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MXPA05011522A - Derivatives of 2-acylamino-4-phenylthiazole, preparation method thereof and application of same in therapeutics. - Google Patents

Derivatives of 2-acylamino-4-phenylthiazole, preparation method thereof and application of same in therapeutics.

Info

Publication number
MXPA05011522A
MXPA05011522A MXPA05011522A MXPA05011522A MXPA05011522A MX PA05011522 A MXPA05011522 A MX PA05011522A MX PA05011522 A MXPA05011522 A MX PA05011522A MX PA05011522 A MXPA05011522 A MX PA05011522A MX PA05011522 A MXPA05011522 A MX PA05011522A
Authority
MX
Mexico
Prior art keywords
phenylthiazole
acylamino
therapeutics
derivatives
preparation
Prior art date
Application number
MXPA05011522A
Other languages
Spanish (es)
Inventor
Bernard Labeeuw
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MXPA05011522A publication Critical patent/MXPA05011522A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Abstract

The invention relates to derivatives of 2-acylamino-4-phenylthiazole, having general formula (I). The invention also relates to the preparation method thereof and to the application of same in therapeutics.
MXPA05011522A 2003-04-25 2004-04-22 Derivatives of 2-acylamino-4-phenylthiazole, preparation method thereof and application of same in therapeutics. MXPA05011522A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0305213A FR2854158B1 (en) 2003-04-25 2003-04-25 2-ACYLAMINO-4-PHENYLETHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
PCT/FR2004/000981 WO2004096798A2 (en) 2003-04-25 2004-04-22 Derivatives of 2-acylamino-4-phenylthiazole, preparation method thereof and use of same as chemokine antagonists

Publications (1)

Publication Number Publication Date
MXPA05011522A true MXPA05011522A (en) 2006-01-23

Family

ID=33104460

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05011522A MXPA05011522A (en) 2003-04-25 2004-04-22 Derivatives of 2-acylamino-4-phenylthiazole, preparation method thereof and application of same in therapeutics.

Country Status (24)

Country Link
US (2) US7504511B2 (en)
EP (1) EP1656373B1 (en)
JP (2) JP4839208B2 (en)
KR (1) KR20060006935A (en)
CN (1) CN1826339A (en)
AR (1) AR044070A1 (en)
AT (1) ATE541843T1 (en)
AU (1) AU2004234101A1 (en)
BR (1) BRPI0409716A (en)
CA (1) CA2521158A1 (en)
CO (1) CO5640106A2 (en)
CR (1) CR8037A (en)
EC (1) ECSP056111A (en)
FR (1) FR2854158B1 (en)
MA (1) MA27769A1 (en)
MX (1) MXPA05011522A (en)
NO (1) NO20054905L (en)
OA (1) OA13049A (en)
RS (1) RS20050769A (en)
RU (1) RU2348630C2 (en)
TN (1) TNSN05254A1 (en)
TW (1) TW200510325A (en)
WO (1) WO2004096798A2 (en)
ZA (1) ZA200508608B (en)

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JO2527B1 (en) * 2004-04-06 2010-03-17 شركة جانسين فارماسوتيكا ان. في Substiuted diaza-spiro-(5,5)-Deacan derivatives and there use as neurokinin antagonist
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US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
WO2007053495A2 (en) * 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
WO2007053498A1 (en) * 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
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CA2647448A1 (en) * 2006-04-12 2007-10-18 Pfizer Limited Pyrrolidine derivatives as modulators of chemokine ccr5 receptors
CN101096363B (en) 2006-06-27 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 2,4,5-three-substituted thiazole compound, preparation method, medicament composition and pharmacy use thereof
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US8754107B2 (en) 2006-11-17 2014-06-17 Abbvie Inc. Aminopyrrolidines as chemokine receptor antagonists
WO2008098949A2 (en) * 2007-02-13 2008-08-21 Ab Science Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors
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