MXPA05007181A - Cristales de la hormona de crecimiento humano y metodos para prepararlos. - Google Patents
Cristales de la hormona de crecimiento humano y metodos para prepararlos.Info
- Publication number
- MXPA05007181A MXPA05007181A MXPA05007181A MXPA05007181A MXPA05007181A MX PA05007181 A MXPA05007181 A MX PA05007181A MX PA05007181 A MXPA05007181 A MX PA05007181A MX PA05007181 A MXPA05007181 A MX PA05007181A MX PA05007181 A MXPA05007181 A MX PA05007181A
- Authority
- MX
- Mexico
- Prior art keywords
- growth hormone
- human growth
- crystals
- methods
- preparing
- Prior art date
Links
- 102000002265 Human Growth Hormone Human genes 0.000 title abstract 5
- 108010000521 Human Growth Hormone Proteins 0.000 title abstract 5
- 239000000854 Human Growth Hormone Substances 0.000 title abstract 5
- 239000013078 crystal Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 5
- 238000009472 formulation Methods 0.000 abstract 2
- 206010056438 Growth hormone deficiency Diseases 0.000 abstract 1
- 230000001668 ameliorated effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000013265 extended release Methods 0.000 abstract 1
- 229940121366 growth hormone derivative Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- AIDS & HIV (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
Abstract
La presente invencion se relaciona con cristales de liberacion prolongada, estables, de la hormona de crecimiento humano o un derivado de la hormona de crecimiento humano y las composiciones o formulaciones que comprenden estos cristales. La invencion tambien proporciona los metodos para producir esos cristales y composiciones. La invencion tambien proporciona los metodos para el tratamiento de un individuo que padece trastornos asociados con la deficiencia de la hormona de crecimiento humano o que se mejoran mediante el tratamiento con la hormona de crecimiento humano utilizando esos cristales y composiciones o formulaciones.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43751902P | 2002-12-31 | 2002-12-31 | |
US51704203P | 2003-11-03 | 2003-11-03 | |
PCT/US2003/041545 WO2004060310A2 (en) | 2002-12-31 | 2003-12-31 | Human growth hormone crystals and methods for preparing them |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05007181A true MXPA05007181A (es) | 2006-04-07 |
Family
ID=32717908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05007181A MXPA05007181A (es) | 2002-12-31 | 2003-12-31 | Cristales de la hormona de crecimiento humano y metodos para prepararlos. |
Country Status (12)
Country | Link |
---|---|
US (1) | US9376479B2 (es) |
EP (2) | EP1581251B1 (es) |
JP (2) | JP4686361B2 (es) |
KR (1) | KR20050090430A (es) |
AU (2) | AU2003303646B2 (es) |
BR (1) | BR0317888A (es) |
CA (1) | CA2512052C (es) |
DK (1) | DK1581251T3 (es) |
MX (1) | MXPA05007181A (es) |
RU (1) | RU2357750C2 (es) |
SG (1) | SG176314A1 (es) |
WO (1) | WO2004060310A2 (es) |
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CA2512001A1 (en) * | 2002-12-31 | 2004-07-22 | Altus Pharmaceuticals Inc. | Complexes of protein crystals and ionic polymers |
DK1581251T3 (da) | 2002-12-31 | 2016-06-27 | Althea Tech Inc | Krystaller af humant væksthormon og fremgangsmåder til fremstilling deraf |
US20090029911A1 (en) * | 2003-09-25 | 2009-01-29 | Ashley Martin Williams | Liquid Human Growth Hormone Formulation Containing Polyethylene Glycol |
US8728525B2 (en) | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
EP1888117A1 (en) * | 2005-05-25 | 2008-02-20 | Novo Nordisk A/S | Stabilized polypeptide formulations |
EP1888118B1 (en) | 2005-05-25 | 2016-08-17 | Novo Nordisk A/S | Polypeptide formulations stabilized with ethylenediamine |
CA2634053A1 (en) * | 2005-12-23 | 2007-07-05 | Altus Pharmaceuticals Inc. | Compositions comprising polycation-complexed protein crystals and methods of treatment using them |
US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
EP2647712A3 (en) | 2006-08-04 | 2013-11-20 | Baxter International Inc | Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes |
CA2661521C (en) * | 2006-08-31 | 2016-04-12 | Novartis Ag | Pharmaceutical compositions comprising hgh for oral delivery |
WO2008076819A2 (en) * | 2006-12-18 | 2008-06-26 | Altus Pharmaceuticals Inc. | Human growth hormone formulations |
WO2008102469A1 (ja) * | 2007-02-23 | 2008-08-28 | Kwansei Gakuin Educational Foundation | 蛋白質結晶化剤および蛋白質結晶化剤を用いた蛋白質結晶化方法 |
EP2078091A4 (en) * | 2007-07-10 | 2010-09-01 | Medimmune Llc | CRYSTALS AND STRUCTURE OF THE VARIANT OF IGG FC HUMAN |
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US8323615B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
US8367427B2 (en) | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8323685B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
RU2734236C2 (ru) * | 2009-02-25 | 2020-10-13 | Софткемо Фарма Корп. | Композиции бендамустина и циклополисахарида |
US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
WO2013075068A1 (en) | 2011-11-18 | 2013-05-23 | Regeneron Pharmaceuticals, Inc. | Polymer protein microparticles |
US20150158926A1 (en) * | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
EP3064213A4 (en) * | 2013-10-28 | 2017-04-26 | Terumo Kabushiki Kaisha | Protein aqueous suspension |
PL3310347T3 (pl) | 2015-06-19 | 2021-12-27 | Opko Biologics Ltd. | Długo działające czynniki krzepnięcia i sposoby wytwarzania |
MX2018004695A (es) * | 2015-10-16 | 2019-03-14 | Regeneron Pharma | Composiciones de proteinas estables. |
EP3481855B1 (en) | 2016-07-11 | 2023-09-06 | OPKO Biologics Ltd. | Long-acting coagulation factor vii and methods of producing same |
JP7104929B2 (ja) * | 2017-07-24 | 2022-07-22 | テルモ株式会社 | 医療用タンパク質とポリアミノ酸とを含む複合体の製造方法および医療用タンパク質とポリアミノ酸とを含む複合体 |
US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
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2003
- 2003-12-31 DK DK03808602.1T patent/DK1581251T3/da active
- 2003-12-31 EP EP03808602.1A patent/EP1581251B1/en not_active Expired - Lifetime
- 2003-12-31 MX MXPA05007181A patent/MXPA05007181A/es unknown
- 2003-12-31 SG SG2007165756A patent/SG176314A1/en unknown
- 2003-12-31 CA CA2512052A patent/CA2512052C/en not_active Expired - Fee Related
- 2003-12-31 RU RU2005124280/15A patent/RU2357750C2/ru not_active IP Right Cessation
- 2003-12-31 BR BR0317888-9A patent/BR0317888A/pt not_active IP Right Cessation
- 2003-12-31 US US10/749,962 patent/US9376479B2/en not_active Expired - Lifetime
- 2003-12-31 WO PCT/US2003/041545 patent/WO2004060310A2/en active Application Filing
- 2003-12-31 JP JP2005508635A patent/JP4686361B2/ja not_active Expired - Fee Related
- 2003-12-31 EP EP11168985A patent/EP2460530A3/en not_active Withdrawn
- 2003-12-31 KR KR1020057012348A patent/KR20050090430A/ko not_active Application Discontinuation
- 2003-12-31 AU AU2003303646A patent/AU2003303646B2/en not_active Ceased
-
2010
- 2010-04-05 JP JP2010087407A patent/JP2010209079A/ja active Pending
- 2010-05-17 AU AU2010201961A patent/AU2010201961A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2004060310A3 (en) | 2004-12-09 |
EP1581251B1 (en) | 2016-03-16 |
AU2010201961A1 (en) | 2010-06-03 |
EP2460530A2 (en) | 2012-06-06 |
DK1581251T3 (da) | 2016-06-27 |
US20040209804A1 (en) | 2004-10-21 |
EP1581251A2 (en) | 2005-10-05 |
SG176314A1 (en) | 2011-12-29 |
AU2003303646A1 (en) | 2004-07-29 |
CA2512052C (en) | 2016-06-21 |
JP4686361B2 (ja) | 2011-05-25 |
KR20050090430A (ko) | 2005-09-13 |
JP2006512416A (ja) | 2006-04-13 |
RU2005124280A (ru) | 2006-01-20 |
EP2460530A3 (en) | 2012-08-29 |
RU2357750C2 (ru) | 2009-06-10 |
BR0317888A (pt) | 2005-12-06 |
WO2004060310A2 (en) | 2004-07-22 |
US9376479B2 (en) | 2016-06-28 |
JP2010209079A (ja) | 2010-09-24 |
CA2512052A1 (en) | 2004-07-22 |
EP1581251A4 (en) | 2009-03-04 |
AU2003303646B2 (en) | 2010-03-04 |
WO2004060310A8 (en) | 2005-06-02 |
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