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MXPA05002014A - Acidos nucleicos inmunoestimuladores. - Google Patents

Acidos nucleicos inmunoestimuladores.

Info

Publication number
MXPA05002014A
MXPA05002014A MXPA05002014A MXPA05002014A MXPA05002014A MX PA05002014 A MXPA05002014 A MX PA05002014A MX PA05002014 A MXPA05002014 A MX PA05002014A MX PA05002014 A MXPA05002014 A MX PA05002014A MX PA05002014 A MXPA05002014 A MX PA05002014A
Authority
MX
Mexico
Prior art keywords
nucleic acids
immunostimulatory nucleic
soft
stimulating
semi
Prior art date
Application number
MXPA05002014A
Other languages
English (en)
Inventor
Arthur M Krieg
Original Assignee
Coley Pharm Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharm Group Inc filed Critical Coley Pharm Group Inc
Publication of MXPA05002014A publication Critical patent/MXPA05002014A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P11/08—Bronchodilators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

La invencion se refiere a una clase de oligonucleotidos inmunoestimuladores CpG suaves y semi-suaves que son utiles para estimular una respuesta inmune.
MXPA05002014A 2002-08-19 2003-08-19 Acidos nucleicos inmunoestimuladores. MXPA05002014A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40447902P 2002-08-19 2002-08-19
US40482002P 2002-08-19 2002-08-19
US42970102P 2002-11-27 2002-11-27
US44737703P 2003-02-14 2003-02-14
PCT/US2003/025935 WO2004016805A2 (en) 2002-08-19 2003-08-19 Immunostimulatory nucleic acids

Publications (1)

Publication Number Publication Date
MXPA05002014A true MXPA05002014A (es) 2005-10-19

Family

ID=31892263

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05002014A MXPA05002014A (es) 2002-08-19 2003-08-19 Acidos nucleicos inmunoestimuladores.

Country Status (27)

Country Link
US (2) US8283328B2 (es)
EP (2) EP2290078B1 (es)
JP (2) JP5414961B2 (es)
KR (2) KR20080011247A (es)
AR (1) AR040996A1 (es)
AU (2) AU2003259916B2 (es)
BR (1) BR0313414A (es)
CA (1) CA2493753C (es)
DK (2) DK2290078T3 (es)
EC (1) ECSP055687A (es)
ES (2) ES2634328T3 (es)
HU (2) HUE035336T2 (es)
IL (1) IL166376A (es)
MA (1) MA27468A1 (es)
MX (1) MXPA05002014A (es)
NO (1) NO20051469L (es)
NZ (2) NZ560722A (es)
OA (1) OA12906A (es)
PE (2) PE20040900A1 (es)
PL (2) PL232260B1 (es)
PT (2) PT2290078T (es)
RS (1) RS20050126A (es)
SI (1) SI2290078T1 (es)
SV (1) SV2008001602A (es)
TW (1) TW200412981A (es)
UY (1) UY27945A1 (es)
WO (1) WO2004016805A2 (es)

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