MXPA01010409A - Beta-lactamase inhibiting compounds. - Google Patents
Beta-lactamase inhibiting compounds.Info
- Publication number
- MXPA01010409A MXPA01010409A MXPA01010409A MXPA01010409A MXPA01010409A MX PA01010409 A MXPA01010409 A MX PA01010409A MX PA01010409 A MXPA01010409 A MX PA01010409A MX PA01010409 A MXPA01010409 A MX PA01010409A MX PA01010409 A MXPA01010409 A MX PA01010409A
- Authority
- MX
- Mexico
- Prior art keywords
- beta
- formula
- compounds
- inhibiting compounds
- lactamase inhibiting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The invention provides compounds of formula (I) and (IV), wherein R1-R11 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting beta -lactamase enzymes, for enhancing the activity of beta -lactam antibiotics, and for treating beta -lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula (I) and (IV), and novel intermediates useful for the synthesis of compounds of formula (I) and (IV).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12948299P | 1999-04-15 | 1999-04-15 | |
| PCT/US2000/009929 WO2000063213A1 (en) | 1999-04-15 | 2000-04-14 | Beta-lactamase inhibiting compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA01010409A true MXPA01010409A (en) | 2003-12-11 |
Family
ID=22440183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA01010409A MXPA01010409A (en) | 1999-04-15 | 2000-04-14 | Beta-lactamase inhibiting compounds. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1169323A1 (en) |
| JP (1) | JP2002542249A (en) |
| AT (1) | ATE330960T1 (en) |
| AU (1) | AU773013B2 (en) |
| CA (1) | CA2371389A1 (en) |
| DE (1) | DE60029023T2 (en) |
| MX (1) | MXPA01010409A (en) |
| WO (1) | WO2000063213A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3866298B2 (en) | 1997-12-29 | 2007-01-10 | リサーチ コーポレイション テクノロジーズ，インコーポレイティド | 2β-Substituted-6-alkylidenepenicillanic acid derivatives as β-lactamase inhibitors |
| US6407091B1 (en) | 1999-04-15 | 2002-06-18 | Research Corporation Technologies, Inc. | β-lactamase inhibiting compounds |
| JP2002356427A (en) * | 2001-05-30 | 2002-12-13 | Shionogi & Co Ltd | beta-LACTAMASE INHIBITOR |
| US6916801B2 (en) | 2001-07-24 | 2005-07-12 | Alamx, Llc | 7-Alkylidene-3-substituted-3-cephem-4-carboxylates as β-lactamase inhibitors |
| US7022691B2 (en) | 2002-04-04 | 2006-04-04 | John D. Buynak | Inhibitors of serine and metallo-β-lactamases |
| CN102731530B (en) * | 2011-04-07 | 2016-05-04 | 天津市医药集团技术发展有限公司 | Cephalosporin compound and synthetic method thereof and application |
| CN107021893A (en) * | 2017-05-05 | 2017-08-08 | 贵州师范学院 | Thio acyl Ammonium Salt Ionic Liquid of one class and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5629306A (en) * | 1994-12-09 | 1997-05-13 | Research Corporation Technologies, Inc. | 7-alkylidene cephalosporanic acid derivatives and methods of using the same |
| US5760027A (en) * | 1996-12-06 | 1998-06-02 | Research Corporation Technologies, Inc. | Use of 7-alkylidene cephalosporins to inhibit elastase activity |
-
2000
- 2000-04-14 MX MXPA01010409A patent/MXPA01010409A/en not_active Application Discontinuation
- 2000-04-14 DE DE60029023T patent/DE60029023T2/en not_active Expired - Fee Related
- 2000-04-14 CA CA002371389A patent/CA2371389A1/en not_active Abandoned
- 2000-04-14 WO PCT/US2000/009929 patent/WO2000063213A1/en not_active Application Discontinuation
- 2000-04-14 AU AU42386/00A patent/AU773013B2/en not_active Ceased
- 2000-04-14 EP EP00922157A patent/EP1169323A1/en not_active Withdrawn
- 2000-04-14 AT AT03015238T patent/ATE330960T1/en not_active IP Right Cessation
- 2000-04-14 JP JP2000612303A patent/JP2002542249A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ATE330960T1 (en) | 2006-07-15 |
| AU4238600A (en) | 2000-11-02 |
| JP2002542249A (en) | 2002-12-10 |
| WO2000063213A1 (en) | 2000-10-26 |
| AU773013B2 (en) | 2004-05-13 |
| CA2371389A1 (en) | 2000-10-26 |
| EP1169323A1 (en) | 2002-01-09 |
| DE60029023T2 (en) | 2007-01-18 |
| DE60029023D1 (en) | 2006-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |