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MX9707732A - Compuestos triciclicos utiles en el tratamiento de desordenes proliferativos de celulas. - Google Patents

Compuestos triciclicos utiles en el tratamiento de desordenes proliferativos de celulas.

Info

Publication number
MX9707732A
MX9707732A MX9707732A MX9707732A MX9707732A MX 9707732 A MX9707732 A MX 9707732A MX 9707732 A MX9707732 A MX 9707732A MX 9707732 A MX9707732 A MX 9707732A MX 9707732 A MX9707732 A MX 9707732A
Authority
MX
Mexico
Prior art keywords
treatment
compounds useful
cell proliferative
proliferative disorders
tricyclic compounds
Prior art date
Application number
MX9707732A
Other languages
English (en)
Inventor
Ronald J Doll
Alan K Mallams
Adriano Afonso
Dinanath F Rane
F George Njoroge
Randall R Rossman
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX9707732A publication Critical patent/MX9707732A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Se describen compuestos novedosos de la formula (1.0). También de describe un método para inhibir la funcion Ras y por lo tanto inhibir el crecimiento anormal de células. El método comprende administrar un compuesto de la formula a un sistema biologico. En particular, el método inhibe el crecimiento anormal de células en un mamífero tal como si fuera un humano.
MX9707732A 1995-04-07 1996-04-03 Compuestos triciclicos utiles en el tratamiento de desordenes proliferativos de celulas. MX9707732A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41898295A 1995-04-07 1995-04-07
PCT/US1996/004168 WO1996031111A1 (en) 1995-04-07 1996-04-03 Tricyclic compounds useful in the treatment of cell proliferative disorders

Publications (1)

Publication Number Publication Date
MX9707732A true MX9707732A (es) 1997-12-31

Family

ID=23660318

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9707732A MX9707732A (es) 1995-04-07 1996-04-03 Compuestos triciclicos utiles en el tratamiento de desordenes proliferativos de celulas.

Country Status (11)

Country Link
US (1) US5891872A (es)
EP (1) EP0819128B1 (es)
JP (1) JPH11503157A (es)
AT (1) ATE220400T1 (es)
AU (1) AU5432596A (es)
CA (1) CA2217680A1 (es)
DE (1) DE69622265T2 (es)
ES (1) ES2175087T3 (es)
IL (1) IL117782A0 (es)
MX (1) MX9707732A (es)
WO (1) WO1996031111A1 (es)

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JP6280554B2 (ja) 2012-09-28 2018-02-14 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｅｒｋ阻害剤である新規化合物
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Also Published As

Publication number Publication date
IL117782A0 (en) 1996-08-04
JPH11503157A (ja) 1999-03-23
ATE220400T1 (de) 2002-07-15
AU5432596A (en) 1996-10-23
US5891872A (en) 1999-04-06
DE69622265T2 (de) 2003-03-20
CA2217680A1 (en) 1996-10-10
ES2175087T3 (es) 2002-11-16
WO1996031111A1 (en) 1996-10-10
EP0819128A1 (en) 1998-01-21
EP0819128B1 (en) 2002-07-10
DE69622265D1 (de) 2002-08-14

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees