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MXPA04005766A - Metodo para la preparacion del escitalopram. - Google Patents

Metodo para la preparacion del escitalopram.

Info

Publication number
MXPA04005766A
MXPA04005766A MXPA04005766A MXPA04005766A MXPA04005766A MX PA04005766 A MXPA04005766 A MX PA04005766A MX PA04005766 A MXPA04005766 A MX PA04005766A MX PA04005766 A MXPA04005766 A MX PA04005766A MX PA04005766 A MXPA04005766 A MX PA04005766A
Authority
MX
Mexico
Prior art keywords
preparation
escitalopram
intermediates
cyanation
formulas
Prior art date
Application number
MXPA04005766A
Other languages
English (en)
Inventor
Ahmadian Haleh
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of MXPA04005766A publication Critical patent/MXPA04005766A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Amplifiers (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)

Abstract

La invencion se refiere a un metodo para la preparacion del escitalopram por cianacion de compuestos intermedios opticamente activos, de las formulas (III) y (II) debajo, y a la preparacion de dichos compuestos intermedios por resolucion optica.
MXPA04005766A 2001-12-14 2002-12-09 Metodo para la preparacion del escitalopram. MXPA04005766A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34045001P 2001-12-14 2001-12-14
DKPA200101881 2001-12-14
PCT/DK2002/000837 WO2003051861A1 (en) 2001-12-14 2002-12-09 Method for the preparation of escitalopram

Publications (1)

Publication Number Publication Date
MXPA04005766A true MXPA04005766A (es) 2004-09-10

Family

ID=34072369

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04005766A MXPA04005766A (es) 2001-12-14 2002-12-09 Metodo para la preparacion del escitalopram.

Country Status (22)

Country Link
US (1) US20050154051A1 (es)
EP (1) EP1458701A1 (es)
JP (1) JP2005513069A (es)
KR (1) KR20040073463A (es)
CN (1) CN1602305A (es)
AR (1) AR037795A1 (es)
AU (1) AU2002351726A1 (es)
BR (1) BR0214327A (es)
CA (1) CA2470225A1 (es)
CO (1) CO5590910A2 (es)
EA (1) EA200400809A1 (es)
HR (1) HRP20040390A2 (es)
HU (1) HUP0402252A3 (es)
IL (1) IL161714A0 (es)
IS (1) IS7239A (es)
MX (1) MXPA04005766A (es)
NO (1) NO20042667L (es)
PL (1) PL368986A1 (es)
RS (1) RS50704A (es)
TW (1) TW200409625A (es)
WO (1) WO2003051861A1 (es)
ZA (1) ZA200403432B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
ES2228274B1 (es) * 2003-09-24 2006-06-01 Astur Pharma, S.A. Sintesis quimioenzimatica de (+)-citalopram y (-)-citalopram.
WO2005047274A1 (en) * 2003-11-12 2005-05-26 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
US20050196453A1 (en) 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
ITMI20040717A1 (it) 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
JP2006008603A (ja) * 2004-06-25 2006-01-12 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
US7989645B2 (en) 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
DE05815687T1 (de) 2004-08-23 2007-10-18 Sun Pharmaceutical Industries Ltd. Verfahren zur herstellung von citalopram und enantiomeren
WO2006025071A1 (en) * 2004-09-02 2006-03-09 Natco Pharma Limited A process for the preparation of escitalopram
EP1877394A1 (en) * 2005-04-04 2008-01-16 Jubilant Organosys Limited Process for the preparation of escitalopram or its acid addition salts
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en) 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
WO2007012954A1 (en) * 2005-07-27 2007-02-01 Aurobindo Pharma Limited An improved process for the preparation of escitalopram
BRPI0617382A2 (pt) 2005-10-14 2017-07-11 H Lundbeck As Métodos para tratar um distúrbio do sistema nervoso central em um paciente, para tratar um paciente sofrendo de condições e uma disfunção sexual, e para reduzir um retardo na eficácia terapêutica em seguida ao início do tratamento
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram
NZ570884A (en) * 2007-09-11 2010-03-26 Lundbeck & Co As H Fractionally crystallising 4-[4-(dimethyl amino)-1-(4'-fluorophenyl)-1-hydroxybutyI]-3-(hydroxymethyl)-benzonitrile and manufacturing escitalopram therefrom
US8022232B2 (en) 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE1042310T1 (de) * 1997-11-11 2001-04-19 Lundbeck & Co As H Verfahren zur herstellung von citaloprame
ATE230738T1 (de) * 1998-10-20 2003-01-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
IL145615A0 (en) * 1999-04-14 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
DE60108105T2 (de) * 2001-08-02 2005-12-08 Infosint Sa Verfahren zur Herstellung von 5-substituierten Isobenzofuranen

Also Published As

Publication number Publication date
CO5590910A2 (es) 2005-12-30
WO2003051861A1 (en) 2003-06-26
ZA200403432B (en) 2005-05-06
EP1458701A1 (en) 2004-09-22
AU2002351726A1 (en) 2003-06-30
HUP0402252A3 (en) 2007-05-29
JP2005513069A (ja) 2005-05-12
RS50704A (en) 2007-02-05
IS7239A (is) 2004-04-29
HRP20040390A2 (en) 2004-08-31
KR20040073463A (ko) 2004-08-19
TW200409625A (en) 2004-06-16
PL368986A1 (en) 2005-04-04
CN1602305A (zh) 2005-03-30
CA2470225A1 (en) 2003-06-26
BR0214327A (pt) 2004-11-03
AR037795A1 (es) 2004-12-01
HUP0402252A2 (hu) 2005-02-28
US20050154051A1 (en) 2005-07-14
IL161714A0 (en) 2004-09-27
NO20042667L (no) 2004-06-24
EA200400809A1 (ru) 2004-12-30

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal