MXPA04001127A - Ensayo de enlazamiento competitivo para la identificacion de inhibidores de polimerasa vhc. - Google Patents
Ensayo de enlazamiento competitivo para la identificacion de inhibidores de polimerasa vhc.Info
- Publication number
- MXPA04001127A MXPA04001127A MXPA04001127A MXPA04001127A MXPA04001127A MX PA04001127 A MXPA04001127 A MX PA04001127A MX PA04001127 A MXPA04001127 A MX PA04001127A MX PA04001127 A MXPA04001127 A MX PA04001127A MX PA04001127 A MXPA04001127 A MX PA04001127A
- Authority
- MX
- Mexico
- Prior art keywords
- hcv polymerase
- binding assay
- competitive binding
- identifying inhibitors
- identifying
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/18—Togaviridae; Flaviviridae
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/91245—Nucleotidyltransferases (2.7.7)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Hydrogenated Pyridines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Un metodo para la identificacion de compuestos que se enlazan a la polimerasa VHC que comprende las etapas de: poner en contacto la polimerasa VHC o un analogo de la misma con una Formula de prueba I: (ver formula) en donde A es O, S, N, NR1, o CR1, en donde R1 es como se define en la presente; ---representa ya sea un enlace doble o sencillo; R2 se selecciona de: H, halogeno, R21, OR21, SR21, COOR21, S02N (R22)2, N( R22)2, CON (R22)2, NR22C (O) R22 o NR22C(O)NR22 en donde R21 y cada una de R22 esta definida en la presente; B es NR3 o CR3 en donde R3 es como se define en la presente; con la condicion de que cuando A no es N, luego una de A o B es ya sea CR1 o CR3, K es N o CR4, en donde R4 esta definida en la presente; L es N o CR5, en donde R5 tiene la misma definicion como R4 como se ha definido anteriormente. M es N o CR7, en donde R7 tiene la misma definicion como R4 como se ha definido anteriormente; R5 es C(Y1)Z en donde Y1 es O o S; y Z es N(R6a)R6 o OR6, en donde R6a es H o alquilo o NR61R62 en donde R61 y R62 estan definidas en la presente; y R6 es H, alquilo, cicloalquilo, alquenilo, Het, alquil-arilo, alquil-Het o R6 es En donde R7, R8 y Q son como se han definido en la presente; Y2 es O o S; R9 es H, alquilo de (C1-6), cicloalquilo de (C3-7) o alquilo de (C1-6)-cicloalquilo de (C3-7), arilo, Het, alquilo de (C1-6)-arilo o alquilo de (C1-6)-Het los cuales estan opcionalmente sustituidos con R90; o R9 se enlaza covalentemente a ya sea R7 o R8 para formar un heterociclo de 5- o 6-miembros; o una sal de la misma; en donde la prueba comprende una etiqueta detectable que se une cualquier posicion adecuada, con lo cual la prueba se enlaza a una polimerasa VHC o a un analogo de la misma y que es capaz de ser desplazada por un inhibidor de la misma.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31027201P | 2001-08-07 | 2001-08-07 | |
| PCT/CA2002/001214 WO2003014377A2 (en) | 2001-08-07 | 2002-08-05 | Competitive binding assay for identifying inhibitors of hcv polymerase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04001127A true MXPA04001127A (es) | 2004-07-08 |
Family
ID=23201740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04001127A MXPA04001127A (es) | 2001-08-07 | 2002-08-05 | Ensayo de enlazamiento competitivo para la identificacion de inhibidores de polimerasa vhc. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7294457B2 (es) |
| EP (1) | EP1417493B1 (es) |
| JP (1) | JP4646514B2 (es) |
| AT (1) | ATE475095T1 (es) |
| CA (1) | CA2450142C (es) |
| DE (1) | DE60237089D1 (es) |
| DK (1) | DK1417493T3 (es) |
| ES (1) | ES2347954T3 (es) |
| HU (1) | HUP0400670A3 (es) |
| IL (1) | IL159981A0 (es) |
| MX (1) | MXPA04001127A (es) |
| NZ (2) | NZ554933A (es) |
| WO (1) | WO2003014377A2 (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2335700A1 (en) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7223785B2 (en) * | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| WO2004100947A2 (en) | 2003-05-06 | 2004-11-25 | Smithkline Beecham Corporation | Novel chemical compounds |
| KR20060054410A (ko) | 2003-08-01 | 2006-05-22 | 제네랩스 테크놀로지스, 인코포레이티드 | 플라비비리다에에 대한 2고리 이미다졸 유도체 |
| TWI478254B (zh) | 2003-11-10 | 2015-03-21 | Chippac Inc | 引線上凸塊之倒裝晶片互連 |
| US8026128B2 (en) | 2004-11-10 | 2011-09-27 | Stats Chippac, Ltd. | Semiconductor device and method of self-confinement of conductive bump material during reflow without solder mask |
| USRE47600E1 (en) | 2003-11-10 | 2019-09-10 | STATS ChipPAC Pte. Ltd. | Semiconductor device and method of forming electrical interconnect with stress relief void |
| US9029196B2 (en) | 2003-11-10 | 2015-05-12 | Stats Chippac, Ltd. | Semiconductor device and method of self-confinement of conductive bump material during reflow without solder mask |
| US8129841B2 (en) | 2006-12-14 | 2012-03-06 | Stats Chippac, Ltd. | Solder joint flip chip interconnection |
| US8574959B2 (en) | 2003-11-10 | 2013-11-05 | Stats Chippac, Ltd. | Semiconductor device and method of forming bump-on-lead interconnection |
| US8216930B2 (en) | 2006-12-14 | 2012-07-10 | Stats Chippac, Ltd. | Solder joint flip chip interconnection having relief structure |
| JPWO2005049622A1 (ja) * | 2003-11-19 | 2007-06-07 | 日本たばこ産業株式会社 | ５−５員縮合複素環化合物及びそのｈｃｖポリメラーゼ阻害剤としての用途 |
| DK2161273T3 (en) * | 2003-12-22 | 2015-07-20 | Leuven K U Res & Dev | Imidazo [4,5-C] pyridine compounds and methods for antiviral therapy |
| TWI368507B (en) * | 2004-02-20 | 2012-07-21 | Boehringer Ingelheim Int | Viral polymerase inhibitors |
| US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
| SI1719773T1 (sl) * | 2004-02-24 | 2009-08-31 | Japan Tobacco Inc | Kondenzirane heterotetraciklične spojine in njihova uporaba kot inhibitorji polimeraze HCV |
| KR20070083484A (ko) * | 2004-07-14 | 2007-08-24 | 피티씨 테라퓨틱스, 인크. | Ｃ형 간염 치료 방법 |
| ATE426601T1 (de) * | 2004-12-21 | 2009-04-15 | Gilead Sciences Inc | Imidazoa4,5-cupyridinverbindung und verfahren zur antiviralen behandlung |
| ATE513833T1 (de) | 2005-03-02 | 2011-07-15 | Fibrogen Inc | Thienopyridinverbindungen und verfahren zu ihrer verwendung |
| US8841779B2 (en) | 2005-03-25 | 2014-09-23 | Stats Chippac, Ltd. | Semiconductor device and method of forming high routing density BOL BONL and BONP interconnect sites on substrate |
| KR20070107154A (ko) | 2005-03-25 | 2007-11-06 | 스태츠 칩팩, 엘티디. | 기판상에 좁은 상호접속 사이트를 갖는 플립 칩 상호접속체 |
| EP1915378A4 (en) * | 2005-08-12 | 2009-07-22 | Boehringer Ingelheim Int | VIRUS POLYMERASE INHIBITORS |
| ZA200806752B (en) * | 2006-01-27 | 2009-10-28 | Fibrogen Inc | Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (HIF) |
| US7696223B2 (en) * | 2006-04-04 | 2010-04-13 | Fibrogen, Inc. | Pyrrolo- and Thiazolo-pyridine compounds, and methods of use thereof |
| ES2339298T3 (es) * | 2006-07-07 | 2010-05-18 | Gilead Sciences, Inc. | Compuesto de piridazina novedoso y uso del mismo. |
| UA99466C2 (en) | 2007-07-06 | 2012-08-27 | Гилиад Сайенсиз, Инк. | Crystalline pyridazine compound |
| CN105037323A (zh) | 2008-11-14 | 2015-11-11 | 菲布罗根有限公司 | 作为hif羟化酶抑制剂的苯并噻喃衍生物 |
| KR20150058284A (ko) | 2012-09-21 | 2015-05-28 | 사노피 | Apj 수용체 조절자로서의 벤조이미다졸-카르복시산 아미드 유도체 |
| CA2899024C (en) | 2013-01-24 | 2022-01-04 | Fibrogen, Inc. | Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid |
| US9815850B2 (en) | 2016-02-05 | 2017-11-14 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| EP3552017B1 (en) | 2016-12-09 | 2022-02-23 | Denali Therapeutics Inc. | Compounds useful as ripk1 inhibitors |
| TW202334089A (zh) | 2021-11-02 | 2023-09-01 | 美商夫雷爾醫療公司 | Ｐｐａｒｇ反向激動劑及其用途 |
| US11999750B2 (en) | 2022-01-12 | 2024-06-04 | Denali Therapeutics Inc. | Crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido [3,2-B][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5316999A (en) * | 1998-07-20 | 2000-02-07 | Advanced Research And Technology Institute, Inc. | Use of nucleic acid molecules as antiviral agents |
| JP2001069995A (ja) * | 1999-07-02 | 2001-03-21 | Japan Tobacco Inc | 結晶構造解析に適したｈｃｖポリメラーゼ及びその利用方法 |
| RU2223761C2 (ru) | 1999-12-27 | 2004-02-20 | Джапан Тобакко Инк. | Соединения с конденсированным кольцом и их использование в качестве лекарственных средств |
| US6770666B2 (en) * | 1999-12-27 | 2004-08-03 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs |
| US6448281B1 (en) * | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| CA2439176A1 (en) | 2001-03-08 | 2002-09-12 | Boehringer Ingelheim (Canada) Ltd. | Assay for identifying inhibitors of the rna dependent rna polymerase (ns5b) of hcv |
| US6841566B2 (en) | 2001-07-20 | 2005-01-11 | Boehringer Ingelheim, Ltd. | Viral polymerase inhibitors |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
-
2002
- 2002-08-02 US US10/211,455 patent/US7294457B2/en not_active Expired - Lifetime
- 2002-08-05 EP EP02753998A patent/EP1417493B1/en not_active Expired - Lifetime
- 2002-08-05 ES ES02753998T patent/ES2347954T3/es not_active Expired - Lifetime
- 2002-08-05 IL IL15998102A patent/IL159981A0/xx not_active IP Right Cessation
- 2002-08-05 NZ NZ554933A patent/NZ554933A/en not_active IP Right Cessation
- 2002-08-05 CA CA002450142A patent/CA2450142C/en not_active Expired - Fee Related
- 2002-08-05 DE DE60237089T patent/DE60237089D1/de not_active Expired - Lifetime
- 2002-08-05 JP JP2003519506A patent/JP4646514B2/ja not_active Expired - Fee Related
- 2002-08-05 HU HU0400670A patent/HUP0400670A3/hu unknown
- 2002-08-05 AT AT02753998T patent/ATE475095T1/de active
- 2002-08-05 NZ NZ531488A patent/NZ531488A/en not_active IP Right Cessation
- 2002-08-05 WO PCT/CA2002/001214 patent/WO2003014377A2/en active Application Filing
- 2002-08-05 DK DK02753998.0T patent/DK1417493T3/da active
- 2002-08-05 MX MXPA04001127A patent/MXPA04001127A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ATE475095T1 (de) | 2010-08-15 |
| HUP0400670A2 (en) | 2006-03-28 |
| EP1417493B1 (en) | 2010-07-21 |
| NZ554933A (en) | 2009-01-31 |
| US20030108862A1 (en) | 2003-06-12 |
| JP4646514B2 (ja) | 2011-03-09 |
| DK1417493T3 (da) | 2010-10-04 |
| IL159981A0 (en) | 2004-06-20 |
| NZ531488A (en) | 2008-06-30 |
| WO2003014377A3 (en) | 2003-12-18 |
| US7294457B2 (en) | 2007-11-13 |
| CA2450142A1 (en) | 2003-02-20 |
| DE60237089D1 (de) | 2010-09-02 |
| WO2003014377A2 (en) | 2003-02-20 |
| ES2347954T3 (es) | 2010-11-26 |
| JP2005500055A (ja) | 2005-01-06 |
| EP1417493A2 (en) | 2004-05-12 |
| HUP0400670A3 (en) | 2006-06-28 |
| CA2450142C (en) | 2009-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |