MXPA05011183A - Sintesis de 2-hidroxi-n, n-dimetil- 3-[[2-[1(r) -(5-metil -2-furanil) propil]amino]-3, 4-dioxo-1 -ciclobuten-1 -il]amino] benzamida. - Google Patents
Sintesis de 2-hidroxi-n, n-dimetil- 3-[[2-[1(r) -(5-metil -2-furanil) propil]amino]-3, 4-dioxo-1 -ciclobuten-1 -il]amino] benzamida.Info
- Publication number
- MXPA05011183A MXPA05011183A MXPA05011183A MXPA05011183A MXPA05011183A MX PA05011183 A MXPA05011183 A MX PA05011183A MX PA05011183 A MXPA05011183 A MX PA05011183A MX PA05011183 A MXPA05011183 A MX PA05011183A MX PA05011183 A MXPA05011183 A MX PA05011183A
- Authority
- MX
- Mexico
- Prior art keywords
- amino
- cyclobuten
- dioxo
- benzamide
- furanyl
- Prior art date
Links
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describe un procedimiento para preparar el compuesto de formula I: (ver formula I) usando los compuestos de las formulas II, Q, y XI o XII: (ver formulas II, Q, Xl, XII) donde A se selecciona del grupo conformado por Br, Cl y I (con preferencia Br); y R representa alquilo de C1-C10; tambien se describen compuestos intermediarios que se preparan en el procedimiento que se describe.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46377303P | 2003-04-18 | 2003-04-18 | |
| PCT/US2004/011882 WO2004094398A2 (en) | 2003-04-18 | 2004-04-16 | Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05011183A true MXPA05011183A (es) | 2005-12-14 |
Family
ID=33310818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05011183A MXPA05011183A (es) | 2003-04-18 | 2004-04-16 | Sintesis de 2-hidroxi-n, n-dimetil- 3-[[2-[1(r) -(5-metil -2-furanil) propil]amino]-3, 4-dioxo-1 -ciclobuten-1 -il]amino] benzamida. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7071342B2 (es) |
| EP (2) | EP1615903B1 (es) |
| JP (2) | JP4440917B2 (es) |
| CN (3) | CN101514193B (es) |
| AR (1) | AR044027A1 (es) |
| AT (1) | ATE457307T1 (es) |
| CA (1) | CA2522748C (es) |
| DE (1) | DE602004025458D1 (es) |
| ES (1) | ES2338657T3 (es) |
| HK (1) | HK1078315A1 (es) |
| MX (1) | MXPA05011183A (es) |
| SG (1) | SG167671A1 (es) |
| WO (1) | WO2004094398A2 (es) |
| ZA (3) | ZA200508129B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| PL380997A1 (pl) * | 2004-01-30 | 2007-04-16 | Schering Corporation | Krystaliczne polimorfy liganda receptora chemokiny -CXC |
| PE20080368A1 (es) | 2006-06-12 | 2008-05-16 | Schering Corp | Sales y formulaciones de 2-hidroxi-n,n-dimetil-3-[[2-[[1(r)-5-metil-2-furanil)propil]amino]-3,4-dioxi-1-ciclobuteno-1-il]amino]benzamida como antagonista selectivo ya sea del receptor cxcr2 o ambos, cxcr1 y cxcr2 |
| CN101932553A (zh) * | 2007-07-03 | 2010-12-29 | 先灵公司 | 合成1,2-取代的3,4-二氧代-1-环丁烯化合物的方法和中间体 |
| JP2010532357A (ja) * | 2007-07-05 | 2010-10-07 | シェーリング コーポレイション | １，２−置換３，４−ジオキソ−１−シクロブテン化合物における制御された結晶サイズのための方法 |
| WO2011158959A1 (ja) | 2010-06-16 | 2011-12-22 | 帝人株式会社 | 環状カルボジイミド化合物の中間体の製造方法 |
| WO2012147897A1 (ja) * | 2011-04-25 | 2012-11-01 | 住友化学株式会社 | アミン化合物の製造方法 |
| TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
| TWI724056B (zh) | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Ｃｘｃｒ２抑制劑 |
| US11052065B2 (en) | 2017-09-27 | 2021-07-06 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer with a combination of programmed death receptor (PD-1) antibodies and a CXCR2 antagonist |
| CN111867579B (zh) | 2018-01-08 | 2023-11-24 | 凯莫森特里克斯股份有限公司 | Ccr6或cxcr2拮抗剂治疗泛发性脓疱型银屑病的方法 |
| TWI849253B (zh) * | 2019-11-11 | 2024-07-21 | 美商富曼西公司 | 用於製備3-溴-1- (3-氯吡啶-2-基) -1h-吡唑-5-羧酸乙酯的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2791613A (en) * | 1953-08-24 | 1957-05-07 | Columbia Southern Chem Corp | Metahaloaniline production using copper oxide-chromic oxide catalysts |
| CH691112A5 (de) | 1995-03-14 | 2001-04-30 | Sumitomo Chemical Co | Verfahren zur Herstellung von Kristallen eines Schwefelsäuresalzes des 3-Amino-2-hydroxyacetophenons mit hoher Schüttdiche und verbesserten Fliesseigenschaften . |
| ZA991105B (en) * | 1998-03-04 | 2000-02-11 | Searle & Co | Synthesis of chiral beta-amino acids. |
| JP2004529911A (ja) * | 2001-02-02 | 2004-09-30 | シェーリング コーポレイション | Ｃｘｃケモカインレセプターアンタゴニストとしての３，４−二置換シクロブテン−１，２−ジオン |
| US20030204085A1 (en) * | 2001-02-02 | 2003-10-30 | Taveras Arthur G. | 3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists |
| US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| IL158262A0 (en) * | 2001-04-16 | 2004-05-12 | Schering Corp | 3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands |
| MXPA04009127A (es) * | 2002-03-18 | 2005-01-25 | Schering Corp | Tratamiento de enfermedades mediadas por quimiocinas. |
-
2004
- 2004-04-16 CN CN2008101738953A patent/CN101514193B/zh not_active Expired - Fee Related
- 2004-04-16 AT AT04759956T patent/ATE457307T1/de not_active IP Right Cessation
- 2004-04-16 WO PCT/US2004/011882 patent/WO2004094398A2/en active Application Filing
- 2004-04-16 EP EP04759956A patent/EP1615903B1/en not_active Expired - Lifetime
- 2004-04-16 CA CA2522748A patent/CA2522748C/en not_active Expired - Fee Related
- 2004-04-16 MX MXPA05011183A patent/MXPA05011183A/es active IP Right Grant
- 2004-04-16 JP JP2006501278A patent/JP4440917B2/ja not_active Expired - Fee Related
- 2004-04-16 US US10/826,456 patent/US7071342B2/en not_active Expired - Lifetime
- 2004-04-16 DE DE602004025458T patent/DE602004025458D1/de not_active Expired - Lifetime
- 2004-04-16 AR ARP040101294A patent/AR044027A1/es not_active Application Discontinuation
- 2004-04-16 CN CNB2004800165225A patent/CN100448860C/zh not_active Expired - Fee Related
- 2004-04-16 ES ES04759956T patent/ES2338657T3/es not_active Expired - Lifetime
- 2004-04-16 SG SG200717017-8A patent/SG167671A1/en unknown
- 2004-04-16 CN CN200810173891.5A patent/CN101514168B/zh not_active Expired - Fee Related
- 2004-04-16 EP EP09014248.0A patent/EP2168956B8/en not_active Expired - Lifetime
-
2005
- 2005-10-07 ZA ZA200508129A patent/ZA200508129B/en unknown
-
2006
- 2006-01-23 HK HK06101053.6A patent/HK1078315A1/xx not_active IP Right Cessation
- 2006-05-09 US US11/430,687 patent/US7462740B2/en not_active Expired - Lifetime
-
2008
- 2008-01-16 ZA ZA200800486A patent/ZA200800486B/en unknown
- 2008-01-16 ZA ZA200800487A patent/ZA200800487B/en unknown
- 2008-10-17 US US12/253,356 patent/US7910775B2/en active Active
-
2009
- 2009-12-01 JP JP2009273993A patent/JP5202503B2/ja not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| HC | Change of company name or juridical status |