MXPA99008695A - Use of a silicone rubber to stabilize the ascorbic acid and new compositions which are composed of - Google Patents
Use of a silicone rubber to stabilize the ascorbic acid and new compositions which are composed ofInfo
- Publication number
- MXPA99008695A MXPA99008695A MXPA/A/1999/008695A MX9908695A MXPA99008695A MX PA99008695 A MXPA99008695 A MX PA99008695A MX 9908695 A MX9908695 A MX 9908695A MX PA99008695 A MXPA99008695 A MX PA99008695A
- Authority
- MX
- Mexico
- Prior art keywords
- composition according
- composition
- silicone rubber
- silicone
- oils
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 85
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Vitamin C Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title claims abstract description 34
- 239000011668 ascorbic acid Substances 0.000 title claims abstract description 34
- 235000010323 ascorbic acid Nutrition 0.000 title claims abstract description 34
- 229960005070 ascorbic acid Drugs 0.000 title claims abstract description 34
- 229920002379 silicone rubber Polymers 0.000 title claims description 22
- 239000004945 silicone rubber Substances 0.000 title claims description 22
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 30
- 239000002537 cosmetic Substances 0.000 claims abstract description 14
- 150000002148 esters Chemical class 0.000 claims abstract description 9
- 150000003839 salts Chemical class 0.000 claims abstract description 8
- 239000011780 sodium chloride Substances 0.000 claims abstract description 8
- 229920000591 gum Polymers 0.000 claims abstract description 5
- 230000000699 topical Effects 0.000 claims abstract description 5
- 210000003491 Skin Anatomy 0.000 claims description 19
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 19
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 19
- 239000003921 oil Substances 0.000 claims description 18
- -1 polydimethylsiloxane Polymers 0.000 claims description 17
- 150000003077 polyols Chemical class 0.000 claims description 13
- 229920005862 polyol Polymers 0.000 claims description 11
- 229920002545 silicone oil Polymers 0.000 claims description 10
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 9
- 239000003995 emulsifying agent Substances 0.000 claims description 8
- 239000006071 cream Substances 0.000 claims description 7
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 238000009499 grossing Methods 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 239000007762 w/o emulsion Substances 0.000 claims description 6
- 230000002335 preservative Effects 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- UQEAIHBTYFGYIE-UHFFFAOYSA-N Hexamethyldisiloxane Chemical group C[Si](C)(C)O[Si](C)(C)C UQEAIHBTYFGYIE-UHFFFAOYSA-N 0.000 claims description 4
- 229940008099 dimethicone Drugs 0.000 claims description 4
- 239000000839 emulsion Substances 0.000 claims description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 239000001993 wax Substances 0.000 claims description 4
- 230000037303 wrinkles Effects 0.000 claims description 4
- 206010001488 Aggression Diseases 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 3
- 230000000240 adjuvant Effects 0.000 claims description 3
- 230000016571 aggressive behavior Effects 0.000 claims description 3
- 239000000945 filler Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 239000006096 absorbing agent Substances 0.000 claims description 2
- 239000011149 active material Substances 0.000 claims description 2
- 230000000111 anti-oxidant Effects 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 235000006708 antioxidants Nutrition 0.000 claims description 2
- 238000004040 coloring Methods 0.000 claims description 2
- 150000002334 glycols Chemical class 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 239000007764 o/w emulsion Substances 0.000 claims description 2
- 239000002304 perfume Substances 0.000 claims description 2
- 230000001172 regenerating Effects 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 235000013311 vegetables Nutrition 0.000 claims description 2
- 229910004759 OSi Inorganic materials 0.000 claims 2
- 239000012071 phase Substances 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 239000000243 solution Substances 0.000 description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 8
- 229940085262 Cetyl dimethicone Drugs 0.000 description 6
- 229930003268 Vitamin C Natural products 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- 235000019154 vitamin C Nutrition 0.000 description 6
- 239000011718 vitamin C Substances 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 4
- 229940086555 cyclomethicone Drugs 0.000 description 4
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 4
- 235000019341 magnesium sulphate Nutrition 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 230000002378 acidificating Effects 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 230000004059 degradation Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 229920001519 homopolymer Polymers 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000004005 microsphere Substances 0.000 description 3
- 150000003700 vitamin C derivatives Chemical class 0.000 description 3
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- BGHCVCJVXZWKCC-UHFFFAOYSA-N Tetradecane Chemical compound CCCCCCCCCCCCCC BGHCVCJVXZWKCC-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 125000005395 methacrylic acid group Chemical group 0.000 description 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N methylene dichloride Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000003531 protein hydrolysate Substances 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 230000000087 stabilizing Effects 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 210000001519 tissues Anatomy 0.000 description 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N 1,2-ethanediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- XDOFQFKRPWOURC-UHFFFAOYSA-M 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC([O-])=O XDOFQFKRPWOURC-UHFFFAOYSA-M 0.000 description 1
- 229960000458 Allantoin Drugs 0.000 description 1
- 229940106189 Ceramides Drugs 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 150000000996 L-ascorbic acids Chemical class 0.000 description 1
- 229940078752 MAGNESIUM ASCORBYL PHOSPHATE Drugs 0.000 description 1
- 210000004080 Milk Anatomy 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010062080 Pigmentation disease Diseases 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- JNYAEWCLZODPBN-CTQIIAAMSA-N Sorbitan Chemical compound OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229960001295 Tocopherol Drugs 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 229940046009 Vitamin E Drugs 0.000 description 1
- 206010047631 Vitamin E deficiency Diseases 0.000 description 1
- 229920004482 WACKER® Polymers 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000011260 aqueous acid Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 229940071097 ascorbyl phosphate Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- PUPZLCDOIYMWBV-UHFFFAOYSA-N butylene glycol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229960005188 collagen Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003750 conditioning Effects 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000003247 decreasing Effects 0.000 description 1
- 230000035614 depigmentation Effects 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 235000004626 essential fatty acids Nutrition 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000001815 facial Effects 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000020686 ginkgo biloba extract Nutrition 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 235000005035 ginseng Nutrition 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- CMBYOWLFQAFZCP-UHFFFAOYSA-N hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 1
- 229940100463 hexyl laurate Drugs 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 230000001264 neutralization Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- MILWSGRFEGYSGM-UHFFFAOYSA-N propane-1,2-diol;propane-1,2,3-triol Chemical compound CC(O)CO.OCC(O)CO MILWSGRFEGYSGM-UHFFFAOYSA-N 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 231100000075 skin burn Toxicity 0.000 description 1
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing Effects 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229930003799 tocopherols Natural products 0.000 description 1
- IIYFAKIEWZDVMP-UHFFFAOYSA-N tridecane Chemical compound CCCCCCCCCCCCC IIYFAKIEWZDVMP-UHFFFAOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Abstract
The present invention relates to the use of a silicone gum to stabilize the ascorbic acid or one of its esters or salts in a topical composition and to new compositions comprising these components and having a pH comprised between 4 and 7. These compositions can be used in the cosmetic, dermatological or veterinary fields
Description
?
USE OF A RUBBER. OF SILICONE TO STABILIZE ASCORBIC ACID AND MOTIONS COMPOSITIONS CONTAINING THESE = ^ * _. r "COMPONENTS
i 5 Field of the invention áfc "a. *. * The invention relates to the use of a
It has been a long time to stabilize the ascidic acid or vitamin C, in suitable galenic presentations due to its beneficial properties.
Brief Description of the Invention Indeed, ascorbic acid has numerous biological functions such as the stimulation of collagen synthesis, the reinforcement of skin tissues against external aggressions (UV radiation, contamination),
depigmentation, anti-free radical activity, compensation of vitamin E deficiency. Some of these beneficial properties have been particularly indicated by ENGLAND ET SEIFTER in the article "The biochemical functions of ascorbic acid" appeared in Ann.
Rev. Nutri., 1986: p < aqa 6 365-406. However, due to its chemical structure
• 5 * (alpha ketolactone) ascorbic acid is very sensitive to the influence of environmental parameters such as light, oxygen, water (due to its pH and the presence of traces of
metals). Inconsistent degradation occurs over time of the ascorbic acid in solution. In addition, emulsions containing ascorbic acid have a tendency to be unstable, ie to separate into two phases over time.
In the state of the art this problem has been treated in various ways. In order to reduce or delay the degradation of ascorbic acid in solution, the authors of US Pat. No. 5,143,043 have advocated stabilizing it by introducing it into
X hydroalcoholic solutions, formed by at least one
-4 and 80% water and with a pH lower than 3.5. Due to the strong acidity of these solutions, their use in the cosmetic and / or pharmaceutical field is hardly considerable. Indeed, a repeated application of these solutions can disturb the balance of the skin and in particular irritate, even burn the skin. It is known, on the other hand, the article by B.R.
Hajratwala entitled "Stability of ascorbic acid", published in the Revue Sciences Pharmaceutiques, on March 15,
In this article the ilization of ascorbic acid in acid aqueous solution 20 is mainly indicated by the addition of a surfactant agent which is an ester
-Oxyethylenated sorbitan mill. In particular, the author has indicated that at a pH of 3.4 and at 25 ° C, the contribution of this agent decreased -4
r the rate of oxidation, consequently of degradation of the ascorbic acid in solution. In addition, this document shows that the use
*. of chelating agent such as ethylene diamine tetraacetic
(EDTA) and the conditioning under nitrogen, in the absence of light, to improve the stability of the ascorbic acid in aqueous solution. An aqueous acid solution of this type, applied
T on the skin, presents the same disadvantages as those described above for hydroalcoholic acid solutions. In addition, the obtained stabilization is still insufficient. t Other modes of stabilization of ascorbic acid
I have been particularly considered for coating (technique described in document FR-A- • i i 1600826) or for granulation of ascorbic acid (technique
, # illustrated by document JP-A-53-127819, for agri-food). But these techniques are on the one hand expensive and
On the other hand, they can alter the ascorbic acid, for example during heating, and / or lead to poor cosmetic compositions, such as granules.
On the other hand, FR-A-1489249 discloses the use of metal salts of phosphorylated ascorbic acid, in particular ascorbyl phosphate * < -of magnesium, in cosmetic compositions. This last compound has an activity similar to that of the ascorbic acid from which it comes but presents some drawbacks that make its use on the skin unlikely. In particular, the magnesium ascorbyl phosphate, being stable only at a basic pH (pH 8 to pH 9), must be incorporated in a basic composition that can be irritating to the skin (whose pH has a value of approximately 5.5). EP-A-0670 157 describes an emulsion comprising an aqueous phase containing ascorbic acid and having an acidic pH of a maximum value of 3.5. Compositions based on carboxylic acid polyols combined with specific emollients and with ascorbic acid are described in WO 98/22075. The recommended pH of these compositions is between 7 and 8. Such acidic or basic pH may have drawbacks.
Therefore, the set of proposals that have been made up to now has not allowed to solve the technical problems related to the instability of the ascorbic acid in solution, in a suitable galenic form that an efficiency and comfort for the cosmetic and / or dermatological fields already a cost compatible with industrial demands. * _f The need for a composition, which can be used in the cosmetic, dermatological and / or
veterinary, containing stabilized ascorbic acid, in free state, ie without additional group particularly stabilizing, and that does not cause any skin irritation, after application. Description of the Invention 15 The applicant firm has now discovered, in a surprising way, that the use of a rubber of
1 i -f silicone allowed to stabilize the ascorbic acid. The interest in using a silicone rubber
«V resides particularly in the fact of being able to use the
Ascorbic acid, in a composition that does not cause skin irritation or burns. The composition of the invention is therefore well supported by the users. In addition, the composition of the invention has the advantage of being comfortable without being greasy. * In addition, the fact that the composition of the invention can incorporate ascorbic acid in the free, protonated state, provides more effective treatments in relation to prior art preparations comprising "derivatives" of hydrolyzable ascorbic acid in contact with the skin. The compositions of the invention can be in particular in the form of milk or creams which can be used in particular in the cosmetic, dermatological and / or veterinary fields. They have a light texture and spread well. They also provide, in the application, a feeling of freshness and provide a brightness of instant color. They allow, in particular, a smoothing of the features and imperfections of the skin. On the other hand, the compositions according to the invention have the advantage of being able to include any type of hydrophilic or lipophilic active agent, the pH of the compositions being neutral or scarcely acidic. On the other hand, the compositions of the invention have good stability properties, particularly at room temperature (20 ° C). The present invention therefore has as an essential object the use of a silicone rubber to stabilize the ascorbic acid or one of its esters or salts
i in a topical composition. In the context of the present invention, "ascorbic acid" or vitamin C is understood to mean ascorbic acid in the free, protonated state or one of its esters or salts. In the context of the present invention, "non-crosslinked linear polydimethylsiloxanes which can be hydroxylated or phenylated and having the consistency of a dense oil or of a clear solid as opposed to the alkyl, are designated by the term" silicone rubber ". alkoxy dimethicones which, when solid, have a waxy opaque appearance, but can also have the appearance of a clear oil when their melting point is lower than room temperature. The silicone rubber can be chosen from polydiorganosiloxanes with a molecular weight of between 100,000 and 2,000,000, and preferably between 100,000 and 1,500,000. These silicone gums preferably have a viscosity equal to or greater than 200,000 cSt (0.2 m2 / s) and preferably greater than 300,000 cSt (0.3m2 / s), viscosity measured in the BROOKFIELD viscometer at 25 ° C. The silicone gum chosen from among the silicone gums of formula (I) below is more particularly used:
wherein: R2 represents -CH3, -OH or -CßHs. R3 represents -CH3, -OH, -C6H5 or -0Si (CH3) 3, x = 0 or an integer ey is an integer with the proviso that yoxey are integers such that the weight average molecular mass is greater than 100,000, and preferably between 100,000 and 1,500,000. Preferred silicone gums of the invention are chosen from dimethicones (polydimethylsiloxanes) and di-ethiols (polydimethylsiloxanes with hydroxyl termination). The silicone rubber can be used alone or as a mixture, particularly with a solvent chosen from volatile silicones, polydimethylsiloxane oils, polyphenylmethylsiloxane oils, isoparaffins,? -f methylene chloride, pentane, dodecane, tridecane, tetradecane or mixtures thereof. Silicone gums are generally marketed by the suppliers in a presolubilized form or not in a proportion of 5 to 20%, and preferably 10 to 15%, in a linear or cyclic polydimethylsiloxane, of low molecular weight, volatile or not volatile Examples of silicone gums are the 96% dimethicone in cyclomethicone sold by
the RHONE POULENC Company under the name "Mirasil
* "< e > DM-500000®", and the dimethicone sold by the WACKER Company under the name "AK 300000®", and the dimethiconols sold under the names of "Q2-1403®" and "Q2-1401® "and" Q2-1503® "by the Dow Corning Company." ff, Another object of the invention is a topical composition in the form of an emulsion comprising ascorbic acid or one of its esters or salts, a silicone gum and an emulsifier. siliconized and having a pH comprised between 4 and 7, and preferably between 5.5 and 6.5 The compositions according to the invention can be
"1 particularly consist of a water-in-oil or oil-in-water emulsion, the silicone gums are those described above.
