MXPA97007819A - System in dispersible particles to insensibilize dien - Google Patents
System in dispersible particles to insensibilize dienInfo
- Publication number
- MXPA97007819A MXPA97007819A MXPA/A/1997/007819A MX9707819A MXPA97007819A MX PA97007819 A MXPA97007819 A MX PA97007819A MX 9707819 A MX9707819 A MX 9707819A MX PA97007819 A MXPA97007819 A MX PA97007819A
- Authority
- MX
- Mexico
- Prior art keywords
- composition according
- clay
- salt
- fluoride
- tooth
- Prior art date
Links
- 239000002245 particle Substances 0.000 title description 5
- RPNUMPOLZDHAAY-UHFFFAOYSA-N DETA Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 44
- 239000004927 clay Substances 0.000 claims abstract description 41
- 229910052570 clay Inorganic materials 0.000 claims abstract description 41
- 210000000515 Tooth Anatomy 0.000 claims abstract description 31
- 229910000271 hectorite Inorganic materials 0.000 claims abstract description 20
- 229940094522 laponite Drugs 0.000 claims description 26
- KRHYYFGTRYWZRS-UHFFFAOYSA-M fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 150000003839 salts Chemical group 0.000 claims description 14
- 239000011780 sodium chloride Substances 0.000 claims description 14
- 239000000499 gel Substances 0.000 claims description 13
- 239000002270 dispersing agent Substances 0.000 claims description 9
- 239000000606 toothpaste Substances 0.000 claims description 9
- 229940034610 Toothpaste Drugs 0.000 claims description 6
- 230000000903 blocking Effects 0.000 claims description 4
- 159000000008 strontium salts Chemical class 0.000 claims description 4
- 239000002981 blocking agent Substances 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 159000000011 group IA salts Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 2
- 150000001860 citric acid derivatives Chemical class 0.000 claims 2
- 235000011180 diphosphates Nutrition 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- 150000002823 nitrates Chemical class 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 1
- 239000003975 dentin desensitizing agent Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 26
- 239000000551 dentifrice Substances 0.000 description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 239000004615 ingredient Substances 0.000 description 17
- 210000004268 Dentin Anatomy 0.000 description 16
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 14
- 239000012530 fluid Substances 0.000 description 12
- 239000000377 silicon dioxide Substances 0.000 description 12
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 12
- 239000011734 sodium Substances 0.000 description 12
- 229910052708 sodium Inorganic materials 0.000 description 12
- 239000002562 thickening agent Substances 0.000 description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 11
- 239000000243 solution Substances 0.000 description 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 9
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 9
- CVHZOJJKTDOEJC-UHFFFAOYSA-N Saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 9
- 239000008213 purified water Substances 0.000 description 9
- 239000000600 sorbitol Substances 0.000 description 9
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 8
- 230000001603 reducing Effects 0.000 description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 7
- 239000011775 sodium fluoride Substances 0.000 description 7
- 235000013024 sodium fluoride Nutrition 0.000 description 7
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 6
- 206010020751 Hypersensitivity Diseases 0.000 description 6
- 201000005794 allergic hypersensitivity disease Diseases 0.000 description 6
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 6
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 6
- 230000009610 hypersensitivity Effects 0.000 description 6
- 238000006722 reduction reaction Methods 0.000 description 6
- 229960001866 silicon dioxide Drugs 0.000 description 6
- 235000012239 silicon dioxide Nutrition 0.000 description 6
- 210000001772 Blood Platelets Anatomy 0.000 description 5
- 229960004029 Silicic Acid Drugs 0.000 description 5
- XOAAWQZATWQOTB-UHFFFAOYSA-N Taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 150000001768 cations Chemical class 0.000 description 5
- 239000006185 dispersion Substances 0.000 description 5
- HWGNBUXHKFFFIH-UHFFFAOYSA-I pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O HWGNBUXHKFFFIH-UHFFFAOYSA-I 0.000 description 5
- 235000019832 sodium triphosphate Nutrition 0.000 description 5
- 229940104261 taurate Drugs 0.000 description 5
- 239000004408 titanium dioxide Substances 0.000 description 5
- CWSZBVAUYPTXTG-UHFFFAOYSA-N 5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OCCO)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 CWSZBVAUYPTXTG-UHFFFAOYSA-N 0.000 description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 4
- FGIUAXJPYTZDNR-UHFFFAOYSA-N Potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- KARVSHNNUWMXFO-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane;hydrate Chemical compound O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Al]O[Al]=O KARVSHNNUWMXFO-UHFFFAOYSA-N 0.000 description 4
- 238000005755 formation reaction Methods 0.000 description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229910052901 montmorillonite Inorganic materials 0.000 description 4
- 229920001888 polyacrylic acid Polymers 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 239000001103 potassium chloride Substances 0.000 description 4
- 235000011164 potassium chloride Nutrition 0.000 description 4
- ZQBJRVYLUFBBEQ-UHFFFAOYSA-N 2-[diamino(3-formamidopropyl)azaniumyl]acetate Chemical compound [O-]C(=O)C[N+](N)(N)CCCNC=O ZQBJRVYLUFBBEQ-UHFFFAOYSA-N 0.000 description 3
- 229960001631 Carbomer Drugs 0.000 description 3
- TYJJADVDDVDEDZ-UHFFFAOYSA-M Potassium bicarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 3
- 229910052586 apatite Inorganic materials 0.000 description 3
- 230000001680 brushing Effects 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- TWYSBDNLTRUTQT-UHFFFAOYSA-A hexadecapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O TWYSBDNLTRUTQT-UHFFFAOYSA-A 0.000 description 3
- 229910052744 lithium Inorganic materials 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000006072 paste Substances 0.000 description 3
- 239000011736 potassium bicarbonate Substances 0.000 description 3
- 235000015497 potassium bicarbonate Nutrition 0.000 description 3
- 229940094025 potassium bicarbonate Drugs 0.000 description 3
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 3
- 159000000001 potassium salts Chemical class 0.000 description 3
- 230000036912 Bioavailability Effects 0.000 description 2
- 210000001736 Capillaries Anatomy 0.000 description 2
- 210000000887 Face Anatomy 0.000 description 2
- 229960003975 Potassium Drugs 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- AHBGXTDRMVNFER-UHFFFAOYSA-L Strontium chloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 description 2
- 210000001138 Tears Anatomy 0.000 description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000035514 bioavailability Effects 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 201000002170 dentin sensitivity Diseases 0.000 description 2
- 238000000586 desensitisation Methods 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N edta Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 150000004673 fluoride salts Chemical class 0.000 description 2
- 239000003349 gelling agent Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006011 modification reaction Methods 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical class [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 235000010333 potassium nitrate Nutrition 0.000 description 2
- 239000004323 potassium nitrate Substances 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- 230000000717 retained Effects 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 229940013553 strontium chloride Drugs 0.000 description 2
- 229910001631 strontium chloride Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001225 therapeutic Effects 0.000 description 2
- 229960003500 triclosan Drugs 0.000 description 2
- 230000001960 triggered Effects 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2R,3R,4S,5R,6S)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2S,3R,4S,5R,6R)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2R,3R,4S,5R,6R)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- 229960003563 Calcium Carbonate Drugs 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 210000003298 Dental Enamel Anatomy 0.000 description 1
- GYQBBRRVRKFJRG-UHFFFAOYSA-L Disodium pyrophosphate Chemical class [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 229940031574 HYDROXYMETHYL CELLULOSE Drugs 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010022114 Injury Diseases 0.000 description 1
- 229940039371 Karaya Gum Drugs 0.000 description 1
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium Ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 1
- 229960002900 Methylcellulose Drugs 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- XAPRFLSJBSXESP-UHFFFAOYSA-N Oxycinchophen Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=C(O)C=1C1=CC=CC=C1 XAPRFLSJBSXESP-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K Potassium citrate Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J Pyrophosphate Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 210000003296 Saliva Anatomy 0.000 description 1
- 229940083542 Sodium Drugs 0.000 description 1
- 229940005550 Sodium alginate Drugs 0.000 description 1
- 229940091252 Sodium supplements Drugs 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N TiO Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 238000005296 abrasive Methods 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- OLSDWRNWUGHKSY-UHFFFAOYSA-J dicalcium;phosphonato phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O OLSDWRNWUGHKSY-UHFFFAOYSA-J 0.000 description 1
- CQAIPTBBCVQRMD-UHFFFAOYSA-L dipotassium;phosphono phosphate Chemical class [K+].[K+].OP(O)(=O)OP([O-])([O-])=O CQAIPTBBCVQRMD-UHFFFAOYSA-L 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229920000591 gum Polymers 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 description 1
- 230000002209 hydrophobic Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 238000010874 in vitro model Methods 0.000 description 1
- 238000009114 investigational therapy Methods 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000003204 osmotic Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 125000004430 oxygen atoms Chemical group O* 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 235000007686 potassium Nutrition 0.000 description 1
- 229960002816 potassium chloride Drugs 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- 229940093928 potassium nitrate Drugs 0.000 description 1
- -1 potassium salts Chemical class 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N silicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- MSXHSNHNTORCAW-UHFFFAOYSA-M sodium 3,4,5,6-tetrahydroxyoxane-2-carboxylate Chemical compound [Na+].OC1OC(C([O-])=O)C(O)C(O)C1O MSXHSNHNTORCAW-UHFFFAOYSA-M 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- VIFHRXBEKXWJKK-UHFFFAOYSA-M sodium;chloride;hexahydrate Chemical compound O.O.O.O.O.O.[Na+].[Cl-] VIFHRXBEKXWJKK-UHFFFAOYSA-M 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
- 229910001929 titanium oxide Inorganic materials 0.000 description 1
- 239000011791 tripotassium citrate Substances 0.000 description 1
- 235000015870 tripotassium citrate Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N β-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
Abstract
The present invention relates to a method for the treatment of hypersensitive teeth, by treating teeth with an oral composition comprising hectorite clay, especially Laponi clay.
Description
SYSTEM IN DISPERSIBLE PARTICLES TO INSENSIBILATE TEETH
1. Pirmp ß The invention The invention refers to? new desensitizers for hypersensitive teeth, and methods for manufacturing and using these desensitizers.
2. Description of the Related Art The de'ntinal hypersensitivity causes pain in the mouth of a patient when sf exposes a nerve of an affected tooth to certain external stimuli, including temperature and tactile stimuli l A possible source of dental hypersensitivity is that it overexposes the dentin of the affected teeth to stimuli due to an injury, illness, or for some other reason. Dentin generally contains channels, called tubules, that allow the transport of material and energy between the outside of the dentine and the inside of the tooth where the nerve resides. Exposure of these tubules to external stimuli can cause irritation of the nerve in a tooth, leading to discomfort. Although the exact mechanism of hypersensitivity remains under investigation, recent research has shown that pain triggered by air currents is related
with the number of tubules exposed per unit area of dentin (Kontturi-Narhi, Dentin Hypersensitivity - Factors Related to the Occurrence of Pain Symptoms, Kuopio University Publications B. Dental Sciences 5). In accordance with the hydrodynamic theory of dentine sensitivity, the mechanical and thermal stimuli of the dentin surface free from the exposed layer induce minute movements of the intratubular fluid. These fluid movements induce pain that encodes nerve responses in the intradental nerves located near the dentine / pulp boundary. Recent research has reinforced the experimental evidence in support of this relationship (B. Matthews and N. Vongsavan Archs Oral Biol, 39 (Suppl.): 875-955, 1994). Dental hypersensitivity is generally treated either by treating the nerve in the tooth to make it less sensitive to stimuli, or by blocking or obstructing the tubules to prevent or limit the nerve's exposure to external stimuli, and to limit fluid movements triggered by the stimulus in the dentinal tubules. Treatments that directly affect the nerve, usually interfere with the balance of electrolytes near the nerve, to affect the outer membranes of the nerve, so that the nerve does not "turn on" as often or as strongly as a nerve.
nerve not treated. Agents useful in the treatment of dental hypersensitivity in this manner include potassium nitrate, as set forth in U.S. Patent No. 3,863,006 to Hodosh issued on January 28, 1975, potassium chloride, as stipulated in US Pat. U.S. Patent No. 4,751,072, to Kim, issued June 14, 1988, potassium bicarbonate, as set forth in the United States Patent Number 4,631,185 to Kim issued December 23, 1986, and strontium chloride, as set forth in United States Patent No. 3,122,483 to Rosenthal, issued February 25, 1964. Tubule occlusion provides an alternative treatment method. Useful reported agents include polymeric agents such as Carbopol, as set forth in U.S. Patent No. 5,270,031, to Lim et al., Issued December 14, 1993, and certain polystyrene granules, as set forth in U.S. Patent No. 5,211,939 to Turesky et al., Issued May 18, 1993. Apatite may also be an agent against hypersensitivity. U.S. Patent Number 4,634,589 to Scheller, issued on 6
January 1987, and the Patent of the United States of America Number 4, 710,372, issued Io. December 1987, also by Scheller, disclose dentifrices for hypersensitive teeth, which contain apatite having an average particle size of less than 10 microns, and optionally a local anesthetic. Other soluble mineral salts are not permitted to exert an interference effect in these patents. Apatite reduces the diameter of the dentin channels. It has also been reported that montmorillonite clay as an insensitizing agent in United States Patent Number 4,992,258 to Mason, issued on February 12, 1991. Unfortunately, montmorillonite clay is not compatible with most of the agents of known fluoride, and therefore, has limited use. In addition, montmorillonite clay loses its ability to thicken a dentifrice, and has a reduced ability to block tubules in the presence of inorganic salts, such as potassium salts, so its use as a desensitizer is limited. Other types of clays have been used in dental applications, although not in an insensitizing capacity. With the advent of transparent gel toothpastes, hectorite clays have been used,
especially Laponite clays, as thickeners for dentifrices, for example as reported in United States Patent Number 4,069,310 by Harrison, and in Mayes, B., "Synthetic Hectorite - A New Toothpaste Binder", International Journal of Cosmetic Science, 1, 329-340 (1979). Although in thickeners thickeners and binders are usually found at about 1 weight percent, the Harrison patent indicates that the thickener may be present in amounts up to 5 weight percent. Actually, the Mason patent discussed above, indicates that the laponite may be one of a number of thickeners used in the toothpaste, despite its teaching of montmorillonite clay as an insensitizer. The Patent of the United States of North America
No. 4,474,750 to Gaffar et al., Issued October 2, 1984, discloses toothpaste, cream, or gel, wherein the thickening agent may be CP or SP laponite, in an amount up to about 10 percent by weight. weight. There is no description in the patent that Laponite is incorporated into an oral composition for the purpose of treating hypersensitive teeth. U.S. Patent No. 4,081,526 to Asakawa et al., Issued March 28, 1978, discloses dentifrice compositions that
they comprise from 0.5 to 13 percent of a hectorite clay, such as Laponite, to remove the plaque from the teeth. In spite of the continuous work in the field of desensitizers, there remains in the art a strong felt need for a long time, of an effective tubular blocking agent which is compatible with fluorides and other conventional dentifrice ingredients. This agent should work well although it should not be of an unpleasant taste to be used. It must be stable for the shelf life typical of a toothpaste, and must be affordable.
SUMMARY OF THE INVENTION The main object of the present invention, therefore, is to provide an effective tubular blocking agent, which is compatible with fluorides and other conventional tooth ingredients, and which is also organoleptically acceptable. The additional objects and advantages of the invention will be stipulated in part in the following description, and in parts will be obvious from this description, or can be learned by practicing the invention. The objects and advantages of the invention can be realized and obtained by means of the instrumentalities and combinations particularly indicated in the
attached claims. In order to achieve the above objects and in accordance with the purpose of the invention, as incorporated herein and amply described, the invention provides an insensitizing agent for hypersensitive teeth, which comprises a hectorite clay, such as Laponite clay. To further achieve the above objects, and in accordance with the purpose of the invention, the invention further provides a method for the treatment of hypersensitive teeth, by contacting the teeth with an insensitizing formulation comprising a therapeutic amount of a hectorite clay. , such as Laponite clay.
DESCRIPTION OF THE PREFERRED MODALITIES Reference will now be made in detail to the presently preferred embodiments of the invention. The invention comprises a composition for the treatment of hypersensitive teeth, such as a dentifrice (either a paste or a gel) or another appropriate oral vehicle. The composition comprises a hectorite clay in an amount and in a formulation sufficient to desensitize the teeth. Preferred hectorite clays include Laponite clays and are preferred
especially treated hectorite clays, termed "synthetic" such as LAPONITE DR and LAPONITE DFR, both sold by Southern Clay Products Inc. These clays have been treated to make them suitable for dental purposes (as thickeners for clear gel dentifrices), and the LAPONITA DFR has been treated by adding fluorine to the clay to prevent the absorption of fluoride from dentifrice formulations. The additional preferred Laponite clays sold under the trade name LAP0NITAR are products of Laporte
Industries Inc. Laponites are synthetic hectorite clays composed of magnesium, lithium, silica, oxygen, hydrogen, and sodium. Like other clays, the Laponites are composed in the dry state of platelets configured in piles. Each plate has a double layer of tetrahedral silica bonded with oxygen atoms. Between the two layers of silica, there is a sheet of cations composed of magnesium and lithium in a ratio of 5.3 to 0.7. These cations coordinate the internal row of oxygens bonded with silica and OH groups. The partial replacement of Magnesium (+2) with Lithium (+1) imparts a global negative charge to the silica surface. The presence of incompletely complexed cations, which are part of the central layer (Mg, Li), imparts a positive charge on the
edges of the plate. Between the individual stacked platelets there are interchangeable cations such as sodium. When a Laponite clay is properly dispersed in water, these interchangeable cations direct the water into the spaces between the platelets by means of the osmotic forces. This inward flow in water volume forces the platelets to separate. When the Laponite clay is properly dispersed in water in the presence of low levels of electrolytes, the anionic silica faces and the cationic edges can be electrostatically attracted to each other. This leads to the formation of what is known as a house of cards structure. Tear tensions can easily alter this house of cards structure. This formation and alteration of the structure by means of tear stress, means that the Laponite clay dispersions have remarkable thixotropic properties that make them attractive as thickeners, especially for transparent gel dentifrices. However, it is important and unexpected, that the concentrations and chemical environmental conditions that favor the formation of structured gel with dispersions of Laponite clay, do not necessarily favor the effectiveness of desensitization. The
Compositions in which Laponite clays are dispersed to prevent or hinder the formation of the gel structure, demonstrate superior performance in the ability to desensitize, as measured by tubule blocking experiments. These compositions typically use higher amounts of clay than those found with compositions that exhibit ideal gel structures. In addition, inorganic dispersants and organic polymeric dispersants improve the desensitization performance of Laponite clay. Laponite clay-containing compositions with these added dispersants have superior efficacy, exhibit pleasing organoleptic characteristics, and are compatible with fluoride and most other tooth ingredients. Lappishite clays treated with fluoride are preferred for their ability to coexist with fluoride in a dentifrice. Dentifrices and mixtures containing fluoride sources and hectorite clays or laponite clays treated with fluoride were examined for the bioavailability of fluoride, and toothpastes containing untreated hectorite clays reduced the availability of sodium fluoride, whereas Clay dentifrices of Fluoride-treated Laponite retained the bioavailability of total fluoride.
Preferably, the dentifrice formulation is in the form of a paste or a gel, comprising about 0.1 weight percent to about 25 weight percent clay. More preferably, the clay comprises from about 1 percent clay to about 20 weight percent of the clay, and more preferably from about 2 percent to about 15 percent. Clay can also be incorporated into other formulations for oral care, such as mouth rinses, as well as tooth formulations. The effectiveness for reducing the flow of the clay can be improved in a surprising manner by the addition of dispersants such as salts, thickeners, or other additives. Preferred salts include: potassium salts, strontium salts (especially preferred salts include insensitizing salts, such as potassium nitrate, potassium chloride, potassium bicarbonate, and strontium chloride), and pyrophosphate salts, especially tetrapyrophosphate salts of potassium and sodium, and potassium and sodium acid pyrophosphate salts. Preferred thickeners include polymeric thickeners, and cellulosic thickeners are especially preferred, including ionically modified cellulosic polymers, such as sodium carboxymethylcellulose, a
product of Aqualon, and a cationically modified cellulosic polymer known as CELQUATR, a product of the National Starch and Chemical Company. When tested by itself, the CELQUATR polymer induced inconsistent reductions in dentin fluid induced by the polymer, measured using the technique stipulated in the examples. In contrast, when tested as part of a prototype dentifrice containing a hectorite clay, consistently high flow reductions were observed. Although the inventors do not wish to be bound by any theory, it appears that the hectorite clays, especially the Laponite clays, comprise a plurality of individual mineral platelets having positively charged shores and negatively charged flat faces. It appears that the modified cationically charged cellulose and other positively charged entities can interact with the anionic face of the clay, resulting in better dispersion of the clay, which leads to an appropriate particle size to penetrate the dentine tubules, and a modification of the electrochemical characteristics of the particle that results in a better electrostatic adhesion of the clay to the wall of the tubule. The aspects of clay chemistry are discussed in more detail in the article
Mayes mentioned above, and in U.S. Patent Number 4,621,070 to Pinnavaia et al., Issued November 4, 1986. Oral rinses utilizing the clay may be in the form of oral solutions or dispersions. Oral rinses may contain flavors, colorants, and other conventional additives that have an organoleptic or therapeutic efficacy. Toothpastes made using hectorite clay will normally be water based, and will contain a humectant, such as glycerin, sorbitol or other sugar alcohol, propylene glycol, or polyethylene glycol. The toothpaste can be a paste or a gel. The gelling agent may be a carboxymethylcellulose, hydroxyethylcellulose, or alkali metal hydroxymethylcellulose, xanthan gum, viscarine, iota-carrageenan, gelatin, starch, glucose, sucrose, polyvinylpyrrolidone, polyvinyl alcohol, tragacanth gum, karaya gum, hydroxypropylcellulose, methylcellulose , and sodium alginate, and magnesium aluminum silicate gel. Preferred are agents that are compatible with fluoride. Additional agents useful in a dentifrice are polishing agents, such as precipitated silica, hydrated silica, and other known abrasive polishing agents, fluoride, detergents, coloring or bleaching agents.
such as titanium dioxide, fragrances and flavorings. Additional therapeutic agents can also be added, such as tartar control agents, antibacterial agents such as Triclosan or chlorhexadine. A dentifrice according to the invention can be made by mixing the ingredients in any conventional manner, for example, by creating a gel with the water and the gelling agent, and then adding the water-soluble ingredients. Finally, a surfactant is added, and then the hydrophobic ingredients are added. The mixture is then packaged in a conventional dentifrice container, such as a tube, and applied to the surface of the teeth through conventional brushing, coating, painting, or other direct or indirect application technique. The benefits of the invention will be demonstrated in the following examples.
E.TEMPfrQS
Test Procedures Dispersions of hectorite clays in water were tested with different ingredients and prototype dentifrices containing hectorite clays, using an in vitro model of sensitivity of the dentin first described
by Pashley (J. Periodontology, Vol. 55, No. 9, page 522, September 1984). Patent of the United States of America Number 5, 270,031 of Lim et al., Issued on December 14, 1993, also describes this methodology. In this method, intact human molars free of caries or restorations, perpendicular to the long axis of the tooth, are sectioned with a metallurgical saw, in thin sections of approximately 0.4 to 0.6 millimeters thick. The sections containing dentin and are free of enamel, are retained for testing. Then these sections are recorded with a solution of EDTA (ethylenediaminetetraacetic acid), to remove the covered layer. The disc is mounted on a divided chamber device as reported in J. Dent. Research, 57: 187 (1978). This special leak test chamber is connected to a pressurized fluid reservoir containing a tissue culture fluid. By using a mixture of pressurized N2 and CO2 gas, the fluid can be maintained at a physiological pH. To further ensure accuracy, the discs are moistened with human saliva to approximately the intraoral condition. The apparatus includes a glass capillary tube mounted on a ruler or other measuring instrument. An air bubble is injected into the glass capillary tube. By measuring the
Displacement of this bubble as a function of time, fluid flow through the dentine disc can be measured. (It has been reported that the fluid 'actually flows out of the dentine tubules from inside a normal human tooth). Following the measurement of the baseline fluid flow in the dentin disc, the experimental mixture or dentifrice is applied to the outer surface of the disc with a nylon brush. After a defined brushing period, the experimental material is rinsed, and the hydraulic conductance is measured after application. In this way, the ability of different experimental materials, both alone and in components of dentifrice systems, can be tested for their ability to obstruct the flow of fluid in the dentinal tubules. Then the percentage of flow reduction induced by brushing can be calculated with the experimental materials.
Examples 1-5 Combinations of clays were prepared
Laponite with water and other specified ingredients, and were tested by reducing the flow using the method stipulated above. Each combination had the composition stipulated in Table 1, and had the flow reduction shown in Table 1. The examples show the
good ability to reduce dentin fluid flow of hectorite clays, especially when the clay is associated with a dispersant, such as a polymeric dispersant or salts.
Table 1 Percentage of flow reduction with laponifrag combination of water
Examples 6-13 The following dentifrice formulations were prepared in the following manner. In a suitable mixer, equipped with a vacuum system, such as a whip mixer for the laboratory scale, or a Koruma mixer for larger batches (pilot plant), the required amount of purified water is added. Key ingredients are added, such as sodium fluoride (or sodium MFP), potassium tetrapyrrophosphate, sodium triphosphate, potassium or strontium salts, as appropriate, to the mixer, followed by sodium saccharin, silicon dioxide , and LAPONITA DF. The above volume is mixed for approximately 10 to 30 minutes (under vacuum), followed by the addition of abrasives, gum premix (humectants and gums), flavoring, and detergents. A final mixture of 20 to 30 minutes is conducted under vacuum to deaerate the product.
Example 6 Ingredient Percentage in Weight
Laponita DF 5.0
Sodium fluoride 0.24
Sorbitol solution 20.0
Glycerin 20.0 Silicon dioxide 1.0
Amorphous silica 10.0
Carboxymethylcellulose 1.5
Carbomer 0.1
Sodium saccharin 0.3
Titanium dioxide 0.5
Cocoamidopropylbetaine 5.0
Sodium triphosphate, anhydrous 1.0
Flavoring 1.5 C.S purified water up to 100.0
Example 7 Ingredient Percentage in Weight
Laponita DF 8.0
Sodium Fluoride 0.32 Potassium Chloride 4.0
Hydrated silica 10.0
Hydroxyethylcellulose 1.5
Sodium saccharin 0.3
Sodium Lauryl Sulfate 1.5 Triclosan 0.3
Sorbitol solution 40.0
Flavoring 1.3 Purified water C.S up to 100.0
Example 8 Ingredient Percentage in Weight
Laponita DF 6.0
Sodium MFP 0.8
Silicon dioxide 2.0
Calcium diphosphate dihydrate 30.0
Carboxymethylcellulose 1.0
Sodium saccharin 0.25
Titanium dioxide 0.5
Cocoamidopropylbetaine 7.0
Sodium cocometyl acid taurate 0.75
Sodium triphosphate, anhydrous 1.0
Sorbitol solution 10.0
Glycerin 25.0
Flavoring 1.2
C.S purified water up to 100.0
Example 9 Ingredient Percentage j in Weight Laponite DF 7. .5 Sodium MFP 0. .8 Silicon dioxide 1. .0 Calcium carbonate 15. .0 Carboxymethylcellulose 1. .0 Carbomer 0, .1
Sodium saccharine 0.3 Titanium dioxide 0.5 Sodium lauryl sulfate 1.5 Sodium diprophophosphate 0.3 Sorbitol solution 30.0 Glycerin 10.0 Flavor 1.3 Purified water C.S. up to 100.0
Example 10 Ingredient Percentage in Weight
Laponita DF 5.0
Potassium Chloride 3.75
Sodium fluoride 0.24 Silicon dioxide 1.5
Amorphous silica 10.0
Carboxymethylcellulose 2.0
Carbomer 0.1
Sodium saccharine 0.35 Titanium oxide 0.5
Cocoamidopropylbetaine 6.0
Sodium cocometyl acid taurate 0.5
Potassium Tetrapyrophosphate 3.0
Triclosano 0.3 Flavor 1.3
Sorbitol solution 40 .0 Purified water C.S. up to 100.0
Example 11 Ingredient Percentage in Weight
Laponita DF 5.0
Sodium fluoride 0.243
Potassium Tetrapyrophosphate 3.0
Potassium citrate 5.0 Hydrated silica 12.0
Hydroxyethylcellulose 1.4
Sodium saccharin 0.3
Sodium cocometyl acid taurate 1.5
Sodium triphosphate, anhydrous 0.5 Sorbitol solution 12.0
Glycerin 12.0
Flavoring 1.2
Purified water C.S.up to 100.0
Example 12 Ingredient Weight Percentage
Laponite DF 5.0 Sodium Fluoride 0.243 Potassium Tetrapyrophosphate 3.0 Potassium Bicarbonate 3.0
Hydrated silica 12.0
Hydroxyethylcellulose 1.4
Sodium saccharin 0.3
Sodium cocometyl acid taurate 1.5
Sodium triphosphate, anhydrous 0.5
Sorbitol solution 12.0
Glycerin 12.0
Flavoring 1.2
Purified water C.S. up to 100.0
Example 13 Ingredient Weight Percentage
Laponita DF 6.0
Sodium chloride hexahydrate 10.0
Silicon dioxide 1.0
Hydrated silica 12.0
Sodium saccharin 0.3
Titanium dioxide 1.0
Carboxymethylcellulose 1.5
Sodium cocometic acid taurate 1.2
Sorbitol solution 12.0
Glycerin 12.0
Flavoring 1.2
Purified water C.S. up to 100.0
Several of the dentifrice formulations described above were tested for their ability to reduce dentin fluid flow. The results of this test are stipulated in Table 2.
Table 2 Percentage of Flow Reduction for Selected Dentifrices
The purpose of the foregoing description is to illustrate some embodiments of the present invention without implying a limitation. It will be apparent to those skilled in the art that various modifications and variations may be made in the apparatus or method of the invention, without departing from the scope or spirit of the invention.
Claims (16)
1. In a composition for the treatment of hypersensitive teeth, comprising an effective desensitizing amount of an insensitizing agent and a carrier therefor, the improvement comprising the desensitizing agent which is hectorite clay.
2. The composition according to claim 1, characterized in that the clay is Laponite clay.
3. The composition according to claim 2, characterized in that the clay contains fluoride.
4. The composition according to claim 1, which further comprises a dispersant.
5. The composition according to claim 4, characterized in that the dispersant is a salt.
6. The composition according to claim 5, characterized in that the salt is an alkaline salt.
The composition according to claim 4, characterized in that the salt is selected from the group consisting of alkaline salts of pyrophosphates, nitrates, halides, citrates, carbonates, bicarbonates, and strontium salts and mixtures thereof. same.
8. The composition according to claim 4, characterized in that the dispersant is a cellulosic compound.
9. The composition according to claim 8, characterized in that the cellulosic compound is cationically modified.
10. The composition according to claim 9, characterized in that the cellulosic compound comprises a cationically modified cellulose.
11. The composition as claimed in claim 10, which further comprises a salt.
12. The composition according to claim 11, characterized in that the salt is an alkaline salt.
13. The composition according to claim 12, characterized in that the salt is selected from the group consisting of alkaline salts of pyrophosphates, nitrates, halides, citrates, carbonates, bicarbonates, and strontium salts and mixtures thereof.
14. A method for the treatment of a hypersensitive tooth, which comprises administering to this tooth a therapeutically effective amount of the composition according to claim 1.
15. A method for the treatment of a hypersensitive tooth, which comprises administering to the tooth a therapeutically effective amount of the composition as claimed in claim 4.
16. In the method for blocking, occluding, or sealing dentinal tubules in hypersensitive teeth, the improvement essentially consists of the step of blocking the hypersensitive tooth tubules with fluoride oral ointments or fluoride toothpaste or gels containing Laponite or fluoride-treated hectorite clay as the essential blocking agent of dentinal tubules of hypersensitive teeth.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US08419816 | 1995-04-11 | ||
PCT/US1996/004852 WO1996032090A1 (en) | 1995-04-11 | 1996-04-10 | Dispersible particulate system for desensitizing teeth |
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MXPA97007819A true MXPA97007819A (en) | 1998-01-01 |
MX9707819A MX9707819A (en) | 1998-01-31 |
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MX9707819A MX9707819A (en) | 1996-04-10 | 1996-04-10 | Dispersible particulate system for desensitizing teeth. |
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