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MXPA06010673A - Reduccion del riesgo de anticuerpos humanos anti-humano a traves de manipulacion del gen v. - Google Patents

Reduccion del riesgo de anticuerpos humanos anti-humano a traves de manipulacion del gen v.

Info

Publication number
MXPA06010673A
MXPA06010673A MXPA06010673A MXPA06010673A MXPA06010673A MX PA06010673 A MXPA06010673 A MX PA06010673A MX PA06010673 A MXPA06010673 A MX PA06010673A MX PA06010673 A MXPA06010673 A MX PA06010673A MX PA06010673 A MXPA06010673 A MX PA06010673A
Authority
MX
Mexico
Prior art keywords
human
risk
reducing
methods
haha
Prior art date
Application number
MXPA06010673A
Other languages
English (en)
Inventor
Larry L Green
Sirid-Aimee Kellermann
Wouter Korver
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MXPA06010673A publication Critical patent/MXPA06010673A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invencion se refiere a los metodos para identificar y crear anticuerpos humanos o humanizados que poseen un riesgo reducido de inducir una respuesta de anticuerpo humano anti-humano (HAHA) cuando son aplicados a un hospedero humano. Otros metodos estan dirigidos a predecir la probabilidad de que ocurra una respuesta HAHA. Se incluyen tambien los metodos para seleccionar los compuestos anti-HAHA.
MXPA06010673A 2004-03-19 2005-03-17 Reduccion del riesgo de anticuerpos humanos anti-humano a traves de manipulacion del gen v. MXPA06010673A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55437204P 2004-03-19 2004-03-19
US57466104P 2004-05-24 2004-05-24
PCT/US2005/009306 WO2005092926A2 (en) 2004-03-19 2005-03-17 Reducing the risk of human and anti-human antibodies through v gene manipulation

Publications (1)

Publication Number Publication Date
MXPA06010673A true MXPA06010673A (es) 2007-06-20

Family

ID=35056783

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA06010673A MXPA06010673A (es) 2004-03-19 2005-03-17 Reduccion del riesgo de anticuerpos humanos anti-humano a traves de manipulacion del gen v.

Country Status (7)

Country Link
US (1) US20050260679A1 (es)
EP (2) EP2418224A3 (es)
JP (1) JP2008507257A (es)
AU (1) AU2005227313A1 (es)
CA (1) CA2564989C (es)
MX (1) MXPA06010673A (es)
WO (1) WO2005092926A2 (es)

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US10296720B2 (en) 2005-11-30 2019-05-21 Gearbox Llc Computational systems and methods related to nutraceuticals
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US7974856B2 (en) 2005-11-30 2011-07-05 The Invention Science Fund I, Llc Computational systems and methods related to nutraceuticals
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US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
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Also Published As

Publication number Publication date
CA2564989C (en) 2014-05-27
EP1729804A2 (en) 2006-12-13
AU2005227313A1 (en) 2005-10-06
US20050260679A1 (en) 2005-11-24
EP2418224A2 (en) 2012-02-15
WO2005092926A2 (en) 2005-10-06
EP2418224A3 (en) 2013-07-24
JP2008507257A (ja) 2008-03-13
CA2564989A1 (en) 2005-10-06
WO2005092926A3 (en) 2006-06-08

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