Similarly, the silicone rubber can be used alone or in admixture with a solvent selected from volatile silicones, polydimethylsiloxane oils, polyphenyl ethylsiloxane oils or mixtures thereof. The ascorbic acid or one of its esters is present in the compositions of the invention in a concentration ranging between 0.1 and 20% and preferably between 2 and 10% by weight relative to the total weight of the composition. The silicone gum is present in the compositions of the invention in a concentration of active material ranging between 1 and 20% and preferably between 2 and 15% by weight with respect to the total weight of the composition. In a particularly preferred embodiment of the invention, the composition further contains at least one polyol. The polyol can be chosen from glycerin, sorbitol or glycols, in particular propylene glycol, butylene glycol and polyethylene glycols. According to a particular embodiment of the invention, the polyol (s) are totally or partially in complexed form with an acrylic or methacrylic polymer. The polymer can also comprise bound water, ie be complexed with a mixture of water and polyol (s). Means acrylic or methacrylic polymer, a homopolymer or a copolymer of acrylic or methacrylic acid or a homopolymer or a copolymer of an acrylic or methacrylic acid derivative. Mention may be made as a complex homopolymer of water and polyols, those sold under the names of Norgel and Lubrajel CG by the Guardian Society. These polymers are glyceryl polyacrylates complexed with more than 65% glycerin and / or propylene glycol and less than 35% by weight of bound water. These polymers provide the complexed polyol and water, and eventually also play the gelling role of the composition. The polyol can be present in a concentration ranging between 5 and 40% and preferably between 15 and 30% by weight relative to the total weight of the composition. The compositions according to the invention can also contain at least one silicone oil. The latter can be chosen in particular from the group comprising volatile silicones such as cyclopentadimethylsiloxane and cyclotetradimethylsiloxane, polydi ethylsiloxanes, polyphenyltrimethylsiloxanes and fluorinated silicones. The silicone oil can be present in a concentration ranging from 2 to 40% and preferably from 10 to 35% by weight relative to the total weight of the composition. The compositions according to the invention also contain at least one silicone emulsifier. The silicone emulsifiers can be chosen from dimethicones copolyols and alkyldimethicone copolyols. The mixture of 4-polyglycerol isostearate / cetyl dimethicone copolyol / hexyl laurate sold under the name "Abil WE 09®" by the company Goldschmidt, cetyl dimethicone copolyol sold under the name " Abil EM 90® "by the Company Goldschmidt and the mixture of cyclomethicone / dimethicone copolyol sold under the name" Q2-3225C "or" Q2-5225C "by the Dow Corning Company. According to a preferred embodiment of the invention, an alkyldimethicone copolyol and particularly the cetyldimethicone copolyol is used. The emulsifier is present in an amount ranging preferably between 0.1 and 10% and better between 0.5 and 5% of the total weight of the composition. The compositions according to the invention can also contain one or more fatty substances selected from silicone waxes or resins, fluorinated oils, oils of animal origin, oils of vegetable origin, mineral oils or synthetic oils. As waxes, silicone waxes such as alkoxydimethylsiloxanes, and more particularly stearoxypolydimethylsiloxanes, alkylpolysiloxanes and polydimethylsiloxanes of mercapto function can be used in particular. As resins, silicone resins such as trimethylsiloxysilicates can be used in particular. In a known manner, the composition of the invention can also contain adjuvants customary in the cosmetic and dermatological fields, such as surfactants, particularly foaming surfactants, hydrophilic or lipophilic active agents as well as ascorbic acid, preservatives, antioxidants, solvents, perfumes, fillers, filters, odor absorbers, coloring matters and lipid vesicles. The amounts of these different adjuvants are those conventionally used in the areas considered, and for example from 0.01% to 15% of the total weight of the composition. As hydrophilic active agents, protein or protein hydrolysates, amino acids, allantoin, sugars and sugar derivatives, starch, hyaluronic acid or plant extracts such as Ginkgo biloba extracts or extracts can be used for example. of Ginseng. As lipophilic active agents, for example, tocopherol (vitamin E) and its derivatives, essential fatty acids, ceramides, and essential oils can be used. As fillers, mention may be made of nylon powder and microspheres (copolymer acrylates). The compositions according to the invention can thus constitute a cosmetic and / or dermatological composition. The subject of the invention is also a use of the composition indicated above for a cosmetic treatment of the skin and in particular with a view to toning it, regenerating it, smoothing wrinkles and / or small wrinkles of the skin, lightening the color, removing the spots pigmentation of the skin, and / or to fight against the damages produced by UV radiation, and / or to reinforce the cutaneous tissues against environmental aggressions (contamination). The subject of the invention is also the use of a composition indicated above for the manufacture of a cream intended for dermatological and / or veterinary treatment. Finally, the subject of the invention is a method of cosmetic treatment, which consists of applying a composition according to the invention to the skin, including the eye contour. Other advantages and characteristics of the invention will appear better on reading the following examples, which are given by way of illustration and not limitation. EXAMPLE 1: Water in oil emulsion.
Phase A: - Demineralized water 25.05% 20 - Glycerin 24% - Propylene glycol 7% - Preservative 0.2% - Vitamin C 5% - Magnesium sulfate 2%
?. ' - Copolymer acrylates (Microspheres) 0.75%
Phase B: DC2 5225C (silicone emulsifier in silicone oil) 8%
- Silicone oil 20 cSt 23%
- Silicone AK 300000 (silicone rubber) 5
The operative way to prepare this composition is as follows: Prepare each phase separately and introduce phase A in phase B under agitation. You get a white cream, bright and stable. This composition is suitable for smoothing the facial features of the face and for lightening the color.
EXAMPLE 2: Water in oil emulsion
Phase A: - Demineralized water 25. 05%
- 24% glycerin
- Propylene glycol 7%
- Preservative 0, 2%
- Vitamin C 5% Magnesium sulfate Copolymer acrylates (Microspheres: 0.75
Phase B: 5 - Cetyldimethicone copolyol (Abil EM90) 0.8%
- * $ - Silicone oil 20 cSt 23% - Cyclomethicone 7, 2% - AK 300000 (silicone rubber) 5%
The operating mode is the same as in the example
1. You get a white cream, bright and stable. This composition is suitable for smoothing the features of the skin and for lightening the color. 15 COMPARATIVE EXAMPLE 2: Water-in-oil emulsion
Phase A: - Demineralized water 25. 05% 20 - Glycerin 24%
- Propylene glycol 7%
- Preservative 0, 2%
- Vitamin C 5%
- Magnesium sulfate 2% - Acrylates copolymer 0.75
Phase B: - Cetyldimethicone copolyol (Abil EM90) 0.8 - Silicone oil 20 cSt 28 - Cyclomethicone 7.2
The operating mode is the same as in the example
A thick cream is obtained, which is unstable and separates rapidly in two phases. EXAMPLE 3: Water in oil emulsion
Phase A Demineralized water 20%
Glycerin 24%
Propylene glycol 13%
Vitamin C 5%
2% magnesium sulfate
Phase B: - Cetyldimethicone copolyol (Abil EM90) 0.8%
- Silicone oil 20 cSt 30.2% - Mirasol DM-50000 (silicone rubber) 5%
The operating mode is identical to that of Example 1. A white, stable cream is obtained, suitable for smoothing skin features and for lightening the color.
It is noted that in relation to this date, the best method known to the applicant to carry out the aforementioned invention, is that which is clear from the present description of the invention. Having described the invention as above, property is claimed as contained in the following:
Claims (29)
1. Use of a silicone rubber to stabilize the ascorbic acid or one of its esters or salts in a topical composition.
2. Use according to claim 1, characterized in that the silicone rubber is chosen from polydiorganosiloxanes with a molecular weight of between 100,000 and 2,000,000, and preferably between 100,000 and 1,500,000.
3. Use according to claim 1 or 2, characterized in that the silicone rubber has a viscosity equal to or greater than 0.2 m2 / s and preferably equal to or greater than 0.3 m2 / s.
4. Use according to any one of claims 1 to 3, characterized in that the silicone rubber is selected from among the silicone gums of formula (I) below wherein: R2 represents -CH3, -OH or -C6H5. R3 represents -CH3, -OH, -C6H5 or -OSi (CH3) 3, x = 0 or an integer ey is an integer with the proviso that yoxey are integers such that the weight average molecular mass is greater than 100,000, and preferably between 100,000 and 1,500,000.
5. Use according to any one of claims 1 to 4, characterized in that the silicone rubber is selected from dimethicones and di-ethi-nools.
6. Use according to any one of claims 1 to 5, characterized in that the silicone rubber is used alone or in a mixture with a solvent selected from volatile silicones, polydimethylsiloxane oils, polyphenylmethylsiloxane oils or mixtures thereof.
7. Topical composition in the form of an emulsion characterized in that it comprises ascorbic acid or one of its esters or salts, a silicone gum, a siliconized emulsifier and has a pH comprised between 4 and 7.
8. Composition according to claim 7, characterized in that the silicone rubber is selected from polydiorganosiloxanes with a molecular weight of between 100,000 and 2,000,000, and preferably between 100,000 and 1,500,000.
9. Composition according to claim 7 or 8, characterized in that the silicone rubber has a viscosity equal to or greater than 0.2 m2 / s and preferably equal to or greater than 0.3 m2 / s.
10. Composition according to any one of claims 7 to 9, characterized in that the silicone rubber is selected from among the silicone gums of formula (I) below: wherein: R2 represents -CH3, -OH or -CeH5. R3 represents -CH3, -OH, -C6H5 or -OSi (CH3) 3, x = 0 or an integer ey is an integer with the proviso that yoxey are integers such that the weight average molecular mass is greater than 100,000, and preferably between 100,000 and 1,500,000.
11. Composition according to any one of claims 7 to 10, characterized in that the silicone rubber is selected from dimethicones and dimethiconols.
12. Composition according to any one of claims 7 to 11, characterized in that the silicone rubber is used alone or in a mixture with a solvent selected from volatile silicones, polydimethylsiloxane oils, polyphenylmethylsiloxane oils or their mixtures.
13. Composition according to any one of claims 7 to 12, characterized in that the ascorbic acid or one of its esters or salts is present in a concentration ranging between 0.1 and 20% and preferably between 2 and 10% in weight in relation to the total weight of the composition.
14. Composition according to any one of claims 7 to 13, characterized in that the silicone rubber is present in a concentration of active material ranging between 1 and 20% and preferably between 2 and 15% by weight relative to the weight total of the composition.
15. Composition according to any one of claims 7 to 14, characterized in that the composition also contains at least one polyol.
16. Composition according to claim 15, characterized in that the polyol is chosen from glycerin, sorbitol or glycols.
17. Composition according to claim 15 or 16, characterized in that the polyol is present in a concentration ranging between 5 and 40% and preferably between 15 and 30% by weight relative to the total weight of the composition.
18. Composition according to any one of claims 7 to 17, characterized in that it also contains at least one silicone oil.
19. Composition according to claim 18, characterized in that the silicone oil is chosen from the group comprising the volatile silicones, the polydimethylsiloxanes, the polyphenyltrimethylsiloxanes and the fluorinated silicones.
20. Composition according to claim 18 or 19, characterized in that the silicone oil is present in a concentration ranging between 2 and 40%, and preferably between 10 and 35% by weight relative to the total weight of the composition.
21. Composition according to any one of claims 7 to 20, characterized in that the emulsifier is a dimethicone copolyol or an alkyldimethicone copolyol.
22. Composition according to any one of claims 7 to 21, characterized in that the emulsifier is present in a concentration ranging between 0.1 and 10%, and preferably between 0.5 and 5% by weight relative to the weight total of the composition.
23. Composition according to any one of claims 7 to 22, characterized in that it also contains one or more fatty substances selected from silicone waxes or resins, fluorinated oils, oils of animal origin, oils of vegetable origin, mineral oils or synthetic oils
24. Composition according to any one of claims 7 to 23, characterized in that it comprises at least one adjuvant selected from hydrophilic or lipophilic surfactants, preservatives, antioxidants, solvents, perfumes, fillers, filters, odor absorbers, the coloring matters and the lipid vesicles.
25. Composition according to any one of claims 7 to 24, characterized in that it consists of a water-in-oil or oil-in-water emulsion.
26. Composition according to any one of claims 7 to 25, characterized in that it constitutes a cosmetic and / or dermatological composition.
27. Use of a composition according to any one of claims 7 to 25 for a cosmetic treatment of the skin with a view to toning it, and regenerating it, smoothing the wrinkles and / or small wrinkles of the skin, lightening the color, eliminating the pigmentary spots of the skin. the skin, and / or to fight against the damages of the UV radiations, and / or to reinforce the cutaneous weaves against the aggressions of the surroundings.
28. Use of a composition according to any one of claims 7 to 26, for the manufacture of a cream intended for a dermatological and / or veterinary treatment. *
29. Cosmetic treatment method, characterized in that it consists of applying on the skin, including the eye contour, a composition according to any one of claims 7 to 26.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9812156 | 1998-09-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA99008695A true MXPA99008695A (en) | 2000-07-01 |
Family
ID=
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6328983B1 (en) | Use of a silicone gum to stabilize ascorbic acid, and novel compositions comprising these components | |
US5853741A (en) | Vitamin C delivery system | |
US5736567A (en) | Stable composition containing ascorbic acid | |
KR100294784B1 (en) | Stable Korean Application Compositions Containing Solid Elastomer-Based Organic Polysiloxanes and Spherical Particles | |
CA2168425A1 (en) | Cosmetic compositions | |
JPH11508555A (en) | Stable N-acetyl cysteine composition | |
JP2010512388A (en) | Composite emulsion composition | |
JPH09504009A (en) | Makeup makeup composition | |
JP2008143820A (en) | Emulsion cosmetic | |
JPH08506583A (en) | Cosmetic composition | |
JP2000513364A (en) | Vitamin C delivery system | |
JP3297391B2 (en) | Lip care composition containing acexamic acid and use thereof | |
JP2001508081A (en) | Gel cosmetic or dermatological composition comprising a mixture of an associative copolymer, a surfactant and an insoluble conditioning | |
JPH11106310A (en) | W/o emulsion composition | |
JPH10503780A (en) | Anti acne cosmetic composition | |
WO1995004517A1 (en) | Cosmetic compositions | |
KR100318105B1 (en) | Combination of procysteine with a polyol | |
JP2004161762A (en) | Composition in form of oil-in-water type emulsion and use of the same, especially use of the same as cosmetic | |
JP3419740B2 (en) | Composition in the form of a water-in-oil emulsion with an evolving shear rate | |
JPH11263721A (en) | Oil-in-water type gommage (peeling) cosmetic | |
GB2422605A (en) | Ionic thickening agent for compositions | |
MXPA99008695A (en) | Use of a silicone rubber to stabilize the ascorbic acid and new compositions which are composed of | |
US20030149102A1 (en) | Composition containing stabilized ascorbic acid, and uses thereof | |
JPH09124437A (en) | Emulsified composition and dermal preparation for external use | |
GB2299022A (en) | Anti-acne cosmetic composition |