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MXPA05011059A - Compuestos de amonio cuaternario y su uso como agentes antimuscarinicos. - Google Patents

Compuestos de amonio cuaternario y su uso como agentes antimuscarinicos.

Info

Publication number
MXPA05011059A
MXPA05011059A MXPA05011059A MXPA05011059A MXPA05011059A MX PA05011059 A MXPA05011059 A MX PA05011059A MX PA05011059 A MXPA05011059 A MX PA05011059A MX PA05011059 A MXPA05011059 A MX PA05011059A MX PA05011059 A MXPA05011059 A MX PA05011059A
Authority
MX
Mexico
Prior art keywords
quaternary ammonium
ammonium compounds
antimuscarinic agents
treatment
compounds
Prior art date
Application number
MXPA05011059A
Other languages
English (en)
Inventor
Sergey Gregory Wolfson
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of MXPA05011059A publication Critical patent/MXPA05011059A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/66—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with quaternised amino groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Nuevos compuestos de amonio cuaternario de la formula (ver formula) y cualquiera de sus estereoisomeros, en la que R1, R2, R3, R4, R5, R6, R7, y X° se definen en esta el presente documento; los compuestos son utiles como medicamentos para el tratamiento de asma, un grupo de trastornos respiratorios denominado enfermedad pulmonar obstructiva cronica (COPD), rinitis alergica, rinorrea debida al catarro comun, y trastorno urinario.
MXPA05011059A 2003-04-15 2004-04-13 Compuestos de amonio cuaternario y su uso como agentes antimuscarinicos. MXPA05011059A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46295603P 2003-04-15 2003-04-15
PCT/IB2004/001290 WO2004091607A1 (en) 2003-04-15 2004-04-13 Quaternary ammonium compounds and their use as antimuscarinic agents

Publications (1)

Publication Number Publication Date
MXPA05011059A true MXPA05011059A (es) 2005-12-12

Family

ID=33300019

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05011059A MXPA05011059A (es) 2003-04-15 2004-04-13 Compuestos de amonio cuaternario y su uso como agentes antimuscarinicos.

Country Status (7)

Country Link
US (1) US20040242569A1 (es)
EP (1) EP1622606A1 (es)
JP (1) JP2006523676A (es)
BR (1) BRPI0409370A (es)
CA (1) CA2522102A1 (es)
MX (1) MXPA05011059A (es)
WO (1) WO2004091607A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2341952A1 (en) * 2001-03-23 2002-09-23 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory pulmonary diseases
US20050130990A1 (en) * 2001-03-23 2005-06-16 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory diseases
ES2315425T3 (es) * 2001-10-26 2009-04-01 PHARMACIA & UPJOHN COMPANY LLC Compuestos de amonio cuaternario y su uso como agentes antimuscarinicos.
US8557804B2 (en) 2002-03-25 2013-10-15 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory diseases
US8039459B2 (en) 2004-07-15 2011-10-18 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory diseases
US20080045602A1 (en) * 2004-12-24 2008-02-21 Casar Renata T Process for Preparation of 3-(2-Hydroxy-5Methylphenyl)-N, N-Disopropyl-3-Phenylpropylamine
CN110372571B (zh) 2018-04-12 2022-11-15 中国科学院大连化学物理研究所 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6717123A (es) * 1966-12-29 1968-07-01
US3505337A (en) * 1967-12-22 1970-04-07 Boehringer Sohn Ingelheim N - hydrocarbyl-substituted noratropinium,haloalkylates and o-acyl derivatives thereof
US5382600A (en) * 1988-01-22 1995-01-17 Pharmacia Aktiebolag 3,3-diphenylpropylamines and pharmaceutical compositions thereof
IL91377A (en) * 1988-09-14 1996-09-12 Nippon Shinyaku Co Ltd Derivatives of botinylamine glycolate
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
PE20020547A1 (es) * 2000-10-24 2002-06-12 Upjohn Co Uso de la tolterodina en tratamientos del asma
US20020169208A1 (en) * 2001-04-03 2002-11-14 Pascal Druzgala Novel anticholinergic compounds and methods of use
ES2315425T3 (es) * 2001-10-26 2009-04-01 PHARMACIA & UPJOHN COMPANY LLC Compuestos de amonio cuaternario y su uso como agentes antimuscarinicos.

Also Published As

Publication number Publication date
JP2006523676A (ja) 2006-10-19
EP1622606A1 (en) 2006-02-08
WO2004091607A1 (en) 2004-10-28
US20040242569A1 (en) 2004-12-02
CA2522102A1 (en) 2004-10-28
BRPI0409370A (pt) 2006-04-25

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal