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MXPA05007885A - Soluciones de hemoglobina polimerizada que tienen cantidad reducida de tetramero y metodo para prepararlas. - Google Patents

Soluciones de hemoglobina polimerizada que tienen cantidad reducida de tetramero y metodo para prepararlas.

Info

Publication number
MXPA05007885A
MXPA05007885A MXPA05007885A MXPA05007885A MXPA05007885A MX PA05007885 A MXPA05007885 A MX PA05007885A MX PA05007885 A MXPA05007885 A MX PA05007885A MX PA05007885 A MXPA05007885 A MX PA05007885A MX PA05007885 A MXPA05007885 A MX PA05007885A
Authority
MX
Mexico
Prior art keywords
tetramer
preparing
reduced amount
polymerized hemoglobin
hemoglobin solutions
Prior art date
Application number
MXPA05007885A
Other languages
English (en)
Inventor
D Doubleday Marc
Original Assignee
Northfield Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northfield Lab filed Critical Northfield Lab
Publication of MXPA05007885A publication Critical patent/MXPA05007885A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invencion se refiere a una solucion de hemoglobina sustancialmente libre de tetramero y a un metodo para producir una solucion de hemoglobina sustancialmente libre de tetramero. El metodo incluye polimerizar una solucion de hemoglobina, tratar la solucion de hemoglobina polimerizada para degradar parcialmente el polimero a tetramero y remover el tetramero de la solucion de hemoglobina.
MXPA05007885A 2003-01-29 2004-01-29 Soluciones de hemoglobina polimerizada que tienen cantidad reducida de tetramero y metodo para prepararlas. MXPA05007885A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44343603P 2003-01-29 2003-01-29
PCT/US2004/002512 WO2004066953A2 (en) 2003-01-29 2004-01-29 Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing

Publications (1)

Publication Number Publication Date
MXPA05007885A true MXPA05007885A (es) 2005-09-21

Family

ID=32825331

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05007885A MXPA05007885A (es) 2003-01-29 2004-01-29 Soluciones de hemoglobina polimerizada que tienen cantidad reducida de tetramero y metodo para prepararlas.

Country Status (14)

Country Link
US (2) US7135553B2 (es)
EP (1) EP1592437A4 (es)
JP (1) JP2006516994A (es)
KR (1) KR20050095636A (es)
CN (1) CN100431602C (es)
AU (1) AU2004207595B2 (es)
BR (1) BRPI0407106A (es)
CA (1) CA2512169A1 (es)
MX (1) MXPA05007885A (es)
NO (1) NO20053745L (es)
NZ (1) NZ541340A (es)
RU (1) RU2337705C2 (es)
WO (1) WO2004066953A2 (es)
ZA (1) ZA200505814B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006516994A (ja) * 2003-01-29 2006-07-13 ノースフィールド ラボラトリーズ、インコーポレイテッド テトラマーの量を低下させた重合ヘモグロビン溶液及び調製するための方法
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
JP2009524436A (ja) * 2006-01-24 2009-07-02 ノースフィールド ラボラトリーズ、インコーポレイテッド 重合したヘモグロビンの培地、並びに島細胞の単離及び移植におけるその使用
RU2361608C1 (ru) * 2008-03-18 2009-07-20 Общество С Ограниченной Ответственностью "Научно-Производственная Компания "Медбиофарм" Кровезаменитель с функцией переноса кислорода, фармацевтическая композиция (варианты)
US8273857B2 (en) 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
US7989593B1 (en) 2010-05-27 2011-08-02 Bing Lou Wong Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
US8048856B1 (en) 2010-06-23 2011-11-01 Billion King, Ltd. Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
US7932356B1 (en) 2010-06-23 2011-04-26 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition
US8889830B2 (en) 2011-03-01 2014-11-18 Chuo University Hemoglobin-albumin complex, and artificial plasma expander and artificial oxygen carrier containing the complex
US8084581B1 (en) 2011-04-29 2011-12-27 Bing Lou Wong Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus
US20130052232A1 (en) 2011-08-31 2013-02-28 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
CN103690978B (zh) * 2013-12-19 2017-01-25 陕西佰美基因股份有限公司 一种用于血红蛋白及血红蛋白氧载体灭活病毒的方法
JP7016124B2 (ja) 2016-07-06 2022-02-04 学校法人 中央大学 虚血性疾患の治療剤
JP7387597B2 (ja) 2017-07-18 2023-11-28 ヴァーテック・バイオ・インコーポレイテッド ヘモグロビンを含む代用血液及び作製方法
JP2021134199A (ja) * 2020-02-28 2021-09-13 学校法人 中央大学 ヘモグロビン微粒子及び人工酸素運搬体

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US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4001200A (en) * 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
US4061736A (en) * 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
US4053590A (en) * 1975-02-27 1977-10-11 Alza Corporation Compositions of matter comprising macromolecular hemoglobin
US4136093A (en) * 1976-04-23 1979-01-23 Biotest-Serum-Institut Gmbh Hemoglobin preparation with increased oxygen release
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Also Published As

Publication number Publication date
AU2004207595B2 (en) 2009-02-05
NZ541340A (en) 2008-04-30
US7135553B2 (en) 2006-11-14
AU2004207595A1 (en) 2004-08-12
US20060287222A1 (en) 2006-12-21
RU2337705C2 (ru) 2008-11-10
WO2004066953A2 (en) 2004-08-12
RU2005127050A (ru) 2006-01-20
BRPI0407106A (pt) 2006-01-24
EP1592437A4 (en) 2007-12-26
NO20053745L (no) 2005-10-03
US20040186047A1 (en) 2004-09-23
EP1592437A2 (en) 2005-11-09
CA2512169A1 (en) 2004-08-12
WO2004066953A3 (en) 2005-04-07
NO20053745D0 (no) 2005-08-04
JP2006516994A (ja) 2006-07-13
US7411044B2 (en) 2008-08-12
KR20050095636A (ko) 2005-09-29
CN100431602C (zh) 2008-11-12
CN1741813A (zh) 2006-03-01
ZA200505814B (en) 2006-05-31

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