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MXPA04003729A - Compuestos de 4-imidazolin-2-ona. - Google Patents

Compuestos de 4-imidazolin-2-ona.

Info

Publication number
MXPA04003729A
MXPA04003729A MXPA04003729A MXPA04003729A MXPA04003729A MX PA04003729 A MXPA04003729 A MX PA04003729A MX PA04003729 A MXPA04003729 A MX PA04003729A MX PA04003729 A MXPA04003729 A MX PA04003729A MX PA04003729 A MXPA04003729 A MX PA04003729A
Authority
MX
Mexico
Prior art keywords
optionally substituted
alkyl
hydrogen
halogeno
general formula
Prior art date
Application number
MXPA04003729A
Other languages
English (en)
Inventor
Hajime Hiramatsu
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of MXPA04003729A publication Critical patent/MXPA04003729A/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)

Abstract

La presente invencion se relaciona con un compuesto de la formula :(ver formula (I):En donde G1 es un alquilo, el cual puede estar sustituido por un atomo de halogeno o un alcoxi, o un grupo de la formula:(ver formula:)en donde el anillo B es un anillo de benceno, el cual puede estar sustituido, etc., Q1 y Q2 pueden ser los mismos o diferentes, y cada uno es un atomo de hidrogeno, un atomo de halogeno o un alquilo, n es 0, 1, 2, 3, ò 4, R1 es un atomo de hidrogeno, un alquilo el cual puede estar sustituido, un cicloalquilo el cual puede estar sustituido, un fenilo el cual puede estar sustituido, etc., Z1,Z2,Z3 y Z4 pueden ser los mismos o diferentes, y cada uno es CH o N, con la condicion de que 3 o mas de Z1,Z2,Z3 y Z4 no deben ser N al mismo tiempo, G2 es un atomo de hidrogeno, -NR3R4, -OR5, etc., en donde R3 a R8 cada uno es, de manera independiente un atomo de hidrogeno, un alquilo el cual puede estar sustituido, un alquenilo, un alquinilo, etc., o una sal farmaceutica mente aceptable de los mismos.
MXPA04003729A 2001-10-22 2002-10-22 Compuestos de 4-imidazolin-2-ona. MXPA04003729A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001324029 2001-10-22
JP2002263680 2002-09-10
PCT/JP2002/010937 WO2003035638A1 (fr) 2001-10-22 2002-10-22 Composes de 4-imidazolin-2-one

Publications (1)

Publication Number Publication Date
MXPA04003729A true MXPA04003729A (es) 2004-07-23

Family

ID=26624024

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04003729A MXPA04003729A (es) 2001-10-22 2002-10-22 Compuestos de 4-imidazolin-2-ona.

Country Status (16)

Country Link
EP (1) EP1439174B1 (es)
JP (1) JP4432492B2 (es)
KR (1) KR100742058B1 (es)
CN (1) CN100402521C (es)
AT (1) ATE550332T1 (es)
BR (1) BR0213465A (es)
CA (1) CA2461100C (es)
HU (1) HUP0401949A3 (es)
IL (2) IL160874A0 (es)
MX (1) MXPA04003729A (es)
MY (1) MY147948A (es)
NO (1) NO20042010L (es)
PH (1) PH12009500610A1 (es)
PL (1) PL210470B1 (es)
TW (1) TWI329642B (es)
WO (1) WO2003035638A1 (es)

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US7473695B2 (en) * 2001-10-22 2009-01-06 Mitsubishi Tanabe Pharma Corporation 4-imidazolin-2-one compounds
US20050197350A1 (en) * 2003-03-31 2005-09-08 Taisho Pharmaceutical Co., Ltd. Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof
PL1628968T3 (pl) * 2003-04-21 2011-09-30 Mitsubishi Tanabe Pharma Corp Związki 4-imidazolino-2-onu
MXPA06012512A (es) * 2004-04-28 2007-02-08 Tanabe Seiyaku Co Compuesto heterociclico.
TWI326282B (en) * 2004-04-28 2010-06-21 Mitsubishi Tanabe Pharma Corp Heterocyclic compound
AU2005318419A1 (en) * 2004-12-23 2006-06-29 Chiesi Farmaceutici S.P.A. Azole derivatives with antimuscarinic activity
EP1849761A1 (en) * 2005-02-02 2007-10-31 Ajinomoto Co., Inc. Process for production of 4-acetylpyrimidines and crystals thereof
EP1951679B1 (en) * 2005-08-18 2015-02-18 Synta Pharmaceuticals Corp. Imidazole compounds that modulate hsp90 activity
JP2007145819A (ja) * 2005-10-28 2007-06-14 Tanabe Seiyaku Co Ltd 医薬組成物
CN101130539B (zh) * 2007-09-26 2012-05-30 浙江大学 吲哚取代咪唑啉-2-酮类衍生物及其制备方法和用途
DE102009043260A1 (de) 2009-09-28 2011-04-28 Merck Patent Gmbh Pyridinyl-imidazolonderivate
DE102009049679A1 (de) 2009-10-19 2011-04-21 Merck Patent Gmbh Pyrazolopyrimidinderivate
DE102010049595A1 (de) 2010-10-26 2012-04-26 Merck Patent Gmbh Chinazolinderivate
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods

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CA2461100A1 (en) 2003-05-01
HUP0401949A2 (hu) 2005-01-28
KR100742058B1 (ko) 2007-07-23
WO2003035638A1 (fr) 2003-05-01
JP4432492B2 (ja) 2010-03-17
CN100402521C (zh) 2008-07-16
JPWO2003035638A1 (ja) 2005-02-10
CN1571781A (zh) 2005-01-26
EP1439174B1 (en) 2012-03-21
EP1439174A4 (en) 2004-12-22
BR0213465A (pt) 2004-11-09
IL160874A (en) 2012-05-31
MY147948A (en) 2013-02-15
ATE550332T1 (de) 2012-04-15
PH12009500610A1 (en) 2016-06-13
HUP0401949A3 (en) 2009-07-28
TWI329642B (en) 2010-09-01
PL369287A1 (en) 2005-04-18
IL160874A0 (en) 2004-08-31
PL210470B1 (pl) 2012-01-31
KR20040047942A (ko) 2004-06-05
NO20042010L (no) 2004-07-09
CA2461100C (en) 2009-12-01
EP1439174A1 (en) 2004-07-21

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