada porcion ciclica incluida en A o B y cada porcion Ar en la formula (I) puede ser sustituida por uno o mas sustituyentes. Estos compuestos y sales o conjugados de los mismos son capaces de bloquear los canales de calcio de tipo N y tipo T y son utiles para tratar condiciones mediadas por la actividad del canal de ion de calcio tal como dolor cronico.
MXPA06011629A 2004-04-09 2005-04-08 Derivados de diarilamina como bloqueadores del canal de calcio. MXPA06011629A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/821,584 US20040259866A1 (en) 1998-06-30 2004-04-09 Calcium channel blockers comprising two benzhydril moieties
US10/928,564 US20050227999A1 (en) 2004-04-09 2004-08-27 Diarylamine derivatives as calcium channel blockers
PCT/CA2005/000544 WO2005097779A1 (en) 2004-04-09 2005-04-08 Diarylamine derivatives as calcium channel blockers

Publications (1)

Publication Number Publication Date
MXPA06011629A true MXPA06011629A (es) 2007-06-12

Family

ID=35061374

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA06011629A MXPA06011629A (es) 2004-04-09 2005-04-08 Derivados de diarilamina como bloqueadores del canal de calcio.

Country Status (3)

Country Link
US (1) US20050227999A1 (es)
CN (1) CN1997641A (es)
MX (1) MXPA06011629A (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
CA2651811A1 (en) * 2006-05-11 2007-11-22 Neuromed Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
WO2008031227A1 (en) * 2006-09-14 2008-03-20 Neuromed Pharmaceuticals Ltd. Diaryl piperidine compounds as calcium channel blockers
EP2074105A4 (en) * 2006-10-13 2010-10-06 Neuromed Pharmaceuticals Ltd CYCLOPROPYL-PIPERAZINE COMPOUNDS AS CALCIUM INHIBITORS
TWI404716B (zh) * 2006-10-17 2013-08-11 Kudos Pharm Ltd 酞嗪酮（ｐｈｔｈａｌａｚｉｎｏｎｅ）衍生物
WO2008147864A2 (en) * 2007-05-22 2008-12-04 Xenon Pharmaceuticals Inc. Methods of using piperazine compounds in treating sodium channel-mediated diseases or conditions
JP5593229B2 (ja) * 2007-10-17 2014-09-17 クドス ファーマシューティカルズ リミテッド ４−［３−（４−シクロプロパンカルボニル−ピペラジン−１−カルボニル）−４−フルオロ−ベンジル］−２ｈ−フタラジン−１−オン
ES2598178T5 (es) 2008-10-07 2023-12-26 Kudos Pharm Ltd Formulación farmacéutica 514
MX2013010306A (es) 2011-03-08 2013-12-09 Zalicus Pharmaceuticals Ltd Formulaciones de dispersion solida y metodos de uso de las mismas.
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
CN103130745B (zh) * 2011-11-28 2017-03-15 中国人民解放军军事医学科学院毒物药物研究所 二芳基哌嗪类化合物及其医药用途
CN107525733B (zh) * 2017-08-09 2020-07-03 中国石油化工股份有限公司 井口井下腐蚀速率关联模型算法及使用此算法的井下腐蚀速率在线监测方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US147529A (en) * 1874-02-17 Improvement in adjustable hanger and loose-pulley attachments
US638787A (en) * 1898-10-15 1899-12-12 Albert Wolf Bucket-strainer.
GB1051527A (es) * 1964-07-31
US4188485A (en) * 1978-06-16 1980-02-12 G. D. Searle & Co. 1-[(10,11-Dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)methyl]-4-substituted piperidines and related compounds
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
FR2584723B1 (fr) * 1985-07-09 1988-02-12 Adir Nouveaux derives du dihydro-2,3 benzofuranne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
DE3600390A1 (de) * 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
US4782071A (en) * 1986-11-03 1988-11-01 Warner-Lambert Company Tetrasubstituted urea cholinergic agents
US5386025A (en) * 1990-02-20 1995-01-31 The Salk Institute Biotechnology/Industrial Associates Calcium channel compositions and methods
US5703071A (en) * 1990-08-29 1997-12-30 Pharmacia & Upjohn Company Tropolone derivatives and pharmaceutical composition thereof for preventing and treating ischemic diseases
TW205034B (es) * 1990-09-13 1993-05-01 Pola Kasei Kogyo Kk
DE4111861A1 (de) * 1991-04-11 1992-10-15 Schwabe Willmar Gmbh & Co Benzopyranone, verfahren zu ihrer herstellung und verwendung
US5344830A (en) * 1992-12-10 1994-09-06 Merck & Co., Inc. N,N-diacylpiperazine tachykinin antagonists
EP0682664B1 (en) * 1993-12-08 2001-03-14 Alcon Laboratories, Inc. Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents
US5623051A (en) * 1994-11-10 1997-04-22 University Of Washington Methods and compositions for screening for presynaptic calcium channel blockers
US6011035A (en) * 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
US6943168B2 (en) * 1998-06-30 2005-09-13 Neuromed Technologies Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6310059B1 (en) * 1998-06-30 2001-10-30 Neuromed Technologies, Inc. Fused ring calcium channel blockers
US6951862B2 (en) * 1998-06-30 2005-10-04 Neuromed Technologies, Inc. Calcium channel blockers comprising two benzhydril moieties
US6387897B1 (en) * 1998-06-30 2002-05-14 Neuromed Technologies, Inc. Preferentially substituted calcium channel blockers
US6492375B2 (en) * 1998-06-30 2002-12-10 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
WO2006024160A1 (en) * 2004-08-30 2006-03-09 Neuromed Pharmaceuticals Ltd. Urea derivatives as calcium channel blockers

Also Published As

Publication number Publication date
CN1997641A (zh) 2007-07-11
US20050227999A1 (en) 2005-10-13

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Legal Events

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